Advances in Brief:

Huizhen Wang, Yiqiang Zhang, Liwen Cao, Hong Han, Jingxiong Wang, Baofeng Yang, Stanley Nattel, and Zhiguo Wang

HERG K⁺ Channel, a Regulator of Tumor Cell Apoptosis and Proliferation
Cancer Res 2002 62: 4843-4848. [Abstract] [Full Text] [PDF]  

Shigehira Saji, Yoko Omoto, Chikako Shimizu, Margaret Warner, Yukiko Hayashi, Shin-ichiro Horiguchi, Toru Watanabe, Shin-ichi Hayashi, Jan-Åke Gustafsson, and Masakazu Toi

Expression of Estrogen Receptor (ER) ßcx Protein in ER-positive Breast Cancer: Specific Correlation with Progesterone Receptor
Cancer Res 2002 62: 4849-4853. [Abstract] [Full Text] [PDF]  

Quintin Pan, Celina G. Kleer, Kenneth L. van Golen, Jennifer Irani, Kristen M. Bottema, Carlos Bias, Magda De Carvalho, Enrique A. Mesri, Diane M. Robins, Robert D. Dick, George J. Brewer, and Sofia D. Merajver

Copper Deficiency Induced by Tetrathiomolybdate Suppresses Tumor Growth and Angiogenesis
Cancer Res 2002 62: 4854-4859. [Abstract] [Full Text] [PDF]  

Issei Imoto, Hitoshi Tsuda, Akira Hirasawa, Masahiko Miura, Masaru Sakamoto, Setsuo Hirohashi, and Johji Inazawa

Expression of cIAP1, a Target for 11q22 Amplification, Correlates with Resistance of Cervical Cancers to Radiotherapy
Cancer Res 2002 62: 4860-4866. [Abstract] [Full Text] [PDF]  

Chaohua Yan, Ye Liang, Karen D. Nylander, and Nina Felice Schor

TrkA as a Life and Death Receptor: Receptor Dose as a Mediator of Function
Cancer Res 2002 62: 4867-4875. [Abstract] [Full Text] [PDF]  

Saul Grinstein, Maria Victoria Preciado, Paolo Gattuso, Paola A. Chabay, William H. Warren, Elena De Matteo, and Victor E. Gould

Demonstration of Epstein-Barr Virus in Carcinomas of Various Sites
Cancer Res 2002 62: 4876-4878. [Abstract] [Full Text] [PDF]  

Samir Attoub, Christine Rivat, Sylvie Rodrigues, Saskia Van Bocxlaer, Monique Bedin, Erik Bruyneel, Christophe Louvet, Michel Kornprobst, Thierry André, Marc Mareel, Jan Mester, and Christian Gespach

The c-kit Tyrosine Kinase Inhibitor STI571 for Colorectal Cancer Therapy
Cancer Res 2002 62: 4879-4883. [Abstract] [Full Text] [PDF]  

Eva Wieckowski, Gui-Qiang Wang, Brian R. Gastman, Leslie A. Goldstein, and Hannah Rabinowich

Granzyme B-mediated Degradation of T-Cell Receptor Chain
Cancer Res 2002 62: 4884-4889. [Abstract] [Full Text] [PDF]  

Ka Man Leung, Lai See Po, Fan Cheung Tsang, Wai Yi Siu, Anita Lau, Horace T. B. Ho, and Randy Y. C. Poon

The Candidate Tumor Suppressor ING1b Can Stabilize p53 by Disrupting the Regulation of p53 by MDM2
Cancer Res 2002 62: 4890-4893. [Abstract] [Full Text] [PDF]  

Kazuki Sasaki, Kae Sato, Yasuto Akiyama, Kazuyoshi Yanagihara, Masaaki Oka, and Ken Yamaguchi

Peptidomics-based Approach Reveals the Secretion of the 29-Residue COOH-Terminal Fragment of the Putative Tumor Suppressor Protein DMBT1 from Pancreatic Adenocarcinoma Cell Lines
Cancer Res 2002 62: 4894-4898. [Abstract] [Full Text] [PDF]  

Takahisa Furuta, Takahiro Ueda, Gregory Aune, Alain Sarasin, Kenneth H. Kraemer, and Yves Pommier

Transcription-coupled Nucleotide Excision Repair as a Determinant of Cisplatin Sensitivity of Human Cells
Cancer Res 2002 62: 4899-4902. [Abstract] [Full Text] [PDF]  

Ximing Tang, Yun Jie Sun, Elizabeth Half, M. Tien Kuo, and Frank Sinicrope

Cyclooxygenase-2 Overexpression Inhibits Death Receptor 5 Expression and Confers Resistance to Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in Human Colon Cancer Cells
Cancer Res 2002 62: 4903-4908. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Beverly A. Tinkelenberg, Michael J. Hansbury, and Robert D. Ladner

dUTPase and Uracil-DNA Glycosylase Are Central Modulators of Antifolate Toxicity in Saccharomyces cerevisiae
Cancer Res 2002 62: 4909-4915. [Abstract] [Full Text] [PDF]  

Ryohei Furumai, Akihisa Matsuyama, Nobuyuki Kobashi, Kun-Hyung Lee, Makoto Nishiyama, Hidenori Nakajima, Akito Tanaka, Yasuhiko Komatsu, Norikazu Nishino, Minoru Yoshida, and Sueharu Horinouchi

FK228 (Depsipeptide) as a Natural Prodrug That Inhibits Class I Histone Deacetylases
Cancer Res 2002 62: 4916-4921. [Abstract] [Full Text] [PDF]  

Lars-Oliver Klotz, Pauline Patak, Niloofar Ale-Agha, Darius P. Buchczyk, Kotb Abdelmohsen, P. Arne Gerber, Claudia von Montfort, and Helmut Sies

2-Methyl-1,4-naphthoquinone, Vitamin K₃, Decreases Gap-Junctional Intercellular Communication via Activation of the Epidermal Growth Factor Receptor/Extracellular Signal-regulated Kinase Cascade
Cancer Res 2002 62: 4922-4928. [Abstract] [Full Text] [PDF]  

Karthikeyan Kandasamy and Rakesh K. Srivastava

Role of the Phosphatidylinositol 3'-Kinase/PTEN/Akt Kinase Pathway in Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis in Non-Small Cell Lung Cancer Cells
Cancer Res 2002 62: 4929-4937. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Tomoki Tokugawa, Hiroyuki Sugihara, Tohru Tani, and Takanori Hattori

Modes of Silencing of p16 in Development of Esophageal Squamous Cell Carcinoma
Cancer Res 2002 62: 4938-4944. [Abstract] [Full Text] [PDF]  

Sanjeev Banerjee, Carlos Bueso-Ramos, and Bharat B. Aggarwal

Suppression of 7,12-Dimethylbenz(a)anthracene-induced Mammary Carcinogenesis in Rats by Resveratrol: Role of Nuclear Factor-B, Cyclooxygenase 2, and Matrix Metalloprotease 9
Cancer Res 2002 62: 4945-4954. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Thomas Illmer, Ulrich S. Schuler, Christian Thiede, Ute I. Schwarz, Richard B. Kim, Sebastian Gotthard, Daniel Freund, Ulrike Schäkel, Gerhard Ehninger, and Markus Schaich

MDR1 Gene Polymorphisms Affect Therapy Outcome in Acute Myeloid Leukemia Patients
Cancer Res 2002 62: 4955-4962. [Abstract] [Full Text] [PDF]  

Gavin J. Gordon, Roderick V. Jensen, Li-Li Hsiao, Steven R. Gullans, Joshua E. Blumenstock, Sridhar Ramaswamy, William G. Richards, David J. Sugarbaker, and Raphael Bueno

Translation of Microarray Data into Clinically Relevant Cancer Diagnostic Tests Using Gene Expression Ratios in Lung Cancer and Mesothelioma
Cancer Res 2002 62: 4963-4967. [Abstract] [Full Text] [PDF]  

Svend O. Freytag, Mark Khil, Hans Stricker, James Peabody, Mani Menon, Mariza DePeralta-Venturina, Daniel Nafziger, Jan Pegg, Dell Paielli, Steve Brown, Ken Barton, Mei Lu, Estuardo Aguilar-Cordova, and Jae Ho Kim

Phase I Study of Replication-competent Adenovirus-mediated Double Suicide Gene Therapy for the Treatment of Locally Recurrent Prostate Cancer
Cancer Res 2002 62: 4968-4976. [Abstract] [Full Text] [PDF]  

Endocrinology:

Hélène Buteau-Lozano, Magali Ancelin, Bernard Lardeux, Julie Milanini, and Martine Perrot-Applanat

Transcriptional Regulation of Vascular Endothelial Growth Factor by Estradiol and Tamoxifen in Breast Cancer Cells: A Complex Interplay between Estrogen Receptors and ß
Cancer Res 2002 62: 4977-4984. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Daniel B. Rubinstein, Alexei Stortchevoi, Michael Boosalis, Raheela Ashfaq, and Thierry Guillaume

Overexpression of DNA-binding Protein B Gene Product in Breast Cancer as Detected by in Vitro-generated Combinatorial Human Immunoglobulin Libraries
Cancer Res 2002 62: 4985-4991. [Abstract] [Full Text] [PDF]  

Hongbing Shen, Luo Wang, Margaret R. Spitz, Waun K. Hong, Li Mao, and Qingyi Wei

A Novel Polymorphism in Human Cytosine DNA-Methyltransferase-3B Promoter Is Associated with an Increased Risk of Lung Cancer
Cancer Res 2002 62: 4992-4995. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Richard LeBlanc, Laurence P. Catley, Teru Hideshima, Suzanne Lentzsch, Constantine S. Mitsiades, Nicholas Mitsiades, Donna Neuberg, Olga Goloubeva, Christine S. Pien, Julian Adams, Deepak Gupta, Paul G. Richardson, Nikhil C. Munshi, and Kenneth C. Anderson

Proteasome Inhibitor PS-341 Inhibits Human Myeloma Cell Growth in Vivo and Prolongs Survival in a Murine Model
Cancer Res 2002 62: 4996-5000. [Abstract] [Full Text] [PDF]  

Lars M. Wagner, Sylvie M. Guichard, Rebecca A. Burger, Christopher L. Morton, Charles M. Straign, Richard A. Ashmun, Linda C. Harris, Peter J. Houghton, Philip M. Potter, and Mary K. Danks

Efficacy and Toxicity of a Virus-directed Enzyme Prodrug Therapy Purging Method: Preclinical Assessment and Application to Bone Marrow Samples from Neuroblastoma Patients
Cancer Res 2002 62: 5001-5007. [Abstract] [Full Text] [PDF]  

Yasunari Ogiso, Akihiro Tomida, and Takashi Tsuruo

Nuclear Localization of Proteasomes Participates in Stress-inducible Resistance of Solid Tumor Cells to Topoisomerase II-directed Drugs
Cancer Res 2002 62: 5008-5012. [Abstract] [Full Text] [PDF]  

Rosa Lillo, Manuel Ramírez, Ángela Álvarez, Silvia Santos, Javier García-Castro, Jaime Fernández de Velasco, María José Avilés, Alfonso Gómez-Pineda, José Luis Díez, Antonio Balas, José Luis Vicario, Juan Antonio Bueren, and Félix García-Sánchez

Efficient and Nontoxic Adenoviral Purging Method for Autologous Transplantation in Breast Cancer Patients
Cancer Res 2002 62: 5013-5018. [Abstract] [Full Text] [PDF]  

Boris Lin, Klaus Podar, Deepak Gupta, Yu-Tzu Tai, Sigui Li, Edie Weller, Teru Hideshima, Suzanne Lentzsch, Faith Davies, Cheng Li, Ellen Weisberg, Robert L. Schlossman, Paul G. Richardson, James D. Griffin, Jeanette Wood, Nikhil C. Munshi, and Kenneth C. Anderson

The Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor PTK787/ZK222584 Inhibits Growth and Migration of Multiple Myeloma Cells in the Bone Marrow Microenvironment
Cancer Res 2002 62: 5019-5026. [Abstract] [Full Text] [PDF]  

Yijiang Shi, Joseph Gera, Liping Hu, Jung-hsin Hsu, Robert Bookstein, Weiqun Li, and Alan Lichtenstein

Enhanced Sensitivity of Multiple Myeloma Cells Containing PTEN Mutations to CCI-779
Cancer Res 2002 62: 5027-5034. [Abstract] [Full Text] [PDF]  

Erin L. Volk, Kate M. Farley, Yan Wu, Fei Li, Robert W. Robey, and Erasmus Schneider

Overexpression of Wild-Type Breast Cancer Resistance Protein Mediates Methotrexate Resistance
Cancer Res 2002 62: 5035-5040. [Abstract] [Full Text] [PDF]  

Zhen Su, Johannes Vieweg, Alon Z. Weizer, Philipp Dahm, Donna Yancey, Vandana Turaga, John Higgins, David Boczkowski, Eli Gilboa, and Jens Dannull

Enhanced Induction of Telomerase-specific CD4⁺ T Cells Using Dendritic Cells Transfected with RNA Encoding a Chimeric Gene Product
Cancer Res 2002 62: 5041-5048. [Abstract] [Full Text] [PDF]  

Immunology:

Erik S. Kass, John W. Greiner, Judith A. Kantor, Kwong Y. Tsang, Fiorella Guadagni, Zhong Chen, Bradly Clark, Roberto De Pascalis, Jeffrey Schlom, and Carter Van Waes

Carcinoembryonic Antigen as a Target for Specific Antitumor Immunotherapy of Head and Neck Cancer
Cancer Res 2002 62: 5049-5057. [Abstract] [Full Text] [PDF]  

John Schmitz, Eva Reali, James W. Hodge, Arti Patel, Garland Davis, Jeffrey Schlom, and John W. Greiner

Identification of an Interferon--inducible Carcinoembryonic Antigen (CEA) CD8⁺ T-Cell Epitope, Which Mediates Tumor Killing in CEA Transgenic Mice
Cancer Res 2002 62: 5058-5064. [Abstract] [Full Text] [PDF]  

Stefan Wirths, Jeannette Reichert, Frank Grünebach, and Peter Brossart

Activated CD8+ T Lymphocytes Induce Differentiation of Monocytes to Dendritic Cells and Restore the Stimulatory Capacity of Interleukin 10-treated Antigen-presenting Cells
Cancer Res 2002 62: 5065-5068. [Abstract] [Full Text] [PDF]  

Kangla Tsung, James P. Dolan, Ying L. Tsung, and Jeffrey A. Norton

Macrophages as Effector Cells in Interleukin 12-induced T Cell-dependent Tumor Rejection
Cancer Res 2002 62: 5069-5075. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Rizwan Haq, James D. Brenton, Mark Takahashi, Dina Finan, Robert Rottapel, and Brent Zanke

Constitutive p38HOG Mitogen-activated Protein Kinase Activation Induces Permanent Cell Cycle Arrest and Senescence
Cancer Res 2002 62: 5076-5082. [Abstract] [Full Text] [PDF]  

Jeannie M. Chapman, Stewart M. Knoepp, Mee Kyeong Byeon, Kelly W. Henderson, and Clifford W. Schweinfest

The Colon Anion Transporter, Down-Regulated in Adenoma, Induces Growth Suppression That Is Abrogated by E1A
Cancer Res 2002 62: 5083-5088. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Sarah J. Welsh, William T. Bellamy, Margaret M. Briehl, and Garth Powis

The Redox Protein Thioredoxin-1 (Trx-1) Increases Hypoxia-inducible Factor 1 Protein Expression: Trx-1 Overexpression Results in Increased Vascular Endothelial Growth Factor Production and Enhanced Tumor Angiogenesis
Cancer Res 2002 62: 5089-5095. [Abstract] [Full Text] [PDF]  

Zhigang Song, Xiantuo Wu, William C. Powell, Robert D. Cardiff, Michael B. Cohen, Robert T. Tin, Robert J. Matusik, Gary J. Miller, and Pradip Roy-Burman

Fibroblast Growth Factor 8 Isoform b Overexpression in Prostate Epithelium: A New Mouse Model for Prostatic Intraepithelial Neoplasia
Cancer Res 2002 62: 5096-5105. [Abstract] [Full Text] [PDF]  

Lisa Mills, Carmen Tellez, Suyun Huang, Cheryl Baker, Marya McCarty, Larry Green, Jean M. Gudas, X. Feng, and Menashe Bar-Eli

Fully Human Antibodies to MCAM/MUC18 Inhibit Tumor Growth and Metastasis of Human Melanoma
Cancer Res 2002 62: 5106-5114. [Abstract] [Full Text] [PDF]  

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