Advances in Brief:

Jimin Shao, Bingsen Zhou, Lijun Zhu, Weihua Qiu, Yate-Ching Yuan, Bixin Xi, and Yun Yen

In Vitro Characterization of Enzymatic Properties and Inhibition of the p53R2 Subunit of Human Ribonucleotide Reductase
Cancer Res 2004 64: 1-6. [Abstract] [Full Text] [PDF]  

Burkhard Brandt, Silke Hermann, Kurt Straif, Nicola Tidow, Horst Buerger, and Jenny Chang-Claude

Modification of Breast Cancer Risk in Young Women by a Polymorphic Sequence in the egfr Gene
Cancer Res 2004 64: 7-12. [Abstract] [Full Text] [PDF]  

Einar K. Rofstad, Berit Mathiesen, and Kanthi Galappathi

Increased Metastatic Dissemination in Human Melanoma Xenografts after Subcurative Radiation Treatment: Radiation-induced Increase in Fraction of Hypoxic Cells and Hypoxia-induced Up-Regulation of Urokinase-Type Plasminogen Activator Receptor
Cancer Res 2004 64: 13-18. [Abstract] [Full Text] [PDF]  

Yan Dong, Soo Ok Lee, Haitao Zhang, James Marshall, Allen C. Gao, and Clement Ip

Prostate Specific Antigen Expression Is Down-Regulated by Selenium through Disruption of Androgen Receptor Signaling
Cancer Res 2004 64: 19-22. [Abstract] [Full Text] [PDF]  

Michelle Y. Alfonso-De Matte and Patricia A. Kruk

Phosphatidylinositol Triphosphate Kinase-dependent and c-Jun NH₂-Terminal Kinase-dependent Induction of Telomerase by Calcium Requires Pyk2
Cancer Res 2004 64: 23-26. [Abstract] [Full Text] [PDF]  

Linda E. Bröker, Cynthia Huisman, Simone W. Span, José A. Rodriguez, Frank A. E. Kruyt, and Giuseppe Giaccone

Cathepsin B Mediates Caspase-Independent Cell Death Induced by Microtubule Stabilizing Agents in Non-Small Cell Lung Cancer Cells
Cancer Res 2004 64: 27-30. [Abstract] [Full Text] [PDF]  

Gregory Maschek, Niramol Savaraj, Waldemar Priebe, Paul Braunschweiger, Kara Hamilton, George F. Tidmarsh, Linda R. De Young, and Theodore J. Lampidis

2-Deoxy-D-glucose Increases the Efficacy of Adriamycin and Paclitaxel in Human Osteosarcoma and Non-Small Cell Lung Cancers In Vivo
Cancer Res 2004 64: 31-34. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Ji-Woong Choi, Sang Chul Park, Gyeong Hoon Kang, Jun O. Liu, and Hong-Duk Youn

Nur77 Activated by Hypoxia-Inducible Factor-1 Overproduces Proopiomelanocortin in von Hippel-Lindau-Mutated Renal Cell Carcinoma
Cancer Res 2004 64: 35-39. [Abstract] [Full Text] [PDF]  

Michael E. Ray, Zeng Quan Yang, Donna Albertson, Celina G. Kleer, Joseph G. Washburn, Jill A. Macoska, and Stephen P. Ethier

Genomic and Expression Analysis of the 8p11–12 Amplicon in Human Breast Cancer Cell Lines
Cancer Res 2004 64: 40-47. [Abstract] [Full Text] [PDF]  

Naomoto Harada, Hiroko Oshima, Masahiro Katoh, Yositaka Tamai, Masanobu Oshima, and Makoto M. Taketo

Hepatocarcinogenesis in Mice with ß-Catenin and Ha-Ras Gene Mutations
Cancer Res 2004 64: 48-54. [Abstract] [Full Text] [PDF]  

Matthew A. Ginos, Grier P. Page, Bryan S. Michalowicz, Ketan J. Patel, Sonja E. Volker, Stefan E. Pambuccian, Frank G. Ondrey, George L. Adams, and Patrick M. Gaffney

Identification of a Gene Expression Signature Associated with Recurrent Disease in Squamous Cell Carcinoma of the Head and Neck
Cancer Res 2004 64: 55-63. [Abstract] [Full Text] [PDF]  

Zhigang C. Wang, Ming Lin, Lee-Jen Wei, Cheng Li, Alexander Miron, Gabriella Lodeiro, Lyndsay Harris, Sridhar Ramaswamy, David M. Tanenbaum, Matthew Meyerson, James D. Iglehart, and Andrea Richardson

Loss of Heterozygosity and Its Correlation with Expression Profiles in Subclasses of Invasive Breast Cancers
Cancer Res 2004 64: 64-71. [Abstract] [Full Text] [PDF]  

Pramod P. Naranatt, Harinivas H. Krishnan, Stan R. Svojanovsky, Clark Bloomer, Sachin Mathur, and Bala Chandran

Host Gene Induction and Transcriptional Reprogramming in Kaposi’s Sarcoma-Associated Herpesvirus (KSHV/HHV-8)-Infected Endothelial, Fibroblast, and B Cells: Insights into Modulation Events Early during Infection
Cancer Res 2004 64: 72-84. [Abstract] [Full Text] [PDF] Supplementary Data  

Alexis Schubert and Stefan Grimm

Cyclophilin D, a Component of the Permeability Transition-Pore, Is an Apoptosis Repressor
Cancer Res 2004 64: 85-93. [Abstract] [Full Text] [PDF]  

Jingxia Li, Gerard Davidson, Yi Huang, Bing-Hua Jiang, Xianglin Shi, Max Costa, and Chuanshu Huang

Nickel Compounds Act through Phosphatidylinositol-3-kinase/Akt-Dependent, p70^S6k-Independent Pathway to Induce Hypoxia Inducible Factor Transactivation and Cap43 Expression in Mouse Epidermal Cl41 Cells
Cancer Res 2004 64: 94-101. [Abstract] [Full Text] [PDF]  

Sarah L. Fenton, Ashraf Dallol, Angelo Agathanggelou, Luke Hesson, Jalal Ahmed-Choudhury, Shairaz Baksh, Claude Sardet, Reinhard Dammann, John D. Minna, Julian Downward, Eamonn R. Maher, and Farida Latif

Identification of the E1A-Regulated Transcription Factor p120^E4F as an Interacting Partner of the RASSF1A Candidate Tumor Suppressor Gene
Cancer Res 2004 64: 102-107. [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

Jing Yi, Jie Yang, Rong He, Fei Gao, Hairong Sang, Xueming Tang, and Richard D. Ye

Emodin Enhances Arsenic Trioxide-Induced Apoptosis via Generation of Reactive Oxygen Species and Inhibition of Survival Signaling
Cancer Res 2004 64: 108-116. [Abstract] [Full Text] [PDF]  

Thomas T. Chen, Eric J. Brown, Eric J. Huang, and William E. Seaman

Expression and Activation of Signal Regulatory Protein on Astrocytomas
Cancer Res 2004 64: 117-127. [Abstract] [Full Text] [PDF]  

Paul R. van Ginkel, Ricardo L. Gee, Rebecca L. Shearer, Lalita Subramanian, Teresa M. Walker, Daniel M. Albert, Lorraine F. Meisner, Brian C. Varnum, and Arthur S. Polans

Expression of the Receptor Tyrosine Kinase Axl Promotes Ocular Melanoma Cell Survival
Cancer Res 2004 64: 128-134. [Abstract] [Full Text] [PDF]  

Sonya Trombino, Alfredo Cesario, Stefano Margaritora, PierLuigi Granone, Giovanni Motta, Carla Falugi, and Patrizia Russo

7-Nicotinic Acetylcholine Receptors Affect Growth Regulation of Human Mesothelioma Cells: Role of Mitogen-Activated Protein Kinase Pathway
Cancer Res 2004 64: 135-145. [Abstract] [Full Text] [PDF]  

Nathalie Rousselet, Lisa Mills, Didier Jean, Carmen Tellez, Menashe Bar-Eli, and Raymond Frade

Inhibition of Tumorigenicity and Metastasis of Human Melanoma Cells by Anti-Cathepsin L Single Chain Variable Fragment
Cancer Res 2004 64: 146-151. [Abstract] [Full Text] [PDF]  

De-En Hu, Stephanie O. M. Dyke, Alistair M. Moore, Lindy L. Thomsen, and Kevin M. Brindle

Tumor Cell-Derived Nitric Oxide Is Involved in the Immune-Rejection of an Immunogenic Murine Lymphoma
Cancer Res 2004 64: 152-161. [Abstract] [Full Text] [PDF]  

Hao Wang, Ryan Schultz, Jerome Hong, Deborah L. Cundiff, Keyi Jiang, and Gerald A. Soff

Cell Surface-Dependent Generation of Angiostatin4.5
Cancer Res 2004 64: 162-168. [Abstract] [Full Text] [PDF]  

Robert G. Oshima, Jacqueline Lesperance, Varinia Munoz, Lionel Hebbard, Barbara Ranscht, Niki Sharan, William J. Muller, Craig A. Hauser, and Robert D. Cardiff

Angiogenic Acceleration of Neu Induced Mammary Tumor Progression and Metastasis
Cancer Res 2004 64: 169-179. [Abstract] [Full Text] [PDF]  

Thierry Massfelder, Herve Lang, Eric Schordan, Veronique Lindner, Sylvie Rothhut, Sandra Welsch, Patricia Simon-Assmann, Mariette Barthelmebs, Didier Jacqmin, and Jean-Jacques Helwig

Parathyroid Hormone-Related Protein Is an Essential Growth Factor for Human Clear Cell Renal Carcinoma and a Target for the von Hippel-Lindau Tumor Suppressor Gene
Cancer Res 2004 64: 180-188. [Abstract] [Full Text] [PDF]  

Carsten Denkert, Wilko Weichert, Sören Pest, Ines Koch, Dirk Licht, Martin Köbel, Angela Reles, Jalid Sehouli, Manfred Dietel, and Steffen Hauptmann

Overexpression of the Embryonic-Lethal Abnormal Vision-like Protein HuR in Ovarian Carcinoma Is a Prognostic Factor and Is Associated with Increased Cyclooxygenase 2 Expression
Cancer Res 2004 64: 189-195. [Abstract] [Full Text] [PDF]  

Theodore J. Koh, John K. Field, Andrea Varro, Triantafillos Liloglou, Pat Fielding, Guanglin Cui, JeanMarie Houghton, Graham J. Dockray, and Timothy C. Wang

Glycine-Extended Gastrin Promotes the Growth of Lung Cancer
Cancer Res 2004 64: 196-201. [Abstract] [Full Text] [PDF]  

Lawrence R. Zukerberg, Robert L. DeBernardo, Sandra D. Kirley, Massimo D’Apuzzo, Maureen P. Lynch, Ramey D. Littell, Linda R. Duska, Landin Boring, and Bo R. Rueda

Loss of Cables, a Cyclin-Dependent Kinase Regulatory Protein, Is Associated with the Development of Endometrial Hyperplasia and Endometrial Cancer
Cancer Res 2004 64: 202-208. [Abstract] [Full Text] [PDF]  

Charles R. Tessier, Glenn A. Doyle, Brad A. Clark, Henry C. Pitot, and Jeff Ross

Mammary Tumor Induction in Transgenic Mice Expressing an RNA-Binding Protein
Cancer Res 2004 64: 209-214. [Abstract] [Full Text] [PDF]  

Felix Herrmann, Hans-Anton Lehr, Ingo Drexler, Gerd Sutter, Jan Hengstler, Ursula Wollscheid, and Barbara Seliger

HER-2/neu-Mediated Regulation of Components of the MHC Class I Antigen-Processing Pathway
Cancer Res 2004 64: 215-220. [Abstract] [Full Text] [PDF]  

Liqun Xia, Aimee Paik, and Jian Jian Li

p53 Activation in Chronic Radiation-Treated Breast Cancer Cells: Regulation of MDM2/p14ARF
Cancer Res 2004 64: 221-228. [Abstract] [Full Text] [PDF]  

Jinyi Shao, B. Mark Evers, and Hongmiao Sheng

Roles of Phosphatidylinositol 3'-Kinase and Mammalian Target of Rapamycin/p70 Ribosomal Protein S6 Kinase in K-Ras-Mediated Transformation of Intestinal Epithelial Cells
Cancer Res 2004 64: 229-235. [Abstract] [Full Text] [PDF]  

Ada Girnita, Leonard Girnita, Fabrizio del Prete, Armando Bartolazzi, Olle Larsson, and Magnus Axelson

Cyclolignans as Inhibitors of the Insulin-Like Growth Factor-1 Receptor and Malignant Cell Growth
Cancer Res 2004 64: 236-242. [Abstract] [Full Text] [PDF]  

Maren Fedrowitz, Kenji Kamino, and Wolfgang Löscher

Significant Differences in the Effects of Magnetic Field Exposure on 7,12-Dimethylbenz(a)anthracene-Induced Mammary Carcinogenesis in Two Substrains of Sprague-Dawley Rats
Cancer Res 2004 64: 243-251. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Anne Boulay, Sabine Zumstein-Mecker, Christine Stephan, Iwan Beuvink, Frederic Zilbermann, Roland Haller, Sonja Tobler, Christoph Heusser, Terence O’Reilly, Barbara Stolz, Andreas Marti, George Thomas, and Heidi A. Lane

Antitumor Efficacy of Intermittent Treatment Schedules with the Rapamycin Derivative RAD001 Correlates with Prolonged Inactivation of Ribosomal Protein S6 Kinase 1 in Peripheral Blood Mononuclear Cells
Cancer Res 2004 64: 252-261. [Abstract] [Full Text] [PDF]  

Steven R. Whittaker, Mike I. Walton, Michelle D. Garrett, and Paul Workman

The Cyclin-dependent Kinase Inhibitor CYC202 (R-Roscovitine) Inhibits Retinoblastoma Protein Phosphorylation, Causes Loss of Cyclin D1, and Activates the Mitogen-activated Protein Kinase Pathway
Cancer Res 2004 64: 262-272. [Abstract] [Full Text] [PDF]  

Khalid Shah, Ching-Hsuan Tung, Chung-Hsun Chang, Eric Slootweg, Terence O’Loughlin, Xandra O. Breakefield, and Ralph Weissleder

In Vivo Imaging of HIV Protease Activity in Amplicon Vector-transduced Gliomas
Cancer Res 2004 64: 273-278. [Abstract] [Full Text] [PDF]  

Thomas W. Davis, Janet M. O’Neal, Mark D. Pagel, Ben S. Zweifel, Pramod P. Mehta, Deborah M. Heuvelman, and Jaime L. Masferrer

Synergy between Celecoxib and Radiotherapy Results from Inhibition of Cyclooxygenase-2-Derived Prostaglandin E₂, a Survival Factor for Tumor and Associated Vasculature
Cancer Res 2004 64: 279-285. [Abstract] [Full Text] [PDF]  

Torsten O. Nielsen, Heather N. Andrews, Maggie Cheang, Jill E. Kucab, Forrest D. Hsu, Joseph Ragaz, C. Blake Gilks, Nikita Makretsov, Chris D. Bajdik, Christy Brookes, Leonard M. Neckers, Valentina Evdokimova, David G. Huntsman, and Sandra E. Dunn

Expression of the Insulin-Like Growth Factor I Receptor and Urokinase Plasminogen Activator in Breast Cancer Is Associated with Poor Survival: Potential for Intervention with 17-Allylamino Geldanamycin
Cancer Res 2004 64: 286-291. [Abstract] [Full Text] [PDF]  

Youssef Jounaidi and David J. Waxman

Use of Replication-Conditional Adenovirus as a Helper System to Enhance Delivery of P450 Prodrug-Activation Genes for Cancer Therapy
Cancer Res 2004 64: 292-303. [Abstract] [Full Text] [PDF]  

Lorea Mendoza, María Valcárcel, Teresa Carrascal, Eider Egilegor, Clarisa Salado, B. Kim Lee Sim, and Fernando Vidal-Vanaclocha

Inhibition of Cytokine-Induced Microvascular Arrest of Tumor Cells by Recombinant Endostatin Prevents Experimental Hepatic Melanoma Metastasis
Cancer Res 2004 64: 304-310. [Abstract] [Full Text] [PDF]  

William Ensminger, James Knol, Susan DeRemer, Erby Wilkinson, Suzette Walker, David Williams, and Jonathan Maybaum

Effects of Dexamethasone or Celecoxib on Biliary Toxicity after Hepatic Arterial Infusion of 5-Fluorodeoxyuridine in a Canine Model
Cancer Res 2004 64: 311-315. [Abstract] [Full Text] [PDF]  

Kevin Camphausen, William Burgan, Michael Cerra, Kelli A. Oswald, Jane B. Trepel, Min-Jung Lee, and Philip J. Tofilon

Enhanced Radiation-Induced Cell Killing and Prolongation of H2AX Foci Expression by the Histone Deacetylase Inhibitor MS-275
Cancer Res 2004 64: 316-321. [Abstract] [Full Text] [PDF]  

Per S. Holm, Hermann Lage, Stephan Bergmann, Karsten Jürchott, Gabriel Glockzin, Alexandra Bernshausen, Klaus Mantwill, Axel Ladhoff, Anke Wichert, Joe S. Mymryk, Thomas Ritter, Manfred Dietel, Bernd Gänsbacher, and Hans-Dieter Royer

Multidrug-resistant Cancer Cells Facilitate E1-independent Adenoviral Replication: Impact for Cancer Gene Therapy
Cancer Res 2004 64: 322-328. [Abstract] [Full Text] [PDF]  

Valeria R. Fantin and Philip Leder

F16, a Mitochondriotoxic Compound, Triggers Apoptosis or Necrosis Depending on the Genetic Background of the Target Carcinoma Cell
Cancer Res 2004 64: 329-336. [Abstract] [Full Text] [PDF]  

Simone Fulda and Klaus-Michael Debatin

Sensitization for Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by the Chemopreventive Agent Resveratrol
Cancer Res 2004 64: 337-346. [Abstract] [Full Text] [PDF]  

Daniel B. Martin, David R. Gifford, Michael E. Wright, Andrew Keller, Eugene Yi, David R. Goodlett, Reudi Aebersold, and Peter S. Nelson

Quantitative Proteomic Analysis of Proteins Released by Neoplastic Prostate Epithelium
Cancer Res 2004 64: 347-355. [Abstract] [Full Text] [PDF]  

Antoine Vekris, Delphine Meynard, Marie-Christine Haaz, Martine Bayssas, Jacques Bonnet, and Jacques Robert

Molecular Determinants of the Cytotoxicity of Platinum Compounds: The Contribution of in Silico Research
Cancer Res 2004 64: 356-362. [Abstract] [Full Text] [PDF]  

Takuya Fukazawa, Yutaka Maeda, Frances M. Sladek, and Laurie B. Owen-Schaub

Development of a Cancer-Targeted Tissue-Specific Promoter System
Cancer Res 2004 64: 363-369. [Abstract] [Full Text] [PDF]  

Yan Ji and George P. Studzinski

Retinoblastoma Protein and CCAAT/Enhancer-Binding Protein ß Are Required for 1,25-Dihydroxyvitamin D₃-Induced Monocytic Differentiation of HL60 Cells
Cancer Res 2004 64: 370-377. [Abstract] [Full Text] [PDF]  

Immunology:

Francesco Lozupone, Daniela Pende, Vito Lelio Burgio, Chiara Castelli, Massimo Spada, Massimo Venditti, Francesca Luciani, Luana Lugini, Cristina Federici, Carlo Ramoni, Licia Rivoltini, Giorgio Parmiani, Filippo Belardelli, Paola Rivera, Stefania Marcenaro, Lorenzo Moretta, and Stefano Fais

Effect Of Human Natural Killer and T Cells on the Growth of Human Autologous Melanoma Xenografts in SCID Mice
Cancer Res 2004 64: 378-385. [Abstract] [Full Text] [PDF]  

Kenji Chamoto, Takemasa Tsuji, Hiromi Funamoto, Akemi Kosaka, Junko Matsuzaki, Takeshi Sato, Hiroyuki Abe, Keishi Fujio, Kazuhiko Yamamoto, Toshio Kitamura, Tsuguhide Takeshima, Yuji Togashi, and Takashi Nishimura

Potentiation of Tumor Eradication by Adoptive Immunotherapy with T-cell Receptor Gene-Transduced T-Helper Type 1 Cells
Cancer Res 2004 64: 386-390. [Abstract] [Full Text] [PDF]  

Nanae Harashima, Kiyoshi Kurihara, Atae Utsunomiya, Ryuji Tanosaki, Shino Hanabuchi, Masato Masuda, Takashi Ohashi, Fumiyo Fukui, Atsuhiko Hasegawa, Takao Masuda, Yoichi Takaue, Jun Okamura, and Mari Kannagi

Graft-versus-Tax Response in Adult T-Cell Leukemia Patients after Hematopoietic Stem Cell Transplantation
Cancer Res 2004 64: 391-399. [Abstract] [Full Text] [PDF]  

Tae Woo Kim, Chien-Fu Hung, David A. K. Boyd, Liangmei He, Cheng-Tao Lin, Dion Kaiserman, Phillip I. Bird, and T-C. Wu

Enhancement of DNA Vaccine Potency by Coadministration of a Tumor Antigen Gene and DNA Encoding Serine Protease Inhibitor-6
Cancer Res 2004 64: 400-405. [Abstract] [Full Text] [PDF]  

Mark J. Dobrzanski, Joyce B. Reome, Joseph A. Hollenbaugh, James C. Hylind, and Richard W. Dutton

Effector Cell-Derived Lymphotoxin and Fas Ligand, but not Perforin, Promote Tc1 and Tc2 Effector Cell-Mediated Tumor Therapy in Established Pulmonary Metastases
Cancer Res 2004 64: 406-414. [Abstract] [Full Text] [PDF]  

Endocrinology:

Takahiko Kogai, Yoko Kanamoto, Lisa H. Che, Katsumi Taki, Farhad Moatamed, James J. Schultz, and Gregory A. Brent

Systemic Retinoic Acid Treatment Induces Sodium/Iodide Symporter Expression and Radioiodide Uptake in Mouse Breast Cancer Models
Cancer Res 2004 64: 415-422. [Abstract] [Full Text] [PDF]  

Sreenivasan Paruthiyil, Hema Parmar, Vaishali Kerekatte, Gerald R. Cunha, Gary L. Firestone, and Dale C. Leitman

Estrogen Receptor ß Inhibits Human Breast Cancer Cell Proliferation and Tumor Formation by Causing a G₂ Cell Cycle Arrest
Cancer Res 2004 64: 423-428. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Christopher J. MacDonald, Henry P. Ciolino, and Grace Chao Yeh

The Drug Salicylamide Is an Antagonist of the Aryl Hydrocarbon Receptor That Inhibits Signal Transduction Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin
Cancer Res 2004 64: 429-434. [Abstract] [Full Text] [PDF]  

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