Advances in Brief:

Inducible Nitric Oxide Synthase (iNOS) Is Expressed Similarly in Multiple Aberrant Crypt Foci and Colorectal Tumors from the Same Patients

Xing Pei Hao, Thomas G. Pretlow, J. Sunil Rao, and Theresa P. Pretlow
Cancer Res 2001 61: 419-422. [Abstract] [Full Text] [PDF]  

Altered Expression of Androgen Receptor in the Malignant Epithelium and Adjacent Stroma Is Associated with Early Relapse in Prostate Cancer

Susan M. Henshall, David I. Quinn, C. Soon Lee, Darren R. Head, David Golovsky, Phillip C. Brenner, Warick Delprado, Phillip D. Stricker, John J. Grygiel, and Robert L. Sutherland
Cancer Res 2001 61: 423-427. [Abstract] [Full Text] [PDF]  

Persistent Genetic Instability in Cancer Cells Induced by Non-DNA-damaging Stress Exposures

Chuan-Yuan Li, John B. Little, Kang Hu, Wen Zhang, Li Zhang, Mark W. Dewhirst, and Qian Huang
Cancer Res 2001 61: 428-432. [Abstract] [Full Text] [PDF]  

Assessment of Tumor Necrosis Factor Receptor and Fas Signaling Pathways by Transcriptional Profiling

Elizabeth J. Manos and David A. Jones
Cancer Res 2001 61: 433-438. [Abstract] [Full Text] [PDF]  

A Novel Response of Cancer Cells to Radiation Involves Autophagy and Formation of Acidic Vesicles

Shoshana Paglin, Timothy Hollister, Thomas Delohery, Nadia Hackett, Melissa McMahill, Eleana Sphicas, Diane Domingo, and Joachim Yahalom
Cancer Res 2001 61: 439-444. [Abstract] [Full Text] [PDF]  

Absence of Endothelial Cells, Central Necrosis, and Fibrosis Are Associated with Aggressive Inflammatory Breast Cancer

Kazuo Shirakawa, Hitoshi Tsuda, Yuji Heike, Kazunori Kato, Rumiko Asada, Motoko Inomata, Hiroki Sasaki, Fujio Kasumi, Masataka Yoshimoto, Toshihiko Iwanaga, Fumio Konishi, Masaaki Terada, and Hiro Wakasugi
Cancer Res 2001 61: 445-451. [Abstract] [Full Text] [PDF]  

Coexpression of CD40 and CD40 Ligand in Cutaneous T-Cell Lymphoma (Mycosis Fungoides)

Monique Storz, Karoline Zepter, Jivko Kamarashev, Reinhard Dummer, Günter Burg, and Andreas C. Häffner
Cancer Res 2001 61: 452-454. [Abstract] [Full Text] [PDF]  

Cadmium-induced Malignant Transformation of Human Prostate Epithelial Cells

William E. Achanzar, Bhalchandra A. Diwan, Jie Liu, Salmaan T. Quader, Mukta M. Webber, and Michael P. Waalkes
Cancer Res 2001 61: 455-458. [Abstract] [Full Text] [PDF]  

Antitumor Immunity Induced by Laser Immunotherapy and Its Adoptive Transfer

Wei R. Chen, Anil K. Singhal, Hong Liu, and Robert E. Nordquist
Cancer Res 2001 61: 459-461. [Abstract] [Full Text] [PDF]  

RB2/p130 Gene-enhanced Expression Down-Regulates Vascular Endothelial Growth Factor Expression and Inhibits Angiogenesis in Vivo

Pier Paolo Claudio, Peter Stiegler, Candace M. Howard, Cristiana Bellan, Corrado Minimo, Gian Marco Tosi, Janusz Rak, Al Kovatich, Paola De Fazio, Pietro Micheli, Mario Caputi, Lorenzo Leoncini, Robert Kerbel, Giovan Giacomo Giordano, and Antonio Giordano
Cancer Res 2001 61: 462-468. [Abstract] [Full Text] [PDF]  

Interferon -dependent Induction of Thymidine Phosphorylase/Platelet-derived Endothelial Growth Factor through -Activated Sequence-like Element in Human Macrophages

Hisatsugu Goto, Kimitoshi Kohno, Saburo Sone, Shin-ichi Akiyama, Michihiko Kuwano, and Mayumi Ono
Cancer Res 2001 61: 469-473. [Abstract] [Full Text] [PDF]  

Synthetic Protein Transduction Domains: Enhanced Transduction Potential in Vitro and in Vivo

Alan Ho, Steven R. Schwarze, Sarah J. Mermelstein, Gabriel Waksman, and Steven F. Dowdy
Cancer Res 2001 61: 474-477. [Abstract] [Full Text] [PDF]  

Soluble Recombinant Endostatin Purified from Escherichia coli: Antiangiogenic Activity and Antitumor Effect

Xiaojun Huang, Michael K. K. Wong, Qun Zhao, Zhenyu Zhu, Kent Z. Q. Wang, Nancy Huang, Caisheng Ye, Elieser Gorelik, and Mengfeng Li
Cancer Res 2001 61: 478-481. [Abstract] [Full Text] [PDF]  

Inhibiting Mutations in the Transforming Growth Factor ß Type 2 Receptor in Recurrent Human Breast Cancer

Chris D. Lücke, Anna Philpott, James C. Metcalfe, Alastair M. Thompson, Luke Hughes-Davies, Paul R. Kemp, and Robin Hesketh
Cancer Res 2001 61: 482-485. [Abstract] [Full Text] [PDF]  

p53 Induction Prevents Accumulation of Aberrant Transcripts in Cancer Cells

Caroline Moyret-Lalle, Cyril Duriez, Joris Van Kerckhove, Christel Gilbert, Qing Wang, and Alain Puisieux
Cancer Res 2001 61: 486-488. [Abstract] [Full Text] [PDF]  

Posttranslational Truncation and Inactivation of Human E-Cadherin Distinguishes Prostate Cancer from Matched Normal Prostate

Michael G. Rashid, Martin G. Sanda, Christopher J. Vallorosi, Jonathan Rios-Doria, Mark A. Rubin, and Mark L. Day
Cancer Res 2001 61: 489-492. [Abstract] [Full Text] [PDF]  

Oligoclonal T-Cell Receptor Usage of Melanocyte Differentiation Antigen-reactive T Cells in Stage IV Melanoma Patients

David Schrama, Mads Hald Andersen, Patrick Terheyden, Louise Schrøder, Lars Østergaard Pedersen, Per thor Straten, and Jürgen C. Becker
Cancer Res 2001 61: 493-496. [Abstract] [Full Text] [PDF]  

15S-Hydroxyeicosatetraenoic Acid Activates Peroxisome Proliferator-activated Receptor and Inhibits Proliferation in PC3 Prostate Carcinoma Cells

Scott B. Shappell, Rajnish A. Gupta, Suzanne Manning, Robert Whitehead, William E. Boeglin, Claus Schneider, Tom Case, James Price, Gregory S. Jack, Thomas M. Wheeler, Robert J. Matusik, Alan R. Brash, and Raymond N. DuBois
Cancer Res 2001 61: 497-503. [Abstract] [Full Text] [PDF]  

Use of Camptothecin-resistant Mammalian Cell Lines to Evaluate the Role of Topoisomerase I in the Antiproliferative Activity of the Indolocarbazole, NB-506, and Its Topoisomerase I Binding Site

Yoshimasa Urasaki, Gary Laco, Yuji Takebayashi, Christian Bailly, Glenda Kohlhagen, and Yves Pommier
Cancer Res 2001 61: 504-508. [Abstract] [Full Text] [PDF]  

Frequent Cytolytic T-Cell Responses to Peptide MAGE-A10_254–262 in Melanoma

Danila Valmori, Valérie Dutoit, Verena Rubio-Godoy, Céline Chambaz, Danielle Liénard, Philippe Guillaume, Pedro Romero, Jean-Charles Cerottini, and Donata Rimoldi
Cancer Res 2001 61: 509-512. [Abstract] [Full Text] [PDF]  

Loss of p53 but not ARF Accelerates Medulloblastoma in Mice Heterozygous for patched

Cynthia Wetmore, Derek E. Eberhart, and Tom Curran
Cancer Res 2001 61: 513-516. [Abstract] [Full Text] [PDF]  

Antitumor Synergy of CV787, a Prostate Cancer-specific Adenovirus, and Paclitaxel and Docetaxel

De-Chao Yu, Yu Chen, Jeanette Dilley, Yuanhao Li, Millicent Embry, Hong Zhang, Natalie Nguyen, Pinky Amin, Joe Oh, and Daniel R. Henderson
Cancer Res 2001 61: 517-525. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Intratumoral Administration of Endostatin Plasmid Inhibits Vascular Growth and Perfusion in MCa-4 Murine Mammary Carcinomas

Ivan Ding, Jian Zhong Sun, Bruce Fenton, Wei Min Liu, Paul Kimsely, Paul Okunieff, and Wang Min
Cancer Res 2001 61: 526-531. [Abstract] [Full Text] [PDF]  

Direct Evidence of the Importance of Stromal Urokinase Plasminogen Activator (uPA) in the Growth of an Experimental Human Breast Cancer Using a Combined uPA Gene-Disrupted and Immunodeficient Xenograft Model

Thomas Leth Frandsen, Claus Holst-Hansen, Boye Schnack Nielsen, Ib Jarle Christensen, Jens R. Nyengaard, Peter Carmeliet, and Nils Brünner
Cancer Res 2001 61: 532-537. [Abstract] [Full Text] [PDF]  

Deregulated Expression of c-mos in Non-Small Cell Lung Carcinomas: Relationship with p53 Status, Genomic Instability, and Tumor Kinetics

Vassilis G. Gorgoulis, Panayotis Zacharatos, George Mariatos, Triantafillos Liloglou, Stavros Kokotas, Nikolaos Kastrinakis, Athanassios Kotsinas, Athanassios Athanasiou, Pericles Foukas, Vassilios Zoumpourlis, Dimitris Kletsas, John Ikonomopoulos, Panayiotis J. Asimacopoulos, Christos Kittas, and John K. Field
Cancer Res 2001 61: 538-549. [Abstract] [Full Text] [PDF]  

Transforming Growth Factor-ß1 Induces Desmoplasia in an Experimental Model of Human Pancreatic Carcinoma

Matthias Löhr, Christian Schmidt, Jörg Ringel, Mario Kluth, Petra Müller, Horst Nizze, and Ralf Jesnowski
Cancer Res 2001 61: 550-555. [Abstract] [Full Text] [PDF]  

Increased Retinoic Acid Responsiveness in Lung Carcinoma Cells that Are Nonresponsive Despite the Presence of Endogenous Retinoic Acid Receptor (RAR) ß by Expression of Exogenous Retinoid Receptors Retinoid X Receptor , RAR, and RAR

Haisu Wan, Waun K. Hong, and Reuben Lotan
Cancer Res 2001 61: 556-564. [Abstract] [Full Text] [PDF]  

Targeted Inactivation of the p21^WAF1/cip1 Gene Enhances Apc-initiated Tumor Formation and the Tumor-promoting Activity of a Western-Style High-Risk Diet by Altering Cell Maturation in the Intestinal Mucosa

Wan Cai Yang, Joseph Mathew, Anna Velcich, Winfried Edelmann, Raju Kucherlapati, Martin Lipkin, Kan Yang, and Leonard H. Augenlicht
Cancer Res 2001 61: 565-569. [Abstract] [Full Text] [PDF]  

The Sp Family of Transcription Factors in the Regulation of the Human and Mouse MUC2 Gene Promoters

Fauzia Aslam, Lisa Palumbo, Leonard H. Augenlicht, and Anna Velcich
Cancer Res 2001 61: 570-576. [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinase-7-mediated Cleavage of Fas Ligand Protects Tumor Cells from Chemotherapeutic Drug Cytotoxicity

Nicholas Mitsiades, Wei-hsuan Yu, Vassiliki Poulaki, Maria Tsokos, and Ivan Stamenkovic
Cancer Res 2001 61: 577-581. [Abstract] [Full Text] [PDF]  

Overexpression of the G-Protein Inwardly Rectifying Potassium Channel 1 (GIRK1) in Primary Breast Carcinomas Correlates with Axillary Lymph Node Metastasis

Bradley K. Stringer, Amiel G. Cooper, and Scott B. Shepard
Cancer Res 2001 61: 582-588. [Abstract] [Full Text] [PDF]  

AKT Activation Up-Regulates Insulin-like Growth Factor I Receptor Expression and Promotes Invasiveness of Human Pancreatic Cancer Cells

Satoshi Tanno, Sachie Tanno, Yasuhiro Mitsuuchi, Deborah A. Altomare, Guang-Hui Xiao, and Joseph R. Testa
Cancer Res 2001 61: 589-593. [Abstract] [Full Text] [PDF]  

Bcl-2 Delays and Alters Hepatic Carcinogenesis Induced by Transforming Growth Factor

Mary E. Vail, Robert H. Pierce, and Nelson Fausto
Cancer Res 2001 61: 594-601. [Abstract] [Full Text] [PDF]  

Raf-induced Transformation Requires an Interleukin 1 Autocrine Loop

Terry Vale, Teri T. Ngo, Michael A. White, and Peter E. Lipsky
Cancer Res 2001 61: 602-607. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

p53 Codon 72 Polymorphism and Various Human Papillomavirus 16 E6 Genotypes Are Risk Factors for Cervical Cancer Development

Ingeborg Zehbe, Gianfranco Voglino, Erik Wilander, Hajo Delius, Antonella Marongiu, Lutz Edler, Fritz Klimek, Sonja Andersson, and Massimo Tommasino
Cancer Res 2001 61: 608-611. [Abstract] [Full Text] [PDF]  

Tobacco Smoke-induced DNA Damage and an Early Age of Smoking Initiation Induce Chromosome Loss at 3p21 in Lung Cancer

Tomoko Hirao, Heather H. Nelson, Tara Devi S. Ashok, John C. Wain, Eugene J. Mark, David C. Christiani, John K. Wiencke, and Karl T. Kelsey
Cancer Res 2001 61: 612-615. [Abstract] [Full Text] [PDF]  

Human Papillomavirus Type 16 E6 Inactivation of p53 in Normal Human Mammary Epithelial Cells Promotes Tamoxifen-mediated Apoptosis

Victoria L. Seewaldt, Krzysztof Mrózek, Eric C. Dietze, Molly Parker, and L. Elizabeth Caldwell
Cancer Res 2001 61: 616-624. [Abstract] [Full Text] [PDF]  

Hypergastrinemia Promotes Adenoma Progression in the APC^Min-/+ Mouse Model of Familial Adenomatous Polyposis

Sue A. Watson and Andrew M. Smith
Cancer Res 2001 61: 625-631. [Abstract] [Full Text] [PDF]  

Endocrinology:

Expression of Estrogen Receptor (ER) Subtypes and ERß Isoforms in Colon Cancer

Martha Campbell-Thompson, I. Jeanette Lynch, and Bhavna Bhardwaj
Cancer Res 2001 61: 632-640. [Abstract] [Full Text] [PDF]  

Immunology:

Intranodal Immunization with Tumor Lysate-pulsed Dendritic Cells Enhances Protective Antitumor Immunity

Laura A. Lambert, Glen R. Gibson, Marybeth Maloney, Brigit Durell, Randolph J. Noelle, and Richard J. Barth, Jr.
Cancer Res 2001 61: 641-646. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Cyclin E is the Only Cyclin-dependent Kinase 2-associated Cyclin that Predicts Metastasis and Survival in Early Stage Non-Small Cell Lung Cancer

Carsten Müller-Tidow, Ralf Metzger, Katrin Kügler, Sven Diederichs, Gregory Idos, Michael Thomas, Barbara Dockhorn-Dworniczak, Paul M. Schneider, H. Phillip Koeffler, Wolfgang E. Berdel, and Hubert Serve
Cancer Res 2001 61: 647-653. [Abstract] [Full Text] [PDF]  

Glycophosphatidylinositol-anchored Protein Deficiency as a Marker of Mutator Phenotypes in Cancer

Rui Chen, James R. Eshleman, Robert A. Brodsky, and M. Edward Medof
Cancer Res 2001 61: 654-658. [Abstract] [Full Text] [PDF]  

Bax Accelerates Tumorigenesis in p53-deficient Mice

C. Michael Knudson, Geoffrey M. Johnson, Yuan Lin, and Stanley J. Korsmeyer
Cancer Res 2001 61: 659-665. [Abstract] [Full Text] [PDF]  

Creation and Characterization of 5-Fluorodeoxyuridine-resistant Arg⁵⁰ Loop Mutants of Human Thymidylate Synthase

Daniel M. Landis, Cory C. Heindel, and Lawrence A. Loeb
Cancer Res 2001 61: 666-672. [Abstract] [Full Text] [PDF]  

Nuclear Factor-B-dependent Expression of Metastasis Suppressor KAI1/CD82 Gene in Lung Cancer Cell Lines Expressing Mutant p53

Tsutomu Shinohara, Toyokazu Miki, Naoki Nishimura, Hiroshi Nokihara, Hirofumi Hamada, Naofumi Mukaida, and Saburo Sone
Cancer Res 2001 61: 673-678. [Abstract] [Full Text] [PDF]  

Homozygous Deletion of CDKN2A (p16^INK4a/p14^ARF) but not within 1p36 or at Other Tumor Suppressor Loci in Neuroblastoma

Patricia M. Thompson, John M. Maris, Michael D. Hogarty, Robert C. Seeger, C. Patrick Reynolds, Garrett M. Brodeur, and Peter S. White
Cancer Res 2001 61: 679-686. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Glucagon-like Peptide (GLP)-2 Reduces Chemotherapy-associated Mortality and Enhances Cell Survival in Cells Expressing a Transfected GLP-2 Receptor

Robin P. Boushey, Bernardo Yusta, and Daniel J. Drucker
Cancer Res 2001 61: 687-693. [Abstract] [Full Text] [PDF]  

Taxane-Antibody Conjugates Afford Potent Cytotoxicity, Enhanced Solubility, and Tumor Target Selectivity

Véronique Guillemard and H. Uri Saragovi
Cancer Res 2001 61: 694-699. [Abstract] [Full Text] [PDF]  

Granulocytic Differentiation of Human NB4 Promyelocytic Leukemia Cells Induced by All-trans Retinoic Acid Metabolites

Nadia Idres, Gérard Benoît, Maria A. Flexor, Michel Lanotte, and Guy G. Chabot
Cancer Res 2001 61: 700-705. [Abstract] [Full Text] [PDF]  

Intratesticular Transplantation of Testicular Cells from Leukemic Rats Causes Transmission of Leukemia

Kirsi Jahnukainen, Mi Hou, Cecilia Petersen, Brian Setchell, and Olle Söder
Cancer Res 2001 61: 706-710. [Abstract] [Full Text] [PDF]  

Targeted Delivery of Tissue Factor to the ED-B Domain of Fibronectin, a Marker of Angiogenesis, Mediates the Infarction of Solid Tumors in Mice

Fredrik Nilsson, Hartwig Kosmehl, Luciano Zardi, and Dario Neri
Cancer Res 2001 61: 711-716. [Abstract] [Full Text] [PDF]  

A Photobiological and Photophysical-based Study of Phototoxicity of Two Chlorins

Brian W. Pogue, Bernhard Ortel, Norah Chen, Robert W. Redmond, and Tayyaba Hasan
Cancer Res 2001 61: 717-724. [Abstract] [Full Text] [PDF]  

Antiproliferative Effects of S-Allylmercaptocysteine on Colon Cancer Cells When Tested Alone or in Combination with Sulindac Sulfide

Haim Shirin, John T. Pinto, Yuichi Kawabata, Jae-Won Soh, Thomas Delohery, Steven F. Moss, Vundavalli Murty, Richard S. Rivlin, Peter R. Holt, and I. Bernard Weinstein
Cancer Res 2001 61: 725-731. [Abstract] [Full Text] [PDF]  

Differential p53-dependent Mechanism of Radiosensitization in Vitro and in Vivo by the Protein Kinase C-specific Inhibitor PKC412

Kathrin Zaugg, Sonia Rocha, Hildegard Resch, Ivan Hegyi, Christoph Oehler, Christoph Glanzmann, Doriano Fabbro, Stephan Bodis, and Martin Pruschy
Cancer Res 2001 61: 732-738. [Abstract] [Full Text] [PDF]  

The HER Tyrosine Kinase Inhibitor CI1033 Enhances Cytotoxicity of 7-Ethyl-10-hydroxycamptothecin and Topotecan by Inhibiting Breast Cancer Resistance Protein-mediated Drug Efflux

Charles Erlichman, Scott A. Boerner, Christopher G. Hallgren, Rebecca Spieker, Xiao-Yang Wang, C. David James, George L. Scheffer, Marc Maliepaard, Douglas D. Ross, Keith C. Bible, and Scott H. Kaufmann
Cancer Res 2001 61: 739-748. [Abstract] [Full Text] [PDF]  

In Vitro and in Vivo Reversal of P-Glycoprotein-mediated Multidrug Resistance by a Novel Potent Modulator, XR9576

Prakash Mistry, Alistair J. Stewart, Wendy Dangerfield, Sade Okiji, Chris Liddle, Douglas Bootle, Jane A. Plumb, David Templeton, and Peter Charlton
Cancer Res 2001 61: 749-758. [Abstract] [Full Text] [PDF]  

Pretreatment with Paclitaxel Enhances Apo-2 Ligand/Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis of Prostate Cancer Cells by Inducing Death Receptors 4 and 5 Protein Levels

Ramadevi Nimmanapalli, Charles L. Perkins, Marianagelli Orlando, Erica O’Bryan, Diep Nguyen, and Kapil N. Bhalla
Cancer Res 2001 61: 759-763. [Abstract] [Full Text] [PDF]  

A Truncated Human Xeroderma Pigmentosum Complementation Group A Protein Expressed from an Adenovirus Sensitizes Human Tumor Cells to Ultraviolet Light and Cisplatin

Elizabeth Rosenberg, Mohiuddin M. Taher, Nancy B. Kuemmerle, Julie Farnsworth, and Kristoffer Valerie
Cancer Res 2001 61: 764-770. [Abstract] [Full Text] [PDF]  

Cumulative and Irreversible Cardiac Mitochondrial Dysfunction Induced by Doxorubicin

Shaoyu Zhou, Anatoli Starkov, M. Kent Froberg, Richard L. Leino, and Kendall B. Wallace
Cancer Res 2001 61: 771-777. [Abstract] [Full Text] [PDF]  

Epidemiology:

Nitrated and Oxidized Plasma Proteins in Smokers and Lung Cancer Patients

Brigitte Pignatelli, Chun-Qi Li, Paolo Boffetta, Qiping Chen, Wolfgang Ahrens, Fredrik Nyberg, Anush Mukeria, Irene Bruske-Hohlfeld, Cristina Fortes, Vali Constantinescu, Harry Ischiropoulos, and Hiroshi Ohshima
Cancer Res 2001 61: 778-784. [Abstract] [Full Text] [PDF]  

Building a Multigenic Model of Breast Cancer Susceptibility: CYP17 and HSD17B1 Are Two Important Candidates

Heather Spencer Feigelson, Roberta McKean-Cowdin, Gerhard A. Coetzee, Daniel O. Stram, Laurence N. Kolonel, and Brian E. Henderson
Cancer Res 2001 61: 785-789. [Abstract] [Full Text] [PDF]  

Correction:

M. V. Fournier et al., Cancer Res., 59:3748–3753, 1999.

Cancer Res 2001 61: 790-792. [Full Text] [PDF]  

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