Reviews:

Endogenous Inhibitors of Nuclear Factor-B, An Opportunity for Cancer Control

Fei Chen
Cancer Res 2004 64: 8135-8138. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Enhancement of Hypoxia-Induced Tumor Cell Death In vitro and Radiation Therapy In vivo by Use of Small Interfering RNA Targeted to Hypoxia-Inducible Factor-1

Xiuwu Zhang, Takashi Kon, He Wang, Fang Li, Qian Huang, Zahid N. Rabbani, John P. Kirkpatrick, Zeljko Vujaskovic, Mark W. Dewhirst, and Chuan-Yuan Li
Cancer Res 2004 64: 8139-8142. [Abstract] [Full Text] [PDF]  

Significant Contribution of Germline BRCA2 Rearrangements in Male Breast Cancer Families

Isabelle Tournier, Brigitte Bressac-de Paillerets, Hagay Sobol, Dominique Stoppa-Lyonnet, Rosette Lidereau, Michel Barrois, Sylvie Mazoyer, Florence Coulet, Agnès Hardouin, Agnès Chompret, Alain Lortholary, Pierre Chappuis, Violaine Bourdon, Valérie Bonadona, Christine Maugard, Brigitte Gilbert, Catherine Nogues, Thierry Frébourg, and Mario Tosi
Cancer Res 2004 64: 8143-8147. [Abstract] [Full Text] [PDF]  

Inhibition of Extracellular-signal Regulated Kinases 1/2 Is Required for Apoptosis of Human Colon Cancer Cells In vitro by Sulindac Metabolites

Pamela L. Rice, K. Scott Beard, Linda J. Driggers, and Dennis J. Ahnen
Cancer Res 2004 64: 8148-8151. [Abstract] [Full Text] [PDF]  

Cul4A Physically Associates with MDM2 and Participates in the Proteolysis of p53

Alo Nag, Srilata Bagchi, and Pradip Raychaudhuri
Cancer Res 2004 64: 8152-8155. [Abstract] [Full Text] [PDF]  

Frequent Aberrant Methylation of the CDH4 Gene Promoter in Human Colorectal and Gastric Cancer

Elena Miotto, Silvia Sabbioni, Angelo Veronese, George A. Calin, Sergio Gullini, Alberto Liboni, Laura Gramantieri, Luigi Bolondi, Eros Ferrazzi, Roberta Gafà, Giovanni Lanza, and Massimo Negrini
Cancer Res 2004 64: 8156-8159. [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology and Genetics:

Overexpression of Glycine-Extended Gastrin Inhibits Parietal Cell Loss and Atrophy in the Mouse Stomach

Guanglin Cui, Theodore J. Koh, Duan Chen, Chun-Mei Zhao, Shigeo Takaishi, Graham J. Dockray, Andrea Varro, Arlin B. Rogers, James G. Fox, and Timothy C. Wang
Cancer Res 2004 64: 8160-8166. [Abstract] [Full Text] [PDF]  

Mechanistic and Predictive Profiling of 5-Fluorouracil Resistance in Human Cancer Cells

Weiguang Wang, James Cassidy, Vincent O’Brien, Kevin M. Ryan, and Elaina Collie-Duguid
Cancer Res 2004 64: 8167-8176. [Abstract] [Full Text] [PDF] Supplementary Data  

Characterization of a Carcinogenesis Rat Model of Ovarian Preneoplasia and Neoplasia

Sherri L. Stewart, Troy D. Querec, Alexander R. Ochman, Briana N. Gruver, Rudi Bao, James S. Babb, Thang S. Wong, Theodoros Koutroukides, Aaron D. Pinnola, Andres Klein-Szanto, Thomas C. Hamilton, and Christos Patriotis
Cancer Res 2004 64: 8177-8183. [Abstract] [Full Text] [PDF] Supplementary Data  

Loss of Estrogen Receptor Signaling Triggers Epigenetic Silencing of Downstream Targets in Breast Cancer

Yu-Wei Leu, Pearlly S. Yan, Meiyun Fan, Victor X. Jin, Joseph C. Liu, Edward M. Curran, Wade V. Welshons, Susan H. Wei, Ramana V. Davuluri, Christoph Plass, Kenneth P. Nephew, and Tim H-M. Huang
Cancer Res 2004 64: 8184-8192. [Abstract] [Full Text] [PDF] Supplementary Data  

Regulation of Protein Catabolism by Muscle-Specific and Cytokine-Inducible Ubiquitin Ligase E3-II during Cancer Cachexia

Keith S. Kwak, Xiaolan Zhou, Vered Solomon, Vickie E. Baracos, James Davis, Anthony W. Bannon, William J. Boyle, David L. Lacey, and H.Q. Han
Cancer Res 2004 64: 8193-8198. [Abstract] [Full Text] [PDF]  

Comparison of the Effect of Mutant and Wild-Type p53 on Global Gene Expression

Thomas J. O’Farrell, Paritosh Ghosh, Nobuaki Dobashi, Carl Y. Sasaki, and Dan L. Longo
Cancer Res 2004 64: 8199-8207. [Abstract] [Full Text] [PDF] Supplementary Data  

Nuclear Hormone Receptor NR4A2 Is Involved in Cell Transformation and Apoptosis

Ning Ke, Gisela Claassen, De-Hua Yu, Aaron Albers, Wufang Fan, Philip Tan, Mirta Grifman, Xiuyuan Hu, Kristin DeFife, Vivian Nguy, Bernd Meyhack, Arndt Brachat, Flossie Wong-Staal, and Qi-Xiang Li
Cancer Res 2004 64: 8208-8212. [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

DNA Microarrays Reveal Relationship of Ewing Family Tumors to Both Endothelial and Fetal Neural Crest-Derived Cells and Define Novel Targets

Martin S. Staege, Christoph Hutter, Ingo Neumann, Sabine Foja, Uwe E. Hattenhorst, Gesine Hansen, Danny Afar, and Stefan E. G. Burdach
Cancer Res 2004 64: 8213-8221. [Abstract] [Full Text] [PDF]  

Inhibition of Melanoma Growth and Metastasis by ATF2-Derived Peptides

Anindita Bhoumik, Lisa Gangi, and Ze’ev Ronai
Cancer Res 2004 64: 8222-8230. [Abstract] [Full Text] [PDF]  

Ionizing Radiation Induces Frequent Translocations with Delayed Replication and Condensation

Kevin S. Breger, Leslie Smith, Mitchell S. Turker, and Mathew J. Thayer
Cancer Res 2004 64: 8231-8238. [Abstract] [Full Text] [PDF] Supplementary Data  

Limited Capability of Regional Lymph Nodes to Eradicate Metastatic Cancer Cells

Hiroshi Nagata, Tsunenori Arai, Yusuke Soejima, Hidekazu Suzuki, Hiromasa Ishii, and Toshifumi Hibi
Cancer Res 2004 64: 8239-8248. [Abstract] [Full Text] [PDF]  

Tumor-Associated Endothelial Cells with Cytogenetic Abnormalities

Kyoko Hida, Yasuhiro Hida, Dhara N. Amin, Alan F. Flint, Dipak Panigrahy, Cynthia C. Morton, and Michael Klagsbrun
Cancer Res 2004 64: 8249-8255. [Abstract] [Full Text] [PDF]  

Physical and Functional Interactions between the Wwox Tumor Suppressor Protein and the AP-2 Transcription Factor

Rami I. Aqeilan, Alexey Palamarchuk, Ronald J. Weigel, Juan J. Herrero, Yuri Pekarsky, and Carlo M. Croce
Cancer Res 2004 64: 8256-8261. [Abstract] [Full Text] [PDF]  

BRAK/CXCL14 Is a Potent Inhibitor of Angiogenesis and a Chemotactic Factor for Immature Dendritic Cells

Thomas D. Shellenberger, Mary Wang, Manu Gujrati, Arumugam Jayakumar, Robert M. Strieter, Marie D. Burdick, Constantin G. Ioannides, Clayton L. Efferson, Adel K. El-Naggar, Dianna Roberts, Gary L. Clayman, and Mitchell J. Frederick
Cancer Res 2004 64: 8262-8270. [Abstract] [Full Text] [PDF] Supplementary Data  

Role of Synaptojanin 2 in Glioma Cell Migration and Invasion

Ya-yu Chuang, Nhan L. Tran, Nicole Rusk, Mitsutoshi Nakada, Michael E. Berens, and Marc Symons
Cancer Res 2004 64: 8271-8275. [Abstract] [Full Text] [PDF] Supplementary Data  

Bone Morphogenetic Protein (BMP)-6 Signaling and BMP Antagonist Noggin in Prostate Cancer

Dominik R. Haudenschild, Sabrina M. Palmer, Timothy A. Moseley, Zongbing You, and A. Hari Reddi
Cancer Res 2004 64: 8276-8284. [Abstract] [Full Text] [PDF]  

Host Acid Sphingomyelinase Regulates Microvascular Function Not Tumor Immunity

Monica Garcia-Barros, Daniel Lacorazza, Howard Petrie, Adriana Haimovitz-Friedman, Carlos Cardon-Cardo, Stephen Nimer, Zvi Fuks, and Richard Kolesnick
Cancer Res 2004 64: 8285-8291. [Abstract] [Full Text] [PDF]  

SHP-2-Dependent Mitogen-Activated Protein Kinase Activation Regulates EGFRvIII but not Wild-Type Epidermal Growth Factor Receptor Phosphorylation and Glioblastoma Cell Survival

Yi Zhan and Donald M. O’Rourke
Cancer Res 2004 64: 8292-8298. [Abstract] [Full Text] [PDF]  

The Nuclear Receptor Coactivator AIB1 Mediates Insulin-like Growth Factor I-induced Phenotypic Changes in Human Breast Cancer Cells

Annabell Oh, Heinz-Joachim List, Ronald Reiter, Aparna Mani, Ying Zhang, Edmund Gehan, Anton Wellstein, and Anna T. Riegel
Cancer Res 2004 64: 8299-8308. [Abstract] [Full Text] [PDF]  

P-Cadherin Is Up-Regulated by the Antiestrogen ICI 182,780 and Promotes Invasion of Human Breast Cancer Cells

Joana Paredes, Christophe Stove, Veronique Stove, Fernanda Milanezi, Veerle Van Marck, Lara Derycke, Marc Mareel, Marc Bracke, and Fernando Schmitt
Cancer Res 2004 64: 8309-8317. [Abstract] [Full Text] [PDF] Supplementary Data  

Transactivation of the EGR1 Gene Contributes to Mutant p53 Gain of Function

Lilach Weisz, Amir Zalcenstein, Perry Stambolsky, Yehudit Cohen, Naomi Goldfinger, Moshe Oren, and Varda Rotter
Cancer Res 2004 64: 8318-8327. [Abstract] [Full Text] [PDF]  

24-Hour Oscillation of Mouse Methionine Aminopeptidase2, a Regulator of Tumor Progression, Is Regulated by Clock Gene Proteins

Hiroo Nakagawa, Satoru Koyanagi, Takako Takiguchi, Yukako Kuramoto, Shinji Soeda, Hiroshi Shimeno, Shun Higuchi, and Shigehiro Ohdo
Cancer Res 2004 64: 8328-8333. [Abstract] [Full Text] [PDF]  

Nuclear ß_II-Tubulin Associates with the Activated Notch Receptor to Modulate Notch Signaling

Tien-Shun Yeh, Rong-Hong Hsieh, Shing-Chuan Shen, Shwu-Huey Wang, Min-Jen Tseng, Chwen-Ming Shih, and Jing-Jer Lin
Cancer Res 2004 64: 8334-8340. [Abstract] [Full Text] [PDF]  

Lymphocyte Transformation by Pim-2 Is Dependent on Nuclear Factor-B Activation

Peter S. Hammerman, Casey J. Fox, Ryan M. Cinalli, Anne Xu, John D. Wagner, Tullia Lindsten, and Craig B. Thompson
Cancer Res 2004 64: 8341-8348. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Interferon Enhances the Effectiveness of Tumor Necrosis Factor-Related Apoptosis–Inducing Ligand Receptor Agonists in a Xenograft Model of Ewing’s Sarcoma

Melinda S. Merchant, Xuezhong Yang, Fraia Melchionda, Maria Romero, Ruth Klein, Carol J. Thiele, Maria Tsokos, H. Udo Kontny, and Crystal L. Mackall
Cancer Res 2004 64: 8349-8356. [Abstract] [Full Text] [PDF]  

STAT1: A Modulator of Chemotherapy-induced Apoptosis

Michelle Thomas, Clodagh E. Finnegan, Katherine M.-A. Rogers, James W. Purcell, Anne Trimble, Patrick G. Johnston, and Marion P. Boland
Cancer Res 2004 64: 8357-8364. [Abstract] [Full Text] [PDF]  

Evidence that TRPM8 Is an Androgen-Dependent Ca²⁺ Channel Required for the Survival of Prostate Cancer Cells

Lei Zhang and Gregory John Barritt
Cancer Res 2004 64: 8365-8373. [Abstract] [Full Text] [PDF]  

The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, through Metabolism to 13-Hydroxyellipticine and Ellipticine N²-Oxide

Marie Stiborová, Jan Sejbal, Lucie Borek-Dohalská, Dagmar Aimová, Jitka Poljaková, Kristina Forsterová, Martina Rupertová, Jirí Wiesner, Jirí Hudecek, Manfred Wiessler, and Eva Frei
Cancer Res 2004 64: 8374-8380. [Abstract] [Full Text] [PDF]  

Ectopic Expression of Interferon Regulatory Factor-1 Promotes Human Breast Cancer Cell Death and Results in Reduced Expression of Survivin

Eva Pizzoferrato, Ye Liu, Andrea Gambotto, Michaele J. Armstrong, Michael T. Stang, William E. Gooding, Sean M. Alber, Stuart H. Shand, Simon C. Watkins, Walter J. Storkus, and John H. Yim
Cancer Res 2004 64: 8381-8388. [Abstract] [Full Text] [PDF]  

Cyclin B1 Is a Critical Target of RhoB in the Cell Suicide Program Triggered by Farnesyl Transferase Inhibition

Uma Kamasani, Minzhou Huang, James B. DuHadaway, Edward V. Prochownik, P. Scott Donover, and George C. Prendergast
Cancer Res 2004 64: 8389-8396. [Abstract] [Full Text] [PDF]  

Phosphatidylinositol 3'-Kinase Activation Leads to Multidrug Resistance Protein-1 Expression and Subsequent Chemoresistance in Advanced Prostate Cancer Cells

John T. Lee, Jr., Linda S. Steelman, and James A. McCubrey
Cancer Res 2004 64: 8397-8404. [Abstract] [Full Text] [PDF]  

Synergistic Interaction between Sphingomyelin and Gemcitabine Potentiates Ceramide-Mediated Apoptosis in Pancreatic Cancer

David E. Modrak, Thomas M. Cardillo, Guy A. Newsome, David M. Goldenberg, and David V. Gold
Cancer Res 2004 64: 8405-8410. [Abstract] [Full Text] [PDF]  

Immunology:

Anti-CD137 Monoclonal Antibody Administration Augments the Antitumor Efficacy of Dendritic Cell-Based Vaccines

Fumito Ito, Qiao Li, Andrew B. Shreiner, Ryuji Okuyama, Maria N. Jure-Kunkel, Seagal Teitz-Tennenbaum, and Alfred E. Chang
Cancer Res 2004 64: 8411-8419. [Abstract] [Full Text] [PDF]  

Increased Survival, Proliferation, and Migration in Metastatic Human Pancreatic Tumor Cells Expressing Functional CXCR4

Federica Marchesi, Paolo Monti, Biagio Eugenio Leone, Alessandro Zerbi, Annunciata Vecchi, Lorenzo Piemonti, Alberto Mantovani, and Paola Allavena
Cancer Res 2004 64: 8420-8427. [Abstract] [Full Text] [PDF]  

Immunological Prevention of a Multigene Cancer Syndrome

Stefania Croci, Giordano Nicoletti, Lorena Landuzzi, Carla De Giovanni, Annalisa Astolfi, Chiara Marini, Emma Di Carlo, Piero Musiani, Guido Forni, Patrizia Nanni, and Pier-Luigi Lollini
Cancer Res 2004 64: 8428-8434. [Abstract] [Full Text] [PDF]  

Highly Successful Therapeutic Vaccinations Combining Dendritic Cells and Tumor Cells Secreting Granulocyte Macrophage Colony-stimulating Factor

Gregory Driessens, Malika Hamdane, Vincent Cool, Thierry Velu, and Catherine Bruyns
Cancer Res 2004 64: 8435-8442. [Abstract] [Full Text] [PDF]  

C-Type Lectin-Like Molecule-1: A Novel Myeloid Cell Surface Marker Associated with Acute Myeloid Leukemia

Alexander B. H. Bakker, Sonja van den Oudenrijn, Arjen Q. Bakker, Nicole Feller, Marja van Meijer, Judith A. Bia, Mandy A. C. Jongeneelen, Therese J. Visser, Nora Bijl, Cecilia A. W. Geuijen, Wilfred E. Marissen, Katarina Radosevic, Mark Throsby, Gerrit Jan Schuurhuis, Gert J. Ossenkoppele, John de Kruif, Jaap Goudsmit, and Ada M. Kruisbeek
Cancer Res 2004 64: 8443-8450. [Abstract] [Full Text] [PDF]  

Bone Marrow Is a Reservoir for CD4⁺CD25⁺ Regulatory T Cells that Traffic through CXCL12/CXCR4 Signals

Linhua Zou, Brian Barnett, Hana Safah, Vincent F. LaRussa, Melina Evdemon-Hogan, Peter Mottram, Shuang Wei, Odile David, Tyler J. Curiel, and Weiping Zou
Cancer Res 2004 64: 8451-8455. [Abstract] [Full Text] [PDF]  

Clinical Research:

Local Administration of Granulocyte/Macrophage Colony-stimulating Factor Increases the Number and Activation State of Dendritic Cells in the Sentinel Lymph Node of Early-Stage Melanoma

Ronald J. C. L. M. Vuylsteke, Barbara G. Molenkamp, Hester A. Gietema, Paul A. M. van Leeuwen, Pepijn G. J. T. B. Wijnands, Wim Vos, Paul J. van Diest, Rik J. Scheper, Sybren Meijer, and Tanja D. de Gruijl
Cancer Res 2004 64: 8456-8460. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

CYP3A4, CYP3A5, and CYP3A43 Genotypes and Haplotypes in the Etiology and Severity of Prostate Cancer

Charnita Zeigler-Johnson, Tara Friebel, Amy H. Walker, Yiting Wang, Elaine Spangler, Saarene Panossian, Margerie Patacsil, Richard Aplenc, Alan J. Wein, S. Bruce Malkowicz, and Timothy R. Rebbeck
Cancer Res 2004 64: 8461-8467. [Abstract] [Full Text] [PDF]  

Reduced Immunoglobulin E and Allergy among Adults with Glioma Compared with Controls

Joseph L. Wiemels, John K. Wiencke, Joseph Patoka, Michelle Moghadassi, Terri Chew, Alex McMillan, Rei Miike, Geoffrey Barger, and Margaret Wrensch
Cancer Res 2004 64: 8468-8473. [Abstract] [Full Text] [PDF] Supplementary Data  

Meeting Reports:

Sixteenth Annual Pezcoller Symposium: Stem Cells and Epigenesis in Cancer

Enrico Mihich and Rudolf Jaenisch
Cancer Res 2004 64: 8474-8477. [Abstract] [Full Text] [PDF]  

In vivo Models for Experimental Therapeutics Relevant to Human Cancer

Miriam S. Gitler, Edward A. Sausville, Melinda Hollingshead, and Robert Shoemaker
Cancer Res 2004 64: 8478-8480. [Full Text] [PDF]  

Letters to the Editor:

Kallikrein 4 Is a Secreted Protein

James P. Simmer, John D. Bartlett, and Fahri Saatcioglu
Cancer Res 2004 64: 8481-8483. [Full Text] [PDF]  

Corrections:

Corrections

Cancer Res 2004 64: 8484. [Full Text] [PDF]  

Corrections

Cancer Res 2004 64: 8484. [Full Text] [PDF]  

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