Advances in Brief:

Human B-Cell Immune Response to the Polymorphic Epithelial Mucin

Aurelia Rughetti, Valeria Turchi, Cinzia Apollonj Ghetti, Giovanni Scambia, Pierluigi Benedetti Panici, Gabrio Roncucci, Salvatore Mancuso, Luigi Frati, and Marianna Nuti
Cancer Res 1993 53: 2457-2459. [Abstract] [PDF]  

Elevated Expression of the Human Mitochondrial Hinge Protein Gene in Cancer

Alvin Y. Liu and Ragen C. Bradner
Cancer Res 1993 53: 2460-2465. [Abstract] [PDF]  

Effect of Angiotensin II Induced Hypertension on Tumor Blood Flow and Interstitial Fluid Pressure

Robert A. Zlotecki, Yves Boucher, Intae Lee, Laurence T. Baxter, and Rakesh K. Jain
Cancer Res 1993 53: 2466-2468. [Abstract] [PDF]  

Specific Tyrosinases Associated with Melanoma Replicative Senescence and Melanogenesis

Mary Strasberg Rieber and Manuel Rieber
Cancer Res 1993 53: 2469-2471. [Abstract] [PDF]  

Detection of ras Gene Mutations in Pancreatic Juice and Peripheral Blood of Patients with Pancreatic Adenocarcinoma

Minoru Tada, Masao Omata, Shigenobu Kawai, Hiromitsu Saisho, Masao Ohto, Randall K. Saiki, and John J. Sninsky
Cancer Res 1993 53: 2472-2474. [Abstract] [PDF]  

Characterization of Insulin-like Growth Factor 1 in Human Primary Brain Tumors

Ann-Christin Sandberg-Nordqvist, Pär-Axel Ståhlbom, Manfred Reinecke, V. Peter Collins, Hans von Holst, and Vicki Sara
Cancer Res 1993 53: 2475-2478. [Abstract] [PDF]  

Expression of the Biochemical Defect of Methionine Dependence in Fresh Patient Tumors in Primary Histoculture

Hui-Yan Guo, Hector Herrera, Ami Groce, and Robert M. Hoffman
Cancer Res 1993 53: 2479-2483. [Abstract] [PDF]  

Biochemistry and Biophysics:

Involvement of Protein Kinase C in the Regulation of Glycolipid Sulfotransferase Activity Levels in Renal Cell Carcinoma Cells

Takahiko Kobayashi, Koichi Honke, Shinsei Gasa, Makoto Sugiura, Tamotsu Miyazaki, Ineo Ishizuka, and Akira Makita
Cancer Res 1993 53: 2484-2489. [Abstract] [PDF]  

Cyclophosphamide Modulates Rat Hepatic Cytochrome P450 2C11 and Steroid 5-Reductase Activity and Messenger RNA Levels through the Combined Action of Acrolein and Phosphoramide Mustard

Thomas K. H. Chang and David J. Waxman
Cancer Res 1993 53: 2490-2497. [Abstract] [PDF]  

Carcinogenesis:

Transplacental Induction of Pancreas Tumors in Hamsters by Ethanol and the Tobacco-specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

Hildegard M. Schüller, Rossanna Jorquera, Arthur Reichert, and Andre Castonguay
Cancer Res 1993 53: 2498-2501. [Abstract] [PDF]  

Chemopreventive Effect of Oltipraz during Different Stages of Experimental Colon Carcinogenesis Induced by Azoxymethane in Male F344 Rats

Chinthalapally V. Rao, Abraham Rivenson, Manish Katiwalla, Gary J. Kelloff, and Bandaru S. Reddy
Cancer Res 1993 53: 2502-2506. [Abstract] [PDF]  

Nonpromoting 12-Deoxyphorbol 13-Esters Inhibit Phorbol 12-Myristate 13-Acetate Induced Tumor Promotion in CD-1 Mouse Skin

Zoltan Szallasi, Ljubica Krsmanovic, and Peter M. Blumberg
Cancer Res 1993 53: 2507-2512. [Abstract] [PDF]  

Clinical Investigations:

High Levels of Urokinase-type Plasminogen Activator and Its Inhibitor PAI-1 in Cytosolic Extracts of Breast Carcinomas Are Associated with Poor Prognosis

Jan Grøndahl-Hansen, Ib Jarle Christensen, Christian Rosenquist, Nils Brünner, Henning T. Mouridsen, Keld Danø, and Mogens Blichert-Toft
Cancer Res 1993 53: 2513-2521. [Abstract] [PDF]  

Endocrinology:

Effects of Insulin-like Growth Factor Receptor Inhibition on Human Melanomas in Culture and in Athymic Mice

Richard W. Furlanetto, Shari E. Harwell, and Raymond B. Baggs
Cancer Res 1993 53: 2522-2526. [Abstract] [PDF]  

Inhibition of Epidermal Growth Factor-like Growth Factor Secretion in Tracheobronchial Epithelial Cells by Vitamin A

Lisa A. Miller, Ling Zhong Cheng, and Reen Wu
Cancer Res 1993 53: 2527-2533. [Abstract] [PDF]  

Antitumor Effect of 22-Oxa-calcitriol, a Noncalcemic Analogue of Calcitriol, in Athymic Mice Implanted with Human Breast Carcinoma and Its Synergism with Tamoxifen

Junko Abe-Hashimoto, Tomoko Kikuchi, Toshio Matsumoto, Yasuho Nishii, Etsuro Ogata, and Kyoji Ikeda
Cancer Res 1993 53: 2534-2537. [Abstract] [PDF]  

Experimental Therapeutics:

Molecular Cloning and Characterization of the Complementary DNA for the M_r 85,000 Protein Overexpressed in Adriamycin-resistant Human Tumor Cells

Yoshikazu Sugimoto, Hirofumi Hamada, Satomi Tsukahara, Kohji Noguchi, Kazuo Yamaguchi, Moriyuki Sato, and Takashi Tsuruo
Cancer Res 1993 53: 2538-2543. [Abstract] [PDF]  

Thaliblastine, a Plant Alkaloid, Circumvents Multidrug Resistance by Direct Binding to P-Glycoprotein

Guan Chen, Cheppail Ramachandran, and Awtar Krishan
Cancer Res 1993 53: 2544-2547. [Abstract] [PDF]  

Effect of Photodynamic Therapy on the Endothelium-dependent Relaxation of Isolated Rat Aortas

Miriam J. Gilissen, L. Elly A. van de Merbel-de Wit, Willem M. Star, Johan F. Koster, and Wim Sluiter
Cancer Res 1993 53: 2548-2552. [Abstract] [PDF]  

Inhibition of Urokinase by 4-substituted Benzo[b]thiophene-2-carboxamidines: An Important New Class of Selective Synthetic Urokinase Inhibitor

Murray J. Towle, Arthur Lee, Emmanuel C. Maduakor, C. Eric Schwartz, Alexander J. Bridges, and Bruce A. Littlefield
Cancer Res 1993 53: 2553-2559. [Abstract] [PDF]  

Monoclonal Antibody Homodimers: Enhanced Antitumor Activity in Nude Mice

Edith A. Wolff, George J. Schreiber, Wesley L. Cosand, and Howard V. Raff
Cancer Res 1993 53: 2560-2565. [Abstract] [PDF]  

Inhibitory Effect of Angiogenesis Inhibitor TNP-470 on Tumor Growth and Metastasis of Human Cell Lines in Vitro and in Vivo

Toru Yanase, Masaki Tamura, Kazuyuki Fujita, Shoji Kodama, and Kenichi Tanaka
Cancer Res 1993 53: 2566-2570. [Abstract] [PDF]  

Phototoxicity, Redox Behavior, and Pharmacokinetics of Benzophenoxazine Analogues in EMT-6 Murine Sarcoma Cells

Louis Cincotta, James W. Foley, and Anthony H. Cincotta
Cancer Res 1993 53: 2571-2580. [Abstract] [PDF]  

Preclinical Antitumor Evaluation of Bis-acetato-ammine-dichloro-cyclohexylamine Platinum(IV): an Orally Active Platinum Drug

Lloyd R. Kelland, George Abel, Mark J. McKeage, Mervyn Jones, Phyllis M. Goddard, Melanie Valenti, Barry A. Murrer, and Kenneth R. Harrap
Cancer Res 1993 53: 2581-2586. [Abstract] [PDF]  

Pharmacokinetics of Piroxantrone in a Phase I Trial of Piroxantrone and Granulocyte-Colony Stimulating Factor

Stacey L. Berg, Diane M. F. Savarese, Frank M. Balis, Andrea M. Denicoff, Marianne Hillig, Joyce A. O'Shaughnessy, David G. Poplack, and Kenneth H. Cowan
Cancer Res 1993 53: 2587-2590. [Abstract] [PDF]  

Overcoming Tumor Necrosis Factor and Drug Resistance of Human Tumor Cell Lines by Combination Treatment with Anti-Fas Antibody and Drugs or Toxins

Hideki Morimoto, Shin Yonehara, and Benjamin Bonavida
Cancer Res 1993 53: 2591-2596. [Abstract] [PDF]  

Human Interleukin 2 Analogues That Preferentially Bind the Intermediate-Affinity Interleukin 2 Receptor Lead to Reduced Secondary Cytokine Secretion: Implications for the Use of These Interleukin 2 Analogues in Cancer Immunotherapy

Keith M. Heaton, Grace Ju, and Elizabeth A. Grimm
Cancer Res 1993 53: 2597-2602. [Abstract] [PDF]  

Cytokine Regulation of Human Monocyte Differentiation in Vitro: The Tumor-Cytotoxic Phenotype Induced by Macrophage Colony-stimulating Factor Is Developmentally Regulated by -Interferon

David H. Munn and Elissa Armstrong
Cancer Res 1993 53: 2603-2613. [Abstract] [PDF]  

Base Transitions Are the Most Frequent Genetic Changes at P53 in Gastric Cancer

Beatrice Renault, Marianne van den Broek, Riccardo Fodde, Juul Wijnen, Natalia S. Pellegata, Dino Amadori, P. Meera Khan, and Guglielmina N. Ranzani
Cancer Res 1993 53: 2614-2617. [Abstract] [PDF]  

Transformation of NIH/3T3 Cells by Ornithine Decarboxylase Overexpression

Jeffrey A. Moshier, Julie Dosescu, Magdalena Skunca, and Gordon D. Luk
Cancer Res 1993 53: 2618-2622. [Abstract] [PDF]  

Sensitization of Tumor Cells to Tumor Necrosis Factor Action by the Protein Kinase Inhibitor Staurosporine

Rudi Beyaert, Bart Vanhaesebroeck, Karen Heyninck, Elke Boone, Dirk De Valck, Klaus Schulze-Osthoff, Guy Haegeman, Frans Van Roy, and Walter Fiers
Cancer Res 1993 53: 2623-2630. [Abstract] [PDF]  

Pathogenesis of Malignant Ascites Formation: Initiating Events That Lead to Fluid Accumulation

Janice A. Nagy, Kemp T. Herzberg, Jane M. Dvorak, and Harold F. Dvorak
Cancer Res 1993 53: 2631-2643. [Abstract] [PDF]  

Culture of Normal and Malignant Primary Human Mammary Epithelial Cells in a Physiological Manner Simulates in Vivo Growth Patterns and Allows Discrimination of Cell Type

Lynn M. Bergstraesser and Sigmund A. Weitzman
Cancer Res 1993 53: 2644-2654. [Abstract] [PDF]  

Elevated High Mobility Group-I(Y) Gene Expression Is Associated with Progressive Transformation of Mouse Mammary Epithelial Cells

Tracy G. Ram, Raymond Reeves, and Howard L. Hosick
Cancer Res 1993 53: 2655-2660. [Abstract] [PDF]  

Laminin Regulates a Tumor Cell Chemotaxis Receptor through the Laminin-binding Integrin Subunit ₆

Christine H. Blood and Bruce R. Zetter
Cancer Res 1993 53: 2661-2666. [Abstract] [PDF]  

Galaptin-mediated Adhesion of Human Ovarian Carcinoma A121 Cells and Detection of Cellular Galaptin-binding Glycoproteins

David M. Skrincosky, Howard J. Allen, and Ralph J. Bernacki
Cancer Res 1993 53: 2667-2675. [Abstract] [PDF]  

Nitric Oxide Mediates Kupffer Cell-induced Reduction of Mitochondrial Energization in Hepatoma Cells: A Comparison with Oxidative Burst

Iwao Kurose, Soichiro Miura, Dai Fukumura, Yoshikazu Yonei, Hidetsugu Saito, Shinichiro Tada, Makoto Suematsu, and Masaharu Tsuchiya
Cancer Res 1993 53: 2676-2682. [Abstract] [PDF]  

Meeting Report:

Second International Symposium on Cytostatic Drug Resistance

Manfred Dietel
Cancer Res 1993 53: 2683-2688. [PDF]  

International Symposium on Polyamines in Cancer: Critical Role of Polyamines in Cancer: Basic Mechanisms and Clinical Approaches

Kenji Nishioka
Cancer Res 1993 53: 2689-2692. [PDF]  

Articles:

Announcements

Cancer Res 1993 53: 2693-2694. [PDF]  

Recent Deaths

Cancer Res 1993 53: 2694 [PDF]  

Calendar of Events

Cancer Res 1993 53: 2694-2695. [PDF]  

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