Advances in Brief:

Targeting Interleukin-4 Receptors for Effective Pancreatic Cancer Therapy

Koji Kawakami, Mariko Kawakami, Syed R. Husain, and Raj K. Puri
Cancer Res 2002 62: 3575-3580. [Abstract] [Full Text] [PDF]  

Prospective Molecular Profiling of Melanoma Metastases Suggests Classifiers of Immune Responsiveness

Ena Wang, Lance D. Miller, Galen A. Ohnmacht, Simone Mocellin, Ainhoa Perez-Diez, David Petersen, Yingdong Zhao, Richard Simon, John I. Powell, Esther Asaki, H. Richard Alexander, Paul H. Duray, Meenhard Herlyn, Nicholas P. Restifo, Edison T. Liu, Steven A. Rosenberg, and Francesco M. Marincola
Cancer Res 2002 62: 3581-3586. [Abstract] [Full Text] [PDF]  

TBX2 Is Preferentially Amplified in BRCA1- and BRCA2-related Breast Tumors

Colleen S. Sinclair, Camilo Adem, Ali Naderi, Cheryl L. Soderberg, Michele Johnson, Linda Wadum, Vicki L. Couch, Thomas A. Sellers, Daniel Schaid, Jeffrey Slezak, Zach Fredericksen, James N. Ingle, Lynn Hartmann, Robert B. Jenkins, and Fergus J. Couch
Cancer Res 2002 62: 3587-3591. [Abstract] [Full Text] [PDF]  

Etiology-specific Gene Expression Profiles in Rat Mammary Carcinomas

Takashi Kuramoto, Keiichirou Morimura, Satoshi Yamashita, Eriko Okochi, Naoko Watanabe, Tsutomu Ohta, Misao Ohki, Shoji Fukushima, Takashi Sugimura, and Toshikazu Ushijima
Cancer Res 2002 62: 3592-3597. [Abstract] [Full Text] [PDF]  

Transactivation-deficient TA-p73 Acts as an Oncogene

Thorsten Stiewe, Sonja Zimmermann, Andreja Frilling, Helmut Esche, and Brigitte M. Pützer
Cancer Res 2002 62: 3598-3602. [Abstract] [Full Text] [PDF]  

Bone Marrow-derived Mesenchymal Stem Cells as Vehicles for Interferon-ß Delivery into Tumors

Matus Studeny, Frank C. Marini, Richard E. Champlin, Claudia Zompetta, Isaiah J. Fidler, and Michael Andreeff
Cancer Res 2002 62: 3603-3608. [Abstract] [Full Text] [PDF]  

Serum Protein Fingerprinting Coupled with a Pattern-matching Algorithm Distinguishes Prostate Cancer from Benign Prostate Hyperplasia and Healthy Men

Bao-Ling Adam, Yinsheng Qu, John W. Davis, Michael D. Ward, Mary Ann Clements, Lisa H. Cazares, O. John Semmes, Paul F. Schellhammer, Yutaka Yasui, Ziding Feng, and George L. Wright, Jr.
Cancer Res 2002 62: 3609-3614. [Abstract] [Full Text] [PDF]  

Phenethyl Isothiocyanate-induced Apoptosis in p53-deficient PC-3 Human Prostate Cancer Cell Line Is Mediated by Extracellular Signal-regulated Kinases

Dong Xiao and Shivendra V. Singh
Cancer Res 2002 62: 3615-3619. [Abstract] [Full Text] [PDF]  

Targeted Expression of Green Fluorescent Protein/Tumor Necrosis Factor-related Apoptosis-inducing Ligand Fusion Protein from Human Telomerase Reverse Transcriptase Promoter Elicits Antitumor Activity without Toxic Effects on Primary Human Hepatocytes

Tongyu Lin, Jian Gu, Lidong Zhang, Xuefeng Huang, L. Clifton Stephens, Steven A. Curley, and Bingliang Fang
Cancer Res 2002 62: 3620-3625. [Abstract] [Full Text] [PDF]  

Radiosensitization of Hypoxic Tumor Cells by Dodecafluoropentane: A Gas-Phase Perfluorochemical Emulsion

Cameron J. Koch, Patricia R. Oprysko, A. Lee Shuman, W. Timothy Jenkins, Gordon Brandt, and Sydney M. Evans
Cancer Res 2002 62: 3626-3629. [Abstract] [Full Text] [PDF]  

Generation of NY-ESO-1-specific CD4+ and CD8+ T Cells by a Single Peptide with Dual MHC Class I and Class II Specificities: A New Strategy for Vaccine Design

Gang Zeng, Yong Li, Mona El-Gamil, John Sidney, Alexandro Sette, Rong-fu Wang, Steven A. Rosenberg, and Paul F. Robbins
Cancer Res 2002 62: 3630-3635. [Abstract] [Full Text] [PDF]  

Genomic Copy Number Analysis of Non-small Cell Lung Cancer Using Array Comparative Genomic Hybridization: Implications of the Phosphatidylinositol 3-Kinase Pathway

Pierre P. Massion, Wen-Lin Kuo, David Stokoe, Adam B. Olshen, Patrick A. Treseler, Koei Chin, Chira Chen, Daniel Polikoff, Ajay N. Jain, Daniel Pinkel, Donna G. Albertson, David M. Jablons, and Joe W. Gray
Cancer Res 2002 62: 3636-3640. [Abstract] [Full Text] [PDF]  

Instabilotyping Reveals Unique Mutational Spectra in Microsatellite-Unstable Gastric Cancers

Yuriko Mori, Fumiaki Sato, Florin M. Selaru, Andreea Olaru, Kellie Perry, Martha C. Kimos, Gen Tamura, Nagahide Matsubara, Suna Wang, Yan Xu, Jing Yin, Tong-Tong Zou, Barbara Leggett, Joanne Young, Toshihiro Nukiwa, O. Colin Stine, John M. Abraham, David Shibata, and Stephen J. Meltzer
Cancer Res 2002 62: 3641-3645. [Abstract] [Full Text] [PDF] Supplementary Data  

Circulating MYCN DNA as a Tumor-specific Marker in Neuroblastoma Patients

Valérie Combaret, Carole Audoynaud, Isabelle Iacono, Marie-Christine Favrot, Matthias Schell, Christophe Bergeron, and Alain Puisieux
Cancer Res 2002 62: 3646-3648. [Abstract] [Full Text] [PDF]  

Raloxifene, a Selective Estrogen Receptor Modulator, Induces Apoptosis in Androgen-responsive Human Prostate Cancer Cell Line LNCaP through an Androgen-independent Pathway

Isaac Yi Kim, Do Hwan Seong, Byung-Chul Kim, Dug Keun Lee, Alan T. Remaley, Fredrick Leach, Ronald A. Morton, and Seong-Jin Kim
Cancer Res 2002 62: 3649-3653. [Abstract] [Full Text] [PDF]  

Plant-derived Human Papillomavirus 16 E7 Oncoprotein Induces Immune Response and Specific Tumor Protection

Rosella Franconi, Paola Di Bonito, Francesco Dibello, Luisa Accardi, Antonio Muller, Alessia Cirilli, Paola Simeone, M. Gabriella Donà, Aldo Venuti, and Colomba Giorgi
Cancer Res 2002 62: 3654-3658. [Abstract] [Full Text] [PDF]  

Inactivation of LKB1/STK11 Is a Common Event in Adenocarcinomas of the Lung

Montserrat Sanchez-Cespedes, Paola Parrella, Manel Esteller, Shuji Nomoto, Barry Trink, James M. Engles, William H. Westra, James G. Herman, and David Sidransky
Cancer Res 2002 62: 3659-3662. [Abstract] [Full Text] [PDF]  

Methylation of Adenomatous Polyposis Coli in Endometrial Cancer Occurs More Frequently in Tumors with Microsatellite Instability Phenotype

Michele Zysman, Asantha Saka, Anna Millar, Julia Knight, William Chapman, and Bharati Bapat
Cancer Res 2002 62: 3663-3666. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Role of the Alternating Reading Frame (P19)-p53 Pathway in an in Vivo Murine Colon Tumor Model

Prashant R. Nambiar, Charles Giardina, Kishore Guda, Wataru Aizu, Rajiv Raja, and Daniel W. Rosenberg
Cancer Res 2002 62: 3667-3674. [Abstract] [Full Text] [PDF]  

Application of Information Theory and Extreme Physical Information to Carcinogenesis

Robert A. Gatenby and B. Roy Frieden
Cancer Res 2002 62: 3675-3684. [Abstract] [Full Text] [PDF]  

Inhibition of Carcinogen-activating Enzymes by 16-Fluoro-5-androsten-17-one

Henry P. Ciolino, Christopher J. MacDonald, and Grace Chao Yeh
Cancer Res 2002 62: 3685-3690. [Abstract] [Full Text] [PDF]  

Endocrinology:

2-Methoxyestradiol Inhibits Proliferation and Induces Apoptosis Independently of Estrogen Receptors and ß

Theresa M. LaVallee, Xiaoguo H. Zhan, Chris J. Herbstritt, Emily C. Kough, Shawn J. Green, and Victor S. Pribluda
Cancer Res 2002 62: 3691-3697. [Abstract] [Full Text] [PDF]  

Frequent Epigenetic Silencing of the CpG Island Promoter of RASSF1A in Thyroid Carcinoma

Undraga Schagdarsurengin, Oliver Gimm, Cuong Hoang-Vu, Henning Dralle, Gerd P. Pfeifer, and Reinhard Dammann
Cancer Res 2002 62: 3698-3701. [Abstract] [Full Text] [PDF]  

HER-2/neu Expression and Gene Amplification in Gastrinomas: Correlations with Tumor Biology, Growth, and Aggressiveness

Stephan U. Goebel, Michiko Iwamoto, Mark Raffeld, Fathia Gibril, Wei Hou, Jose Serrano, and Robert T. Jensen
Cancer Res 2002 62: 3702-3710. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Activity of a New Vascular Targeting Agent, ZD6126, in Pulmonary Metastases by Human Lung Adenocarcinoma in Nude Mice

Hisatsugu Goto, Seiji Yano, Helong Zhang, Yuka Matsumori, Hirohisa Ogawa, David C. Blakey, and Saburo Sone
Cancer Res 2002 62: 3711-3715. [Abstract] [Full Text] [PDF]  

Novel Mutation of Topoisomerase I in Rendering Cells Resistant to Camptothecin

Jang-Yang Chang, Jin-Fen Liu, Shin-Hun Juang, Tsang-Wu Liu, and Li-Tzong Chen
Cancer Res 2002 62: 3716-3721. [Abstract] [Full Text] [PDF]  

Neoglycans, Carbodiimide-modified Glycosaminoglycans: A New Class of Anticancer Agents That Inhibit Cancer Cell Proliferation and Induce Apoptosis

Carla Y. Pumphrey, Allison M. Theus, Shulin Li, Rudolph S. Parrish, and Ralph D. Sanderson
Cancer Res 2002 62: 3722-3728. [Abstract] [Full Text] [PDF]  

Platelet-derived Growth Factor (PDGF) Autocrine Signaling Regulates Survival and Mitogenic Pathways in Glioblastoma Cells: Evidence That the Novel PDGF-C and PDGF-D Ligands May Play a Role in the Development of Brain Tumors

Nathalie A. Lokker, Carol M. Sullivan, Stanley J. Hollenbach, Mark A. Israel, and Neill A. Giese
Cancer Res 2002 62: 3729-3735. [Abstract] [Full Text] [PDF]  

The Anti-CD30 Monoclonal Antibody SGN-30 Promotes Growth Arrest and DNA Fragmentation in Vitro and Affects Antitumor Activity in Models of Hodgkin’s Disease

Alan F. Wahl, Kerry Klussman, Jennifer D. Thompson, Judy H. Chen, Leigh V. Francisco, Grant Risdon, Dana F. Chace, Clay B. Siegall, and Joseph A. Francisco
Cancer Res 2002 62: 3736-3742. [Abstract] [Full Text] [PDF]  

Identification of Human Uroplakin II Promoter and Its Use in the Construction of CG8840, a Urothelium-specific Adenovirus Variant That Eliminates Established Bladder Tumors in Combination with Docetaxel

Jane Zhang, Nagarajan Ramesh, Yu Chen, Yuanhao Li, Jeanette Dilley, Peter Working, and De-Chao Yu
Cancer Res 2002 62: 3743-3750. [Abstract] [Full Text] [PDF]  

Immunology:

A Pivotal Role for CC Chemokine Receptor 5 in T-Cell Migration to Tumor Sites Induced by Interleukin 12 Treatment in Tumor-bearing Mice

Yasuhiro Uekusa, Wen-Gong Yu, Takao Mukai, Ping Gao, Nobuya Yamaguchi, Masako Murai, Kouji Matsushima, Satoshi Obika, Takeshi Imanishi, Yuji Higashibata, Shintaro Nomura, Yukihiko Kitamura, Hiromi Fujiwara, and Toshiyuki Hamaoka
Cancer Res 2002 62: 3751-3758. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Alterations in Gene Expression and Activity during Squamous Cell Carcinoma Development

Magdalena M. Serewko, Claudia Popa, Alison L. Dahler, Louise Smith, Geoff M. Strutton, William Coman, Anthony J. Dicker, and Nicholas A. Saunders
Cancer Res 2002 62: 3759-3765. [Abstract] [Full Text] [PDF]  

Aberrant Expression of HMGA2 in Uterine Leiomyoma Associated with Loss of TSC2 Tumor Suppressor Gene Function

Deborah S. Hunter, Michael Klotzbücher, Hiroyuki Kugoh, Sheng-Li Cai, Johanna P. Mullen, Guidalberto Manfioletti, Ulrike Fuhrman, and Cheryl L. Walker
Cancer Res 2002 62: 3766-3772. [Abstract] [Full Text] [PDF]  

A Common DNA-binding Site for SZF1 and the BRCA1-associated Zinc Finger Protein, ZBRK1

Hongzhuang Peng, Lei Zheng, Wen-Hwa Lee, John J. Rux, and Frank J. Rauscher, III
Cancer Res 2002 62: 3773-3781. [Abstract] [Full Text] [PDF]  

Universal and Radiation-specific Loci Influence Murine Susceptibility to Radiation-induced Pulmonary Fibrosis

Christina K. Haston, Xinhui Zhou, Laura Gumbiner-Russo, Roxanna Irani, Robert Dejournett, Xiangjun Gu, Michael Weil, Christopher I. Amos, and Elizabeth L. Travis
Cancer Res 2002 62: 3782-3788. [Abstract] [Full Text] [PDF]  

Evaluation of Candidate Genes MAP2K4, MADH4, ACVR1B, and BRCA2 in Familial Pancreatic Cancer: Deleterious BRCA2 Mutations in 17%

Kathleen M. Murphy, Kieran A. Brune, Constance Griffin, Jennifer E. Sollenberger, Gloria M. Petersen, Ravi Bansal, Ralph H. Hruban, and Scott E. Kern
Cancer Res 2002 62: 3789-3793. [Abstract] [Full Text] [PDF]  

Hypermethylation of HIC-1 and 17p Allelic Loss in Medulloblastoma

Brian R. Rood, Huizhen Zhang, David M. Weitman, and Philip H. Cogen
Cancer Res 2002 62: 3794-3797. [Abstract] [Full Text] [PDF]  

A Novel Low-Penetrance Locus for Familial Glioma at 15q23-q26.3

Niina Paunu, Päivi Lahermo, Päivi Onkamo, Vesa Ollikainen, Immo Rantala, Pauli Helén, Kalle O. J. Simola, Juha Kere, and Hannu Haapasalo
Cancer Res 2002 62: 3798-3802. [Abstract] [Full Text] [PDF]  

Identification of Cyclin D1 and Other Novel Targets for the von Hippel-Lindau Tumor Suppressor Gene by Expression Array Analysis and Investigation of Cyclin D1 Genotype as a Modifier in von Hippel-Lindau Disease

Malgorzata Zatyka, Nancy Fernandes da Silva, Steven C. Clifford, Mark R. Morris, Michael S. Wiesener, Kai-Uwe Eckardt, Richard S. Houlston, Frances M. Richards, Farida Latif, and Eamonn R. Maher
Cancer Res 2002 62: 3803-3811. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Expression of the Coxsackie Adenovirus Receptor in Normal Prostate and in Primary and Metastatic Prostate Carcinoma: Potential Relevance to Gene Therapy

Katherine A. Rauen, Daniel Sudilovsky, Jason L. Le, Karen L. Chew, Byron Hann, Vivian Weinberg, Lars D. Schmitt, and Frank McCormick
Cancer Res 2002 62: 3812-3818. [Abstract] [Full Text] [PDF]  

Clinical and Biological Significance of S-Phase Kinase-associated Protein 2 (Skp2) Gene Expression in Gastric Carcinoma: Modulation of Malignant Phenotype by Skp2 Overexpression, Possibly via p27 Proteolysis

Taka-aki Masuda, Hiroshi Inoue, Hideto Sonoda, Shinji Mine, Yasuji Yoshikawa, Keiko Nakayama, Kei-Ichi Nakayama, and Masaki Mori
Cancer Res 2002 62: 3819-3825. [Abstract] [Full Text] [PDF]  

Comparative Oncological Studies of Feline Bronchioloalveolar Lung Carcinoma, Its Derived Cell Line and Xenograft

Deborah A. Grossman, Alan L. Hiti, Elizabeth A. McNiel, Yin Ye, Mary L. Alpaugh, and Sanford H. Barsky
Cancer Res 2002 62: 3826-3833. [Abstract] [Full Text] [PDF]  

Angioarrestin: An Antiangiogenic Protein with Tumor-inhibiting Properties

Mohanraj Dhanabal, William J. LaRochelle, Michael Jeffers, John Herrmann, Luca Rastelli, William F. McDonald, Rajeev A. Chillakuru, Meijia Yang, Ferenc L. Boldog, Muralidhara Padigaru, Kelly D. McQueeney, Frank Wu, Stacey A. Minskoff, Richard A. Shimkets, and Henri S. Lichenstein
Cancer Res 2002 62: 3834-3841. [Abstract] [Full Text] [PDF]  

Cyclin B and E2F-1 Expression in Prostate Carcinoma Cells Treated with the Novel Retinoid CD437 Are Regulated by the Ubiquitin-mediated Pathway

Lulu Farhana, Marcia Dawson, Arun K. Rishi, Yuxiang Zhang, Eric Van Buren, Charu Trivedi, Uwe Reichert, Guowei Fang, Marc W. Kirschner, and Joseph A. Fontana
Cancer Res 2002 62: 3842-3849. [Abstract] [Full Text] [PDF]  

Ganglioside G_M3 Overexpression Induces Apoptosis and Reduces Malignant Potential in Murine Bladder Cancer

Ryuji Watanabe, Chikara Ohyama, Hiroshi Aoki, Toshiko Takahashi, Makoto Satoh, Seiichi Saito, Senji Hoshi, Atsushi Ishii, Masaki Saito, and Yoichi Arai
Cancer Res 2002 62: 3850-3854. [Abstract] [Full Text] [PDF]  

Stromelysin-1 Promoter Mutations Impair Gelatinase B Activation in High Microsatellite Instability Sporadic Colorectal Tumors

Alberto Morán, Pilar Iniesta, Carmen de Juan, Rosa González-Quevedo, Andrés Sánchez-Pernaute, Eduardo Díaz-Rubio, Santiago Ramón y Cajal, Antonio Torres, Jose Luis Balibrea, and Manuel Benito
Cancer Res 2002 62: 3855-3860. [Abstract] [Full Text] [PDF]  

SYT-SSX Is Critical for Cyclin D1 Expression in Synovial Sarcoma Cells: A Gain of Function of the t(X;18)(p11.2;q11.2) Translocation

Yuntao Xie, Björn Skytting, Gunnar Nilsson, Alessandra Gasbarri, Karl Haslam, Armando Bartolazzi, Bertha Brodin, Nils Mandahl, and Olle Larsson
Cancer Res 2002 62: 3861-3867. [Abstract] [Full Text] [PDF]  

Dietary Curcumin Inhibits Chemotherapy-induced Apoptosis in Models of Human Breast Cancer

Sivagurunathan Somasundaram, Natalie A. Edmund, Dominic T. Moore, George W. Small, Yue Y. Shi, and Robert Z. Orlowski
Cancer Res 2002 62: 3868-3875. [Abstract] [Full Text] [PDF]  

Cytokines Modulate Telomerase Activity in a Human Multiple Myeloma Cell Line

Masaharu Akiyama, Teru Hideshima, Toshiaki Hayashi, Yu-Tzu Tai, Constantine S. Mitsiades, Nicholas Mitsiades, Dharminder Chauhan, Paul Richardson, Nikhil C. Munshi, and Kenneth C. Anderson
Cancer Res 2002 62: 3876-3882. [Abstract] [Full Text] [PDF]  

Meeting Report:

Thirteenth Annual Pezcoller Symposium: Focusing Analytical Tools on Complexity in Cancer

Enrico Mihich, Jean Feunteun, and Stephen Friend
Cancer Res 2002 62: 3883-3887. [Abstract] [Full Text] [PDF] Supplementary Data  

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