Advances in Brief:

Kenneth B. Ewan, Rhonda L. Henshall-Powell, Shraddha A. Ravani, Maria Jose Pajares, Carlos Arteaga, Ray Warters, Rosemary J. Akhurst, and Mary Helen Barcellos-Hoff

Transforming Growth Factor-ß1 Mediates Cellular Response to DNA Damage in Situ
Cancer Res 2002 62: 5627-5631. [Abstract] [Full Text] [PDF]  

Jose D. Debes, Lucy J. Schmidt, Haojie Huang, and Donald J. Tindall

p300 Mediates Androgen-independent Transactivation of the Androgen Receptor by Interleukin 6
Cancer Res 2002 62: 5632-5636. [Abstract] [Full Text] [PDF]  

David M. Shibata, Fumiaki Sato, Yuriko Mori, Kellie Perry, Jing Yin, Suna Wang, Yan Xu, Andreea Olaru, Florin Selaru, Kevin Spring, Joanne Young, John M. Abraham, and Stephen J. Meltzer

Hypermethylation of HPP1 Is Associated with hMLH1 Hypermethylation in Gastric Adenocarcinomas
Cancer Res 2002 62: 5637-5640. [Abstract] [Full Text] [PDF]  

Barbara E. Wright, Jacqueline M. Reimers, Karen H. Schmidt, and Dennis K. Reschke

Hypermutable Bases in the p53 Cancer Gene Are at Vulnerable Positions in DNA Secondary Structures
Cancer Res 2002 62: 5641-5644. [Abstract] [Full Text] [PDF]  

Heidi L. Kenerson, Lauri D. Aicher, Lawrence D. True, and Raymond S. Yeung

Activated Mammalian Target of Rapamycin Pathway in the Pathogenesis of Tuberous Sclerosis Complex Renal Tumors
Cancer Res 2002 62: 5645-5650. [Abstract] [Full Text] [PDF]  

Meiko Takahashi, Manabu Fujita, Yoichi Furukawa, Ryuji Hamamoto, Takashi Shimokawa, Nobutomo Miwa, Michio Ogawa, and Yusuke Nakamura

Isolation of a Novel Human Gene, APCDD1, as a Direct Target of the ß-Catenin/T-Cell Factor 4 Complex with Probable Involvement in Colorectal Carcinogenesis
Cancer Res 2002 62: 5651-5656. [Abstract] [Full Text] [PDF]  

Moneeb Ehtesham, Peter Kabos, Andrea Kabosova, Toomas Neuman, Keith L. Black, and John S. Yu

The Use of Interleukin 12-secreting Neural Stem Cells for the Treatment of Intracranial Glioma
Cancer Res 2002 62: 5657-5663. [Abstract] [Full Text] [PDF]  

David Schrama, Eva Fuchs, Eva-Bettina Bröcker, Per thor Straten, and Jürgen C. Becker

Identical T-cell Receptor Transcripts in Multiple Melanoma Metastases
Cancer Res 2002 62: 5664-5667. [Abstract] [Full Text] [PDF]  

Toshiyuki Tsunoda, Junichi Inokuchi, Iwai Baba, Koji Okumura, Seiji Naito, Takehiko Sasazuki, and Senji Shirasawa

A Novel Mechanism of Nuclear Factor B Activation through the Binding between Inhibitor of Nuclear Factor-B and the Processed NH₂-terminal Region of Mig-6
Cancer Res 2002 62: 5668-5671. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Yolanda Pérez, Hana Lahrech, Miquel E. Cabañas, Ramon Barnadas, Manel Sabés, Chantal Rémy, and Carles Arús

Measurement by Nuclear Magnetic Resonance Diffusion of the Dimensions of the Mobile Lipid Compartment in C6 Cells
Cancer Res 2002 62: 5672-5677. [Abstract] [Full Text] [PDF]  

Marie Stiborová, Václav Martínek, Helena Rydlová, Petr Hodek, and Eva Frei

Sudan I Is a Potential Carcinogen for Humans: Evidence for Its Metabolic Activation and Detoxication by Human Recombinant Cytochrome P450 1A1 and Liver Microsomes
Cancer Res 2002 62: 5678-5684. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Sandra Loeppen, Daniela Schneider, Frank Gaunitz, Rolf Gebhardt, Raffael Kurek, Albrecht Buchmann, and Michael Schwarz

Overexpression of Glutamine Synthetase Is Associated with ß-Catenin-Mutations in Mouse Liver Tumors during Promotion of Hepatocarcinogenesis by Phenobarbital
Cancer Res 2002 62: 5685-5688. [Abstract] [Full Text] [PDF]  

Chuanshu Huang, Jingxia Li, Qingdong Ke, Stephen S. Leonard, Bing-Hua Jiang, Xiao-Song Zhong, Max Costa, Vincent Castranova, and Xianglin Shi

Ultraviolet-induced Phosphorylation of p70^S6K at Thr³⁸⁹ and Thr⁴²¹/Ser⁴²⁴ Involves Hydrogen Peroxide and Mammalian Target of Rapamycin but not Akt and Atypical Protein Kinase C
Cancer Res 2002 62: 5689-5697. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Paula Wells, Roger N. Gunn, Malcolm Alison, Colin Steel, Mathew Golding, Alex S. Ranicar, Frank Brady, Safiye Osman, Terry Jones, and Pat Price

Assessment of Proliferation in Vivo Using 2-[¹¹C]Thymidine Positron Emission Tomography in Advanced Intra-abdominal Malignancies
Cancer Res 2002 62: 5698-5702. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Sangkyou Lee, Wentao Yang, Keng-Hsueh Lan, Shankar Sellappan, Kristine Klos, Gabriel Hortobagyi, Mien-Chie Hung, and Dihua Yu

Enhanced Sensitization to Taxol-induced Apoptosis by Herceptin Pretreatment in ErbB2-overexpressing Breast Cancer Cells
Cancer Res 2002 62: 5703-5710. [Abstract] [Full Text] [PDF]  

Eun-Yi Moon and Adam Lerner

Benzylamide Sulindac Analogues Induce Changes in Cell Shape, Loss of Microtubules and G₂-M Arrest in a Chronic Lymphocytic Leukemia (CLL) Cell Line and Apoptosis in Primary CLL Cells
Cancer Res 2002 62: 5711-5719. [Abstract] [Full Text] [PDF]  

Samuel F. Huang, Sun-Jin Kim, Anh T. Lee, Takashi Karashima, Cora Bucana, Daniel Kedar, Paul Sweeney, Badar Mian, Dominic Fan, David Shepherd, Isaiah J. Fidler, Colin P. Dinney, and Jerald J. Killion

Inhibition of Growth and Metastasis of Orthotopic Human Prostate Cancer in Athymic Mice by Combination Therapy with Pegylated Interferon--2b and Docetaxel
Cancer Res 2002 62: 5720-5726. [Abstract] [Full Text] [PDF]  

Xiaojun Huang, Michael K. Wong, Huiming Yi, Simon Watkins, A. Douglas Laird, Stanley F. Wolf, and Elieser Gorelik

Combined Therapy of Local and Metastatic 4T1 Breast Tumor in Mice Using SU6668, an Inhibitor of Angiogenic Receptor Tyrosine Kinases, and the Immunostimulator B7.2-IgG Fusion Protein
Cancer Res 2002 62: 5727-5735. [Abstract] [Full Text] [PDF]  

Martine L. M. Lamfers, Jacques Grill, Clemens M. F. Dirven, Victor W. van Beusechem, Birgit Geoerger, Jaap van den Berg, Ramon Alemany, Juan Fueyo, David T. Curiel, Gilles Vassal, Herbert M. Pinedo, W. Peter Vandertop, and Winald R. Gerritsen

Potential of the Conditionally Replicative Adenovirus Ad5-24RGD in the Treatment of Malignant Gliomas and Its Enhanced Effect with Radiotherapy
Cancer Res 2002 62: 5736-5742. [Abstract] [Full Text] [PDF]  

Qiang Yu, JiHyun La Rose, Hongliang Zhang, Haruyuki Takemura, Kurt W. Kohn, and Yves Pommier

UCN-01 Inhibits p53 Up-Regulation and Abrogates -Radiation-induced G₂-M Checkpoint Independently of p53 by Targeting Both of the Checkpoint Kinases, Chk2 and Chk1
Cancer Res 2002 62: 5743-5748. [Abstract] [Full Text] [PDF]  

Alan E. Wakeling, Simon P. Guy, Jim R. Woodburn, Susan E. Ashton, Brenda J. Curry, Andrew J. Barker, and Keith H. Gibson

ZD1839 (Iressa): An Orally Active Inhibitor of Epidermal Growth Factor Signaling with Potential for Cancer Therapy
Cancer Res 2002 62: 5749-5754. [Abstract] [Full Text] [PDF]  

Zhengsheng Yao, Meili Zhang, Donald B. Axworthy, Karen J. Wong, Kayhan Garmestani, Luke Park, Chang W. Park, Robert W. Mallett, Louis J. Theodore, Eric K. Yau, Thomas A. Waldmann, Martin W. Brechbiel, Chang H. Paik, Ira Pastan, and Jorge A. Carrasquillo

Radioimmunotherapy of A431 Xenografted Mice with Pretargeted B3 Antibody-Streptavidin and ⁹⁰Y-labeled 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic Acid (DOTA)-Biotin
Cancer Res 2002 62: 5755-5760. [Abstract] [Full Text] [PDF]  

Ramadevi Nimmanapalli, Erica O’Bryan, Mei Huang, Purva Bali, Pearlie Kay Burnette, Thomas Loughran, James Tepperberg, Richard Jove, and Kapil Bhalla

Molecular Characterization and Sensitivity of STI-571 (Imatinib Mesylate, Gleevec)-resistant, Bcr-Abl-positive, Human Acute Leukemia Cells to SRC Kinase Inhibitor PD180970 and 17-Allylamino-17-demethoxygeldanamycin
Cancer Res 2002 62: 5761-5769. [Abstract] [Full Text] [PDF]  

Wilhelmina M. Aarts, Jeffrey Schlom, and James W. Hodge

Vector-based Vaccine/Cytokine Combination Therapy to Enhance Induction of Immune Responses to a Self-Antigen and Antitumor Activity
Cancer Res 2002 62: 5770-5777. [Abstract] [Full Text] [PDF]  

Ovidiu C. Trifan, William F. Durham, Valerie S. Salazar, Jennifer Horton, Benjamin D. Levine, Ben S. Zweifel, Thomas W. Davis, and Jaime L. Masferrer

Cyclooxygenase-2 Inhibition with Celecoxib Enhances Antitumor Efficacy and Reduces Diarrhea Side Effect of CPT-11
Cancer Res 2002 62: 5778-5784. [Abstract] [Full Text] [PDF]  

Immunology:

Christian Scheffold, Martin Kornacker, Yolanda C. Scheffold, Christopher H. Contag, and Robert S. Negrin

Visualization of Effective Tumor Targeting by CD8+ Natural Killer T Cells Redirected with Bispecific Antibody F(ab')₂HER2xCD3
Cancer Res 2002 62: 5785-5791. [Abstract] [Full Text] [PDF]  

Gretchen L. Eiben, Markwin P. Velders, Hans Schreiber, Maria Cristina Cassetti, Jeffrey K. Pullen, Larry R. Smith, and W. Martin Kast

Establishment of an HLA-A*0201 Human Papillomavirus Type 16 Tumor Model to Determine the Efficacy of Vaccination Strategies in HLA-A*0201 Transgenic Mice
Cancer Res 2002 62: 5792-5799. [Abstract] [Full Text] [PDF]  

Takuji Naka, Kenji Sugamura, Bonnie L. Hylander, Michael B. Widmer, Youcef M. Rustum, and Elizabeth A. Repasky

Effects of Tumor Necrosis Factor-related Apoptosis-inducing Ligand Alone and in Combination with Chemotherapeutic Agents on Patients’ Colon Tumors Grown in SCID Mice
Cancer Res 2002 62: 5800-5806. [Abstract] [Full Text] [PDF]  

Jun Lu and Esteban Celis

Recognition of Prostate Tumor Cells by Cytotoxic T Lymphocytes Specific for Prostate-specific Membrane Antigen
Cancer Res 2002 62: 5807-5812. [Abstract] [Full Text] [PDF]  

Koji Kono, Akihiro Takahashi, Fumiko Ichihara, Hidemitsu Sugai, Hideki Fujii, and Yoshirou Matsumoto

Impaired Antibody-dependent Cellular Cytotoxicity Mediated by Herceptin in Patients with Gastric Cancer
Cancer Res 2002 62: 5813-5817. [Abstract] [Full Text] [PDF]  

Toni Weinschenk, Cécile Gouttefangeas, Markus Schirle, Florian Obermayr, Steffen Walter, Oliver Schoor, Raffael Kurek, Wolfgang Loeser, Karl-Horst Bichler, Dorothee Wernet, Stefan Stevanovic, and Hans-Georg Rammensee

Integrated Functional Genomics Approach for the Design of Patient-individual Antitumor Vaccines
Cancer Res 2002 62: 5818-5827. [Abstract] [Full Text] [PDF]  

Priscilla P. L. Chiu, Evgueni Ivakine, Steven Mortin-Toth, and Jayne S. Danska

Susceptibility to Lymphoid Neoplasia in Immunodeficient Strains of Nonobese Diabetic Mice
Cancer Res 2002 62: 5828-5834. [Abstract] [Full Text] [PDF]  

Cyril J. Cohen, Noa Hoffmann, Marganit Farago, Hennie R. Hoogenboom, Lea Eisenbach, and Yoram Reiter

Direct Detection and Quantitation of a Distinct T-Cell Epitope Derived from Tumor-specific Epithelial Cell-associated Mucin Using Human Recombinant Antibodies Endowed with the Antigen-specific, Major Histocompatibility Complex-restricted Specificity of T Cells
Cancer Res 2002 62: 5835-5844. [Abstract] [Full Text] [PDF]  

John M. Timmerman, Gita Singh, Gary Hermanson, Peter Hobart, Debra K. Czerwinski, Behnaz Taidi, Ranjani Rajapaksa, Clemens B. Caspar, Adrienne van Beckhoven, and Ronald Levy

Immunogenicity of a Plasmid DNA Vaccine Encoding Chimeric Idiotype in Patients with B-Cell Lymphoma
Cancer Res 2002 62: 5845-5852. [Abstract] [Full Text] [PDF]  

Tomohide Tatsumi, Andrea Gambotto, Paul D. Robbins, and Walter J. Storkus

Interleukin 18 Gene Transfer Expands the Repertoire of Antitumor Th1-type Immunity Elicited by Dendritic Cell-based Vaccines in Association with Enhanced Therapeutic Efficacy
Cancer Res 2002 62: 5853-5858. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Satoshi Nagayama, Toyomasa Katagiri, Tatsuhiko Tsunoda, Taisuke Hosaka, Yasuaki Nakashima, Nobuhito Araki, Katsuyuki Kusuzaki, Tomitaka Nakayama, Tadao Tsuboyama, Takashi Nakamura, Masayuki Imamura, Yusuke Nakamura, and Junya Toguchida

Genome-wide Analysis of Gene Expression in Synovial Sarcomas Using a cDNA Microarray
Cancer Res 2002 62: 5859-5866. [Abstract] [Full Text] [PDF]  

Iúri D. Louro, Evans C. Bailey, Xingnan Li, Lindsey S. South, Peggy R. McKie-Bell, Bradley K. Yoder, Conway C. Huang, Martin R. Johnson, Aubrey E. Hill, Ronald L. Johnson, and J. Michael Ruppert

Comparative Gene Expression Profile Analysis of GLI and c-MYC in an Epithelial Model of Malignant Transformation
Cancer Res 2002 62: 5867-5873. [Abstract] [Full Text] [PDF] Supplementary Data  

Ashraf Dallol, Nancy Fernandes Da Silva, Paolo Viacava, John D. Minna, Ivan Bieche, Eamonn R. Maher, and Farida Latif

SLIT2, a Human Homologue of the Drosophila Slit2 Gene, Has Tumor Suppressor Activity and Is Frequently Inactivated in Lung and Breast Cancers
Cancer Res 2002 62: 5874-5880. [Abstract] [Full Text] [PDF]  

Toshiya Atsumi, Jason Chesney, Christine Metz, Lin Leng, Seamas Donnelly, Zenji Makita, Robert Mitchell, and Richard Bucala

High Expression of Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (iPFK-2; PFKFB3) in Human Cancers
Cancer Res 2002 62: 5881-5887. [Abstract] [Full Text] [PDF]  

Alexandre I. Belenkov, Jean-Pierre Paiement, Lawrence C. Panasci, Brett P. Monia, and Terry Y. K. Chow

An Antisense Oligonucleotide Targeted to Human Ku86 Messenger RNA Sensitizes M059K Malignant Glioma Cells to Ionizing Radiation, Bleomycin, and Etoposide but not DNA Cross-Linking Agents
Cancer Res 2002 62: 5888-5896. [Abstract] [Full Text] [PDF]  

Kenichi Harada, Shinichi Toyooka, Narayan Shivapurkar, Anirban Maitra, Jyotsna L. Reddy, Hittu Matta, Kuniharu Miyajima, Charles F. Timmons, Gail E. Tomlinson, Domenico Mastrangelo, Robert J. Hay, Preet M. Chaudhary, and Adi F. Gazdar

Deregulation of Caspase 8 and 10 Expression in Pediatric Tumors and Cell Lines
Cancer Res 2002 62: 5897-5901. [Abstract] [Full Text] [PDF]  

Manel Esteller, Mingzhou Guo, Victor Moreno, Miquel Angel Peinado, Gabriel Capella, Oliver Galm, Stephen B. Baylin, and James G. Herman

Hypermethylation-associated Inactivation of the Cellular Retinol-Binding-Protein 1 Gene in Human Cancer
Cancer Res 2002 62: 5902-5905. [Abstract] [Full Text] [PDF]  

Meryl E. Lusher, Janet C. Lindsey, Farida Latif, Andrew D. J. Pearson, David W. Ellison, and Steven C. Clifford

Biallelic Epigenetic Inactivation of the RASSF1A Tumor Suppressor Gene in Medulloblastoma Development
Cancer Res 2002 62: 5906-5911. [Abstract] [Full Text] [PDF]  

Tumor Biology:

David R. Collingridge, Veronica A. Carroll, Mathias Glaser, Eric O. Aboagye, Safiye Osman, Oliver C. Hutchinson, Henryk Barthel, Sajinder K. Luthra, Frank Brady, Roy Bicknell, Pat Price, and Adrian L. Harris

The Development of [¹²⁴I]Iodinated-VG76e: A Novel Tracer for Imaging Vascular Endothelial Growth Factor in Vivo Using Positron Emission Tomography
Cancer Res 2002 62: 5912-5919. [Abstract] [Full Text] [PDF]  

Rüdiger Neef, Martina A. Kuske, Elma Pröls, and Judith P. Johnson

Identification of the Human PHLDA1/TDAG51 Gene: Down-Regulation in Metastatic Melanoma Contributes to Apoptosis Resistance and Growth Deregulation
Cancer Res 2002 62: 5920-5929. [Abstract] [Full Text] [PDF]  

Chris J. Scotton, Julia L. Wilson, Kate Scott, Gordon Stamp, George D. Wilbanks, Simon Fricker, Gary Bridger, and Frances R. Balkwill

Multiple Actions of the Chemokine CXCL12 on Epithelial Tumor Cells in Human Ovarian Cancer
Cancer Res 2002 62: 5930-5938. [Abstract] [Full Text] [PDF]  

Mattias Höglund, David Gisselsson, Gunnar B. Hansen, Torbjörn Säll, Felix Mitelman, and Mef Nilbert

Dissecting Karyotypic Patterns in Colorectal Tumors: Two Distinct but Overlapping Pathways in the Adenoma-Carcinoma Transition
Cancer Res 2002 62: 5939-5946. [Abstract] [Full Text] [PDF]  

Michael Shtutman, Jacob Zhurinsky, Moshe Oren, Elina Levina, and Avri Ben-Ze’ev

PML Is a Target Gene of ß-Catenin and Plakoglobin, and Coactivates ß-Catenin-mediated Transcription
Cancer Res 2002 62: 5947-5954. [Abstract] [Full Text] [PDF]  

Toshiaki Hamamoto, Hideyuki Beppu, Hitoshi Okada, Masahiro Kawabata, Tadaichi Kitamura, Kohei Miyazono, and Mitsuyasu Kato

Compound Disruption of Smad2 Accelerates Malignant Progression of Intestinal Tumors in Apc Knockout Mice
Cancer Res 2002 62: 5955-5961. [Abstract] [Full Text] [PDF]  

Ina Poser, Michaela Golob, Michael Weidner, Reinhard Buettner, and Anja K. Bosserhoff

Down-Regulation of COOH-Terminal Binding Protein Expression in Malignant Melanomas Leads to Induction of MIA Expression
Cancer Res 2002 62: 5962-5966. [Abstract] [Full Text] [PDF]  

Minoru Shiraga, Seiji Yano, Akihiko Yamamoto, Hirohisa Ogawa, Hisatsugu Goto, Toyokazu Miki, Keisuke Miki, Helong Zhang, and Saburo Sone

Organ Heterogeneity of Host-derived Matrix Metalloproteinase Expression and Its Involvement in Multiple-Organ Metastasis by Lung Cancer Cell Lines
Cancer Res 2002 62: 5967-5973. [Abstract] [Full Text] [PDF]  

Shahrokh F. Shariat, Emanuel Gottenger, Cuong Nguyen, Weitao Song, Michael W. Kattan, John Andenoro, Thomas M. Wheeler, David M. Spencer, and Kevin M. Slawin

Preoperative Blood Reverse Transcriptase-PCR Assays for Prostate-specific Antigen and Human Glandular Kallikrein for Prediction of Prostate Cancer Progression after Radical Prostatectomy
Cancer Res 2002 62: 5974-5979. [Abstract] [Full Text] [PDF]  

Zheng Li, Zhen Hang Meng, Aejaz Sayeed, Refaat Shalaby, Britt-Marie Ljung, and Shanaz H. Dairkee

Genome-wide Allelotyping of a New in Vitro Model System Reveals Early Events in Breast Cancer Progression
Cancer Res 2002 62: 5980-5987. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Jeremy R. Jass, Vicki L. J. Whitehall, Joanne Young, Barbara Leggett, Stephen J. Meltzer, Nagahide Matsubara, Richard Fishel, Päivi Laiho, and Lauri A. Aaltonen

Correspondence re: P. Laiho et al., Low-Level Microsatellite Instability in Most Colorectal Carcinomas. Cancer Res., 62: 1166–1170, 2002.
Cancer Res 2002 62: 5988-5990. [Full Text] [PDF]  

Erratum:

Correction for vol 62, p 5083
Cancer Res 2002 62: 5992. [Full Text] [PDF]  

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