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Cell Competition and Its Possible Relation to Cancer

Department of Molecular Genetics, Albet Einstein College of Medicine, Bronx, New York

Requests for reprints: Nicholas E. Baker, Department of Molecular Genetics, Albet Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461. Phone: 718-430-2854; Fax: 718-430-8778; E-mail: nbaker{at}aecom.yu.edu.

Key Words: cell competition • myc • warts

Cell competition can occur when cells of different genotypes share the same developing compartment, with one genotype displacing the other as a result of a proliferative advantage. Studies of cell competition in Drosophila have identified an active process of cell assassination and corpse engulfment, and also roles for Myc and the Warts/Hippo tumor suppressor pathway. Here, we discuss the possible relevance of cell competition to cancer. [Cancer Res 2008;68(14):5505–7]