Advances in Brief:

H2-Ea Deficiency Is a Risk Factor for Bleomycin-Induced Lung Fibrosis in Mice

Min Du, Roxanna A. Irani, David N. Stivers, Sang-Joon Lee, and Elizabeth L. Travis
Cancer Res 2004 64: 6835-6839. [Abstract] [Full Text] [PDF]  

A Recurrent Chromosome Breakpoint in Breast Cancer at the NRG1/Neuregulin 1/Heregulin Gene

Huai-En Huang, Suet-Feung Chin, Christophe Ginestier, Valérie-Jeanne Bardou, José Adélaïde, N. Gopalakrishna Iyer, Maria J. Garcia, Jessica C. Pole, Grace M. Callagy, Stephen M. Hewitt, William J. Gullick, Jocelyne Jacquemier, Carlos Caldas, Max Chaffanet, Daniel Birnbaum, and Paul A. W. Edwards
Cancer Res 2004 64: 6840-6844. [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data  

Schedule-dependent Inhibition of Hypoxia-inducible Factor-1 Protein Accumulation, Angiogenesis, and Tumor Growth by Topotecan in U251-HRE Glioblastoma Xenografts

Annamaria Rapisarda, Jessica Zalek, Melinda Hollingshead, Till Braunschweig, Badarch Uranchimeg, Carrie A. Bonomi, Suzanne D. Borgel, John P. Carter, Stephen M. Hewitt, Robert H. Shoemaker, and Giovanni Melillo
Cancer Res 2004 64: 6845-6848. [Abstract] [Full Text] [PDF]  

Nitric Oxide, a Mediator of Inflammation, Suppresses Tumorigenesis

S. Perwez Hussain, Glennwood E. Trivers, Lorne J. Hofseth, Peijun He, Irfan Shaikh, Leah E. Mechanic, Saira Doja, Weidong Jiang, Jeffrey Subleski, Lynnette Shorts, Diana Haines, Victor E. Laubach, Robert H. Wiltrout, Draginja Djurickovic, and Curtis C. Harris
Cancer Res 2004 64: 6849-6853. [Abstract] [Full Text] [PDF] Supplementary Data  

JAGGED1 Expression Is Associated with Prostate Cancer Metastasis and Recurrence

Sandro Santagata, Francesca Demichelis, Alberto Riva, Sooryanarayana Varambally, Matthias D. Hofer, Jeffery L. Kutok, Robert Kim, Jeffery Tang, James E. Montie, Arul M. Chinnaiyan, Mark A. Rubin, and Jon C. Aster
Cancer Res 2004 64: 6854-6857. [Abstract] [Full Text] [PDF] Supplementary Data  

Convection-Enhanced Delivery of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand with Systemic Administration of Temozolomide Prolongs Survival in an Intracranial Glioblastoma Xenograft Model

Ryuta Saito, John R. Bringas, Amith Panner, Matyas Tamas, Russell O. Pieper, Mitchel S. Berger, and Krystof S. Bankiewicz
Cancer Res 2004 64: 6858-6862. [Abstract] [Full Text] [PDF]  

p73 G4C14-to-A4T14 Polymorphism and Risk of Lung Cancer

Guojun Li, Li-E Wang, Robert M. Chamberlain, Christopher I. Amos, Margaret R. Spitz, and Qingyi Wei
Cancer Res 2004 64: 6863-6866. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology and Genetics:

Monoallelic Methylation of the APC Promoter Is Altered in Normal Gastric Mucosa Associated with Neoplastic Lesions

Geneviève Clément, Fred T. Bosman, Charlotte Fontolliet, and Jean Benhattar
Cancer Res 2004 64: 6867-6873. [Abstract] [Full Text] [PDF]  

Growth Factor Independence-1 Is Expressed in Primary Human Neuroendocrine Lung Carcinomas and Mediates the Differentiation of Murine Pulmonary Neuroendocrine Cells

Avedis Kazanjian, Deeann Wallis, Nicholas Au, Rupesh Nigam, Koen J. T. Venken, Philip T. Cagle, Burton F. Dickey, Hugo J. Bellen, C. Blake Gilks, and H. Leighton Grimes
Cancer Res 2004 64: 6874-6882. [Abstract] [Full Text] [PDF] Supplementary Data  

Prediction of Clinical Outcome Using Gene Expression Profiling and Artificial Neural Networks for Patients with Neuroblastoma

Jun S. Wei, Braden T. Greer, Frank Westermann, Seth M. Steinberg, Chang-Gue Son, Qing-Rong Chen, Craig C. Whiteford, Sven Bilke, Alexei L. Krasnoselsky, Nicola Cenacchi, Daniel Catchpoole, Frank Berthold, Manfred Schwab, and Javed Khan
Cancer Res 2004 64: 6883-6891. [Abstract] [Full Text] [PDF]  

Genetic Pathways to Glioblastoma: A Population-Based Study

Hiroko Ohgaki, Pierre Dessen, Benjamin Jourde, Sonja Horstmann, Tomofumi Nishikawa, Pier-Luigi Di Patre, Christoph Burkhard, Danielle Schüler, Nicole M. Probst-Hensch, Paulo César Maiorka, Nathalie Baeza, Paola Pisani, Yasuhiro Yonekawa, M. Gazi Yasargil, Urs M. Lütolf, and Paul Kleihues
Cancer Res 2004 64: 6892-6899. [Abstract] [Full Text] [PDF]  

Maspin Expression Is Transactivated by p63 and Is Critical for the Modulation of Lung Cancer Progression

Sejin Kim, Joungho Han, Jhingook Kim, and Chaehwa Park
Cancer Res 2004 64: 6900-6905. [Abstract] [Full Text] [PDF]  

PTEN Gene Targeting Reveals a Radiation-Induced Size Checkpoint in Human Cancer Cells

Carolyn Lee, Jung-Sik Kim, and Todd Waldman
Cancer Res 2004 64: 6906-6914. [Abstract] [Full Text] [PDF]  

Mutations of BRAF and KRAS Precede the Development of Ovarian Serous Borderline Tumors

Chung-Liang Ho, Robert J. Kurman, Reiko Dehari, Tian-Li Wang, and Ie-Ming Shih
Cancer Res 2004 64: 6915-6918. [Abstract] [Full Text] [PDF]  

Spontaneous Mutations in Digestive Tract of Old Mice Show Tissue-Specific Patterns of Genomic Instability

Tetsuya Ono, Hironobu Ikehata, Vishnu Priya Pithani, Yoshihiko Uehara, Yali Chen, Yoshitaka Kinouchi, Toru Shimosegawa, and Yoshio Hosoi
Cancer Res 2004 64: 6919-6923. [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

Inhibition of gp130 Signaling in Breast Cancer Blocks Constitutive Activation of Stat3 and Inhibits in Vivo Malignancy

Katri S. Selander, Li Li, Latania Watson, Melinda Merrell, Heike Dahmen, Peter C. Heinrich, Gerhard Müller-Newen, and Kevin W. Harris
Cancer Res 2004 64: 6924-6933. [Abstract] [Full Text] [PDF]  

Oncogenic Action of Secreted Phospholipase A₂ in Prostate Cancer

Paul Sved, Kieran F. Scott, Duncan McLeod, Nicholas J. C. King, Jas Singh, Tania Tsatralis, Blagoy Nikolov, John Boulas, Laxman Nallan, Michael H. Gelb, Mila Sajinovic, Garry G. Graham, Pamela J. Russell, and Qihan Dong
Cancer Res 2004 64: 6934-6940. [Abstract] [Full Text] [PDF]  

Chromosome Transfer Induced Aneuploidy Results in Complex Dysregulation of the Cellular Transcriptome in Immortalized and Cancer Cells

Madhvi B. Upender, Jens K. Habermann, Lisa M. McShane, Edward L. Korn, J. Carl Barrett, Michael J. Difilippantonio, and Thomas Ried
Cancer Res 2004 64: 6941-6949. [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Expression Profiling of Tumor–Stromal Interactions between Pancreatic Cancer Cells and Stromal Fibroblasts

Norihiro Sato, Naoki Maehara, and Michael Goggins
Cancer Res 2004 64: 6950-6956. [Abstract] [Full Text] [PDF]  

Cystatin M: A Novel Candidate Tumor Suppressor Gene for Breast Cancer

Jun Zhang, Ravi Shridhar, Qun Dai, Jin Song, Shayne C. Barlow, Lijia Yin, Bonnie F. Sloane, Fred R. Miller, Carol Meschonat, Benjamin D. L. Li, Fleurette Abreo, and Daniel Keppler
Cancer Res 2004 64: 6957-6964. [Abstract] [Full Text] [PDF]  

A Protective Role for Matrix Metalloproteinase-3 in Squamous Cell Carcinoma

Lisa J. McCawley, Howard C. Crawford, Lloyd E. King, Jr., John Mudgett, and Lynn M. Matrisian
Cancer Res 2004 64: 6965-6972. [Abstract] [Full Text] [PDF]  

Down-Regulation of the Homeodomain Factor Cdx2 in Colorectal Cancer by Collagen Type I: An Active Role for the Tumor Environment in Malignant Tumor Progression

Thomas Brabletz, Simone Spaderna, Jochen Kolb, Falk Hlubek, Gerhard Faller, Christiane J. Bruns, Andreas Jung, Jens Nentwich, Isabelle Duluc, Claire Domon-Dell, Thomas Kirchner, and Jean-Noel Freund
Cancer Res 2004 64: 6973-6977. [Abstract] [Full Text] [PDF]  

Signaling and Transcriptional Changes Critical for Transformation of Human Cells by Simian Virus 40 Small Tumor Antigen or Protein Phosphatase 2A B56 Knockdown

Carlos S. Moreno, Sumathi Ramachandran, Danita G. Ashby, Noelani Laycock, Courtney A. Plattner, Wen Chen, William C. Hahn, and David C. Pallas
Cancer Res 2004 64: 6978-6988. [Abstract] [Full Text] [PDF] Supplementary Data  

Dysadherin Expression Facilitates Cell Motility and Metastatic Potential of Human Pancreatic Cancer Cells

Takeshi Shimamura, Jun Yasuda, Yoshinori Ino, Masahiro Gotoh, Akira Tsuchiya, Atsushi Nakajima, Michiie Sakamoto, Yae Kanai, and Setsuo Hirohashi
Cancer Res 2004 64: 6989-6995. [Abstract] [Full Text] [PDF]  

Ether à go-go Potassium Channels as Human Cervical Cancer Markers

Luz María Barajas Farias, Deysi Bermúdez Ocaña, Lorenza Díaz, Fernando Larrea, Euclides Avila-Chávez, Adriana Cadena, Luz María Hinojosa, Gerardo Lara, Luis Alberto Villanueva, Carlos Vargas, Elizabeth Hernández-Gallegos, Ignacio Camacho-Arroyo, Alfonso Dueñas-González, Enrique Pérez-Cárdenas, Luis A. Pardo, Angélica Morales, Lucía Taja-Chayeb, Juan Escamilla, Carmen Sánchez-Peña, and Javier Camacho
Cancer Res 2004 64: 6996-7001. [Abstract] [Full Text] [PDF]  

Deregulated Akt3 Activity Promotes Development of Malignant Melanoma

Jill M. Stahl, Arati Sharma, Mitchell Cheung, Melissa Zimmerman, Jin Q. Cheng, Marcus W. Bosenberg, Mark Kester, Lakshman Sandirasegarane, and Gavin P. Robertson
Cancer Res 2004 64: 7002-7010. [Abstract] [Full Text] [PDF]  

Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma

Rossella Galli, Elena Binda, Ugo Orfanelli, Barbara Cipelletti, Angela Gritti, Simona De Vitis, Roberta Fiocco, Chiara Foroni, Francesco Dimeco, and Angelo Vescovi
Cancer Res 2004 64: 7011-7021. [Abstract] [Full Text] [PDF]  

A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

Jeffrey Wyckoff, Weigang Wang, Elaine Y. Lin, Yarong Wang, Fiona Pixley, E. Richard Stanley, Thomas Graf, Jeffrey W. Pollard, Jeffrey Segall, and John Condeelis
Cancer Res 2004 64: 7022-7029. [Abstract] [Full Text] [PDF] Supplementary Data  

Regulation of -Fetoprotein by Nuclear Factor-B Protects Hepatocytes from Tumor Necrosis Factor- Cytotoxicity during Fetal Liver Development and Hepatic Oncogenesis

Lakita G. Cavin, Manickam Venkatraman, Valentina M. Factor, Swayamjot Kaur, Insa Schroeder, Frank Mercurio, Amer A. Beg, Snorri S. Thorgeirsson, and Marcello Arsura
Cancer Res 2004 64: 7030-7038. [Abstract] [Full Text] [PDF] Supplementary Data  

Pancreatic Insulinomas in Multiple Endocrine Neoplasia, Type I Knockout Mice Can Develop in the Absence of Chromosome Instability or Microsatellite Instability

Peter C. Scacheri, Alyssa L. Kennedy, Koei Chin, Meghan T. Miller, J. Graeme Hodgson, Joe W. Gray, Stephen J. Marx, Allen M. Spiegel, and Francis S. Collins
Cancer Res 2004 64: 7039-7044. [Abstract] [Full Text] [PDF]  

Proinvasive Properties of Ovarian Cancer Ascites-Derived Membrane Vesicles

Laura E. Graves, Edgardo V. Ariztia, Jason R. Navari, Heather J. Matzel, M. Sharon Stack, and David A. Fishman
Cancer Res 2004 64: 7045-7049. [Abstract] [Full Text] [PDF]  

Role of the Human ST6GalNAc-I and ST6GalNAc-II in the Synthesis of the Cancer-Associated Sialyl-Tn Antigen

Nuno T. Marcos, Sandra Pinho, Catarina Grandela, Andrea Cruz, Bénédicte Samyn-Petit, Anne Harduin-Lepers, Raquel Almeida, Filipe Silva, Vanessa Morais, Julia Costa, Jan Kihlberg, Henrik Clausen, and Celso A. Reis
Cancer Res 2004 64: 7050-7057. [Abstract] [Full Text] [PDF]  

Cleavage of Lumican by Membrane-Type Matrix Metalloproteinase-1 Abrogates This Proteoglycan-Mediated Suppression of Tumor Cell Colony Formation in Soft Agar

Yingyi Li, Takanori Aoki, Yuya Mori, Munirah Ahmad, Hisashi Miyamori, Takahisa Takino, and Hiroshi Sato
Cancer Res 2004 64: 7058-7064. [Abstract] [Full Text] [PDF]  

Apoptosis Resistance of MCF-7 Breast Carcinoma Cells to Ionizing Radiation Is Independent of p53 and Cell Cycle Control but Caused by the Lack of Caspase-3 and a Caffeine-Inhibitable Event

Frank Essmann, Ingo H. Engels, Gudrun Totzke, Klaus Schulze-Osthoff, and Reiner U. Jänicke
Cancer Res 2004 64: 7065-7072. [Abstract] [Full Text] [PDF]  

The Role of Defective Mismatch Repair in Small Bowel Adenocarcinoma in Celiac Disease

D. Dean Potter, Joseph A. Murray, John H. Donohue, Lawrence J. Burgart, David M. Nagorney, Jon A. van Heerden, Matthew F. Plevak, Alan R. Zinsmeister, and Stephen N. Thibodeau
Cancer Res 2004 64: 7073-7077. [Abstract] [Full Text] [PDF]  

Development of an Autocrine Neuregulin Signaling Loop with Malignant Transformation of Human Breast Epithelial Cells

Qunfang Li, Sharlin Ahmed, and Jeffrey A. Loeb
Cancer Res 2004 64: 7078-7085. [Abstract] [Full Text] [PDF]  

Persistent c-FLIP(L) Expression Is Necessary and Sufficient to Maintain Resistance to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand–Mediated Apoptosis in Prostate Cancer

Xiaoping Zhang, Tai-Guang Jin, Hongmei Yang, William C. DeWolf, Roya Khosravi-Far, and Aria F. Olumi
Cancer Res 2004 64: 7086-7091. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Suppression of Colorectal Cancer Liver Metastasis and Extension of Survival by Expression of Apolipoprotein(a) Kringles

Hyun-Kyung Yu, Jang-Seong Kim, Ho-Jeong Lee, Jin-Hyung Ahn, Suk-Keun Lee, Soon-Won Hong, and Yeup Yoon
Cancer Res 2004 64: 7092-7098. [Abstract] [Full Text] [PDF]  

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

Scott M. Wilhelm, Christopher Carter, LiYa Tang, Dean Wilkie, Angela McNabola, Hong Rong, Charles Chen, Xiaomei Zhang, Patrick Vincent, Mark McHugh, Yichen Cao, Jaleel Shujath, Susan Gawlak, Deepa Eveleigh, Bruce Rowley, Li Liu, Lila Adnane, Mark Lynch, Daniel Auclair, Ian Taylor, Rich Gedrich, Andrei Voznesensky, Bernd Riedl, Leonard E. Post, Gideon Bollag, and Pamela A. Trail
Cancer Res 2004 64: 7099-7109. [Abstract] [Full Text] [PDF]  

Cdc7 Inhibition Reveals a p53-Dependent Replication Checkpoint That Is Defective in Cancer Cells

Alessia Montagnoli, Pierluigi Tenca, Francesco Sola, Daniela Carpani, Deborah Brotherton, Clara Albanese, and Corrado Santocanale
Cancer Res 2004 64: 7110-7116. [Abstract] [Full Text] [PDF]  

Inhibition of the Raf–MEK1/2–ERK1/2 Signaling Pathway, Bcl-_xL Down-Regulation, and Chemosensitization of Non-Hodgkin’s Lymphoma B Cells by Rituximab

Ali R. Jazirehi, Mario I. Vega, Devasis Chatterjee, Lee Goodglick, and Benjamin Bonavida
Cancer Res 2004 64: 7117-7126. [Abstract] [Full Text] [PDF]  

Antitumor Effect of a Novel Proapoptotic Peptide that Impairs the Phosphorylation by the Protein Kinase 2 (Casein Kinase 2)

Silvio E. Perea, Osvaldo Reyes, Yaquelin Puchades, Osmani Mendoza, Nelson S. Vispo, Isis Torrens, Alicia Santos, Ricardo Silva, Boris Acevedo, Ernesto López, Viviana Falcón, and Daniel F. Alonso
Cancer Res 2004 64: 7127-7129. [Abstract] [Full Text] [PDF]  

Celastraceae Sesquiterpenes as a New Class of Modulators That Bind Specifically to Human P-Glycoprotein and Reverse Cellular Multidrug Resistance

Francisco Muñoz-Martínez, Peihua Lu, Fernando Cortés-Selva, José María Pérez-Victoria, Ignacio A. Jiménez, Ángel G. Ravelo, Frances J. Sharom, Francisco Gamarro, and Santiago Castanys
Cancer Res 2004 64: 7130-7138. [Abstract] [Full Text] [PDF]  

ATR Affecting Cell Radiosensitivity Is Dependent on Homologous Recombination Repair but Independent of Nonhomologous End Joining

Hongyan Wang, Huichen Wang, Simon N. Powell, George Iliakis, and Ya Wang
Cancer Res 2004 64: 7139-7143. [Abstract] [Full Text] [PDF]  

Radiation Sensitivity, H2AX Phosphorylation, and Kinetics of Repair of DNA Strand Breaks in Irradiated Cervical Cancer Cell Lines

Judit P. Banáth, Susan H. MacPhail, and Peggy L. Olive
Cancer Res 2004 64: 7144-7149. [Abstract] [Full Text] [PDF]  

Crucial Role for Interferon in the Synergism between Tumor Vasculature-Targeted Tumor Necrosis Factor (NGR-TNF) and Doxorubicin

Angelina Sacchi, Anna Gasparri, Flavio Curnis, Matteo Bellone, and Angelo Corti
Cancer Res 2004 64: 7150-7155. [Abstract] [Full Text] [PDF]  

Endocrinology:

Changes in Androgen Receptor Nongenotropic Signaling Correlate with Transition of LNCaP Cells to Androgen Independence

Emmanual Unni, Shihua Sun, Bicheng Nan, Michael J. McPhaul, Boris Cheskis, Michael A. Mancini, and Marco Marcelli
Cancer Res 2004 64: 7156-7168. [Abstract] [Full Text] [PDF]  

Haploid Inactivation of the Amplified-in-Breast Cancer 3 Coactivator Reduces the Inhibitory Effect of Peroxisome Proliferator-Activated Receptor and Retinoid X Receptor on Cell Proliferation and Accelerates Polyoma Middle-T Antigen-Induced Mammary Tumorigenesis in Mice

Hao Zhang, Shao-Qing Kuang, Lan Liao, Suoling Zhou, and Jianming Xu
Cancer Res 2004 64: 7169-7177. [Abstract] [Full Text] [PDF]  

Meeting Report:

Symposium on Androgen Action in Prostate Cancer

Donald Tindall, Frances McFarland Horne, Andrew Hruszkewycz, Suresh Mohla, Marc Shuman, Zhou Wang, and Philip Kantoff
Cancer Res 2004 64: 7178-7180. [Full Text] [PDF]  

Corrections:

Corrections

Cancer Res 2004 64: 7181. [Full Text] [PDF]  

Corrections

Cancer Res 2004 64: 7181. [Full Text] [PDF]  

Corrections

Cancer Res 2004 64: 7181. [Full Text] [PDF]  

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