Reviews:

Endogenous Inhibitors of Angiogenesis

Pia Nyberg, Liang Xie, and Raghu Kalluri
Cancer Res 2005 65: 3967-3979. [Abstract] [Full Text] [PDF]  

Lost in Transcription: p21 Repression, Mechanisms, and Consequences

Andrei L. Gartel and Senthil K. Radhakrishnan
Cancer Res 2005 65: 3980-3985. [Abstract] [Full Text] [PDF]  

Priority Reports:

Expression of Kinase Suppressor of Ras1 Enhances Cisplatin-Induced Extracellular Signal–Regulated Kinase Activation and Cisplatin Sensitivity

Min Kim, Ying Yan, Robert L. Kortum, Scott M. Stoeger, Magdalene K. Sgagias, Kwangmoon Lee, Robert E. Lewis, and Kenneth H. Cowan
Cancer Res 2005 65: 3986-3992. [Abstract] [Full Text] [PDF]  

Mesalazine Improves Replication Fidelity in Cultured Colorectal Cells

Christoph Gasche, Ajay Goel, Loki Natarajan, and C. Richard Boland
Cancer Res 2005 65: 3993-3997. [Abstract] [Full Text] [PDF]  

CD4⁺CD25⁺ Regulatory Lymphocytes Induce Regression of Intestinal Tumors in Apc^Min/+ Mice

Susan E. Erdman, Jane J. Sohn, Varada P. Rao, Prashant R. Nambiar, Zhongming Ge, James G. Fox, and David B. Schauer
Cancer Res 2005 65: 3998-4004. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Metastasizing Melanoma Formation Caused by Expression of Activated N-Ras^Q61K on an INK4a-Deficient Background

Julien Ackermann, Manon Frutschi, Kostas Kaloulis, Thomas McKee, Andreas Trumpp, and Friedrich Beermann
Cancer Res 2005 65: 4005-4011. [Abstract] [Full Text] [PDF] Supplementary Data  

SMARCB1/INI1 Tumor Suppressor Gene Is Frequently Inactivated in Epithelioid Sarcomas

Piergiorgio Modena, Elena Lualdi, Federica Facchinetti, Lisa Galli, Manuel R. Teixeira, Silvana Pilotti, and Gabriella Sozzi
Cancer Res 2005 65: 4012-4019. [Abstract] [Full Text] [PDF] Supplementary Data  

DNA Ligase III as a Candidate Component of Backup Pathways of Nonhomologous End Joining

Huichen Wang, Bustanur Rosidi, Ronel Perrault, Minli Wang, Lihua Zhang, Frank Windhofer, and George Iliakis
Cancer Res 2005 65: 4020-4030. [Abstract] [Full Text] [PDF]  

An Expression-Based Site of Origin Diagnostic Method Designed for Clinical Application to Cancer of Unknown Origin

Richard W. Tothill, Adam Kowalczyk, Danny Rischin, Alex Bousioutas, Izhak Haviv, Ryan K. van Laar, Paul M. Waring, John Zalcberg, Robyn Ward, Andrew V. Biankin, Robert L. Sutherland, Susan M. Henshall, Kwun Fong, Jonathan R. Pollack, David D.L. Bowtell, and Andrew J. Holloway
Cancer Res 2005 65: 4031-4040. [Abstract] [Full Text] [PDF] Supplementary Data  

bHLH-zip Transcription Factor Spz1 Mediates Mitogen-Activated Protein Kinase Cell Proliferation, Transformation, and Tumorigenesis

Shih-Hsien Hsu, Hsiu-Mei Hsieh-Li, Hsin-Yi Huang, Pei-Hsin Huang, and Hung Li
Cancer Res 2005 65: 4041-4050. [Abstract] [Full Text] [PDF]  

Gene Expression Profiling and Genetic Markers in Glioblastoma Survival

Jeremy N. Rich, Christopher Hans, Beatrix Jones, Edwin S. Iversen, Roger E. McLendon, B.K. Ahmed Rasheed, Adrian Dobra, Holly K. Dressman, Darell D. Bigner, Joseph R. Nevins, and Mike West
Cancer Res 2005 65: 4051-4058. [Abstract] [Full Text] [PDF] Supplementary Data  

A Cell Proliferation Signature Is a Marker of Extremely Poor Outcome in a Subpopulation of Breast Cancer Patients

Hongyue Dai, Laura van't Veer, John Lamb, Yudong D. He, Mao Mao, Bernard M. Fine, Rene Bernards, Marc van de Vijver, Paul Deutsch, Alan Sachs, Roland Stoughton, and Stephen Friend
Cancer Res 2005 65: 4059-4066. [Abstract] [Full Text] [PDF] Supplementary Data  

E2F-Dependent Repression of Topoisomerase II Regulates Heterochromatin Formation and Apoptosis in Cells with Melanoma-Prone Mutation

Wan Jiao, Huei-Min Lin, Jamie Timmons, Akhilesh K. Nagaich, Shu-Wing Ng, Tom Misteli, and Sushil G. Rane
Cancer Res 2005 65: 4067-4077. [Abstract] [Full Text] [PDF]  

YB-1 Provokes Breast Cancer through the Induction of Chromosomal Instability That Emerges from Mitotic Failure and Centrosome Amplification

Stephan Bergmann, Brigitte Royer-Pokora, Ellen Fietze, Karsten Jürchott, Barbara Hildebrandt, Detlef Trost, Frauke Leenders, Jenny-Chang Claude, Franz Theuring, Ralf Bargou, Manfred Dietel, and Hans-Dieter Royer
Cancer Res 2005 65: 4078-4087. [Abstract] [Full Text] [PDF]  

High-Resolution Genome-Wide Mapping of Genetic Alterations in Human Glial Brain Tumors

Markus Bredel, Claudia Bredel, Dejan Juric, Griffith R. Harsh, Hannes Vogel, Lawrence D. Recht, and Branimir I. Sikic
Cancer Res 2005 65: 4088-4096. [Abstract] [Full Text] [PDF] Supplementary Data  

Detection of Prostate Cancer with a Blood-Based Assay for Early Prostate Cancer Antigen

Barbara Paul, Rajiv Dhir, Douglas Landsittel, Moira R. Hitchens, and Robert H. Getzenberg
Cancer Res 2005 65: 4097-4100. [Abstract] [Full Text] [PDF]  

Association of DNA Methylation of Phosphoserine Aminotransferase with Response to Endocrine Therapy in Patients with Recurrent Breast Cancer

John W.M. Martens, Inko Nimmrich, Thomas Koenig, Maxime P. Look, Nadia Harbeck, Fabian Model, Antje Kluth, Joan Bolt-de Vries, Anieta M. Sieuwerts, Henk Portengen, Marion E. Meijer-Van Gelder, Christian Piepenbrock, Alexander Olek, Heinz Höfler, Marion Kiechle, Jan G.M. Klijn, Manfred Schmitt, Sabine Maier, and John A. Foekens
Cancer Res 2005 65: 4101-4117. [Abstract] [Full Text] [PDF] Supplementary Data  

Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN) Has Nuclear Localization Signal–Like Sequences for Nuclear Import Mediated by Major Vault Protein

Ji-Hyun Chung, Margaret E. Ginn-Pease, and Charis Eng
Cancer Res 2005 65: 4108-4116. [Abstract] [Full Text] [PDF]  

BRCA2 Regulates Homologous Recombination in Response to DNA Damage: Implications for Genome Stability and Carcinogenesis

Christine Abaji, Isabelle Cousineau, and Abdellah Belmaaza
Cancer Res 2005 65: 4117-4125. [Abstract] [Full Text] [PDF]  

Serum Antibodies to Huntingtin Interacting Protein-1: A New Blood Test for Prostate Cancer

Sarah V. Bradley, Katherine I. Oravecz-Wilson, Gaelle Bougeard, Ikuko Mizukami, Lina Li, Anthony J. Munaco, Arun Sreekumar, Michael N. Corradetti, Arul M. Chinnaiyan, Martin G. Sanda, and Theodora S. Ross
Cancer Res 2005 65: 4126-4133. [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

Gene Expression Profiling Reveals Cross-talk between Melanoma and Fibroblasts: Implications for Host-Tumor Interactions in Metastasis

Paul G. Gallagher, Yongde Bao, Alyson Prorock, Paola Zigrino, Roswitha Nischt, Vincenzo Politi, Cornelia Mauch, Bojan Dragulev, and Jay William Fox
Cancer Res 2005 65: 4134-4146. [Abstract] [Full Text] [PDF]  

The Role of Hypoxia-Inducible Factor-1 in Three-dimensional Tumor Growth, Apoptosis, and Regulation by the Insulin-Signaling Pathway

Russell D. Leek, Ian Stratford, and Adrian L. Harris
Cancer Res 2005 65: 4147-4152. [Abstract] [Full Text] [PDF]  

Regulation of Tumor Angiogenesis by Fastatin, the Fourth FAS1 Domain of ßig-h3, via vß3 Integrin

Ju-Ock Nam, Ha-Won Jeong, Byung-Heon Lee, Rang-Woon Park, and In-San Kim
Cancer Res 2005 65: 4153-4161. [Abstract] [Full Text] [PDF]  

Human Carcinoma Cell Growth and Invasiveness Is Impaired by the Propeptide of the Ubiquitous Proprotein Convertase Furin

Ricardo López de Cicco, Daniel E. Bassi, Stanley Zucker, Nabil G. Seidah, and Andrés J.P. Klein-Szanto
Cancer Res 2005 65: 4162-4171. [Abstract] [Full Text] [PDF]  

Expression of Human Endogenous Retrovirus K in Melanomas and Melanoma Cell Lines

Kristina Büscher, Uwe Trefzer, Maja Hofmann, Wolfram Sterry, Reinhard Kurth, and Joachim Denner
Cancer Res 2005 65: 4172-4180. [Abstract] [Full Text] [PDF]  

Inhibitors of the Arachidonic Acid Pathway and Peroxisome Proliferator–Activated Receptor Ligands Have Superadditive Effects on Lung Cancer Growth Inhibition

Ingalill Avis, Alfredo Martínez, Jordi Tauler, Enrique Zudaire, Anatoly Mayburd, Raed Abu-Ghazaleh, Frank Ondrey, and James L. Mulshine
Cancer Res 2005 65: 4181-4190. [Abstract] [Full Text] [PDF]  

Distinct Structural Domains within C19ORF5 Support Association with Stabilized Microtubules and Mitochondrial Aggregation and Genome Destruction

Leyuan Liu, Amy Vo, Guoqin Liu, and Wallace L. McKeehan
Cancer Res 2005 65: 4191-4201. [Abstract] [Full Text] [PDF]  

Early Detection of Tumor Response to Chemotherapy by 3'-Deoxy-3'-[¹⁸F]Fluorothymidine Positron Emission Tomography: The Effect of Cisplatin on a Fibrosarcoma Tumor Model In vivo

Julius Leyton, John R. Latigo, Meg Perumal, Harmandeep Dhaliwal, Qimin He, and Eric O. Aboagye
Cancer Res 2005 65: 4202-4210. [Abstract] [Full Text] [PDF]  

Role of Hepatic Cytochrome P450s in the Pharmacokinetics and Toxicity of Cyclophosphamide: Studies with the Hepatic Cytochrome P450 Reductase Null Mouse

Georgia J. Pass, Dianne Carrie, Michael Boylan, Sally Lorimore, Eric Wright, Brian Houston, Colin J. Henderson, and C. Roland Wolf
Cancer Res 2005 65: 4211-4217. [Abstract] [Full Text] [PDF]  

Functional Epigenomics Identifies Genes Frequently Silenced in Prostate Cancer

Dimitri Lodygin, Alexey Epanchintsev, Antje Menssen, Joachim Diebold, and Heiko Hermeking
Cancer Res 2005 65: 4218-4227. [Abstract] [Full Text] [PDF] Supplementary Data  

Transforming Growth Factor-ß Suppresses Nonmetastatic Colon Cancer through Smad4 and Adaptor Protein ELF at an Early Stage of Tumorigenesis

Yi Tang, Varalakshmi Katuri, Radhika Srinivasan, Franz Fogt, Robert Redman, Girish Anand, Anan Said, Thomas Fishbein, Michael Zasloff, E. Premkumar Reddy, Bibhuti Mishra, and Lopa Mishra
Cancer Res 2005 65: 4228-4237. [Abstract] [Full Text] [PDF] Supplementary Data  

Targeted Expression of BRAF^V600E in Thyroid Cells of Transgenic Mice Results in Papillary Thyroid Cancers that Undergo Dedifferentiation

Jeffrey A. Knauf, Xiaolan Ma, Eric P. Smith, Lei Zhang, Norisato Mitsutake, Xiao-Hui Liao, Samuel Refetoff, Yuri E. Nikiforov, and James A. Fagin
Cancer Res 2005 65: 4238-4245. [Abstract] [Full Text] [PDF]  

Real-time In vivo Dual-color Imaging of Intracapillary Cancer Cell and Nucleus Deformation and Migration

Kensuke Yamauchi, Meng Yang, Ping Jiang, Norio Yamamoto, Mingxu Xu, Yasuyuki Amoh, Kazuhiko Tsuji, Michael Bouvet, Hiroyuki Tsuchiya, Katsuro Tomita, A.R. Moossa, and Robert M. Hoffman
Cancer Res 2005 65: 4246-4252. [Abstract] [Full Text] [PDF]  

HER2 Overexpression Increases Sensitivity to Gefitinib, an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, through Inhibition of HER2/HER3 Heterodimer Formation in Lung Cancer Cells

Akira Hirata, Fumihito Hosoi, Miho Miyagawa, Shu-ichi Ueda, Seiji Naito, Teruhiko Fujii, Michihiko Kuwano, and Mayumi Ono
Cancer Res 2005 65: 4253-4260. [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinases 9 and 10 Inhibit Protein Kinase C–Potentiated, p53-Mediated Apoptosis

Eric Meyer, Jean-Yves Vollmer, Raymonde Bovey, and Ivan Stamenkovic
Cancer Res 2005 65: 4261-4272. [Abstract] [Full Text] [PDF]  

Nuclear Factor-B Induced by Doxorubicin Is Deficient in Phosphorylation and Acetylation and Represses Nuclear Factor-B–Dependent Transcription in Cancer Cells

Wai Chi Ho, Kathleen M. Dickson, and Philip A. Barker
Cancer Res 2005 65: 4273-4281. [Abstract] [Full Text] [PDF]  

Stimulation of Mitochondrial Activity by p43 Overexpression Induces Human Dermal Fibroblast Transformation

Stéphanie Grandemange, Pascal Seyer, Angel Carazo, Philippe Bécuwe, Laurence Pessemesse, Muriel Busson, Cécile Marsac, Pascal Roger, François Casas, Gérard Cabello, and Chantal Wrutniak-Cabello
Cancer Res 2005 65: 4282-4291. [Abstract] [Full Text] [PDF]  

-Melanocortin and Endothelin-1 Activate Antiapoptotic Pathways and Reduce DNA Damage in Human Melanocytes

Ana Luisa Kadekaro, Renny Kavanagh, Hiromi Kanto, Silva Terzieva, Jennifer Hauser, Nobuhiko Kobayashi, Sandy Schwemberger, James Cornelius, George Babcock, Howard G. Shertzer, Glynis Scott, and Zalfa A. Abdel-Malek
Cancer Res 2005 65: 4292-4299. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Synergistic Antitumor Response of Interleukin 2 with Melphalan in Isolated Limb Perfusion in Soft Tissue Sarcoma–Bearing Rats

Saske Hoving, Flavia Brunstein, Gisela aan de Wiel-Ambagtsheer, Sandra T. van Tiel, Gert de Boeck, Ernst A. de Bruijn, Alexander M.M. Eggermont, and Timo L.M. ten Hagen
Cancer Res 2005 65: 4300-4308. [Abstract] [Full Text] [PDF]  

Versatile Prostate Cancer Treatment with Inducible Caspase and Interleukin-12

Ekaterina Yu. Nikitina, Smruti A. Desai, Xiuqin Zhao, Weitao Song, Annie Z. Luo, Rama D. Gangula, Kevin M. Slawin, and David M. Spencer
Cancer Res 2005 65: 4309-4319. [Abstract] [Full Text] [PDF] Supplementary Data  

ABCB5-Mediated Doxorubicin Transport and Chemoresistance in Human Malignant Melanoma

Natasha Y. Frank, Armen Margaryan, Ying Huang, Tobias Schatton, Ana Maria Waaga-Gasser, Martin Gasser, Mohamed H. Sayegh, Wolfgang Sadee, and Markus H. Frank
Cancer Res 2005 65: 4320-4333. [Abstract] [Full Text] [PDF]  

Treatment of Chemotherapy-Resistant Human Ovarian Cancer Xenografts in C.B-17/SCID Mice by Intraperitoneal Administration of Clostridium perfringens Enterotoxin

Alessandro D. Santin, Stefania Cané, Stefania Bellone, Michela Palmieri, Eric R. Siegel, Maria Thomas, Juan J. Roman, Alexander Burnett, Martin J. Cannon, and Sergio Pecorelli
Cancer Res 2005 65: 4334-4342. [Abstract] [Full Text] [PDF]  

Assessment of a Combined, Adenovirus-Mediated Oncolytic and Immunostimulatory Tumor Therapy

Kathrin Maria Bernt, Shaoheng Ni, Anh-Thu Tieu, and André Lieber
Cancer Res 2005 65: 4343-4352. [Abstract] [Full Text] [PDF] Supplementary Data  

Canstatin Acts on Endothelial and Tumor Cells via Mitochondrial Damage Initiated through Interaction with _vß₃ and _vß₅ Integrins

Claire Magnon, Ariane Galaup, Brian Mullan, Valérie Rouffiac, Jean-Michel Bidart, Frank Griscelli, Paule Opolon, and Michel Perricaudet
Cancer Res 2005 65: 4353-4361. [Abstract] [Full Text] [PDF]  

CK2 Inhibits Apoptosis and Changes Its Cellular Localization Following Ionizing Radiation

Kazuhiko Yamane and Timothy J. Kinsella
Cancer Res 2005 65: 4362-4367. [Abstract] [Full Text] [PDF]  

Inhibition of the DNA-Dependent Protein Kinase Catalytic Subunit Radiosensitizes Malignant Glioma Cells by Inducing Autophagy

Shigeru Daido, Akitsugu Yamamoto, Keishi Fujiwara, Raymond Sawaya, Seiji Kondo, and Yasuko Kondo
Cancer Res 2005 65: 4368-4375. [Abstract] [Full Text] [PDF]  

Immune Selection and Emergence of Aggressive Tumor Variants as Negative Consequences of Fas-Mediated Cytotoxicity and Altered IFN--Regulated Gene Expression

Kebin Liu, Sheila A. Caldwell, and Scott I. Abrams
Cancer Res 2005 65: 4376-4388. [Abstract] [Full Text] [PDF]  

AZD2171: A Highly Potent, Orally Bioavailable, Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitor for the Treatment of Cancer

Stephen R. Wedge, Jane Kendrew, Laurent F. Hennequin, Paula J. Valentine, Simon T. Barry, Sandra R. Brave, Neil R. Smith, Neil H. James, Michael Dukes, Jon O. Curwen, Rosemary Chester, Janet A. Jackson, Sarah J. Boffey, Lyndsey L. Kilburn, Sharon Barnett, Graham H.P. Richmond, Peter F. Wadsworth, Mike Walker, Alison L. Bigley, Sian T. Taylor, Lee Cooper, Sarah Beck, Juliane M. Jürgensmeier, and Donald J. Ogilvie
Cancer Res 2005 65: 4389-4400. [Abstract] [Full Text] [PDF]  

Selective Killing of Adriamycin-Resistant (G₂ Checkpoint-Deficient and MRP1-Expressing) Cancer Cells by Docetaxel

Zoya N. Demidenko, Dorota Halicka, Jan Kunicki, James A. McCubrey, Zbigniew Darzynkiewicz, and Mikhail V. Blagosklonny
Cancer Res 2005 65: 4401-4407. [Abstract] [Full Text] [PDF]  

A Monoclonal Antibody that Binds Anionic Phospholipids on Tumor Blood Vessels Enhances the Antitumor Effect of Docetaxel on Human Breast Tumors in Mice

Xianming Huang, Mary Bennett, and Philip E. Thorpe
Cancer Res 2005 65: 4408-4416. [Abstract] [Full Text] [PDF]  

1'-Acetoxychavicol Acetate Is a Novel Nuclear Factor B Inhibitor with Significant Activity against Multiple Myeloma In vitro and In vivo

Keisuke Ito, Tomonori Nakazato, Ming Ji Xian, Taketo Yamada, Nobumichi Hozumi, Akira Murakami, Hajime Ohigashi, Yasuo Ikeda, and Masahiro Kizaki
Cancer Res 2005 65: 4417-4424. [Abstract] [Full Text] [PDF]  

The Human Multidrug Resistance Protein MRP5 Transports Folates and Can Mediate Cellular Resistance against Antifolates

Peter Wielinga, Jan Hendrik Hooijberg, Sjofn Gunnarsdottir, Ietje Kathmann, Glen Reid, Noam Zelcer, Kasper van der Born, Marcel de Haas, Ingrid van der Heijden, Gertjan Kaspers, Jan Wijnholds, Gerrit Jansen, Godefridus Peters, and Piet Borst
Cancer Res 2005 65: 4425-4430. [Abstract] [Full Text] [PDF]  

Enhancement of Folate Receptor Expression in Tumor Cells Through the Glucocorticoid Receptor: A Promising Means to Improved Tumor Detection and Targeting

Thuyet Tran, Aymen Shatnawi, Xuan Zheng, Karen M.M. Kelley, and Manohar Ratnam
Cancer Res 2005 65: 4431-4441. [Abstract] [Full Text] [PDF]  

Omega-3 Polyunsaturated Fatty Acids Regulate Syndecan-1 Expression in Human Breast Cancer Cells

Haiguo Sun, Isabelle M. Berquin, and Iris J. Edwards
Cancer Res 2005 65: 4442-4447. [Abstract] [Full Text] [PDF]  

Milk Thistle and Prostate Cancer: Differential Effects of Pure Flavonolignans from Silybum marianum on Antiproliferative End Points in Human Prostate Carcinoma Cells

Paula R. Davis-Searles, Yuka Nakanishi, Nam-Cheol Kim, Tyler N. Graf, Nicholas H. Oberlies, Mansukh C. Wani, Monroe E. Wall, Rajesh Agarwal, and David J. Kroll
Cancer Res 2005 65: 4448-4457. [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

Phenotypic Profiling of Engineered Mouse Melanomas with Manipulated Histamine Production Identifies Histamine H2 Receptor and Rho-C as Histamine-Regulated Melanoma Progression Markers

Zoltán Pós, Géza Sáfrány, Kerstin Müller, Sára Tóth, András Falus, and Hargita Hegyesi
Cancer Res 2005 65: 4458-4466. [Abstract] [Full Text] [PDF]  

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