Review Articles:

Carcinoma Invasion and Metastasis: A Role for Epithelial-Mesenchymal Transition?

Erik W. Thompson, Donald F. Newgreen, and David Tarin
Cancer Res 2005 65: 5991-5995. [Full Text] [PDF]  

Note from the Reviews Section Editorial Board

George C. Prendergast, Martine Roussel, Eric Rowinsky, and Dan Welch
Cancer Res 2005 65: 5991. [Full Text] [PDF]  

The Fallacy of Epithelial Mesenchymal Transition in Neoplasia

David Tarin, Erik W. Thompson, and Donald F. Newgreen
Cancer Res 2005 65: 5996-6001. [Abstract] [Full Text] [PDF]  

Perspectives in Cancer Research:

Functional Idiotopes: Tumor Antigen–Directed Expression of CD8⁺ T-Cell Epitopes Nested in Unique NH₂-terminal V_H Sequence of Antiidiotypic Antibodies?

Kouichiro Kawano, Soldano Ferrone, and Constantin G. Ioannides
Cancer Res 2005 65: 6001-6004. [Abstract] [Full Text] [PDF]  

Priority Reports:

8-Oxoguanine Formation Induced by Chronic UVB Exposure Makes Ogg1 Knockout Mice Susceptible to Skin Carcinogenesis

Makoto Kunisada, Kunihiko Sakumi, Yohei Tominaga, Arief Budiyanto, Masato Ueda, Masamitsu Ichihashi, Yusaku Nakabeppu, and Chikako Nishigori
Cancer Res 2005 65: 6006-6010. [Abstract] [Full Text] [PDF]  

5-Lipoxygenase, a Marker for Early Pancreatic Intraepithelial Neoplastic Lesions

Rene Hennig, Paul Grippo, Xian-Zhong Ding, Sambasiva M. Rao, Markus W. Buchler, Helmut Friess, Mark S. Talamonti, Richard H. Bell, and Thomas E. Adrian
Cancer Res 2005 65: 6011-6016. [Abstract] [Full Text] [PDF]  

Dual Induction of Apoptosis and Senescence in Cancer Cells by Chk2 Activation: Checkpoint Activation as a Strategy against Cancer

Chang-Rung Chen, Wenxian Wang, Harry A. Rogoff, Xiaotong Li, William Mang, and Chiang J. Li
Cancer Res 2005 65: 6017-6021. [Abstract] [Full Text] [PDF]  

RLIP76 Is a Major Determinant of Radiation Sensitivity

Sanjay Awasthi, Sharad S. Singhal, Sushma Yadav, Jyotsana Singhal, Kenneth Drake, Aalok Nadkar, Ewa Zajac, Dilki Wickramarachchi, Nancy Rowe, Adly Yacoub, Paul Boor, Seema Dwivedi, Paul Dent, Wendy E. Jarman, Berchmans John, and Yogesh C. Awasthi
Cancer Res 2005 65: 6022-6028. [Abstract] [Full Text] [PDF] Supplementary Data  

MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

Jennifer A. Chan, Anna M. Krichevsky, and Kenneth S. Kosik
Cancer Res 2005 65: 6029-6033. [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

Epidermal Expression of the Translation Inhibitor Programmed Cell Death 4 Suppresses Tumorigenesis

Aaron P. Jansen, Corinne E. Camalier, and Nancy H. Colburn
Cancer Res 2005 65: 6034-6041. [Abstract] [Full Text] [PDF]  

The RhoGAP Protein DLC-1 Functions as a Metastasis Suppressor in Breast Cancer Cells

Steve Goodison, Jing Yuan, Derek Sloan, Ryung Kim, Cheng Li, Nicholas C. Popescu, and Virginia Urquidi
Cancer Res 2005 65: 6042-6053. [Abstract] [Full Text] [PDF]  

Rho GDP Dissociation Inhibitor Protects Cancer Cells against Drug-Induced Apoptosis

Baolin Zhang, Yaqin Zhang, Marie-Claire Dagher, and Emily Shacter
Cancer Res 2005 65: 6054-6062. [Abstract] [Full Text] [PDF]  

Poor Survival Associated with the BRAF V600E Mutation in Microsatellite-Stable Colon Cancers

Wade S. Samowitz, Carol Sweeney, Jennifer Herrick, Hans Albertsen, Theodore R. Levin, Maureen A. Murtaugh, Roger K. Wolff, and Martha L. Slattery
Cancer Res 2005 65: 6063-6069. [Abstract] [Full Text] [PDF]  

A Robust Algorithm for Copy Number Detection Using High-Density Oligonucleotide Single Nucleotide Polymorphism Genotyping Arrays

Yasuhito Nannya, Masashi Sanada, Kumi Nakazaki, Noriko Hosoya, Lili Wang, Akira Hangaishi, Mineo Kurokawa, Shigeru Chiba, Dione K. Bailey, Giulia C. Kennedy, and Seishi Ogawa
Cancer Res 2005 65: 6071-6079. [Abstract] [Full Text] [PDF] Supplementary Data  

The Integrity of the Charged Pocket in the BTB/POZ Domain Is Essential for the Phenotype Induced by the Leukemia-Associated t(11;17) Fusion Protein PLZF/RAR

Elena Puccetti, Xiaomin Zheng, Daria Brambilla, Anita Seshire, Tim Beissert, Simone Boehrer, Heike Nürnberger, Dieter Hoelzer, Oliver Gerhard Ottmann, Clara Nervi, and Martin Ruthardt
Cancer Res 2005 65: 6080-6088. [Abstract] [Full Text] [PDF]  

Synergistic Induction of DOC-2/DAB2 Gene Expression in Transitional Cell Carcinoma in the Presence of GATA6 and Histone Deacetylase Inhibitor

Jian Zhou, Gina Hernandez, Szu-wei Tu, Jessica Scholes, Hong Chen, Ching-Ping Tseng, and Jer-Tsong Hsieh
Cancer Res 2005 65: 6089-6096. [Abstract] [Full Text] [PDF] Supplementary Data  

Nitric Oxide–Induced Apoptosis in Lymphoblastoid and Fibroblast Cells Dependent on the Phosphorylation and Activation of p53

Laura M. McLaughlin and Bruce Demple
Cancer Res 2005 65: 6097-6104. [Abstract] [Full Text] [PDF]  

A Five-Amino-Acid Peptide Blocks Met- and Ron-Dependent Cell Migration

Alexandra Matzke, Peter Herrlich, Helmut Ponta, and Véronique Orian-Rousseau
Cancer Res 2005 65: 6105-6110. [Abstract] [Full Text] [PDF]  

Caspase-Mediated p65 Cleavage Promotes TRAIL-Induced Apoptosis

Hun Sik Kim, Inik Chang, Ja Young Kim, Kyung-Hee Choi, and Myung-Shik Lee
Cancer Res 2005 65: 6111-6119. [Abstract] [Full Text] [PDF] Supplementary Data  

Epidermal Growth Factor–Induced Signaling in Breast Cancer Cells Results in Selective Target Gene Activation by Orphan Nuclear Receptor Estrogen-Related Receptor

Janelle B. Barry and Vincent Giguère
Cancer Res 2005 65: 6120-6129. [Abstract] [Full Text] [PDF]  

Cell and Tumor Biology:

A Mouse Model of Human Breast Cancer Metastasis to Human Bone

Charlotte Kuperwasser, Scott Dessain, Benjamin E. Bierbaum, Dan Garnet, Kara Sperandio, Gregory P. Gauvin, Stephen P. Naber, Robert A. Weinberg, and Michael Rosenblatt
Cancer Res 2005 65: 6130-6138. [Abstract] [Full Text] [PDF]  

Antisense-Mediated Suppression of Hyaluronan Synthase 2 Inhibits the Tumorigenesis and Progression of Breast Cancer

Lishanthi Udabage, Gary R. Brownlee, Mark Waltham, Tony Blick, Emma C. Walker, Paraskevi Heldin, Susan K. Nilsson, Erik W. Thompson, and Tracey J. Brown
Cancer Res 2005 65: 6139-6150. [Abstract] [Full Text] [PDF]  

A Noninvasive Approach for Assessing Tumor Hypoxia in Xenografts: Developing a Urinary Marker for Hypoxia

Daniel W. Nelson, Hongbin Cao, Yonghua Zhu, Bulbin Sunar-Reeder, Clara Y.H. Choi, James D. Faix, J. Martin Brown, Albert C. Koong, Amato J. Giaccia, and Quynh-Thu Le
Cancer Res 2005 65: 6151-6158. [Abstract] [Full Text] [PDF]  

The Novel Gene EG-1 Stimulates Cellular Proliferation

Ming Lu, Liping Zhang, Raymond Scott Maul, Maryam R. Sartippour, Andrew Norris, Julian Whitelegge, Jian Yu Rao, and Mai N. Brooks
Cancer Res 2005 65: 6159-6166. [Abstract] [Full Text] [PDF]  

Proteolytic Processing Converts the Repelling Signal Sema3E into an Inducer of Invasive Growth and Lung Metastasis

Claus Christensen, Noona Ambartsumian, Giorgio Gilestro, Birthe Thomsen, Paolo Comoglio, Luca Tamagnone, Per Guldberg, and Eugene Lukanidin
Cancer Res 2005 65: 6167-6177. [Abstract] [Full Text] [PDF] Supplementary Data  

Stromal Cell–Derived Factor-1 and CXCR4 Expression in Hemangioblastoma and Clear Cell-Renal Cell Carcinoma: von Hippel-Lindau Loss-of-Function Induces Expression of a Ligand and Its Receptor

David Zagzag, Balaji Krishnamachary, Herman Yee, Hiroaki Okuyama, Luis Chiriboga, M. Aktar Ali, Jonathan Melamed, and Gregg L. Semenza
Cancer Res 2005 65: 6178-6188. [Abstract] [Full Text] [PDF]  

Suppression of Prostate Tumor Cell Growth by Stromal Cell Prostaglandin D Synthase–Derived Products

Jeri Kim, Peiying Yang, Milind Suraokar, Anita L. Sabichi, Norma D. Llansa, Gabriela Mendoza, Vemparalla Subbarayan, Christopher J. Logothetis, Robert A. Newman, Scott M. Lippman, and David G. Menter
Cancer Res 2005 65: 6189-6198. [Abstract] [Full Text] [PDF]  

Activation of the Canonical Wnt Pathway during Genital Keratinocyte Transformation: A Model for Cervical Cancer Progression

Aykut Üren, Shannon Fallen, Hang Yuan, Alp Usubütün, Türkan Küçükali, Richard Schlegel, and Jeffrey A. Toretsky
Cancer Res 2005 65: 6199-6206. [Abstract] [Full Text] [PDF]  

Side Population Is Enriched in Tumorigenic, Stem-Like Cancer Cells, whereas ABCG2⁺ and ABCG2^– Cancer Cells Are Similarly Tumorigenic

Lubna Patrawala, Tammy Calhoun, Robin Schneider-Broussard, Jianjun Zhou, Kent Claypool, and Dean G. Tang
Cancer Res 2005 65: 6207-6219. [Abstract] [Full Text] [PDF]  

Introduction of Sd^a Carbohydrate Antigen in Gastrointestinal Cancer Cells Eliminates Selectin Ligands and Inhibits Metastasis

Yuki I. Kawamura, Rei Kawashima, Ryuko Fukunaga, Kazunari Hirai, Noriko Toyama-Sorimachi, Makoto Tokuhara, Toshio Shimizu, and Taeko Dohi
Cancer Res 2005 65: 6220-6227. [Abstract] [Full Text] [PDF]  

CaSm-Mediated Cellular Transformation Is Associated with Altered Gene Expression and Messenger RNA Stability

Melissa M. Fraser, Patricia M. Watson, Mostafa M. Fraig, Joseph R. Kelley, Peter S. Nelson, Alice M. Boylan, David J. Cole, and Dennis K. Watson
Cancer Res 2005 65: 6228-6236. [Abstract] [Full Text] [PDF]  

The Transcription Factor Snail Induces Tumor Cell Invasion through Modulation of the Epithelial Cell Differentiation Program

Bram De Craene, Barbara Gilbert, Christophe Stove, Erik Bruyneel, Frans van Roy, and Geert Berx
Cancer Res 2005 65: 6237-6244. [Abstract] [Full Text] [PDF] Supplementary Data  

Glypican-3 Promotes the Growth of Hepatocellular Carcinoma by Stimulating Canonical Wnt Signaling

Mariana I. Capurro, Yun-Yan Xiang, Corrinne Lobe, and Jorge Filmus
Cancer Res 2005 65: 6245-6254. [Abstract] [Full Text] [PDF]  

Enforced Expression of Superoxide Dismutase 2/Manganese Superoxide Dismutase Disrupts Autocrine Interleukin-6 Stimulation in Human Multiple Myeloma Cells and Enhances Dexamethasone-Induced Apoptosis

David R. Hodge, Weihua Xiao, Benjamin Peng, James C. Cherry, David J. Munroe, and William L. Farrar
Cancer Res 2005 65: 6255-6263. [Abstract] [Full Text] [PDF]  

LY294002 and LY303511 Sensitize Tumor Cells to Drug-Induced Apoptosis via Intracellular Hydrogen Peroxide Production Independent of the Phosphoinositide 3-Kinase-Akt Pathway

Tze Wei Poh and Shazib Pervaiz
Cancer Res 2005 65: 6264-6274. [Abstract] [Full Text] [PDF]  

Prostaglandin E₂ Activates Mitogen-Activated Protein Kinase/Erk Pathway Signaling and Cell Proliferation in Non–Small Cell Lung Cancer Cells in an Epidermal Growth Factor Receptor–Independent Manner

Kostyantyn Krysan, Karen L. Reckamp, Harnisha Dalwadi, Sherven Sharma, Enrique Rozengurt, Mariam Dohadwala, and Steven M. Dubinett
Cancer Res 2005 65: 6275-6281. [Abstract] [Full Text] [PDF]  

Proteasome Inhibitors Trigger NOXA-Mediated Apoptosis in Melanoma and Myeloma Cells

Jian-Zhong Qin, Jeffrey Ziffra, Lawrence Stennett, Barbara Bodner, Brian K. Bonish, Vijaya Chaturvedi, Frank Bennett, Pamela M. Pollock, Jeffrey M. Trent, Mary J.C. Hendrix, Paola Rizzo, Lucio Miele, and Brian J. Nickoloff
Cancer Res 2005 65: 6282-6293. [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Differential Regulation of Noxa in Normal Melanocytes and Melanoma Cells by Proteasome Inhibition: Therapeutic Implications

Yolanda Fernández, Monique Verhaegen, Thomas P. Miller, Jenny L. Rush, Philipp Steiner, Anthony W. Opipari, Jr., Scott W. Lowe, and María S. Soengas
Cancer Res 2005 65: 6294-6304. [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data  

Epigenetic Reactivation of Tumor Suppressor Genes by a Novel Small-Molecule Inhibitor of Human DNA Methyltransferases

Bodo Brueckner, Regine Garcia Boy, Pawel Siedlecki, Tanja Musch, H. Christian Kliem, Piotr Zielenkiewicz, Sandor Suhai, Manfred Wiessler, and Frank Lyko
Cancer Res 2005 65: 6305-6311. [Abstract] [Full Text] [PDF]  

Susceptibility of Cholangiocarcinoma Cells to Parthenolide-Induced Apoptosis

Jong-Hyun Kim, Lan Liu, Seung-Ok Lee, Yong-Tae Kim, Kyung-Ran You, and Dae-Ghon Kim
Cancer Res 2005 65: 6312-6320. [Abstract] [Full Text] [PDF]  

Natural Killer Cell–Mediated Lysis of Hepatoma Cells via Specific Induction of NKG2D Ligands by the Histone Deacetylase Inhibitor Sodium Valproate

Sorin Armeanu, Michael Bitzer, Ulrich M. Lauer, Sascha Venturelli, Anita Pathil, Matthias Krusch, Stephan Kaiser, Jürgen Jobst, Irina Smirnow, Annika Wagner, Alexander Steinle, and Helmut R. Salih
Cancer Res 2005 65: 6321-6329. [Abstract] [Full Text] [PDF]  

Tomographic Fluorescence Mapping of Tumor Targets

Xavier Montet, Vasilis Ntziachristos, Jan Grimm, and Ralph Weissleder
Cancer Res 2005 65: 6330-6336. [Abstract] [Full Text] [PDF]  

A New Three-Dimensional Ultrasound Microimaging Technology for Preclinical Studies Using a Transgenic Prostate Cancer Mouse Model

Lauren A. Wirtzfeld, Guojun Wu, Michael Bygrave, Yasuto Yamasaki, Hideki Sakai, Madeleine Moussa, Jonathan I. Izawa, Dónal B. Downey, Norman M. Greenberg, Aaron Fenster, Jim W. Xuan, and James C. Lacefield
Cancer Res 2005 65: 6337-6345. [Abstract] [Full Text] [PDF] Supplementary Data  

Inactivation of Anthracyclines by Cellular Peroxidase

Krzysztof J. Reszka, Brett A. Wagner, Lynn M. Teesch, Bradley E. Britigan, Douglas R. Spitz, and C. Patrick Burns
Cancer Res 2005 65: 6346-6353. [Abstract] [Full Text] [PDF]  

Activation of Nuclear Factor-B Contributes to Induction of Death Receptors and Apoptosis by the Synthetic Retinoid CD437 in DU145 Human Prostate Cancer Cells

Fengshuo Jin, Xiangguo Liu, Zhongmei Zhou, Ping Yue, Reuben Lotan, Fadlo R. Khuri, Leland W.K. Chung, and Shi-Yong Sun
Cancer Res 2005 65: 6354-6363. [Abstract] [Full Text] [PDF]  

Tunicamycin Enhances Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis in Human Prostate Cancer Cells

Takumi Shiraishi, Tatsushi Yoshida, Susumu Nakata, Mano Horinaka, Miki Wakada, Yoichi Mizutani, Tsuneharu Miki, and Toshiyuki Sakai
Cancer Res 2005 65: 6364-6370. [Abstract] [Full Text] [PDF]  

Multiepitope HER2 Targeting Enhances Photoimmunotherapy of HER2-Overexpressing Cancer Cells with Pyropheophorbide-a Immunoconjugates

Mark D. Savellano, Brian W. Pogue, P. Jack Hoopes, Ellen S. Vitetta, and Keith D. Paulsen
Cancer Res 2005 65: 6371-6379. [Abstract] [Full Text] [PDF]  

Identification of a Novel Synthetic Thiazolidin Compound Capable of Inducing c-Jun NH₂-Terminal Kinase–Dependent Apoptosis in Human Colon Cancer Cells

Fuminori Teraishi, Shuhong Wu, Lidong Zhang, Wei Guo, John J. Davis, Fengqin Dong, and Bingliang Fang
Cancer Res 2005 65: 6380-6387. [Abstract] [Full Text] [PDF]  

Therapeutic Synergism of Gemcitabine and CpG-Oligodeoxynucleotides in an Orthotopic Human Pancreatic Carcinoma Xenograft

Graziella Pratesi, Giovanna Petrangolini, Monica Tortoreto, Alessandro Addis, Sara Belluco, Anna Rossini, Silvia Selleri, Cristiano Rumio, Sylvie Menard, and Andrea Balsari
Cancer Res 2005 65: 6388-6393. [Abstract] [Full Text] [PDF]  

The Role of Base Excision Repair in the Sensitivity and Resistance to Temozolomide-Mediated Cell Death

Ram N. Trivedi, Karen H. Almeida, Jamie L. Fornsaglio, Sandra Schamus, and Robert W. Sobol
Cancer Res 2005 65: 6394-6400. [Abstract] [Full Text] [PDF] Supplementary Data  

Epidermal Growth Factor Receptors Harboring Kinase Domain Mutations Associate with the Heat Shock Protein 90 Chaperone and Are Destabilized following Exposure to Geldanamycins

Takeshi Shimamura, April M. Lowell, Jeffrey A. Engelman, and Geoffrey I. Shapiro
Cancer Res 2005 65: 6401-6408. [Abstract] [Full Text] [PDF]  

Immunology:

BCR/ABL Promotes Dendritic Cell–Mediated Natural Killer Cell Activation

Magali Terme, Christophe Borg, François Guilhot, Carole Masurier, Caroline Flament, Erwin F. Wagner, Sophie Caillat-Zucman, Alain Bernheim, Ali G. Turhan, Anne Caignard, and Laurence Zitvogel
Cancer Res 2005 65: 6409-6417. [Abstract] [Full Text] [PDF]  

Immunoselective Pressure and Human Leukocyte Antigen Class I Antigen Machinery Defects in Microsatellite Unstable Colorectal Cancers

Matthias Kloor, Christina Becker, Axel Benner, Stefan M. Woerner, Johannes Gebert, Soldano Ferrone, and Magnus von Knebel Doeberitz
Cancer Res 2005 65: 6418-6424. [Abstract] [Full Text] [PDF]  

Characterization of a Proapoptotic Antiganglioside GM2 Monoclonal Antibody and Evaluation of Its Therapeutic Effect on Melanoma and Small Cell Lung Carcinoma Xenografts

Marc W. Retter, Jeffrey C. Johnson, David W. Peckham, Jeannette E. Bannink, Chaitanya S. Bangur, Karen Dresser, Feng Cai, Teresa M. Foy, Neil A. Fanger, Gary R. Fanger, Bruce Woda, and Kenneth L. Rock
Cancer Res 2005 65: 6425-6434. [Abstract] [Full Text] [PDF]  

Human CTL Epitopes Prostatic Acid Phosphatase-3 and Six-Transmembrane Epithelial Antigen of Prostate-3 as Candidates for Prostate Cancer Immunotherapy

Arthur Machlenkin, Adrian Paz, Erez Bar Haim, Ofir Goldberger, Eran Finkel, Boaz Tirosh, Ilan Volovitz, Ezra Vadai, Gilles Lugassy, Shmuel Cytron, Francois Lemonnier, Esther Tzehoval, and Lea Eisenbach
Cancer Res 2005 65: 6435-6442. [Abstract] [Full Text] [PDF] Supplementary Data  

Expression of a Natural Tumor Antigen by Thymic Epithelial Cells Impairs the Tumor-Protective CD4+ T-Cell Repertoire

Rinke Bos, Suzanne van Duikeren, Thorbald van Hall, Patricia Kaaijk, Richard Taubert, Bruno Kyewski, Ludger Klein, Cornelis J.M. Melief, and Rienk Offringa
Cancer Res 2005 65: 6443-6449. [Abstract] [Full Text] [PDF]  

Endocrinology:

Progesterone Receptor in Non–Small Cell Lung Cancer—A Potent Prognostic Factor and Possible Target for Endocrine Therapy

Hironori Ishibashi, Takashi Suzuki, Satoshi Suzuki, Hiromichi Niikawa, Liangying Lu, Yasuhiro Miki, Takuya Moriya, Shin-ichi Hayashi, Masashi Handa, Takashi Kondo, and Hironobu Sasano
Cancer Res 2005 65: 6450-6458. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Polymorphisms Associated with Asthma Are Inversely Related to Glioblastoma Multiforme

Judith Schwartzbaum, Anders Ahlbom, Beatrice Malmer, Stefan Lönn, Anthony J. Brookes, Hani Doss, Waldemar Debinski, Roger Henriksson, and Maria Feychting
Cancer Res 2005 65: 6459-6465. [Abstract] [Full Text] [PDF]  

Differences in Glycosylation Patterns of Heat Shock Protein, gp96: Implications for Prostate Cancer Prevention

Robert Suriano, Salil K. Ghosh, Badithe T. Ashok, Abraham Mittelman, Yuangen Chen, Asesh Banerjee, and Raj K. Tiwari
Cancer Res 2005 65: 6466-6475. [Abstract] [Full Text] [PDF]  

Retinoid Targeting of Different D-Type Cyclins through Distinct Chemopreventive Mechanisms

Yan Ma, Qing Feng, David Sekula, J. Alan Diehl, Sarah J. Freemantle, and Ethan Dmitrovsky
Cancer Res 2005 65: 6476-6483. [Abstract] [Full Text] [PDF]  

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