Reviews:

Classification of Proliferative Pulmonary Lesions of the Mouse: Recommendations of the Mouse Models of Human Cancers Consortium

Alexander Yu. Nikitin, Ana Alcaraz, Miriam R. Anver, Roderick T. Bronson, Robert D. Cardiff, Darlene Dixon, Armando E. Fraire, Edward W. Gabrielson, William T. Gunning, Diana C. Haines, Matthew H. Kaufman, R. Ilona Linnoila, Robert R. Maronpot, Alan S. Rabson, Robert L. Reddick, Sabine Rehm, Nora Rozengurt, Hildegard M. Schuller, Elena N. Shmidt, William D. Travis, Jerrold M. Ward, and Tyler Jacks
Cancer Res 2004 64: 2307-2316. [Abstract] [Full Text] [PDF] Supplementary Data  

Cure of Fisher Rats Bearing Radioresistant F98 Glioma Treated with cis-Platinum and Irradiated with Monochromatic Synchrotron X-Rays

Marie-Claude Biston, Aurélie Joubert, Jean-François Adam, Hélène Elleaume, Sylvain Bohic, Anne-Marie Charvet, François Estève, Nicolas Foray, and Jacques Balosso
Cancer Res 2004 64: 2317-2323. [Abstract] [Full Text] [PDF]  

Advances in Brief:

Alternative Lengthening of Telomeres Is Characterized by High Rates of Telomeric Exchange

J. Arturo Londoño-Vallejo, Héra Der-Sarkissian, Lucien Cazes, Silvia Bacchetti, and Roger R. Reddel
Cancer Res 2004 64: 2324-2327. [Abstract] [Full Text] [PDF]  

The Matrix Metalloproteinase Inhibitor Prinomastat Enhances Photodynamic Therapy Responsiveness in a Mouse Tumor Model

Angela Ferrario, Christophe F. Chantrain, Karl von Tiehl, Sue Buckley, Natalie Rucker, David R. Shalinsky, Hiroyuki Shimada, Yves A. DeClerck, and Charles J. Gomer
Cancer Res 2004 64: 2328-2332. [Abstract] [Full Text] [PDF]  

Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro

Peter J. Houghton, Glen S. Germain, Franklin C. Harwood, John D. Schuetz, Clinton F. Stewart, Elisabeth Buchdunger, and Peter Traxler
Cancer Res 2004 64: 2333-2337. [Abstract] [Full Text] [PDF]  

^V599EB-RAF is an Oncogene in Melanocytes

Claudia Wellbrock, Lesley Ogilvie, Douglas Hedley, Maria Karasarides, Jan Martin, Dan Niculescu-Duvaz, Caroline J. Springer, and Richard Marais
Cancer Res 2004 64: 2338-2342. [Abstract] [Full Text] [PDF]  

The HER-2-Targeting Antibodies Trastuzumab and Pertuzumab Synergistically Inhibit the Survival of Breast Cancer Cells

Rita Nahta, Mien-Chie Hung, and Francisco J. Esteva
Cancer Res 2004 64: 2343-2346. [Abstract] [Full Text] [PDF]  

Chemoprevention of Cancer of the Upper Respiratory Tract of the Syrian Golden Hamster by Aerosol Administration of Difluoromethylornithine and 5-Fluorouracil

Lee W. Wattenberg, Timothy S. Wiedmann, and Richard D. Estensen
Cancer Res 2004 64: 2347-2349. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology and Genetics:

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

S. Perwez Hussain, Paul Amstad, Peijun He, Ana Robles, Shawn Lupold, Ichiro Kaneko, Masato Ichimiya, Sagar Sengupta, Leah Mechanic, Shu Okamura, Lorne J. Hofseth, Matthew Moake, Makoto Nagashima, Kathleen S. Forrester, and Curtis C. Harris
Cancer Res 2004 64: 2350-2356. [Abstract] [Full Text] [PDF]  

Identification of a Novel Mammary-Restricted Cytochrome P450, CYP4Z1, with Overexpression in Breast Carcinoma

Michael A. Rieger, Reinhard Ebner, David R. Bell, Andrea Kiessling, Jacques Rohayem, Marc Schmitz, Achim Temme, E. Peter Rieber, and Bernd Weigle
Cancer Res 2004 64: 2357-2364. [Abstract] [Full Text] [PDF]  

Kallikrein 4 is a Predominantly Nuclear Protein and Is Overexpressed in Prostate Cancer

Zhijun Xi, Tove Irene Klokk, Kemal Korkmaz, Piotr Kurys, Cem Elbi, Bjørn Risberg, Håvard Danielsen, Massimo Loda, and Fahri Saatcioglu
Cancer Res 2004 64: 2365-2370. [Abstract] [Full Text] [PDF]  

Chromatin Assembly Factor-1, a Marker of Clinical Value to Distinguish Quiescent from Proliferating Cells

Sophie E. Polo, Stamatios E. Theocharis, Jerzy Klijanienko, Alexia Savignoni, Bernard Asselain, Philippe Vielh, and Geneviève Almouzni
Cancer Res 2004 64: 2371-2381. [Abstract] [Full Text] [PDF] Supplementary Data  

Epidermal Growth Factor Receptor-Mediated Activation of Stat3 during Multistage Skin Carcinogenesis

Keith Syson Chan, Steve Carbajal, Kaoru Kiguchi, John Clifford, Shigetoshi Sano, and John DiGiovanni
Cancer Res 2004 64: 2382-2389. [Abstract] [Full Text] [PDF]  

ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

Tom Stiff, Mark O’Driscoll, Nicole Rief, Kuniyoshi Iwabuchi, Markus Löbrich, and Penny A. Jeggo
Cancer Res 2004 64: 2390-2396. [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Expression Profile of Gastric Carcinoma: Identification of Genes and Tags Potentially Involved in Invasion, Metastasis, and Carcinogenesis by Serial Analysis of Gene Expression

Naohide Oue, Yoichi Hamai, Yoshitsugu Mitani, Shunji Matsumura, Yasuhiro Oshimo, Phyu Phyu Aung, Kazuya Kuraoka, Hirofumi Nakayama, and Wataru Yasui
Cancer Res 2004 64: 2397-2405. [Abstract] [Full Text] [PDF] Supplementary Data  

Oncogene Expression and Genetic Background Influence the Frequency of DNA Copy Number Abnormalities in Mouse Pancreatic Islet Cell Carcinomas

Jeffrey H. Hager, J. Graeme Hodgson, Jane Fridlyand, Sujatmi Hariono, Joe W. Gray, and Douglas Hanahan
Cancer Res 2004 64: 2406-2410. [Abstract] [Full Text] [PDF] Supplementary Data  

Hypermethylation and Silencing of the Putative Tumor Suppressor Tazarotene-Induced Gene 1 in Human Cancers

Emile M. Youssef, Xu-qi Chen, Eisaku Higuchi, Yutaka Kondo, Guillermo Garcia-Manero, Reuben Lotan, and Jean-Pierre J. Issa
Cancer Res 2004 64: 2411-2417. [Abstract] [Full Text] [PDF]  

Identification of Soluble NH₂-Terminal Fragment of Glypican-3 as a Serological Marker for Early-Stage Hepatocellular Carcinoma

Yoshitaka Hippo, Kiyotaka Watanabe, Akira Watanabe, Yutaka Midorikawa, Shogo Yamamoto, Sigeo Ihara, Susumu Tokita, Hiroko Iwanari, Yukio Ito, Kiyotaka Nakano, Jun-ichi Nezu, Hiroyuki Tsunoda, Takeshi Yoshino, Iwao Ohizumi, Masayuki Tsuchiya, Shin Ohnishi, Masatoshi Makuuchi, Takao Hamakubo, Tatsuhiko Kodama, and Hiroyuki Aburatani
Cancer Res 2004 64: 2418-2423. [Abstract] [Full Text] [PDF]  

Epigenetic Profiling in Chronic Lymphocytic Leukemia Reveals Novel Methylation Targets

Laura J. Rush, Aparna Raval, Pauline Funchain, Amy J. Johnson, Lisa Smith, David M. Lucas, Melania Bembea, Te-Hui Liu, Nyla A. Heerema, Laura Rassenti, Sandya Liyanarachchi, Ramana Davuluri, John C. Byrd, and Christoph Plass
Cancer Res 2004 64: 2424-2433. [Abstract] [Full Text] [PDF]  

Identification of Genes Uniquely Involved in Frequent Microsatellite Instability Colon Carcinogenesis by Expression Profiling Combined with Epigenetic Scanning

Yuriko Mori, Jing Yin, Fumiaki Sato, Anca Sterian, Lisa A. Simms, Florin M. Selaru, Karsten Schulmann, Yan Xu, Andreea Olaru, Suna Wang, Elena Deacu, John M. Abraham, Joanne Young, Barbara A. Leggett, and Stephen J. Meltzer
Cancer Res 2004 64: 2434-2438. [Abstract] [Full Text] [PDF] Supplementary Data  

Cell and Tumor Biology:

Identification of Retinoid-Modulated Proteins in Squamous Carcinoma Cells Using High-Throughput Immunoblotting

Hyun-Jung Kim and Reuben Lotan
Cancer Res 2004 64: 2439-2448. [Abstract] [Full Text] [PDF]  

Transdominant TAp73 Isoforms Are Frequently Up-regulated in Ovarian Cancer. Evidence for Their Role as Epigenetic p53 Inhibitors in Vivo

Nicole Concin, Kirsten Becker, Neda Slade, Susan Erster, Elizabeth Mueller-Holzner, Hanno Ulmer, Guenter Daxenbichler, Alain Zeimet, Robert Zeillinger, Christian Marth, and Ute M. Moll
Cancer Res 2004 64: 2449-2460. [Abstract] [Full Text] [PDF]  

A Role for Endothelin-2 and Its Receptors in Breast Tumor Cell Invasion

Matthew J. Grimshaw, Thorsten Hagemann, Ayse Ayhan, Cheryl E. Gillett, Claudia Binder, and Frances R. Balkwill
Cancer Res 2004 64: 2461-2468. [Abstract] [Full Text] [PDF]  

Differential Gene Expression in Metastasizing Cells Shed from Kidney Tumors

Maximilian Bockhorn, Sylvie Roberge, Cristina Sousa, Rakesh K. Jain, and Lance L. Munn
Cancer Res 2004 64: 2469-2473. [Abstract] [Full Text] [PDF]  

GW112, A Novel Antiapoptotic Protein That Promotes Tumor Growth

Xiuwu Zhang, Qian Huang, Zhonghui Yang, Yongping Li, and Chuan-Yuan Li
Cancer Res 2004 64: 2474-2481. [Abstract] [Full Text] [PDF]  

Identification of Channels Promoting Calcium Spikes and Waves in HT1080 Tumor Cells: Their Apparent Roles in Cell Motility and Invasion

Ji-Biao Huang, Andrei L. Kindzelskii, Andrea J. Clark, and Howard R. Petty
Cancer Res 2004 64: 2482-2489. [Abstract] [Full Text] [PDF]  

The tyrp1-Tag/tyrp1-FGFR1-DN Bigenic Mouse: A Model for Selective Inhibition of Tumor Development, Angiogenesis, and Invasion into the Neural Tissue by Blockade of Fibroblast Growth Factor Receptor Activity

Benoit Rousseau, Frédéric Larrieu-Lahargue, Sophie Javerzat, Frédéric Guilhem-Ducléon, Friedrich Beermann, and Andreas Bikfalvi
Cancer Res 2004 64: 2490-2495. [Abstract] [Full Text] [PDF]  

Molecular Classification and Survival Prediction in Human Gliomas Based on Proteome Analysis

Yasuo Iwadate, Tsukasa Sakaida, Takaki Hiwasa, Yuichiro Nagai, Hiroshi Ishikura, Masaki Takiguchi, and Akira Yamaura
Cancer Res 2004 64: 2496-2501. [Abstract] [Full Text] [PDF]  

Dependence of Paclitaxel Sensitivity on a Functional Spindle Assembly Checkpoint

Tamotsu Sudo, Masayuki Nitta, Hideyuki Saya, and Naoto T. Ueno
Cancer Res 2004 64: 2502-2508. [Abstract] [Full Text] [PDF]  

Endogenous Control of Cell Cycle Progression by Autocrine Transforming Growth Factor ß in Breast Cancer Cells

Sudhakar Ammanamanchi, Manoranjani P. M. Tillekeratne, Tien C. Ko, and Michael G. Brattain
Cancer Res 2004 64: 2509-2515. [Abstract] [Full Text] [PDF]  

Insulin-Like Growth Factor Binding Protein-3 Interacts with Autocrine Motility Factor/Phosphoglucose Isomerase (AMF/PGI) and Inhibits the AMF/PGI Function

Suresh Mishra, Avrahram Raz, and Liam J. Murphy
Cancer Res 2004 64: 2516-2522. [Abstract] [Full Text] [PDF]  

Identification of Aryl Hydrocarbon Receptor as a Putative Wnt/ß-Catenin Pathway Target Gene in Prostate Cancer Cells

Dennis R. Chesire, Thomas A. Dunn, Charles M. Ewing, Jun Luo, and William B. Isaacs
Cancer Res 2004 64: 2523-2533. [Abstract] [Full Text] [PDF]  

Stromal Cell-Derived Factor-1 Promotes Melanoma Cell Invasion across Basement Membranes Involving Stimulation of Membrane-Type 1 Matrix Metalloproteinase and Rho GTPase Activities

Rubén A. Bartolomé, Beatriz G. Gálvez, Natividad Longo, Françoise Baleux, Goos N. P. van Muijen, Paloma Sánchez-Mateos, Alicia G. Arroyo, and Joaquin Teixidó
Cancer Res 2004 64: 2534-2543. [Abstract] [Full Text] [PDF]  

Inverse PCR-Based RFLP Scanning Identifies Low-Level Mutation Signatures in Colon Cells and Tumors

Wei-Hua Liu, Manjit Kaur, Gang Wang, Penny Zhu, Yuzhi Zhang, and G. Mike Makrigiorgos
Cancer Res 2004 64: 2544-2551. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Topical Treatment with Inhibitors of the Phosphatidylinositol 3'-Kinase/Akt and Raf/Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Pathways Reduces Melanoma Development in Severe Combined Immunodeficient Mice

Barbara Bedogni, Melony S. O’Neill, Scott M. Welford, Donna M. Bouley, Amato J. Giaccia, Nicholas C. Denko, and Marianne Broome Powell
Cancer Res 2004 64: 2552-2560. [Abstract] [Full Text] [PDF]  

Selectivity of an Oncolytic Herpes Simplex Virus for Cells Expressing the DF3/MUC1 Antigen

Hideki Kasuya, Timothy M. Pawlik, John T. Mullen, James M. Donahue, Hideo Nakamura, Soundararajalu Chandrasekhar, Hiroshi Kawasaki, Enid Choi, and Kenneth K. Tanabe
Cancer Res 2004 64: 2561-2567. [Abstract] [Full Text] [PDF]  

Calmodulin-Dependent Cyclic Nucleotide Phosphodiesterase (PDE1) Is a Pharmacological Target of Differentiation-Inducing Factor-1, an Antitumor Agent Isolated from Dictyostelium

Kasumi Shimizu, Taku Murata, Toshiro Tagawa, Katsunori Takahashi, Ryoki Ishikawa, Yumiko Abe, Kohei Hosaka, and Yuzuru Kubohara
Cancer Res 2004 64: 2568-2571. [Abstract] [Full Text] [PDF]  

Distribution of Liposomes into Brain and Rat Brain Tumor Models by Convection-Enhanced Delivery Monitored with Magnetic Resonance Imaging

Ryuta Saito, John R. Bringas, Tracy R. McKnight, Michael F. Wendland, Christoph Mamot, Daryl C. Drummond, Dmitri B. Kirpotin, John W. Park, Mitchel S. Berger, and Krys S. Bankiewicz
Cancer Res 2004 64: 2572-2579. [Abstract] [Full Text] [PDF]  

Cotreatment with Histone Deacetylase Inhibitor LAQ824 Enhances Apo-2L/Tumor Necrosis Factor-Related Apoptosis Inducing Ligand-Induced Death Inducing Signaling Complex Activity and Apoptosis of Human Acute Leukemia Cells

Fei Guo, Celia Sigua, Jianguo Tao, Purva Bali, Prince George, Yunqing Li, Sylvie Wittmann, Lynn Moscinski, Peter Atadja, and Kapil Bhalla
Cancer Res 2004 64: 2580-2589. [Abstract] [Full Text] [PDF]  

The Histone Deacetylase Inhibitor MS-275 Interacts Synergistically with Fludarabine to Induce Apoptosis in Human Leukemia Cells

Sonia C. Maggio, Roberto R. Rosato, Lora B. Kramer, Yun Dai, Mohamed Rahmani, David S. Paik, Ann C. Czarnik, Shawn G. Payne, Sarah Spiegel, and Steven Grant
Cancer Res 2004 64: 2590-2600. [Abstract] [Full Text] [PDF]  

Blockade of Epidermal Growth Factor- or Heregulin-Dependent ErbB2 Activation with the Anti-ErbB2 Monoclonal Antibody 2C4 Has Divergent Downstream Signaling and Growth Effects

James G. Jackson, Patricia St. Clair, Mark X. Sliwkowski, and Michael G. Brattain
Cancer Res 2004 64: 2601-2609. [Abstract] [Full Text] [PDF]  

Immunology:

Human CTLs to Wild-Type and Enhanced Epitopes of a Novel Prostate and Breast Tumor-Associated Protein, TARP, Lyse Human Breast Cancer Cells

SangKon Oh, Masaki Terabe, C. David Pendleton, Anu Bhattacharyya, Tapan K. Bera, Malka Epel, Yoram Reiter, John Phillips, W. Marston Linehan, Claude Kasten-Sportes, Ira Pastan, and Jay A. Berzofsky
Cancer Res 2004 64: 2610-2618. [Abstract] [Full Text] [PDF]  

Endocrinology:

Androgen Receptor Signaling: Mechanism of Interleukin-6 Inhibition

Li Jia, Catherine S-Y. Choong, Carmela Ricciardelli, Joshua Kim, Wayne D. Tilley, and Gerhard A Coetzee
Cancer Res 2004 64: 2619-2626. [Abstract] [Full Text] [PDF]  

The Tumor Suppressor p53 Down-Regulates Glucose Transporters GLUT1 and GLUT4 Gene Expression

Fabiana Schwartzenberg-Bar-Yoseph, Michal Armoni, and Eddy Karnieli
Cancer Res 2004 64: 2627-2633. [Abstract] [Full Text] [PDF]  

Epidemiology:

Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds

Alison P. Klein, Kieran A. Brune, Gloria M. Petersen, Michael Goggins, Anne C. Tersmette, G. Johan A. Offerhaus, Constance Griffin, John L. Cameron, Charles J. Yeo, Scott Kern, and Ralph H. Hruban
Cancer Res 2004 64: 2634-2638. [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Correspondence re: S. Heckl et al., Intracellular Visualization of Prostate Cancer Using Magnetic Resonance Imaging. Cancer Res 2003;63:4766–72.

Eric Wickstrom and Klaus Braun
Cancer Res 2004 64: 2639. [Full Text] [PDF]  

Correspondence re: M. Leone et al., Cancer Prevention by Tea Polyphenols Is Linked to Their Direct Inhibition of Antiapoptotic Bcl-2-Family Proteins. Cancer Res 2003;63:8118–21.

Hasan Mukhtar and Maurizio Pellecchia
Cancer Res 2004 64: 2639-2640. [Full Text] [PDF]  

Corrections:

Corrections

Cancer Res 2004 64: 2641. [Full Text] [PDF]  

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