Advances in Brief:

Hydrogen Peroxide Mediates Activation of Nuclear Factor of Activated T Cells (NFAT) by Nickel Subsulfide

Chuanshu Huang, Jingxia Li, Max Costa, Zhuo Zhang, Stephen S. Leonard, Vincent Castranova, Val Vallyathan, Gong Ju, and Xianglin Shi
Cancer Res 2001 61: 8051-8057. [Abstract] [Full Text] [PDF]  

In Situ Expression of Interleukin-4 (IL-4) Receptors in Human Brain Tumors and Cytotoxicity of a Recombinant IL-4 Cytotoxin in Primary Glioblastoma Cell Cultures

Bharat H. Joshi, Pamela Leland, Anthony Asher, Richard A. Prayson, Frederick Varricchio, and Raj K. Puri
Cancer Res 2001 61: 8058-8061. [Abstract] [Full Text] [PDF]  

Destabilization of CHK2 by a Missense Mutation Associated with Li-Fraumeni Syndrome

Sean Bong Lee, Sang Hyon Kim, Daphne W. Bell, Doke C. R. Wahrer, Taryn A. Schiripo, Melissa M. Jorczak, Dennis C. Sgroi, Judy E. Garber, Frederick P. Li, Kim E. Nichols, Jenny M. Varley, Andrew K. Godwin, Kristen M. Shannon, Ed Harlow, and Daniel A. Haber
Cancer Res 2001 61: 8062-8067. [Abstract] [Full Text] [PDF]  

WWOX, the FRA16D Gene, Behaves as a Suppressor of Tumor Growth

Andrzej K. Bednarek, Catherine L. Keck-Waggoner, Rachael L. Daniel, Kendra J. Laflin, P. Leif Bergsagel, Kaoru Kiguchi, Andrew J. Brenner, and C. Marcelo Aldaz
Cancer Res 2001 61: 8068-8073. [Abstract] [Full Text] [PDF]  

Cytoplasmic Localization of the Oncogenic Protein Ski in Human Cutaneous Melanomas in Vivo: Functional Implications for Transforming Growth Factor ß Signaling

Jon A. Reed, Elise Bales, Weidong Xu, Nihal A. Okan, Debdutta Bandyopadhyay, and Estela E. Medrano
Cancer Res 2001 61: 8074-8078. [Abstract] [Full Text] [PDF]  

LYVE-1 Is Not Restricted to the Lymph Vessels: Expression in Normal Liver Blood Sinusoids and Down-Regulation in Human Liver Cancer and Cirrhosis

Carla Mouta Carreira, Selim M. Nasser, Emmanuelle di Tomaso, Timothy P. Padera, Yves Boucher, Stanislav I. Tomarev, and Rakesh K. Jain
Cancer Res 2001 61: 8079-8084. [Abstract] [Full Text] [PDF]  

ß-Catenin Expression Is Altered in Human Colonic Aberrant Crypt Foci

Xing Pei Hao, Thomas G. Pretlow, J. Sunil Rao, and Theresa P. Pretlow
Cancer Res 2001 61: 8085-8088. [Abstract] [Full Text] [PDF]  

Expression of the Invasion Factor Laminin 2 in Colorectal Carcinomas Is Regulated by ß-Catenin

Falk Hlubek, Andreas Jung, Nicole Kotzor, Thomas Kirchner, and Thomas Brabletz
Cancer Res 2001 61: 8089-8093. [Abstract] [Full Text] [PDF]  

Hypermethylation in Human Cancers of the RIZ1 Tumor Suppressor Gene, a Member of a Histone/Protein Methyltransferase Superfamily

Yong Du, Tobias Carling, Wei Fang, Zhe Piao, Jin-Chuan Sheu, and Shi Huang
Cancer Res 2001 61: 8094-8099. [Abstract] [Full Text] [PDF]  

Mining the Melanosome for Tumor Vaccine Targets: P.polypeptide Is a Novel Tumor-associated Antigen

Christopher E. Touloukian, Wolfgang W. Leitner, Paul F. Robbins, Steven A. Rosenberg, and Nicholas P. Restifo
Cancer Res 2001 61: 8100-8104. [Abstract] [Full Text] [PDF]  

Comparative Analysis of Necrotic and Apoptotic Tumor Cells As a Source of Antigen(s) in Dendritic Cell-based Immunization

Yoshihito Kotera, Koichi Shimizu, and James J. Mulé
Cancer Res 2001 61: 8105-8109. [Abstract] [Full Text] [PDF]  

Modulation of the Immune Response by Systemic Targeting of Antigens to Lymph Nodes

Martin Trepel, Wadih Arap, and Renata Pasqualini
Cancer Res 2001 61: 8110-8112. [Abstract] [Full Text] [PDF]  

O⁶-Methylguanine-DNA Methyltransferase Promoter Hypermethylation Shifts the p53 Mutational Spectrum in Non-Small Cell Lung Cancer

Patrick Wolf, Ying Chuan Hu, Kara Doffek, David Sidransky, and Steven A. Ahrendt
Cancer Res 2001 61: 8113-8117. [Abstract] [Full Text] [PDF]  

KIT Activation Is a Ubiquitous Feature of Gastrointestinal Stromal Tumors

Brian P. Rubin, Samuel Singer, Connie Tsao, Anette Duensing, Marcia L. Lux, Robert Ruiz, Michele K. Hibbard, Chang-Jie Chen, Sheng Xiao, David A. Tuveson, George D. Demetri, Christopher D. M. Fletcher, and Jonathan A. Fletcher
Cancer Res 2001 61: 8118-8121. [Abstract] [Full Text] [PDF]  

T-Cell Receptor Chain Alternate Reading Frame Protein (TARP) Expression in Prostate Cancer Cells Leads to an Increased Growth Rate and Induction of Caveolins and Amphiregulin

Curt D. Wolfgang, Magnus Essand, Byungkook Lee, and Ira Pastan
Cancer Res 2001 61: 8122-8126. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Induction of Antitumor Immunity via Intratumoral Tetra-Costimulator Protein Transfer

Guoxing Zheng, Aoshuang Chen, Raymond E. Sterner, Paul J. Zhang, Tao Pan, Nadya Kiyatkin, and Mark L. Tykocinski
Cancer Res 2001 61: 8127-8134. [Abstract] [Full Text] [PDF]  

Malignant Transformation in a Nontumorigenic Human Prostatic Epithelial Cell Line

Simon W. Hayward, Yuzhuo Wang, Mei Cao, Yun Kit Hom, Baohui Zhang, Gary D. Grossfeld, Daniel Sudilovsky, and Gerald R. Cunha
Cancer Res 2001 61: 8135-8142. [Abstract] [Full Text] [PDF]  

The Consequences of Chromosomal Aneuploidy on Gene Expression Profiles in a Cell Line Model for Prostate Carcinogenesis

John L. Phillips, Simon W. Hayward, Yuzhuo Wang, James Vasselli, Christian Pavlovich, Hesed Padilla-Nash, John R. Pezullo, B. Michael Ghadimi, Gary D. Grossfeld, Alexandra Rivera, W. Marston Linehan, Gerald R. Cunha, and Thomas Ried
Cancer Res 2001 61: 8143-8149. [Abstract] [Full Text] [PDF]  

Induction of Melanoma in Murine Macrophage Inflammatory Protein 2 Transgenic Mice Heterozygous for Inhibitor of Kinase/Alternate Reading Frame

Jinming Yang, Jing Luan, Yingchun Yu, Cunxi Li, Ronald A. DePinho, Lynda Chin, and Ann Richmond
Cancer Res 2001 61: 8150-8157. [Abstract] [Full Text] [PDF]  

UV-induced DNA Damage and Mutations in Hupki (Human p53 Knock-in) Mice Recapitulate p53 Hotspot Alterations in Sun-exposed Human Skin

Jun-Li Luo, Wei-Min Tong, Jung-Hoon Yoon, Manfred Hergenhahn, Riita Koomagi, Qin Yang, Dominique Galendo, Gerd P. Pfeifer, Zhao-Qi Wang, and Monica Hollstein
Cancer Res 2001 61: 8158-8163. [Abstract] [Full Text] [PDF]  

A New Selective and Potent Inhibitor of Human Cytochrome P450 1B1 and Its Application to Antimutagenesis

Young-Jin Chun, Sanghee Kim, Donghak Kim, Sang-Kwang Lee, and F. Peter Guengerich
Cancer Res 2001 61: 8164-8170. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Inhibition of Angiogenesis-driven Kaposi’s Sarcoma Tumor Growth in Nude Mice by Oral N-Acetylcysteine

Adriana Albini, Monica Morini, Francesco D’Agostini, Nicoletta Ferrari, Francesco Campelli, Giuseppe Arena, Douglas M. Noonan, Carlo Pesce, and Silvio De Flora
Cancer Res 2001 61: 8171-8178. [Abstract] [Full Text] [PDF]  

Quantitative Imaging and Microlocalization of Boron-10 in Brain Tumors and Infiltrating Tumor Cells by SIMS Ion Microscopy: Relevance to Neutron Capture Therapy

Duane R. Smith, Subhash Chandra, Rolf F. Barth, Weilian Yang, Darrel D. Joel, and Jeffrey A. Coderre
Cancer Res 2001 61: 8179-8187. [Abstract] [Full Text] [PDF]  

A Genetically Engineered Influenza A Virus with ras-Dependent Oncolytic Properties

Michael Bergmann, Ingrid Romirer, Monika Sachet, Reinhard Fleischhacker, Adolfo García-Sastre, Peter Palese, Klaus Wolff, Hubert Pehamberger, Raimund Jakesz, and Thomas Muster
Cancer Res 2001 61: 8188-8193. [Abstract] [Full Text] [PDF]  

Molecular Basis for the Synergistic Interaction of Adriamycin with the Formaldehyde-releasing Prodrug Pivaloyloxymethyl Butyrate (AN-9)

Suzanne M. Cutts, Ada Rephaeli, Abraham Nudelman, Inesa Hmelnitsky, and Don R. Phillips
Cancer Res 2001 61: 8194-8202. [Abstract] [Full Text] [PDF]  

The Phosphatidylinositide 3'-Kinase/Akt Survival Pathway Is a Target for the Anticancer and Radiosensitizing Agent PKC412, an Inhibitor of Protein Kinase C

Angela Tenzer, Daniel Zingg, Sonia Rocha, Brian Hemmings, Doriano Fabbro, Christoph Glanzmann, P. August Schubiger, Stephan Bodis, and Martin Pruschy
Cancer Res 2001 61: 8203-8210. [Abstract] [Full Text] [PDF]  

Radiosensitization of p53 Mutant Cells by PD0166285, a Novel G₂ Checkpoint Abrogator

Yuli Wang, Jun Li, Robert N. Booher, Alan Kraker, Theodore Lawrence, Wilbur R. Leopold, and Yi Sun
Cancer Res 2001 61: 8211-8217. [Abstract] [Full Text] [PDF]  

Immunology:

Phases of Apoptosis of Melanoma Cells, but not of Normal Melanocytes, Differently Affect Maturation of Myeloid Dendritic Cells

Gabriella Pietra, Roberta Mortarini, Giorgio Parmiani, and Andrea Anichini
Cancer Res 2001 61: 8218-8226. [Abstract] [Full Text] [PDF]  

Immunization with Wild-Type p53 Gene Sequences Coadministered with Flt3 Ligand Induces an Antigen-specific Type 1 T-Cell Response

Prahlad Parajuli, Vladimir Pisarev, Jennifer Sublet, Amy Steffel, Michelle Varney, Rakesh Singh, Drake LaFace, and James E. Talmadge
Cancer Res 2001 61: 8227-8234. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

New Amplified and Highly Expressed Genes Discovered in the ERBB2 Amplicon in Breast Cancer by cDNA Microarrays

Päivikki Kauraniemi, Maarit Bärlund, Outi Monni, and Anne Kallioniemi
Cancer Res 2001 61: 8235-8240. [Abstract] [Full Text] [PDF]  

Identification of Cytogenetic Subgroups and Karyotypic Pathways in Transitional Cell Carcinoma

Mattias Höglund, Torbjörn Säll, Sverre Heim, Felix Mitelman, Nils Mandahl, and Imad Fadl-Elmula
Cancer Res 2001 61: 8241-8246. [Abstract] [Full Text] [PDF]  

Diverse Mechanisms of ß-Catenin Deregulation in Ovarian Endometrioid Adenocarcinomas

Rong Wu, Yali Zhai, Eric R. Fearon, and Kathleen R. Cho
Cancer Res 2001 61: 8247-8255. [Abstract] [Full Text] [PDF]  

p53R2-dependent Pathway for DNA Synthesis in a p53-regulated Cell Cycle Checkpoint

Tatsuya Yamaguchi, Koichi Matsuda, Yoji Sagiya, Manabu Iwadate, Masayuki A. Fujino, Yusuke Nakamura, and Hirofumi Arakawa
Cancer Res 2001 61: 8256-8262. [Abstract] [Full Text] [PDF]  

Independent Amplification of Two Gene Clusters on Chromosome 4 in Rat Endometrial Cancer: Identification and Molecular Characterization

Anna Walentinsson, Khalil Helou, Ville Wallenius, Hans J. Hedrich, Claude Szpirer, and Göran Levan
Cancer Res 2001 61: 8263-8273. [Abstract] [Full Text] [PDF]  

Intrachromosomal Genomic Instability in Human Sporadic Colorectal Cancer Measured by Genome-Wide Allelotyping and Inter-(Simple Sequence Repeat) PCR

Garth R. Anderson, Bruce M. Brenner, Helen Swede, Neng Chen, W. Michael Henry, Jeffrey M. Conroy, Matthew J. Karpenko, Jean-Pierre Issa, Jeremy D. Bartos, Joslyn K. Brunelle, Gerald P. Jahreis, Morton S. Kahlenberg, Mark Basik, Sheila Sait, Miguel A. Rodriguez-Bigas, Norma J. Nowak, Nicholas J. Petrelli, Thomas B. Shows, and Daniel L. Stoler
Cancer Res 2001 61: 8274-8283. [Abstract] [Full Text] [PDF]  

p16^INK4a Lesions Are Common, Early Abnormalities that Undergo Clonal Expansion in Barrett’s Metaplastic Epithelium

David J. Wong, Thomas G. Paulson, Laura J. Prevo, Patricia C. Galipeau, Gary Longton, Patricia L. Blount, and Brian J. Reid
Cancer Res 2001 61: 8284-8289. [Abstract] [Full Text] [PDF]  

Loss of DNA Mismatch Repair Imparts Defective cdc2 Signaling and G₂ Arrest Responses without Altering Survival after Ionizing Radiation

Tao Yan, Jane E. Schupp, Hwa-shin Hwang, Mark W. Wagner, Suzanne E. Berry, Sue Strickfaden, Martina L. Veigl, W. David Sedwick, David A. Boothman, and Timothy J. Kinsella
Cancer Res 2001 61: 8290-8297. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Transgenic Polyoma Middle-T Mice Model Premalignant Mammary Disease

Jeannie E. Maglione, Drew Moghanaki, Lawrence J. T. Young, Cathyryne K. Manner, Lesley G. Ellies, Sasha O. Joseph, Benjamin Nicholson, Robert D. Cardiff, and Carol L. MacLeod
Cancer Res 2001 61: 8298-8305. [Abstract] [Full Text] [PDF]  

Transforming Growth Factor-ß1 Increases Survival of Human Melanoma through Stroma Remodeling

Carola Berking, Richelle Takemoto, Helmut Schaider, Louise Showe, Kapaettu Satyamoorthy, Paul Robbins, and Meenhard Herlyn
Cancer Res 2001 61: 8306-8316. [Abstract] [Full Text] [PDF]  

Increased p53 Mutation Frequency during Tumor Progression—Results from a Breast Cancer Cohort

Torbjörn Norberg, Sigrid Klaar, Gunilla Kärf, Hans Nordgren, Lars Holmberg, and Jonas Bergh
Cancer Res 2001 61: 8317-8321. [Abstract] [Full Text] [PDF]  

Induction of Glucose-regulated Protein 78 by Chronic Hypoxia in Human Gastric Tumor Cells through a Protein Kinase C-/ERK/AP-1 Signaling Cascade

Min Sup Song, Yong Keun Park, Je-Ho Lee, and Kyoungsook Park
Cancer Res 2001 61: 8322-8330. [Abstract] [Full Text] [PDF]  

Heterogeneous Transforming Growth Factor (TGF)-ß Unresponsiveness and Loss of TGF-ß Receptor Type II Expression Caused by Histone Deacetylation in Lung Cancer Cell Lines

Hirotaka Osada, Yoshio Tatematsu, Akira Masuda, Toshiko Saito, Miyabi Sugiyama, Kiyoshi Yanagisawa, and Takashi Takahashi
Cancer Res 2001 61: 8331-8339. [Abstract] [Full Text] [PDF]  

Endothelin-1 Induces Tumor Proteinase Activation and Invasiveness of Ovarian Carcinoma Cells

Laura Rosanò, Marco Varmi, Debora Salani, Valeriana Di Castro, Francesca Spinella, Pier Giorgio Natali, and Anna Bagnato
Cancer Res 2001 61: 8340-8346. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: J. W. Baish and R. K. Jain, Fractals and Cancer. Cancer Res., 60: 3683–3688, 2000.

Hsiao-Wen Chung, Hsiao-Jen Chung, J. W. Baish, and R. K. Jain
Cancer Res 2001 61: 8347-8348. [Full Text] [PDF]  

TßR-I(6A) Polymorphism Is not a Tumor Susceptibility Allele in Macedonian Colorectal Cancer Patients Correspondence re: B. Pasche et al. Type I TßR-I(6A) Is a Candidate Tumor Susceptibility Allele. Cancer Res., 58: 2727–2732, 1998.

Ana-Marija Stefanovska, Georgi D. Efremov, Aleksandar J. Dimovski, Djingis Jasar, Gjorgi Zografski, Toni Josifovski, Milco Panovski, Renata Jankova, Mirko Spiroski, Boris Pasche, Yansong Bian, Jennifer Reich, Alfred Rademaker, Prema Kolachana, and Kenneth Offit
Cancer Res 2001 61: 8351 [Full Text] [PDF]  

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