Reviews:

Lucy A. Carver, Jan E. Schnitzer, Richard G. W. Anderson, and Suresh Mohla

Role of Caveolae and Lipid Rafts in Cancer: Workshop Summary and Future Needs
Cancer Res 2003 63: 6571-6574. [Full Text] [PDF]  

Advances in Brief:

Keishi Yamashita, Koshi Mimori, Hiroshi Inoue, Masaki Mori, and David Sidransky

A Tumor-suppressive Role for Trypsin in Human Cancer Progression
Cancer Res 2003 63: 6575-6578. [Abstract] [Full Text] [PDF]  

Erica J. Peterson, Oliver Bögler, and Shirley M. Taylor

p53-Mediated Repression of DNA Methyltransferase 1 Expression by Specific DNA Binding
Cancer Res 2003 63: 6579-6582. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Bingsen Zhou, Xiyong Liu, Xueli Mo, Lijun Xue, Dana Darwish, Weihua Qiu, Jennifer Shih, Edward B. Hwu, Frank Luh, and Yun Yen

The Human Ribonucleotide Reductase Subunit hRRM2 Complements p53R2 in Response to UV-Induced DNA Repair in Cells with Mutant p53
Cancer Res 2003 63: 6583-6594. [Abstract] [Full Text] [PDF]  

Jayadev Raju and Ranjana P. Bird

Energy Restriction Reduces the Number of Advanced Aberrant Crypt Foci and Attenuates the Expression of Colonic Transforming Growth Factor ß and Cyclooxygenase Isoforms in Zucker Obese (fa/fa) Rats
Cancer Res 2003 63: 6595-6601. [Abstract] [Full Text] [PDF]  

Lisa E. Olson, Djahida Bedja, Sara J. Alvey, A. J. Cardounel, Kathleen L. Gabrielson, and Roger H. Reeves

Protection from Doxorubicin-Induced Cardiac Toxicity in Mice with a Null Allele of Carbonyl Reductase 1
Cancer Res 2003 63: 6602-6606. [Abstract] [Full Text] [PDF]  

Cécile Vissac-Sabatier, Véronique Coxam, Pierre Déchelotte, Christel Picherit, Marie-Nöelle Horcajada, Marie-Jeanne Davicco, Patrice Lebecque, Yves-Jean Bignon, and Dominique Bernard-Gallon

Phytoestrogen-Rich Diets Modulate Expression of Brca1 and Brca2 Tumor Suppressor Genes in Mammary Glands of Female Wistar Rats
Cancer Res 2003 63: 6607-6612. [Abstract] [Full Text] [PDF]  

Sophie Godard, Gad Getz, Mauro Delorenzi, Pierre Farmer, Hiroyuki Kobayashi, Isabelle Desbaillets, Michimasa Nozaki, Annie-Claire Diserens, Marie-France Hamou, Pierre-Yves Dietrich, Luca Regli, Robert C. Janzer, Philipp Bucher, Roger Stupp, Nicolas de Tribolet, Eytan Domany, and Monika E. Hegi

Classification of Human Astrocytic Gliomas on the Basis of Gene Expression: A Correlated Group of Genes with Angiogenic Activity Emerges As a Strong Predictor of Subtypes
Cancer Res 2003 63: 6613-6625. [Abstract] [Full Text] [PDF] Supplementary Data  

Dahu Chen, Weidong Xu, Elise Bales, Clemencia Colmenares, Maralice Conacci-Sorrell, Shunsuke Ishii, Ed Stavnezer, Judith Campisi, David E. Fisher, Avri Ben-Ze’ev, and Estela E. Medrano

SKI Activates Wnt/ß-Catenin Signaling in Human Melanoma
Cancer Res 2003 63: 6626-6634. [Abstract] [Full Text] [PDF]  

Natalia L. Komarova and Dominik Wodarz

Evolutionary Dynamics of Mutator Phenotypes in Cancer: Implications for Chemotherapy
Cancer Res 2003 63: 6635-6642. [Abstract] [Full Text] [PDF] Supplementary Data  

Magali Olivier, David E. Goldgar, Nayanta Sodha, Hiroko Ohgaki, Paul Kleihues, Pierre Hainaut, and Rosalind A. Eeles

Li-Fraumeni and Related Syndromes: Correlation between Tumor Type, Family Structure, and TP53 Genotype
Cancer Res 2003 63: 6643-6650. [Abstract] [Full Text] [PDF]  

Yasuhiro Ito, Yuichi Oike, Kunio Yasunaga, Koichi Hamada, Keishi Miyata, Shun-ichiro Matsumoto, Sumio Sugano, Hidenobu Tanihara, Yasuhiko Masuho, and Toshio Suda

Inhibition of Angiogenesis and Vascular Leakiness by Angiopoietin-Related Protein 4
Cancer Res 2003 63: 6651-6657. [Abstract] [Full Text] [PDF]  

Jinqiu Zhang, Hangyee Wong, Sriram Ramanan, Denis Cheong, Adrian Leong, and Shing Chuan Hooi

The Proline-Rich Acidic Protein Is Epigenetically Regulated and Inhibits Growth of Cancer Cell Lines
Cancer Res 2003 63: 6658-6665. [Abstract] [Full Text] [PDF]  

Caroline A. Heckman, Thai Cao, Lina Somsouk, Hong Duan, John W. Mehew, Chun-yi Zhang, and Linda M. Boxer

Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2
Cancer Res 2003 63: 6666-6673. [Abstract] [Full Text] [PDF]  

Simon J. Allison and Jo Milner

Loss of p53 Has Site-Specific Effects on Histone H3 Modification, Including Serine 10 Phosphorylation Important for Maintenance of Ploidy
Cancer Res 2003 63: 6674-6679. [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

Ling-Huei Yih and Te-Chang Lee

Induction of C-Anaphase and Diplochromosome through Dysregulation of Spindle Assembly Checkpoint by Sodium Arsenite in Human Fibroblasts
Cancer Res 2003 63: 6680-6688. [Abstract] [Full Text] [PDF]  

Constantine S. Mitsiades, Nicholas S. Mitsiades, Ron T. Bronson, Dharminder Chauhan, Nikhil Munshi, Steven P. Treon, Christopher A. Maxwell, Linda Pilarski, Teru Hideshima, Robert M. Hoffman, and Kenneth C. Anderson

Fluorescence Imaging of Multiple Myeloma Cells in a Clinically Relevant SCID/NOD in Vivo Model: Biologic and Clinical Implications
Cancer Res 2003 63: 6689-6696. [Abstract] [Full Text] [PDF]  

Amanda Jetzt, John A. Howe, Mark T. Horn, Eugene Maxwell, Zhizhang Yin, Duane Johnson, and C. Chandra Kumar

Adenoviral-Mediated Expression of a Kinase-Dead Mutant of Akt Induces Apoptosis Selectively in Tumor Cells and Suppresses Tumor Growth in Mice
Cancer Res 2003 63: 6697-6706. [Abstract] [Full Text] [PDF]  

Meliha Burcu Irmak, Gulayse Ince, Mehmet Ozturk, and Rengul Cetin-Atalay

Acquired Tolerance of Hepatocellular Carcinoma Cells to Selenium Deficiency: A Selective Survival Mechanism?
Cancer Res 2003 63: 6707-6715. [Abstract] [Full Text] [PDF]  

Karine Bernard, Elizabeth Litman, James L. Fitzpatrick, Yiqun G. Shellman, Gretchen Argast, Kirsi Polvinen, Allen D. Everett, Kenji Fukasawa, David A. Norris, Natalie G. Ahn, and Katheryn A. Resing

Functional Proteomic Analysis of Melanoma Progression
Cancer Res 2003 63: 6716-6725. [Abstract] [Full Text] [PDF]  

Masakazu Yasumaru, Shingo Tsuji, Masahiko Tsujii, Takanobu Irie, Masato Komori, Arata Kimura, Tsutomu Nishida, Yoshimi Kakiuchi, Naoki Kawai, Hiroaki Murata, Masayoshi Horimoto, Yutaka Sasaki, Norio Hayashi, Sunao Kawano, and Masatsugu Hori

Inhibition of Angiotensin II Activity Enhanced the Antitumor Effect of Cyclooxygenase-2 Inhibitors via Insulin-Like Growth Factor I Receptor Pathway
Cancer Res 2003 63: 6726-6734. [Abstract] [Full Text] [PDF]  

Cristina Maccalli, Yong F. Li, Mona El-Gamil, Steven A. Rosenberg, and Paul F. Robbins

Identification of a Colorectal Tumor-Associated Antigen (COA-1) Recognized by CD4⁺ T Lymphocytes
Cancer Res 2003 63: 6735-6743. [Abstract] [Full Text] [PDF]  

Kunrong Cheng, Piotr Zimniak, and Jean-Pierre Raufman

Transactivation of the Epidermal Growth Factor Receptor Mediates Cholinergic Agonist-Induced Proliferation of H508 Human Colon Cancer Cells
Cancer Res 2003 63: 6744-6750. [Abstract] [Full Text] [PDF]  

Adela R. Cardones, Takashi Murakami, and Sam T. Hwang

CXCR4 Enhances Adhesion of B16 Tumor Cells to Endothelial Cells in Vitro and in Vivo via ß₁ Integrin
Cancer Res 2003 63: 6751-6757. [Abstract] [Full Text] [PDF]  

Jing Nie and Duanqing Pei

Direct Activation of Pro-Matrix Metalloproteinase-2 by Leukolysin/Membrane-type 6 Matrix Metalloproteinase/Matrix Metalloproteinase 25 at the Asn¹⁰⁹-Tyr Bond
Cancer Res 2003 63: 6758-6762. [Abstract] [Full Text] [PDF]  

Sichuan Xi, Qing Zhang, William E. Gooding, Thomas E. Smithgall, and Jennifer Rubin Grandis

Constitutive Activation of Stat5b Contributes to Carcinogenesis in Vivo
Cancer Res 2003 63: 6763-6771. [Abstract] [Full Text] [PDF]  

Pamela A. Davol, Robert Bagdasaryan, Gerald J. Elfenbein, Abby L. Maizel, and A. Raymond Frackelton, Jr.

Shc Proteins Are Strong, Independent Prognostic Markers for Both Node-Negative and Node-Positive Primary Breast Cancer
Cancer Res 2003 63: 6772-6783. [Abstract] [Full Text] [PDF]  

Giorgio Stassi, Matilde Todaro, Monica Zerilli, Lucia Ricci-Vitiani, Diana Di Liberto, Mariella Patti, Adamaria Florena, Francesca Di Gaudio, Giuseppe Di Gesù, and Ruggero De Maria

Thyroid Cancer Resistance to Chemotherapeutic Drugs via Autocrine Production of Interleukin-4 and Interleukin-10
Cancer Res 2003 63: 6784-6790. [Abstract] [Full Text] [PDF]  

Fumihiro Tanaka, Hiroki Oyanagi, Kazumasa Takenaka, Shinya Ishikawa, Kazuhiro Yanagihara, Ryo Miyahara, Yozo Kawano, Mio Li, Yosuke Otake, and Hiromi Wada

Glomeruloid Microvascular Proliferation Is Superior to Intratumoral Microvessel Density as a Prognostic Marker in Non-Small Cell Lung Cancer
Cancer Res 2003 63: 6791-6794. [Abstract] [Full Text] [PDF]  

Ying Xiang, Zhengfu Wang, Junko Murakami, Sarah Plummer, Eric A. Klein, John D. Carpten, Jeffrey M. Trent, William B. Isaacs, Graham Casey, and Robert H. Silverman

Effects of RNase L Mutations Associated with Prostate Cancer on Apoptosis Induced by 2',5'-Oligoadenylates
Cancer Res 2003 63: 6795-6801. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Dongpo Cai, Anita Iyer, Kyriacos N. Felekkis, Richard I. Near, Zhijun Luo, Jonathan Chernoff, Chris Albanese, Richard G. Pestell, and Adam Lerner

AND-34/BCAR3, a GDP Exchange Factor Whose Overexpression Confers Antiestrogen Resistance, Activates Rac, PAK1, and the Cyclin D1 Promoter
Cancer Res 2003 63: 6802-6808. [Abstract] [Full Text] [PDF]  

Keisuke Oshima, Hiroaki Kawasaki, Yasushi Soda, Kenzaburo Tani, Shigetaka Asano, and Kazunari Taira

Maxizymes and Small Hairpin-Type RNAs That Are Driven by a tRNA Promoter Specifically Cleave a Chimeric Gene Associated with Leukemia in Vitro and in Vivo
Cancer Res 2003 63: 6809-6814. [Abstract] [Full Text] [PDF]  

Lily Yang, Zehong Cao, Hui Yan, and William C. Wood

Coexistence of High Levels of Apoptotic Signaling and Inhibitor of Apoptosis Proteins in Human Tumor Cells: Implication for Cancer Specific Therapy
Cancer Res 2003 63: 6815-6824. [Abstract] [Full Text] [PDF]  

Danhua Xiao, John T. Pinto, Jae-Won Soh, Atsuko Deguchi, Gregg G. Gundersen, Alexander F. Palazzo, Jung-Taek Yoon, Haim Shirin, and I. Bernard Weinstein

Induction of Apoptosis by the Garlic-Derived Compound S-Allylmercaptocysteine (SAMC) Is Associated with Microtubule Depolymerization and c-Jun NH₂-Terminal Kinase 1 Activation
Cancer Res 2003 63: 6825-6837. [Abstract] [Full Text] [PDF]  

Moritz F. Kircher, Jennifer R. Allport, Edward E. Graves, Victoria Love, Lee Josephson, Andrew H. Lichtman, and Ralph Weissleder

In Vivo High Resolution Three-Dimensional Imaging of Antigen-Specific Cytotoxic T-Lymphocyte Trafficking to Tumors
Cancer Res 2003 63: 6838-6846. [Abstract] [Full Text] [PDF] Supplementary Data  

Margaret Ramnaraine, Weihong Pan, Michael Goblirsch, Christine Lynch, Victor Lewis, Paul Orchard, Patrick Mantyh, and Denis R. Clohisy

Direct and Bystander Killing of Sarcomas by Novel Cytosine Deaminase Fusion Gene
Cancer Res 2003 63: 6847-6854. [Abstract] [Full Text] [PDF]  

Paul A. Clarke, Mark L. George, Sandra Easdale, David Cunningham, R. Ian Swift, Mark E. Hill, Diana M. Tait, and Paul Workman

Molecular Pharmacology of Cancer Therapy in Human Colorectal Cancer by Gene Expression Profiling
Cancer Res 2003 63: 6855-6863. [Abstract] [Full Text] [PDF] Supplementary Data  

Mu Wang, Amy L. Caruano, Michael R. Lewis, Laura A. Meyer, Robert P. VanderWaal, and Carolyn J. Anderson

Subcellular Localization of Radiolabeled Somatostatin Analogues: Implications for Targeted Radiotherapy of Cancer
Cancer Res 2003 63: 6864-6869. [Abstract] [Full Text] [PDF]  

Anthony Boitano, Jonathan A. Ellman, Gary D. Glick, and Anthony W. Opipari, Jr.

The Proapoptotic Benzodiazepine Bz-423 Affects the Growth and Survival of Malignant B Cells
Cancer Res 2003 63: 6870-6876. [Abstract] [Full Text] [PDF]  

Yolanda Cuevas, Rubén Hernández-Alcoceba, Julian Aragones, Salvador Naranjo-Suárez, María C. Castellanos, Miguel A. Esteban, Silvia Martín-Puig, Manuel O. Landazuri, and Luis del Peso

Specific Oncolytic Effect of a New Hypoxia-Inducible Factor-Dependent Replicative Adenovirus on von Hippel-Lindau-Defective Renal Cell Carcinomas
Cancer Res 2003 63: 6877-6884. [Abstract] [Full Text] [PDF]  

Jin Hyup Lee and Jeen-Woo Park

Protective Role of -Phenyl-N-t-butylnitrone against Ionizing Radiation in U937 Cells and Mice
Cancer Res 2003 63: 6885-6893. [Abstract] [Full Text] [PDF]  

Sonia Arora, Jin-Ming Yang, Terri Goss Kinzy, Ryutaro Utsumi, Tadashi Okamoto, Takashi Kitayama, Pedro A. Ortiz, and William N. Hait

Identification and Characterization of an Inhibitor of Eukaryotic Elongation Factor 2 Kinase against Human Cancer Cell Lines
Cancer Res 2003 63: 6894-6899. [Abstract] [Full Text] [PDF]  

Hilde Stubdal, Noah Perin, Marilyn Lemmon, Patricia Holman, Maxine Bauzon, Philip M. Potter, Mary K. Danks, Ali Fattaey, Thomas Dubensky, and Leisa Johnson

A Prodrug Strategy Using ONYX-015-Based Replicating Adenoviruses to Deliver Rabbit Carboxylesterase to Tumor Cells for Conversion of CPT-11 to SN-38
Cancer Res 2003 63: 6900-6908. [Abstract] [Full Text] [PDF]  

Xinyu Zheng, Mathias Lundberg, Anna Karlsson, and Magnus Johansson

Lipid-mediated Protein Delivery of Suicide Nucleoside Kinases
Cancer Res 2003 63: 6909-6913. [Abstract] [Full Text] [PDF]  

Shairoz Ramji, Chunja Lee, Tadanobu Inaba, Adam V. Patterson, and David S. Riddick

Human NADPH-Cytochrome P450 Reductase Overexpression Does Not Enhance the Aerobic Cytotoxicity of Doxorubicin in Human Breast Cancer Cell Lines
Cancer Res 2003 63: 6914-6919. [Abstract] [Full Text] [PDF]  

Debabrata Saha, Konjeti R. Sekhar, Carolyn Cao, Jason D. Morrow, Hak Choy, and Michael L. Freeman

The Antiangiogenic Agent SU5416 Down-Regulates Phorbol Ester-Mediated Induction of Cyclooxygenase 2 Expression by Inhibiting Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activity
Cancer Res 2003 63: 6920-6927. [Abstract] [Full Text] [PDF]  

Jeffrey P. MacKeigan, Casey M. Clements, John D. Lich, R. Marshall Pope, Yaacov Hod, and Jenny P-Y. Ting

Proteomic Profiling Drug-Induced Apoptosis in Non-Small Cell Lung Carcinoma: Identification of RS/DJ-1 and RhoGDI
Cancer Res 2003 63: 6928-6934. [Abstract] [Full Text] [PDF]  

Blaine W. Robinson, Michael M. Im, Mats Ljungman, Françoise Praz, and Donna S. Shewach

Enhanced Radiosensitization with Gemcitabine in Mismatch Repair-Deficient HCT116 Cells
Cancer Res 2003 63: 6935-6941. [Abstract] [Full Text] [PDF]  

Hideki Tanaka, Nobuko Ohshima, Mami Ikenoya, Kinuyo Komori, Fumitaka Katoh, and Hiroyoshi Hidaka

HMN-176, an Active Metabolite of the Synthetic Antitumor Agent HMN-214, Restores Chemosensitivity to Multidrug-Resistant Cells by Targeting the Transcription Factor NF-Y
Cancer Res 2003 63: 6942-6947. [Abstract] [Full Text] [PDF]  

Immunology:

Monica Rodolfo, Roberto Luksch, Elisabeth Stockert, Yao-Tseng Chen, Paola Collini, Tiziana Ranzani, Claudia Lombardo, Piero Dalerba, Licia Rivoltini, Flavio Arienti, Franca Fossati-Bellani, Lloyd J. Old, Giorgio Parmiani, and Chiara Castelli

Antigen-Specific Immunity in Neuroblastoma Patients: Antibody and T-Cell Recognition of NY-ESO-1 Tumor Antigen
Cancer Res 2003 63: 6948-6955. [Abstract] [Full Text] [PDF]  

Arvin S. Yang, Claude E. Monken, and Edmund C. Lattime

Intratumoral Vaccination with Vaccinia-Expressed Tumor Antigen and Granulocyte Macrophage Colony-Stimulating Factor Overcomes Immunological Ignorance to Tumor Antigen
Cancer Res 2003 63: 6956-6961. [Abstract] [Full Text] [PDF]  

Clinical Research:

Naoki Shinojima, Kenji Tada, Shoji Shiraishi, Takanori Kamiryo, Masato Kochi, Hideo Nakamura, Keishi Makino, Hideyuki Saya, Hirofumi Hirano, Jun-ichi Kuratsu, Koji Oka, Yasuji Ishimaru, and Yukitaka Ushio

Prognostic Value of Epidermal Growth Factor Receptor in Patients with Glioblastoma Multiforme
Cancer Res 2003 63: 6962-6970. [Abstract] [Full Text] [PDF]  

Mark A. Rogers, Paul Clarke, Jason Noble, Nicholas P. Munro, Alan Paul, Peter J. Selby, and Rosamonde E. Banks

Proteomic Profiling of Urinary Proteins in Renal Cancer by Surface Enhanced Laser Desorption Ionization and Neural-Network Analysis: Identification of Key Issues Affecting Potential Clinical Utility
Cancer Res 2003 63: 6971-6983. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Christopher A. Haiman, Sean O. Henderson, Philip Bretsky, Laurence N. Kolonel, and Brian E. Henderson

Genetic Variation in Angiotensin I-Converting Enzyme (ACE) and Breast Cancer Risk: The Multiethnic Cohort
Cancer Res 2003 63: 6984-6987. [Abstract] [Full Text] [PDF]  

Ke Zu and Clement Ip

Synergy between Selenium and Vitamin E in Apoptosis Induction Is Associated with Activation of Distinctive Initiator Caspases in Human Prostate Cancer Cells
Cancer Res 2003 63: 6988-6995. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Rotem Sorek, Ortal Basechess, Hershel M. Safer, Zhining Wang, and Maxwell P. Lee

Expressed Sequence Tags: Clean before Using. Correspondence re: Z. Wang et al., Computational Analysis and Experimental Validation of Tumor-associated Alternative RNA Splicing in Human Cancer. Cancer Res., 63: 655–657, 2003.
Cancer Res 2003 63: 6996-6997. [Full Text] [PDF]  

Quinten Waisfisz, Gerard Pals, and Hans Joenje

Correspondence re: M. S. van der Heijden et al., Fanconi Anemia Gene Mutations in Young-onset Pancreatic Cancer. Cancer Res.,63: 2585–2588, 2003.
Cancer Res 2003 63: 6998. [Full Text] [PDF]  

Michiel S. van der Heijden, Ralph H. Hruban, and Scott E. Kern

Reply
Cancer Res 2003 63: 6999-7001. [Full Text] [PDF]  

Obituary:

Michael Potter

In Memoriam: Lloyd W. Law (1910–2002)
Cancer Res 2003 63: 7002. [Full Text] [PDF]  

Correction:

Cancer Res 2003 63: 7004. [Full Text] [PDF]  

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