Perspectives in Cancer Research:

Scott M. Lippman and Waun Ki Hong

Cancer Prevention Science and Practice
Cancer Res 2002 62: 5119-5125. [Full Text] [PDF]  

Advances in Brief:

Elles M. J. Boon, Ronald van der Neut, Marc van de Wetering, Hans Clevers, and Steven T. Pals

Wnt Signaling Regulates Expression of the Receptor Tyrosine Kinase Met in Colorectal Cancer
Cancer Res 2002 62: 5126-5128. [Abstract] [Full Text] [PDF]  

Mika Yageta, Masami Kuramochi, Mari Masuda, Takeshi Fukami, Hiroshi Fukuhara, Tomoko Maruyama, Masabumi Shibuya, and Yoshinori Murakami

Direct Association of TSLC1 and DAL-1, Two Distinct Tumor Suppressor Proteins in Lung Cancer
Cancer Res 2002 62: 5129-5133. [Abstract] [Full Text] [PDF]  

Alexander Yu Nikitin, Chia-Yang Liu, Andrea Flesken-Nikitin, Chi-Fen Chen, Phang-Lang Chen, and Wen-Hwa Lee

Cell Lineage-specific Effects Associated with Multiple Deficiencies of Tumor Susceptibility Genes in Msh2^-/-Rb^+/- Mice
Cancer Res 2002 62: 5134-5138. [Abstract] [Full Text] [PDF]  

Sabine Zitzmann, Volker Ehemann, and Manfred Schwab

Arginine-Glycine-Aspartic Acid (RGD)-Peptide Binds to Both Tumor and Tumor-Endothelial Cells in Vivo
Cancer Res 2002 62: 5139-5143. [Abstract] [Full Text] [PDF]  

Christopher E. Touloukian, Wolfgang W. Leitner, Paul F. Robbins, Yong F. Li, Xiaoqiang Kang, Rejean Lapointe, Patrick Hwu, Steven A. Rosenberg, and Nicholas P. Restifo

Expression of a "Self-"Antigen by Human Tumor Cells Enhances Tumor Antigen-specific CD4⁺ T-Cell Function
Cancer Res 2002 62: 5144-5147. [Abstract] [Full Text] [PDF]  

Delphine Duguay, François Mercier, John Stagg, Daniel Martineau, Jonathan Bramson, Marc Servant, Rongtuan Lin, Jacques Galipeau, and John Hiscott

In Vivo Interferon Regulatory Factor 3 Tumor Suppressor Activity in B16 Melanoma Tumors
Cancer Res 2002 62: 5148-5152. [Abstract] [Full Text] [PDF]  

Mingshan Yan, Xianghong Kuang, Wenan Qiang, Jianjun Shen, Kent Claypool, William S. Lynn, and Paul K. Y. Wong

Prevention of Thymic Lymphoma Development in Atm-/- Mice by Dexamethasone
Cancer Res 2002 62: 5153-5157. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Penny E. Lovat, Serafina Oliverio, Marco Ranalli, Marco Corazzari, Carlo Rodolfo, Francesca Bernassola, Karen Aughton, Mauro Maccarrone, Quentin D. Campbell Hewson, Andy D. J. Pearson, Gerry Melino, Mauro Piacentini, and Christopher P. F. Redfern

GADD153 and 12-Lipoxygenase Mediate Fenretinide-induced Apoptosis of Neuroblastoma
Cancer Res 2002 62: 5158-5167. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Takahide Ota, Shiho Suto, Hiroshi Katayama, Zhen-Bo Han, Fumio Suzuki, Masayo Maeda, Mikio Tanino, Yasuhiko Terada, and Masaaki Tatsuka

Increased Mitotic Phosphorylation of Histone H3 Attributable to AIM-1/Aurora-B Overexpression Contributes to Chromosome Number Instability
Cancer Res 2002 62: 5168-5177. [Abstract] [Full Text] [PDF]  

Konstantin T. Christov, Richard C. Moon, Daniel D. Lantvit, Charles W. Boone, Vernon E. Steele, Ronald A. Lubet, Gary J. Kelloff, and John M. Pezzuto

9-cis-Retinoic Acid but Not 4-(Hydroxyphenyl)retinamide Inhibits Prostate Intraepithelial Neoplasia in Noble Rats
Cancer Res 2002 62: 5178-5182. [Abstract] [Full Text] [PDF]  

Eric J. Morinello, Hasan Koc, Asoka Ranasinghe, and James A. Swenberg

Differential Induction of N²,3-Ethenoguanine in Rat Brain and Liver after Exposure to Vinyl Chloride
Cancer Res 2002 62: 5183-5188. [Abstract] [Full Text] [PDF]  

Eric J. Morinello, Amy-Joan L. Ham, Asoka Ranasinghe, Jun Nakamura, Patricia B. Upton, and James A. Swenberg

Molecular Dosimetry and Repair of N²,3-Ethenoguanine in Rats Exposed to Vinyl Chloride
Cancer Res 2002 62: 5189-5195. [Abstract] [Full Text] [PDF]  

Rajesh K. Thimmulappa, Kim H. Mai, Sorachai Srisuma, Thomas W. Kensler, Masayuki Yamamoto, and Shyam Biswal

Identification of Nrf2-regulated Genes Induced by the Chemopreventive Agent Sulforaphane by Oligonucleotide Microarray
Cancer Res 2002 62: 5196-5203. [Abstract] [Full Text] [PDF]  

Sergio Huerta, James R. Arteaga, Ronald W. Irwin, Takayuki Ikezoe, David Heber, and H. Phillip Koeffler

PC-SPES Inhibits Colon Cancer Growth in Vitro and in Vivo
Cancer Res 2002 62: 5204-5209. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Heikki Joensuu, Anu Anttonen, Minna Eriksson, Riitta Mäkitaro, Henrik Alfthan, Vuokko Kinnula, and Sirpa Leppä

Soluble Syndecan-1 and Serum Basic Fibroblast Growth Factor Are New Prognostic Factors in Lung Cancer
Cancer Res 2002 62: 5210-5217. [Abstract] [Full Text] [PDF]  

Robert A. Gatenby, Edward T. Gawlinski, Catherine M. Tangen, Robert C. Flanigan, and E. David Crawford

The Possible Role of Postoperative Azotemia in Enhanced Survival of Patients with Metastatic Renal Cancer after Cytoreductive Nephrectomy
Cancer Res 2002 62: 5218-5222. [Abstract] [Full Text] [PDF]  

Endocrinology:

Wei-Qun Ding, Zhi-Jie Cheng, Judy McElhiney, Susan M. Kuntz, and Laurence J. Miller

Silencing of Secretin Receptor Function by Dimerization with a Misspliced Variant Secretin Receptor in Ductal Pancreatic Adenocarcinoma
Cancer Res 2002 62: 5223-5229. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Frank Pajonk, Judith Himmelsbach, Katrin Riess, Alfred Sommer, and William H. McBride

The Human Immunodeficiency Virus (HIV)-1 Protease Inhibitor Saquinavir Inhibits Proteasome Function and Causes Apoptosis and Radiosensitization in Non-HIV-associated Human Cancer Cells
Cancer Res 2002 62: 5230-5235. [Abstract] [Full Text] [PDF]  

Julie L. Bronder and Richard G. Moran

Antifolates Targeting Purine Synthesis Allow Entry of Tumor Cells into S Phase Regardless of p53 Function
Cancer Res 2002 62: 5236-5241. [Abstract] [Full Text] [PDF]  

Pasi A. Jänne, Michele L. Taffaro, Ravi Salgia, and Bruce E. Johnson

Inhibition of Epidermal Growth Factor Receptor Signaling in Malignant Pleural Mesothelioma
Cancer Res 2002 62: 5242-5247. [Abstract] [Full Text] [PDF]  

Katherine B. Peters and J. Martin Brown

Tirapazamine: A Hypoxia-activated Topoisomerase II Poison
Cancer Res 2002 62: 5248-5253. [Abstract] [Full Text] [PDF]  

Ingo K. Mellinghoff, Chris Tran, and Charles L. Sawyers

Growth Inhibitory Effects of the Dual ErbB1/ErbB2 Tyrosine Kinase Inhibitor PKI-166 on Human Prostate Cancer Xenografts
Cancer Res 2002 62: 5254-5259. [Abstract] [Full Text] [PDF]  

Immunology:

George Miller, Svenja Lahrs, Venu G. Pillarisetty, Alaap B. Shah, and Ronald P. DeMatteo

Adenovirus Infection Enhances Dendritic Cell Immunostimulatory Properties and Induces Natural Killer and T-Cell-mediated Tumor Protection
Cancer Res 2002 62: 5260-5266. [Abstract] [Full Text] [PDF]  

Rajasekharan Somasundaram, Lutz Jacob, Rolf Swoboda, Laura Caputo, Hong Song, Saroj Basak, Dimitri Monos, David Peritt, Francesco Marincola, Dewei Cai, Brigitte Birebent, Ellen Bloome, Jin Kim, Klara Berencsi, Michael Mastrangelo, and Dorothee Herlyn

Inhibition of Cytolytic T Lymphocyte Proliferation by Autologous CD4⁺/CD25⁺ Regulatory T Cells in a Colorectal Carcinoma Patient Is Mediated by Transforming Growth Factor-ß
Cancer Res 2002 62: 5267-5272. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Lin Lin, Charles T. Miller, Jorge I. Contreras, Michael S. Prescott, Susan L. Dagenais, Rong Wu, John Yee, Mark B. Orringer, David E. Misek, Samir M. Hanash, Thomas W. Glover, and David G. Beer

The Hepatocyte Nuclear Factor 3 Gene, HNF3 (FOXA1), on Chromosome Band 14q13 Is Amplified and Overexpressed in Esophageal and Lung Adenocarcinomas
Cancer Res 2002 62: 5273-5279. [Abstract] [Full Text] [PDF]  

Weiqin Jiang, Zongjian Zhu, Neehar Bhatia, Rajesh Agarwal, and Henry J. Thompson

Mechanisms of Energy Restriction: Effects of Corticosterone on Cell Growth, Cell Cycle Machinery, and Apoptosis
Cancer Res 2002 62: 5280-5287. [Abstract] [Full Text] [PDF]  

Daniel R. Lloyd and Philip C. Hanawalt

p53 Controls Global Nucleotide Excision Repair of Low Levels of Structurally Diverse Benzo(g)chrysene-DNA Adducts in Human Fibroblasts
Cancer Res 2002 62: 5288-5294. [Abstract] [Full Text] [PDF]  

Laura A. Kresty, Susan R. Mallery, Thomas J. Knobloch, Huijuan Song, Mary Lloyd, Bruce C. Casto, and Christopher M. Weghorst

Alterations of p16^INK4a and p14^ARF in Patients with Severe Oral Epithelial Dysplasia
Cancer Res 2002 62: 5295-5300. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Zoe N. Demou and Larry V. McIntire

Fully Automated Three-Dimensional Tracking of Cancer Cells in Collagen Gels: Determination of Motility Phenotypes at the Cellular Level
Cancer Res 2002 62: 5301-5307. [Abstract] [Full Text] [PDF]  

Hong Sheng, Sara Goich, Aiqin Wang, Marina Grachtchouk, Lori Lowe, Rong Mo, Kui Lin, Frederic J. de Sauvage, Hiroshi Sasaki, Chi-chung Hui, and Andrzej A. Dlugosz

Dissecting the Oncogenic Potential of Gli2: Deletion of an NH₂-Terminal Fragment Alters Skin Tumor Phenotype
Cancer Res 2002 62: 5308-5316. [Abstract] [Full Text] [PDF]  

Seyedhossein Aharinejad, Dietmar Abraham, Patrick Paulus, Hojatollah Abri, Michael Hofmann, Karl Grossschmidt, Romana Schäfer, E. Richard Stanley, and Reinhold Hofbauer

Colony-stimulating Factor-1 Antisense Treatment Suppresses Growth of Human Tumor Xenografts in Mice
Cancer Res 2002 62: 5317-5324. [Abstract] [Full Text] [PDF]  

Alfonso Calvo, Nianqing Xiao, Jason Kang, Carolyn J. M. Best, Isabel Leiva, Michael R. Emmert-Buck, Cheryl Jorcyk, and Jeffrey E. Green

Alterations in Gene Expression Profiles during Prostate Cancer Progression: Functional Correlations to Tumorigenicity and Down-Regulation of Selenoprotein-P in Mouse and Human Tumors
Cancer Res 2002 62: 5325-5335. [Abstract] [Full Text] [PDF]  

Qiang Ding, Jerry Stewart, Jr., Charles W. Prince, Pi-Ling Chang, Mohit Trikha, Xiaosi Han, J. Robert Grammer, and Candece L. Gladson

Promotion of Malignant Astrocytoma Cell Migration by Osteopontin Expressed in the Normal Brain: Differences in Integrin Signaling during Cell Adhesion to Osteopontin Versus Vitronectin
Cancer Res 2002 62: 5336-5343. [Abstract] [Full Text] [PDF]  

Jose C. Juarez, Xiaojun Guan, Natalya V. Shipulina, Marian L. Plunkett, Graham C. Parry, David Elliot Shaw, Jing-Chuan Zhang, Shafaat A. Rabbani, Keith R. McCrae, Andrew P. Mazar, William T. Morgan, and Fernando Doñate

Histidine-Proline-rich Glycoprotein Has Potent Antiangiogenic Activity Mediated through the Histidine-Proline-rich Domain
Cancer Res 2002 62: 5344-5350. [Abstract] [Full Text] [PDF]  

Christine A. Iacobuzio-Donahue, Pedram Argani, Paula M. Hempen, Jessa Jones, and Scott E. Kern

The Desmoplastic Response to Infiltrating Breast Carcinoma: Gene Expression at the Site of Primary Invasion and Implications for Comparisons between Tumor Types
Cancer Res 2002 62: 5351-5357. [Abstract] [Full Text] [PDF]  

Lindsay Gillan, Daniela Matei, David A. Fishman, C. S. Gerbin, Beth Y. Karlan, and David D. Chang

Periostin Secreted by Epithelial Ovarian Carcinoma Is a Ligand for _Vß₃ and _Vß₅ Integrins and Promotes Cell Motility
Cancer Res 2002 62: 5358-5364. [Abstract] [Full Text] [PDF]  

Isaac Yi Kim, Byung-Chul Kim, Do Hwan Seong, Dug Keun Lee, Jeong-Meen Seo, Young Jin Hong, Heung-Tae Kim, Ronald A. Morton, and Seong-Jin Kim

Raloxifene, a Mixed Estrogen Agonist/Antagonist, Induces Apoptosis in Androgen-independent Human Prostate Cancer Cell Lines
Cancer Res 2002 62: 5365-5369. [Abstract] [Full Text] [PDF]  

Dalit Hecht, Dale Jung, Vinay V. Prabhu, Peter J. Munson, Matthew P. Hoffman, and Hynda K. Kleinman

Metallothionein Promotes Laminin-1-induced Acinar Differentiation in Vitro and Reduces Tumor Growth in Vivo
Cancer Res 2002 62: 5370-5374. [Abstract] [Full Text] [PDF]  

Abigail S. Haka, Karen E. Shafer-Peltier, Maryann Fitzmaurice, Joseph Crowe, Ramachandra R. Dasari, and Michael S. Feld

Identifying Microcalcifications in Benign and Malignant Breast Lesions by Probing Differences in Their Chemical Composition Using Raman Spectroscopy
Cancer Res 2002 62: 5375-5380. [Abstract] [Full Text] [PDF]  

Meeting Report:

Donald M. McDonald and Peter Baluk

Significance of Blood Vessel Leakiness in Cancer
Cancer Res 2002 62: 5381-5385. [Abstract] [Full Text] [PDF]  

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