Advances in Brief:

Cyclooxygenase-2 Expression Is Related to Nuclear Grade in Ductal Carcinoma in Situ and Is Increased in Its Normal Adjacent Epithelium

Veronica Shim, Mona L. Gauthier, Daniel Sudilovsky, Kristin Mantei, Karen L. Chew, Dan H. Moore, Imok Cha, Thea D. Tlsty, and Laura J. Esserman
Cancer Res 2003 63: 2347-2350. [Abstract] [Full Text] [PDF]  

Np63 and TAp63 Regulate Transcription of Genes with Distinct Biological Functions in Cancer and Development

Guojun Wu, Shuji Nomoto, Mohammad Obaidul Hoque, Tatiana Dracheva, Motonabu Osada, Chyi-Chia Richard Lee, Seung Myung Dong, Zhongmin Guo, Nicole Benoit, Yoram Cohen, Peggy Rechthand, Joseph Califano, Chul-so Moon, Edward Ratovitski, Jin Jen, David Sidransky, and Barry Trink
Cancer Res 2003 63: 2351-2357. [Abstract] [Full Text] [PDF]  

Haem, not Protein or Inorganic Iron, Is Responsible for Endogenous Intestinal N-Nitrosation Arising from Red Meat

Amanda Jane Cross, Jim R. A. Pollock, and Sheila Anne Bingham
Cancer Res 2003 63: 2358-2360. [Abstract] [Full Text] [PDF]  

Adenoma Multiplicity in Irradiated Apc^Min Mice Is Modified by Chromosome 16 Segments from BALB/c

Natalie L. Degg, Michael M. Weil, Alan Edwards, Jackie Haines, Margaret Coster, John Moody, Michele Ellender, Roger Cox, and Andrew Silver
Cancer Res 2003 63: 2361-2363. [Abstract] [Full Text] [PDF]  

BALB/c Alleles for Prkdc and Cdkn2a Interact to Modify Tumor Susceptibility in Trp53+/- Mice

Anneke C. Blackburn, Jennifer S. Brown, Stephen P. Naber, Christopher N. Otis, Jeff T. Wood, and D. Joseph Jerry
Cancer Res 2003 63: 2364-2368. [Abstract] [Full Text] [PDF]  

Adenoviral Gene Transfer of Tumor Necrosis Factor-related Apoptosis-Inducing Ligand Overcomes an Impaired Response of Hepatoma Cells but Causes Severe Apoptosis in Primary Human Hepatocytes

Sorin Armeanu, Ulrich M. Lauer, Irina Smirnow, Martin Schenk, Thomas S. Weiss, Michael Gregor, and Michael Bitzer
Cancer Res 2003 63: 2369-2372. [Abstract] [Full Text] [PDF]  

p29ING4 and p28ING5 Bind to p53 and p300, and Enhance p53 Activity

Masayuki Shiseki, Makoto Nagashima, Remy M. Pedeux, Mariko Kitahama-Shiseki, Koh Miura, Shu Okamura, Hitoshi Onogi, Yuichiro Higashimoto, Ettore Appella, Jun Yokota, and Curtis C. Harris
Cancer Res 2003 63: 2373-2378. [Abstract] [Full Text] [PDF]  

Biochemistry and Biophysics:

Neurotensin Stimulates Protein Kinase C-dependent Mitogenic Signaling in Human Pancreatic Carcinoma Cell Line PANC-1

Sushovan Guha, J. Adrian Lunn, Chintda Santiskulvong, and Enrique Rozengurt
Cancer Res 2003 63: 2379-2387. [Abstract] [Full Text] [PDF]  

Carcinogenesis:

Identification of Mucin-depleted Foci in the Unsectioned Colon of Azoxymethane-treated Rats: Correlation with Carcinogenesis

Giovanna Caderni, Angelo Pietro Femia, Augusto Giannini, Alessandro Favuzza, Cristina Luceri, Maddalena Salvadori, and Piero Dolara
Cancer Res 2003 63: 2388-2392. [Abstract] [Full Text] [PDF]  

Enhancing Major Histocompatibility Complex Class I Antigen Presentation by Targeting Antigen to Centrosomes

Chien-Fu Hung, Wen-Fang Cheng, Liangmei He, Morris Ling, Jeremy Juang, Cheng-Tao Lin, and T-C. Wu
Cancer Res 2003 63: 2393-2398. [Abstract] [Full Text] [PDF]  

Perillyl Alcohol as a Chemopreventive Agent in N-Nitrosomethylbenzylamine-induced Rat Esophageal Tumorigenesis

Beth W. Liston, Ronald Nines, Peter S. Carlton, Ashok Gupta, Robeena Aziz, Wendy Frankel, and Gary D. Stoner
Cancer Res 2003 63: 2399-2403. [Abstract] [Full Text] [PDF]  

Disruption of Protein Kinase C Results in Impairment of Wound Healing and Enhancement of Tumor Formation in Mouse Skin Carcinogenesis

Kazuhiro Chida, Takeshi Hara, Takaaki Hirai, Chieko Konishi, Kenji Nakamura, Kazuki Nakao, Atsu Aiba, Motoya Katsuki, and Toshio Kuroki
Cancer Res 2003 63: 2404-2408. [Abstract] [Full Text] [PDF]  

Clinical Investigations:

Metabolic Activation of Temozolomide Measured in Vivo Using Positron Emission Tomography

Azeem Saleem, Gavin D. Brown, Frank Brady, Eric O. Aboagye, Safiye Osman, Sajinder K. Luthra, Alex S. O. Ranicar, Cathryn S. Brock, Malcolm F. G. Stevens, Edward Newlands, Terry Jones, and Pat Price
Cancer Res 2003 63: 2409-2415. [Abstract] [Full Text] [PDF]  

Endocrinology:

Loss of Coordinated Androgen Regulation in Nonmalignant Ovarian Epithelial Cells with BRCA1/2 Mutations and Ovarian Cancer Cells

Andreas Evangelou, Michelle Letarte, Igor Jurisica, Mujahid Sultan, Kathleen J. Murphy, Barry Rosen, and Theodore J. Brown
Cancer Res 2003 63: 2416-2424. [Abstract] [Full Text] [PDF]  

Hormonal and Dietary Modulation of Mammary Carcinogenesis in Mouse Mammary Tumor Virus-c-erbB-2 Transgenic Mice

XiaoHe Yang, Susan M. Edgerton, Stanley D. Kosanke, Terza L. Mason, Kathy M. Alvarez, Naxin Liu, Robert T. Chatterton, Bolin Liu, Qi Wang, Aeree Kim, Satya Murthy, and Ann D. Thor
Cancer Res 2003 63: 2425-2433. [Abstract] [Full Text] [PDF]  

Estrogen Receptor ß Protein in Human Breast Cancer: Correlation with Clinical Tumor Parameters

Suzanne A. W. Fuqua, Rachel Schiff, Irma Parra, John T. Moore, Syed K. Mohsin, C. Kent Osborne, Gary M. Clark, and D. Craig Allred
Cancer Res 2003 63: 2434-2439. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Breast Cancer Risk Associated with Genotypic Polymorphism of the Nonhomologous End-Joining Genes: A Multigenic Study on Cancer Susceptibility

Yi-Ping Fu, Jyh-Cherng Yu, Ting-Chih Cheng, M. Ann Lou, Giu-Cheng Hsu, Chia-Yun Wu, Sou-Tong Chen, Hurng-Sheng Wu, Pei-Ei Wu, and Chen-Yang Shen
Cancer Res 2003 63: 2440-2446. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics:

Therapeutic Targeting of the Endothelin A Receptor in Human Ovarian Carcinoma

Laura Rosanò, Francesca Spinella, Debora Salani, Valeriana Di Castro, Aldo Venuti, Maria Rita Nicotra, Pier Giorgio Natali, and Anna Bagnato
Cancer Res 2003 63: 2447-2453. [Abstract] [Full Text] [PDF]  

Synergistic Down-Regulation of Urokinase Plasminogen Activator Receptor and Matrix Metalloproteinase-9 in SNB19 Glioblastoma Cells Efficiently Inhibits Glioma Cell Invasion, Angiogenesis, and Tumor Growth

Sajani S. Lakka, Christopher S. Gondi, Niranjan Yanamandra, Dzung H. Dinh, William C. Olivero, Meena Gujrati, and Jasti S. Rao
Cancer Res 2003 63: 2454-2461. [Abstract] [Full Text] [PDF]  

Use of a Vaccine Strain of Measles Virus Genetically Engineered to Produce Carcinoembryonic Antigen as a Novel Therapeutic Agent against Glioblastoma Multiforme

Loi K. Phuong, Cory Allen, Kah-Whye Peng, Caterina Giannini, Suzanne Greiner, Cynthia J. TenEyck, Prasanna K. Mishra, Slobodan I. Macura, Stephen J. Russell, and Evanthia C. Galanis
Cancer Res 2003 63: 2462-2469. [Abstract] [Full Text] [PDF]  

Immuno-Gene Therapy of Established Prostate Tumors Using Chimeric Receptor-redirected Human Lymphocytes

Jehonathan H. Pinthus, Tova Waks, Keren Kaufman-Francis, Daniel G. Schindler, Alon Harmelin, Hannah Kanety, Jacob Ramon, and Zelig Eshhar
Cancer Res 2003 63: 2470-2476. [Abstract] [Full Text] [PDF]  

High-Resolution Magnetic Resonance Imaging of the Efficacy of the Cytosine Analogue 1-[2-C-Cyano-2-deoxy-ß-D-arabino-pentofuranosyl]-N⁴-palmitoyl Cytosine (CS-682) in a Liver-Metastasis Athymic Nude Mouse Model

Ming Wu, Richard Mazurchuk, Neeta D. Chaudhary, Joseph Spernyak, Jean Veith, Paula Pera, William Greco, Robert M. Hoffman, Tomowo Kobayashi, and Ralph J. Bernacki
Cancer Res 2003 63: 2477-2482. [Abstract] [Full Text] [PDF]  

RRR--Tocopheryl Succinate-induced Apoptosis of Human Breast Cancer Cells Involves Bax Translocation to Mitochondria

Weiping Yu, Bob G. Sanders, and Kimberly Kline
Cancer Res 2003 63: 2483-2491. [Abstract] [Full Text] [PDF]  

Effect of the Multidrug Resistance Protein on the Transport of the Antiandrogen Flutamide

Matthew J. Grzywacz, Jin-Ming Yang, and William N. Hait
Cancer Res 2003 63: 2492-2498. [Abstract] [Full Text] [PDF]  

Local Intracerebral Delivery of Endogenous Inhibitors by Osmotic Minipumps Effectively Suppresses Glioma Growth in Vivo

Carlo Giussani, Giorgio Carrabba, Mauro Pluderi, Valeria Lucini, Marilou Pannacci, Dario Caronzolo, Francesco Costa, Matteo Minotti, Giustino Tomei, Roberto Villani, Andreas Bikfalvi, and Lorenzo Bello
Cancer Res 2003 63: 2499-2505. [Abstract] [Full Text] [PDF]  

Identification of the Human IAI.3B Promoter Element and Its Use in the Construction of a Replication-selective Adenovirus for Ovarian Cancer Therapy

Katsuyuki Hamada, Shohei Kohno, Mari Iwamoto, Hiroko Yokota, Masato Okada, Masatoshi Tagawa, Susumu Hirose, Kenshi Yamasaki, Yuji Shirakata, Koji Hashimoto, and Masaharu Ito
Cancer Res 2003 63: 2506-2512. [Abstract] [Full Text] [PDF]  

Enhancement of Radiation Response by Roscovitine in Human Breast Carcinoma in Vitro and in Vivo

Laurence Maggiorella, Eric Deutsch, Valérie Frascogna, Nicole Chavaudra, Laurence Jeanson, Fabien Milliat, François Eschwege, and Jean Bourhis
Cancer Res 2003 63: 2513-2517. [Abstract] [Full Text] [PDF]  

Immunology:

LAG-3 Enables DNA Vaccination to Persistently Prevent Mammary Carcinogenesis in HER-2/neu Transgenic BALB/c Mice

Paola Cappello, Frederic Triebel, Manuela Iezzi, Cristiana Caorsi, Elena Quaglino, Pier-Luigi Lollini, Augusto Amici, Emma Di Carlo, Piero Musiani, Mirella Giovarelli, and Guido Forni
Cancer Res 2003 63: 2518-2525. [Abstract] [Full Text] [PDF]  

Archaeosomes Induce Enhanced Cytotoxic T Lymphocyte Responses to Entrapped Soluble Protein in the Absence of Interleukin 12 and Protect against Tumor Challenge

Lakshmi Krishnan, Subash Sad, Girishchandra B. Patel, and G. Dennis Sprott
Cancer Res 2003 63: 2526-2534. [Abstract] [Full Text] [PDF]  

Lack of Terminally Differentiated Tumor-specific CD8⁺ T Cells at Tumor Site in Spite of Antitumor Immunity to Self-Antigens in Human Metastatic Melanoma

Roberta Mortarini, Adriano Piris, Andrea Maurichi, Alessandra Molla, Ilaria Bersani, Aldo Bono, Cesare Bartoli, Mario Santinami, Claudia Lombardo, Fernando Ravagnani, Natale Cascinelli, Giorgio Parmiani, and Andrea Anichini
Cancer Res 2003 63: 2535-2545. [Abstract] [Full Text] [PDF]  

Polarization Effects of 4-1BB during CD28 Costimulation in Generating Tumor-reactive T Cells for Cancer Immunotherapy

Qiao Li, Abbey Carr, Fumito Ito, Seagal Teitz-Tennenbaum, and Alfred E. Chang
Cancer Res 2003 63: 2546-2552. [Abstract] [Full Text] [PDF]  

Targeted Immunotherapy Using Reconstituted Chaperone Complexes of Heat Shock Protein 110 and Melanoma-associated Antigen gp100

Xiang-Yang Wang, Xing Chen, Masoud H. Manjili, Elizabeth Repasky, Robert Henderson, and John R. Subjeck
Cancer Res 2003 63: 2553-2560. [Abstract] [Full Text] [PDF]  

Expansion of Tumor-specific CD8+ T Cell Clones in Patients with Relapsed Myeloma after Donor Lymphocyte Infusion

Enrica Orsini, Roberto Bellucci, Edwin P. Alyea, Robert Schlossman, Christine Canning, Stephen McLaughlin, Paolo Ghia, Kenneth C. Anderson, and Jerome Ritz
Cancer Res 2003 63: 2561-2568. [Abstract] [Full Text] [PDF]  

Molecular Biology and Genetics:

Distinctive Patterns of Gene Expression in Premalignant Gastric Mucosa and Gastric Cancer

Alex Boussioutas, Hong Li, Jia Liu, Paul Waring, Stephen Lade, Andrew J. Holloway, Douglas Taupin, Kylie Gorringe, Izhak Haviv, Paul V. Desmond, and David D. L. Bowtell
Cancer Res 2003 63: 2569-2577. [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor Classification Based on Gene Expression Profiling Shows That Uveal Melanomas with and without Monosomy 3 Represent Two Distinct Entities

Frank Tschentscher, Johannes Hüsing, Tanja Hölter, Elisabeth Kruse, Irina Gana Dresen, Karl-Heinz Jöckel, Gerasimos Anastassiou, Harald Schilling, Norbert Bornfeld, Bernhard Horsthemke, Dietmar Rudolf Lohmann, and Michael Zeschnigk
Cancer Res 2003 63: 2578-2584. [Abstract] [Full Text] [PDF]  

Fanconi Anemia Gene Mutations in Young-onset Pancreatic Cancer

Michiel S. van der Heijden, Charles J. Yeo, Ralph H. Hruban, and Scott E. Kern
Cancer Res 2003 63: 2585-2588. [Abstract] [Full Text] [PDF]  

Assembly of Functional ALT-associated Promyelocytic Leukemia Bodies Requires Nijmegen Breakage Syndrome 1

Guikai Wu, Xianzhi Jiang, Wen-Hwa Lee, and Phang-Lang Chen
Cancer Res 2003 63: 2589-2595. [Abstract] [Full Text] [PDF]  

p53 Interacts with hRAD51 and hRAD54, and Directly Modulates Homologous Recombination

Steven P. Linke, Sagar Sengupta, Nissim Khabie, Beth A. Jeffries, Sabine Buchhop, Stefan Miska, Wilhelm Henning, Remy Pedeux, Xin W. Wang, Lorne J. Hofseth, Qin Yang, Susan H. Garfield, Horst-Werner Stürzbecher, and Curtis C. Harris
Cancer Res 2003 63: 2596-2605. [Abstract] [Full Text] [PDF] Supplementary Data  

Allelic Losses on Chromosome 6q25 in Hodgkin and Reed Sternberg Cells

Daniel Re, Petr Starostik, Nadia Massoudi, Andrea Staratschek-Jox, Volker Dries, Roman K. Thomas, Volker Diehl, and Jürgen Wolf
Cancer Res 2003 63: 2606-2609. [Abstract] [Full Text] [PDF]  

A Transforming Growth Factorß1 Signal Peptide Variant Increases Secretion in Vitro and Is Associated with Increased Incidence of Invasive Breast Cancer

Alison M. Dunning, Peter D. Ellis, Simon McBride, Heidi L Kirschenlohr, Catherine S. Healey, Paul R. Kemp, Robert N. Luben, Jenny Chang-Claude, Arto Mannermaa, Vesa Kataja, Paul D. P. Pharoah, Douglas F. Easton, Bruce A. J. Ponder, and James C. Metcalfe
Cancer Res 2003 63: 2610-2615. [Abstract] [Full Text] [PDF]  

p53-independent Activation of the hdm2-P2 Promoter through Multiple Transcription Factor Response Elements Results in Elevated hdm2 Expression in Estrogen Receptor -positive Breast Cancer Cells

Monika Phelps, Matthew Darley, John N. Primrose, and Jeremy P. Blaydes
Cancer Res 2003 63: 2616-2623. [Abstract] [Full Text] [PDF]  

Requirement of a Specific Sp1 Site for Histone Deacetylase-mediated Repression of Transforming Growth Factor ß Type II Receptor Expression in Human Pancreatic Cancer Cells

Shujie Zhao, Kolaparthi Venkatasubbarao, Senlin Li, and James W. Freeman
Cancer Res 2003 63: 2624-2630. [Abstract] [Full Text] [PDF]  

Osteoblast-related Transcription Factors Runx2 (Cbfa1/AML3) and MSX2 Mediate the Expression of Bone Sialoprotein in Human Metastatic Breast Cancer Cells

George L. Barnes, Amjad Javed, Sylvan M. Waller, Mohammad H. Kamal, Kerri E. Hebert, Mohammad Q. Hassan, Akeila Bellahcene, Andre J. van Wijnen, Marian F. Young, Jane B. Lian, Gary S. Stein, and Louis C. Gerstenfeld
Cancer Res 2003 63: 2631-2637. [Abstract] [Full Text] [PDF]  

Tumor Biology:

Evaluation of the Prognostic Potential of Hyaluronic Acid and Hyaluronidase (HYAL1) for Prostate Cancer

J. Timothy Posey, Mark S. Soloway, Sinan Ekici, Mario Sofer, Francisco Civantos, Robert C. Duncan, and Vinata B. Lokeshwar
Cancer Res 2003 63: 2638-2644. [Abstract] [Full Text] [PDF]  

Prostate-specific Membrane Antigen Association with Filamin A Modulates Its Internalization and NAALADase Activity

Gopalakrishnapillai Anilkumar, Sigrid A. Rajasekaran, Song Wang, Oliver Hankinson, Neil H. Bander, and Ayyappan K. Rajasekaran
Cancer Res 2003 63: 2645-2648. [Abstract] [Full Text] [PDF]  

Molecular Profiling of Pancreatic Adenocarcinoma and Chronic Pancreatitis Identifies Multiple Genes Differentially Regulated in Pancreatic Cancer

Craig D. Logsdon, Diane M. Simeone, Charles Binkley, Thiruvengadam Arumugam, Joel K. Greenson, Thomas J. Giordano, David E. Misek, and Samir Hanash
Cancer Res 2003 63: 2649-2657. [Abstract] [Full Text] [PDF]  

Transactivation of Vimentin by ß-Catenin in Human Breast Cancer Cells

Christine Gilles, Myriam Polette, Mélanie Mestdagt, Béatrice Nawrocki-Raby, Philippe Ruggeri, Philippe Birembaut, and Jean-Michel Foidart
Cancer Res 2003 63: 2658-2664. [Abstract] [Full Text] [PDF]  

EWI2/PGRL Associates with the Metastasis Suppressor KAI1/CD82 and Inhibits the Migration of Prostate Cancer Cells

Xin A. Zhang, William S. Lane, Stephanie Charrin, Eric Rubinstein, and Lei Liu
Cancer Res 2003 63: 2665-2674. [Abstract] [Full Text] [PDF]  

Up-Regulation of Hypoxia-inducible Factor 2 in Renal Cell Carcinoma Associated with Loss of Tsc-2 Tumor Suppressor Gene

Matt Yu Liu, Lorenz Poellinger, and Cheryl L. Walker
Cancer Res 2003 63: 2675-2680. [Abstract] [Full Text] [PDF]  

3'-[¹⁸F]Fluoro-3'-Deoxythymidine ([¹⁸F]-FLT) as Positron Emission Tomography Tracer for Imaging Proliferation in a Murine B-Cell Lymphoma Model and in the Human Disease

Martin Wagner, Ulrike Seitz, Andreas Buck, Bernd Neumaier, Stefan Schultheiß, Markus Bangerter, Martin Bommer, Frank Leithäuser, Edgar Wawra, Gerd Munzert, and Sven N. Reske
Cancer Res 2003 63: 2681-2687. [Abstract] [Full Text] [PDF]  

Genetic Reversion in an Acute Myelogenous Leukemia Cell Line from a Fanconi Anemia Patient with Biallelic Mutations in BRCA2

Hideyuki Ikeda, Maiko Matsushita, Quinten Waisfisz, Akitoshi Kinoshita, Anneke B. Oostra, Aggie W. M. Nieuwint, Johan P. de Winter, Maureen E. Hoatlin, Yohko Kawai, Masao S. Sasaki, Alan D. D’Andrea, Yutaka Kawakami, and Hans Joenje
Cancer Res 2003 63: 2688-2694. [Abstract] [Full Text] [PDF]  

Virology:

Seroreactivity to Epidermodysplasia Verruciformis-related Human Papillomavirus Types Is Associated with Nonmelanoma Skin Cancer

Mariet C. W. Feltkamp, René Broer, Franca M. di Summa, Linda Struijk, Els van der Meijden, Bert P. J. Verlaan, Rudi G. J. Westendorp, Jan ter Schegget, Willy J. M. Spaan, and Jan Nico Bouwes Bavinck
Cancer Res 2003 63: 2695-2700. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: B-L. Adam et al., Serum Protein Fingerprinting Coupled with a Pattern-matching Algorithm Distinguishes Prostate Cancer from Benign Prostate Hyperplasia and Healthy Men. Cancer Res., 62: 3609–3614, 2002

Pär Stattin, Matti Hakama, George L. Wright, Jr., and Paul F. Schellhammer
Cancer Res 2003 63: 2701-2702. [Full Text] [PDF]  

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