Advances in Brief:

Microarray-based Copy Number and Expression Profiling in Dedifferentiated and Pleomorphic Liposarcoma

Björn Fritz, Falk Schubert, Gunnar Wrobel, Carsten Schwaenen, Swen Wessendorf, Michelle Nessling, Christian Korz, Ralf J. Rieker, Kate Montgomery, Raju Kucherlapati, Gunhild Mechtersheimer, Roland Eils, Stefan Joos, and Peter Lichter
Cancer Res 2002 62: 2993-2998. [Abstract] [Full Text] [PDF]  

Nkx3.1 Mutant Mice Recapitulate Early Stages of Prostate Carcinogenesis

Minjung J. Kim, Rajula Bhatia-Gaur, Whitney A. Banach-Petrosky, Nishita Desai, Yuzhuo Wang, Simon W. Hayward, Gerald R. Cunha, Robert D. Cardiff, Michael M. Shen, and Cory Abate-Shen
Cancer Res 2002 62: 2999-3004. [Abstract] [Full Text] [PDF]  

Molecular Profiling of Non-Small Cell Lung Cancer and Correlation with Disease-free Survival

Dennis A. Wigle, Igor Jurisica, Niki Radulovich, Melania Pintilie, Janet Rossant, Ni Liu, Chao Lu, James Woodgett, Isolde Seiden, Michael Johnston, Shaf Keshavjee, Gail Darling, Timothy Winton, Bobby-Joe Breitkreutz, Paul Jorgenson, Mike Tyers, Frances A. Shepherd, and Ming Sound Tsao
Cancer Res 2002 62: 3005-3008. [Abstract] [Full Text] [PDF]  

T-cell Factor-4 Frameshift Mutations Occur Frequently in Human Microsatellite Instability-high Colorectal Carcinomas but Do Not Contribute to Carcinogenesis

Stefan Ruckert, Elke Hiendlmeyer, Wolfgang M. Brueckl, Ursula Oswald, Kurt Beyser, Wolfgang Dietmaier, Angela Haynl, Claudia Koch, Josef Rüschoff, Thomas Brabletz, Thomas Kirchner, and Andreas Jung
Cancer Res 2002 62: 3009-3013. [Abstract] [Full Text] [PDF]  

VHL-mediated Hypoxia Regulation of Cyclin D1 in Renal Carcinoma Cells

Ranjit S. Bindra, James R. Vasselli, Robert Stearman, W. Marston Linehan, and Richard D. Klausner
Cancer Res 2002 62: 3014-3019. [Abstract] [Full Text] [PDF]  

The Waardenburg Syndrome Type 4 Gene, SOX10, Is a Novel Tumor-associated Antigen Identified in a Patient with a Dramatic Response to Immunotherapy

Hung T. Khong and Steven A. Rosenberg
Cancer Res 2002 62: 3020-3023. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

p53 Transgenic Mice Are Highly Susceptible to 1, 2-Dimethylhydrazine-induced Uterine Sarcomas

Zhongqiu Zhang, Jie Li, Laura E. Lantry, Yian Wang, Roger W. Wiseman, Ronald A. Lubet, and Ming You
Cancer Res 2002 62: 3024-3029. [Abstract] [Full Text] [PDF]  

Disruption of the NAD(P)H:Quinone Oxidoreductase 1 (NQO1) Gene in Mice Causes Myelogenous Hyperplasia

Delwin J. Long, II, Amos Gaikwad, Asha Multani, Sen Pathak, Charles A. Montgomery, Frank J. Gonzalez, and Anil K. Jaiswal
Cancer Res 2002 62: 3030-3036. [Abstract] [Full Text] [PDF]  

Inactivation and Degradation of O⁶-Alkylguanine-DNA Alkyltransferase after Reaction with Nitric Oxide

Liping Liu, Meng Xu-Welliver, Sreenivas Kanugula, and Anthony E. Pegg
Cancer Res 2002 62: 3037-3043. [Abstract] [Full Text] [PDF]  

A Dominant Negative c-jun Specifically Blocks Okadaic Acid-induced Skin Tumor Promotion

Eric J. Thompson, Jacalyn MacGowan, Matthew R. Young, Nancy Colburn, and G. Tim Bowden
Cancer Res 2002 62: 3044-3047. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Recessive Transmission of a Multiple Endocrine Neoplasia Syndrome in the Rat

Andreas Fritz, Axel Walch, Kamilla Piotrowska, Michael Rosemann, Ekkehard Schäffer, Karin Weber, Andreas Timper, Gerhild Wildner, Jochen Graw, Heinz Höfler, and Michael J. Atkinson
Cancer Res 2002 62: 3048-3051. [Abstract] [Full Text] [PDF]  

Effect of Germ-Line Genetic Variation on Breast Cancer Survival in a Population-based Study

Ellen L. Goode, Alison M. Dunning, Bettina Kuschel, Catherine S. Healey, Nicholas E. Day, Bruce A. J. Ponder, Douglas F. Easton, and Paul P. D. Pharoah
Cancer Res 2002 62: 3052-3057. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Polymorphisms of the Estrogen-metabolizing Genes CYP17 and Catechol-O-methyltransferase and Risk of Epithelial Ovarian Cancer

Elizabeth I. O. Garner, Erika E. Stokes, Ross S. Berkowitz, Samuel C. Mok, and Daniel W. Cramer
Cancer Res 2002 62: 3058-3062. [Abstract] [Full Text] [PDF]  

Dietary Feeding of Silibinin Inhibits Advance Human Prostate Carcinoma Growth in Athymic Nude Mice and Increases Plasma Insulin-like Growth Factor-binding Protein-3 Levels

Rana P. Singh, Sivanandhan Dhanalakshmi, Anil K. Tyagi, Daniel C. F. Chan, Chapla Agarwal, and Rajesh Agarwal
Cancer Res 2002 62: 3063-3069. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Chemotherapy-induced O⁶-Benzylguanine-resistant Alkyltransferase Mutations in Mismatch-deficient Colon Cancer

Lili Liu, Stuart Schwartz, Brian M. Davis, and Stanton L. Gerson
Cancer Res 2002 62: 3070-3076. [Abstract] [Full Text] [PDF]  

rAAV-mediated Long-term Liver-generated Expression of an Angiogenesis Inhibitor Can Restrict Renal Tumor Growth in Mice

Andrew M. Davidoff, Amit C. Nathwani, William W. Spurbeck, Catherine Y. C. Ng, Junfang Zhou, and Elio F. Vanin
Cancer Res 2002 62: 3077-3083. [Abstract] [Full Text] [PDF]  

A Novel Targeting Modality to Enhance Adenoviral Replication by Vitamin D₃ in Androgen-independent Human Prostate Cancer Cells and Tumors

Chia-Ling Hsieh, Ling Yang, Li Miao, Fang Yeung, Chinghai Kao, Hua Yang, Haiyen E. Zhau, and Leland W. K. Chung
Cancer Res 2002 62: 3084-3092. [Abstract] [Full Text] [PDF]  

Induction and Regulation of Tumor Necrosis Factor-related Apoptosis-inducing Ligand/Apo-2 Ligand-mediated Apoptosis in Renal Cell Carcinoma

Thomas S. Griffith, Jonathan M. Fialkov, David L. Scott, Takeo Azuhata, Richard D. Williams, Nathan R. Wall, Dario C. Altieri, and Anthony D. Sandler
Cancer Res 2002 62: 3093-3099. [Abstract] [Full Text] [PDF]  

Arabinosylguanine Is Phosphorylated by Both Cytoplasmic Deoxycytidine Kinase and Mitochondrial Deoxyguanosine Kinase

Carlos O. Rodriguez, Jr., Beverly S. Mitchell, Mary Ayres, Staffan Eriksson, and Varsha Gandhi
Cancer Res 2002 62: 3100-3105. [Abstract] [Full Text] [PDF]  

CXCR4 Neutralization, a Novel Therapeutic Approach for Non-Hodgkin’s Lymphoma

Francesco Bertolini, Chiara Dell’Agnola, Patrizia Mancuso, Cristina Rabascio, Alessandra Burlini, Silvia Monestiroli, Alberto Gobbi, Giancarlo Pruneri, and Giovanni Martinelli
Cancer Res 2002 62: 3106-3112. [Abstract] [Full Text] [PDF]  

2-Aroylindoles, a Novel Class of Potent, Orally Active Small Molecule Tubulin Inhibitors

Thomas Beckers, Thomas Reissmann, Mathias Schmidt, Angelika M. Burger, Heinz H. Fiebig, Udo Vanhoefer, Herwig Pongratz, Harald Hufsky, Jörg Hockemeyer, Markus Frieser, and Siavosh Mahboobi
Cancer Res 2002 62: 3113-3119. [Abstract] [Full Text] [PDF]  

Significant Antitumor Effect from Bone-seeking, -Particle-emitting ²²³Ra Demonstrated in an Experimental Skeletal Metastases Model

Gjermund Henriksen, Knut Breistøl, Øyvind S. Bruland, Øystein Fodstad, and Roy H. Larsen
Cancer Res 2002 62: 3120-3125. [Abstract] [Full Text] [PDF]  

Mechanisms of Growth Arrest by c-myc Antisense Oligonucleotides in MCF-7 Breast Cancer Cells: Implications for the Antiproliferative Effects of Antiestrogens

Jason S. Carroll, Alexander Swarbrick, Elizabeth A. Musgrove, and Robert L. Sutherland
Cancer Res 2002 62: 3126-3131. [Abstract] [Full Text] [PDF]  

Degradation of HER2 by Ansamycins Induces Growth Arrest and Apoptosis in Cells with HER2 Overexpression via a HER3, Phosphatidylinositol 3'-Kinase-AKT-dependent Pathway

Pamela N. Münster, Douglas C. Marchion, Andrea D. Basso, and Neal Rosen
Cancer Res 2002 62: 3132-3137. [Abstract] [Full Text] [PDF]  

Tumor-targeted Delivery of Polyethylene Glycol-conjugated D-Amino Acid Oxidase for Antitumor Therapy via Enzymatic Generation of Hydrogen Peroxide

Jun Fang, Tomohiro Sawa, Takaaki Akaike, and Hiroshi Maeda
Cancer Res 2002 62: 3138-3143. [Abstract] [Full Text] [PDF]  

Analysis of Methotrexate and Folate Transport by Multidrug Resistance Protein 4 (ABCC4): MRP4 Is a Component of the Methotrexate Efflux System

Zhe-Sheng Chen, Kun Lee, Susan Walther, Rebecca Blanchard Raftogianis, Michihiko Kuwano, Hao Zeng, and Gary D. Kruh
Cancer Res 2002 62: 3144-3150. [Abstract] [Full Text] [PDF]  

The Efficacy of ErbB Receptor-targeted Anticancer Therapeutics Is Influenced by the Availability of Epidermal Growth Factor-related Peptides

Andrea B. Motoyama, Nancy E. Hynes, and Heidi A. Lane
Cancer Res 2002 62: 3151-3158. [Abstract] [Full Text] [PDF]  

Molecular Targeting of the Epidermal Growth Factor Receptor for Neutron Capture Therapy of Gliomas

Rolf. F. Barth, Weilian Yang, Dianne M. Adams, Joan H. Rotaru, Supriya Shukla, Masaru Sekido, Werner Tjarks, Robert A. Fenstermaker, Michael Ciesielski, Marta M. Nawrocky, and Jeffrey A. Coderre
Cancer Res 2002 62: 3159-3166. [Abstract] [Full Text] [PDF]  

Immunology:

An Anti-ICAM-2 (CD102) Monoclonal Antibody Induces Immune-mediated Regressions of Transplanted ICAM-2-negative Colon Carcinomas

Ignacio Melero, Izaskun Gabari, Angel L. Corbí, Miguel Relloso, Guillermo Mazzolini, Volker Schmitz, Mercedes Rodriguez-Calvillo, Iñigo Tirapu, Emilio Camafeita, Juan P. Albar, and Jesús Prieto
Cancer Res 2002 62: 3167-3174. [Abstract] [Full Text] [PDF]  

Immunogenicity of a p210^BCR-ABL Fusion Domain Candidate DNA Vaccine Targeted to Dendritic Cells by a Recombinant Adeno-associated Virus Vector in Vitro

Ji-Yao Sun, Robert S. Krouse, Stephen J. Forman, David Senitzer, Irena Sniecinski, Saswati Chatterjee, and K. K. Wong, Jr.
Cancer Res 2002 62: 3175-3183. [Abstract] [Full Text] [PDF]  

Isolation and Characterization of Human Recombinant Antibodies Endowed with the Antigen-specific, Major Histocompatibility Complex-restricted Specificity of T Cells Directed toward the Widely Expressed Tumor T-cell Epitopes of the Telomerase Catalytic Subunit

Avital Lev, Galit Denkberg, Cyril J. Cohen, Maty Tzukerman, Karl L. Skorecki, Patrick Chames, Hennie R. Hoogenboom, and Yoram Reiter
Cancer Res 2002 62: 3184-3194. [Abstract] [Full Text] [PDF]  

In Vivo Antitumor Effect of CD40L-transduced Tumor Cells as a Vaccine for B-Cell Lymphoma

Javier Briones, John Timmerman, and Ronald Levy
Cancer Res 2002 62: 3195-3199. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Cyclin D1 Is a Candidate Oncogene in Cutaneous Melanoma

Edward R. Sauter, Un-Cheol Yeo, Andrea von Stemm, Weizhu Zhu, Samuel Litwin, David S. Tichansky, Giuseppa Pistritto, Mark Nesbit, Dan Pinkel, Meenhard Herlyn, and Boris C. Bastian
Cancer Res 2002 62: 3200-3206. [Abstract] [Full Text] [PDF]  

A Candidate Tumor Suppressor Gene, H37, from the Human Lung Cancer Tumor Suppressor Locus 3p21.3

Juliana J. Oh, Alison R. West, Michael C. Fishbein, and Dennis J. Slamon
Cancer Res 2002 62: 3207-3213. [Abstract] [Full Text] [PDF]  

Expressed CpG Island Sequence Tag Microarray for Dual Screening of DNA Hypermethylation and Gene Silencing in Cancer Cells

Huidong Shi, Pearlly S. Yan, Chuan-Mu Chen, Farahnaz Rahmatpanah, Catherine Lofton-Day, Charles W. Caldwell, and Tim Hui-Ming Huang
Cancer Res 2002 62: 3214-3220. [Abstract] [Full Text] [PDF]  

mdmx Is a Negative Regulator of p53 Activity in Vivo

Rick A. Finch, Dorit B. Donoviel, David Potter, Min Shi, Amy Fan, Deon D. Freed, Ching-yun Wang, Brian P. Zambrowicz, Ramiro Ramirez-Solis, Arthur T. Sands, and Nan Zhang
Cancer Res 2002 62: 3221-3225. [Abstract] [Full Text] [PDF]  

Ectopic Expression of a COOH-terminal Fragment of the Human Telomerase Reverse Transcriptase Leads to Telomere Dysfunction and Reduction of Growth and Tumorigenicity in HeLa Cells

Jun Jian Huang, Marie C. Lin, Yun Xiu Bai, Da Dao Jing, Benjamin C. Y. Wong, Su Wen Han, Jian Lin, Bing Xu, Cui-fen Huang, and Hsiang-fu Kung
Cancer Res 2002 62: 3226-3232. [Abstract] [Full Text] [PDF]  

Gene Profiling of Cell Cycle Progression through S-Phase Reveals Sequential Expression of Genes Required for DNA Replication and Nucleosome Assembly

Caroline M. J. van der Meijden, David S. Lapointe, Mai X. Luong, Daniel Peric-Hupkes, Brian Cho, Janet L. Stein, Andre J. van Wijnen, and Gary S. Stein
Cancer Res 2002 62: 3233-3243. [Abstract] [Full Text] [PDF]  

Laser Capture Microdissection and Microarray Expression Analysis of Lung Adenocarcinoma Reveals Tobacco Smoking- and Prognosis-related Molecular Profiles

Koh Miura, Elise D. Bowman, Richard Simon, Amy C. Peng, Ana I. Robles, Raymond T. Jones, Toyomasa Katagiri, Ping He, Hiroki Mizukami, Lu Charboneau, Takefumi Kikuchi, Lance A. Liotta, Yusuke Nakamura, and Curtis C. Harris
Cancer Res 2002 62: 3244-3250. [Abstract] [Full Text] [PDF]  

Splice Variants but not Mutations of DNA Polymerase ß Are Common in Bladder Cancer

Tracy E. Thompson, Peter K. Rogan, John I. Risinger, and Jack A. Taylor
Cancer Res 2002 62: 3251-3256. [Abstract] [Full Text] [PDF]  

Targets of c-Jun NH₂-terminal Kinase 2-mediated Tumor Growth Regulation Revealed by Serial Analysis of Gene Expression

Olga Potapova, Sergey V. Anisimov, Myriam Gorospe, Ryan H. Dougherty, William A. Gaarde, Kenneth R. Boheler, and Nikki J. Holbrook
Cancer Res 2002 62: 3257-3263. [Abstract] [Full Text] [PDF]  

Induction of Gene Amplification as a Gain-of-Function Phenotype of Mutant p53 Proteins

Sally El-Hizawi, James P. Lagowski, Molly Kulesz-Martin, and Amador Albor
Cancer Res 2002 62: 3264-3270. [Abstract] [Full Text] [PDF]  

The DNA Polymerase ß Replication Error Spectrum in the Adenomatous Polyposis Coli Gene Contains Human Colon Tumor Mutational Hotspots

Brindha P. Muniappan and William G. Thilly
Cancer Res 2002 62: 3271-3275. [Abstract] [Full Text] [PDF]  

Inactivation of E2f1 Enhances Tumorigenesis in a Myc Transgenic Model

Robert J. Rounbehler, Pamela M. Rogers, Claudio J. Conti, and David G. Johnson
Cancer Res 2002 62: 3276-3281. [Abstract] [Full Text] [PDF]  

Peroxisome Proliferator-activated Receptors Modulate K-Ras-mediated Transformation of Intestinal Epithelial Cells

Jinyi Shao, Hongmiao Sheng, and Raymond N. DuBois
Cancer Res 2002 62: 3282-3288. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Changes in Tenascin-C Isoform Expression in Invasive and Preinvasive Breast Disease

Matthew Adams, J. Louise Jones, Rosemary A. Walker, J. Howard Pringle, and Stephen C. Bell
Cancer Res 2002 62: 3289-3297. [Abstract] [Full Text] [PDF]  

Stromal Cells Promote Angiogenesis and Growth of Human Prostate Tumors in a Differential Reactive Stroma (DRS) Xenograft Model

Jennifer A. Tuxhorn, Stephanie J. McAlhany, Truong D. Dang, Gustavo E. Ayala, and David R. Rowley
Cancer Res 2002 62: 3298-3307. [Abstract] [Full Text] [PDF]  

Identification of Differentially Expressed Genes in Normal and Malignant Prostate by Electronic Profiling of Expressed Sequence Tags

Yan W. Asmann, Farhad Kosari, Kai Wang, John C. Cheville, and George Vasmatzis
Cancer Res 2002 62: 3308-3314. [Abstract] [Full Text] [PDF]  

Human Papillomavirus E6-induced Degradation of E6TP1 Is Mediated by E6AP Ubiquitin Ligase

Qingshen Gao, Ajay Kumar, Latika Singh, Jon M. Huibregtse, Sylvie Beaudenon, Seetha Srinivasan, David E. Wazer, Hamid Band, and Vimla Band
Cancer Res 2002 62: 3315-3321. [Abstract] [Full Text] [PDF]  

Overexpression of Icat Induces G₂ Arrest and Cell Death in Tumor Cell Mutants for Adenomatous Polyposis Coli, ß-catenin, or Axin

Takashi Sekiya, Tsutomu Nakamura, Yasuhiro Kazuki, Mitsuo Oshimura, Kazuyoshi Kohu, Ken-ichi Tago, Susumu Ohwada, and Tetsu Akiyama
Cancer Res 2002 62: 3322-3326. [Abstract] [Full Text] [PDF]  

Erratum:

Correction for vol. 62, p. 1978

Cancer Res 2002 62: 3328 [Full Text] [PDF]  

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