Priority Reports:

Gene Expression Profiles in Pancreatic Intraepithelial Neoplasia Reflect the Effects of Hedgehog Signaling on Pancreatic Ductal Epithelial Cells

Nijaguna B. Prasad, Andrew V. Biankin, Noriyoshi Fukushima, Anirban Maitra, Surajit Dhara, Abdel G. Elkahloun, Ralph H. Hruban, Michael Goggins, and Steven D. Leach
Cancer Res 2005 65: 1619-1626. [Abstract] [Full Text] [PDF] Supplementary Data  

Evidence for Nonautonomous Effect of p53 Tumor Suppressor in Carcinogenesis

Hippokratis Kiaris, Ioulia Chatzistamou, George Trimis, Matrisa Frangou-Plemmenou, Agatha Pafiti-Kondi, and Anastasios Kalofoutis
Cancer Res 2005 65: 1627-1630. [Abstract] [Full Text] [PDF]  

Circumventing Multidrug Resistance in Cancer by ß-Galactoside Binding Protein, an Antiproliferative Cytokine

Roald Ravatn, Valerie Wells, Leigh Nelson, David Vettori, Livio Mallucci, and Khew-Voon Chin
Cancer Res 2005 65: 1631-1634. [Abstract] [Full Text] [PDF]  

Cannabinoid Receptor as a Novel Target for the Treatment of Prostate Cancer

Sami Sarfaraz, Farrukh Afaq, Vaqar M. Adhami, and Hasan Mukhtar
Cancer Res 2005 65: 1635-1641. [Abstract] [Full Text] [PDF]  

Somatic Mutations of the HER2 Kinase Domain in Lung Adenocarcinomas

Hisayuki Shigematsu, Takao Takahashi, Masaharu Nomura, Kuntal Majmudar, Makoto Suzuki, Huei Lee, Ignacio I. Wistuba, Kwun M. Fong, Shinichi Toyooka, Nobuyoshi Shimizu, Takehiko Fujisawa, John D. Minna, and Adi F. Gazdar
Cancer Res 2005 65: 1642-1646. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology and Genetics:

PUMA Overexpression Induces Reactive Oxygen Species Generation and Proteasome-Mediated Stathmin Degradation in Colorectal Cancer Cells

Zhihe Liu, Huimei Lu, Honglian Shi, Yuchun Du, Jian Yu, Sheng Gu, Xian Chen, Ke Jian Liu, and Chien-an A. Hu
Cancer Res 2005 65: 1647-1654. [Abstract] [Full Text] [PDF]  

Positive Contribution of Pathogenic Mutations in the Mitochondrial Genome to the Promotion of Cancer by Prevention from Apoptosis

Yujiro Shidara, Kumi Yamagata, Takashi Kanamori, Kazutoshi Nakano, Jennifer Q. Kwong, Giovanni Manfredi, Hideaki Oda, and Shigeo Ohta
Cancer Res 2005 65: 1655-1663. [Abstract] [Full Text] [PDF] Supplementary Data  

Loss of Heterozygosity Patterns Provide Fingerprints for Genetic Heterogeneity in Multistep Cancer Progression of Tobacco Smoke–Induced Non–Small Cell Lung Cancer

Hongjie Pan, Joseph Califano, Jose F. Ponte, Andrea L. Russo, Kuang-hung Cheng, Arunthathi Thiagalingam, Pratima Nemani, David Sidransky, and Sam Thiagalingam
Cancer Res 2005 65: 1664-1669. [Abstract] [Full Text] [PDF]  

Deficiency in the Catalytic Subunit of DNA-Dependent Protein Kinase Causes Down-Regulation of ATM

Yuanlin Peng, Rick G. Woods, Heather Beamish, Ruiqiong Ye, Susan P. Lees-Miller, Martin F. Lavin, and Joel S. Bedford
Cancer Res 2005 65: 1670-1677. [Abstract] [Full Text] [PDF]  

Integrated Array-Comparative Genomic Hybridization and Expression Array Profiles Identify Clinically Relevant Molecular Subtypes of Glioblastoma

Janice M. Nigro, Anjan Misra, Li Zhang, Ivan Smirnov, Howard Colman, Chandi Griffin, Natalie Ozburn, Mingang Chen, Edward Pan, Dimpy Koul, W.K. Alfred Yung, Burt G. Feuerstein, and Kenneth D. Aldape
Cancer Res 2005 65: 1678-1686. [Abstract] [Full Text] [PDF] Supplementary Data  

Overexpression of Soluble TRAIL Induces Apoptosis in Human Lung Adenocarcinoma and Inhibits Growth of Tumor Xenografts in Nude Mice

Juan Shi, Dexian Zheng, Yanxin Liu, Mai Har Sham, Paul Tam, Farzin Farzaneh, and Ruian Xu
Cancer Res 2005 65: 1687-1692. [Abstract] [Full Text] [PDF]  

Large-scale Transcriptome Analyses Reveal New Genetic Marker Candidates of Head, Neck, and Thyroid Cancer

Eduardo M. Reis, Elida P.B. Ojopi, Fernando L. Alberto, Paula Rahal, Fernando Tsukumo, Ulises M. Mancini, Gustavo S. Guimarães, Gloria M.A. Thompson, Cleber Camacho, Elisabete Miracca, André L. Carvalho, Abimael A. Machado, Apuã C.M. Paquola, Janete M. Cerutti, Aline M. da Silva, Gonçalo G. Pereira, Sandro R. Valentini, Maria A. Nagai, Luiz Paulo Kowalski, Sergio Verjovski-Almeida, Eloiza H. Tajara, Emmanuel Dias-Neto, and Head and Neck Annotation Consortium
Cancer Res 2005 65: 1693-1699. [Abstract] [Full Text] [PDF] Supplementary Data  

Cell and Tumor Biology:

Elevated Serum Levels of Stromal-Derived Factor-1 Are Associated with Increased Osteoclast Activity and Osteolytic Bone Disease in Multiple Myeloma Patients

Andrew C.W. Zannettino, Amanda N. Farrugia, Angela Kortesidis, Jim Manavis, L. Bik To, Sally K. Martin, Peter Diamond, Hirokazu Tamamura, Tsvee Lapidot, Nobutaka Fujii, and Stan Gronthos
Cancer Res 2005 65: 1700-1709. [Abstract] [Full Text] [PDF]  

Osteoprotegerin in Prostate Cancer Bone Metastasis

Eva Corey, Lisha G. Brown, Jeffrey A. Kiefer, Janna E. Quinn, Tiffany E.M. Pitts, Julie M. Blair, and Robert L. Vessella
Cancer Res 2005 65: 1710-1718. [Abstract] [Full Text] [PDF]  

Differential Effects of Neuropeptide Y on the Growth and Vascularization of Neural Crest–Derived Tumors

Joanna Kitlinska, Ken Abe, Lydia Kuo, Jennifer Pons, Muchieh Yu, Lijun Li, Jason Tilan, Lindsay Everhart, Edward W. Lee, Zofia Zukowska, and Jeffrey A. Toretsky
Cancer Res 2005 65: 1719-1728. [Abstract] [Full Text] [PDF]  

RET-Familial Medullary Thyroid Carcinoma Mutants Y791F and S891A Activate a Src/JAK/STAT3 Pathway, Independent of Glial Cell Line–Derived Neurotrophic Factor

Ivan Plaza Menacho, Roelof Koster, Almer M. van der Sloot, Wim J. Quax, Jan Osinga, Tineke van der Sluis, Harry Hollema, Grzegorz M. Burzynski, Oliver Gimm, Charles H.C.M. Buys, Bart J.L. Eggen, and Robert M.W. Hofstra
Cancer Res 2005 65: 1729-1737. [Abstract] [Full Text] [PDF]  

Kaposi's Sarcoma–Associated Herpesvirus Viral IFN Regulatory Factor 1 Inhibits Transforming Growth Factor-ß Signaling

Taegun Seo, Junsoo Park, and Joonho Choe
Cancer Res 2005 65: 1738-1747. [Abstract] [Full Text] [PDF]  

An Expression Signature Classifies Chemotherapy-Resistant Pediatric Osteosarcoma

Michelle B. Mintz, Rebecca Sowers, Kevin M. Brown, Sara C. Hilmer, BethAnne Mazza, Andrew G. Huvos, Paul A. Meyers, Bonnie LaFleur, Wendy S. McDonough, Michael M. Henry, Keri E. Ramsey, Cristina R. Antonescu, Wen Chen, John H. Healey, Aaron Daluski, Michael E. Berens, Tobey J. MacDonald, Richard Gorlick, and Dietrich A. Stephan
Cancer Res 2005 65: 1748-1754. [Abstract] [Full Text] [PDF]  

Skin Carcinoma Arising From Donor Cells in a Kidney Transplant Recipient

Sélim Aractingi, Jean Kanitakis, Sylvie Euvrard, Caroline Le Danff, Isabelle Peguillet, Kiarash Khosrotehrani, Olivier Lantz, and Edgardo D. Carosella
Cancer Res 2005 65: 1755-1760. [Abstract] [Full Text] [PDF]  

Adoptive Transfer of Tumor-Reactive Transforming Growth Factor-ß–Insensitive CD8⁺ T Cells: Eradication of Autologous Mouse Prostate Cancer

Qiang Zhang, Ximing Yang, Michael Pins, Borko Javonovic, Timothy Kuzel, Seong-Jin Kim, Luk Van Parijs, Norman M. Greenberg, Victoria Liu, Yinglu Guo, and Chung Lee
Cancer Res 2005 65: 1761-1769. [Abstract] [Full Text] [PDF]  

Multidrug Transporter ABCG2 Prevents Tumor Cell Death Induced by the Epidermal Growth Factor Receptor Inhibitor Iressa (ZD1839, Gefitinib)

N. Barry Elkind, Zsófia Szentpétery, Ágota Apáti, Csilla Özvegy-Laczka, György Várady, Olga Ujhelly, Katalin Szabó, László Homolya, András Váradi, László Buday, György Kéri, Katalin Német, and Balázs Sarkadi
Cancer Res 2005 65: 1770-1777. [Abstract] [Full Text] [PDF]  

Identification of Metastasis-Associated Receptor Tyrosine Kinases in Non–Small Cell Lung Cancer

Carsten Müller-Tidow, Sven Diederichs, Etmar Bulk, Thorsten Pohle, Björn Steffen, Joachim Schwäble, Sylvia Plewka, Michael Thomas, Ralf Metzger, Paul M. Schneider, Christian H. Brandts, Wolfgang E. Berdel, and Hubert Serve
Cancer Res 2005 65: 1778-1782. [Abstract] [Full Text] [PDF]  

E-cadherin Suppression Accelerates Squamous Cell Carcinoma Progression in Three-Dimensional, Human Tissue Constructs

Alexander Margulis, Weitian Zhang, Addy Alt-Holland, Howard C. Crawford, Norbert E. Fusenig, and Jonathan A. Garlick
Cancer Res 2005 65: 1783-1791. [Abstract] [Full Text] [PDF]  

p38 Regulates Cyclooxygenase-2 in Human Mammary Epithelial Cells and Is Activated in Premalignant Tissue

Mona L. Gauthier, Curtis R. Pickering, Caroline J. Miller, Colleen A. Fordyce, Karen L. Chew, Hal K. Berman, and Thea D. Tlsty
Cancer Res 2005 65: 1792-1799. [Abstract] [Full Text] [PDF]  

Epigenetic Up-regulation of C-C Chemokine Receptor 7 and C-X-C Chemokine Receptor 4 Expression in Melanoma Cells

Takuji Mori, Joseph Kim, Tomoki Yamano, Hiroya Takeuchi, Sharon Huang, Naoyuki Umetani, Kazuo Koyanagi, and Dave S.B. Hoon
Cancer Res 2005 65: 1800-1807. [Abstract] [Full Text] [PDF]  

Transitional Cell Hyperplasia and Carcinomas in Urinary Bladders of Transgenic Mice with Keratin 5 Promoter-Driven Cyclooxygenase-2 Overexpression

Russell D. Klein, Carolyn S. Van Pelt, Anita L. Sabichi, Jorge dela Cerda, Susan M. Fischer, Gerhard Fürstenberger, and Karin Müller-Decker
Cancer Res 2005 65: 1808-1813. [Abstract] [Full Text] [PDF]  

Iterative Microarray and RNA Interference–Based Interrogation of the Src-Induced Invasive Phenotype

Rosalyn B. Irby, Renae L. Malek, Greg Bloom, Jennifer Tsai, Noah Letwin, Bryan C. Frank, Kathleen Verratti, Timothy J. Yeatman, and Norman H. Lee
Cancer Res 2005 65: 1814-1821. [Abstract] [Full Text] [PDF]  

Prostaglandin E₂ Enhances Intestinal Adenoma Growth via Activation of the Ras-Mitogen-Activated Protein Kinase Cascade

Dingzhi Wang, F. Gregory Buchanan, Haibin Wang, Sudhansu K. Dey, and Raymond N. DuBois
Cancer Res 2005 65: 1822-1829. [Abstract] [Full Text] [PDF]  

Specificity of the Methylation-Suppressed A Isoform of Candidate Tumor Suppressor RASSF1 for Microtubule Hyperstabilization Is Determined by Cell Death Inducer C19ORF5

Leyuan Liu, Amy Vo, and Wallace L. McKeehan
Cancer Res 2005 65: 1830-1838. [Abstract] [Full Text] [PDF]  

The Growth Arrest Function of the Human Oncoprotein Mouse Double Minute-2 Is Disabled by Downstream Mutation in Cancer Cells

Ruizhe Zhou, Rebecca Frum, Sumitra Deb, and Swati P. Deb
Cancer Res 2005 65: 1839-1848. [Abstract] [Full Text] [PDF]  

Androgens Up-regulate the Insulin-like Growth Factor-I Receptor in Prostate Cancer Cells

Giuseppe Pandini, Rossana Mineo, Francesco Frasca, Charles T. Roberts, Jr., Marco Marcelli, Riccardo Vigneri, and Antonino Belfiore
Cancer Res 2005 65: 1849-1857. [Abstract] [Full Text] [PDF]  

ErbB2 Promotes Src Synthesis and Stability: Novel Mechanisms of Src Activation That Confer Breast Cancer Metastasis

Ming Tan, Ping Li, Kristine S. Klos, Jing Lu, Keng-Hsueh Lan, Yoichi Nagata, Dexing Fang, Tong Jing, and Dihua Yu
Cancer Res 2005 65: 1858-1867. [Abstract] [Full Text] [PDF]  

Induction of Claudin-4 by Nonsteroidal Anti-inflammatory Drugs and Its Contribution to Their Chemopreventive Effect

Shinji Mima, Shinji Tsutsumi, Hironori Ushijima, Miho Takeda, Ikue Fukuda, Kazumi Yokomizo, Keitarou Suzuki, Kuniaki Sano, Tohru Nakanishi, Wataru Tomisato, Tomofusa Tsuchiya, and Tohru Mizushima
Cancer Res 2005 65: 1868-1876. [Abstract] [Full Text] [PDF]  

Activin A Suppresses Neuroblastoma Xenograft Tumor Growth via Antimitotic and Antiangiogenic Mechanisms

Ekaterini Panopoulou, Carol Murphy, Heidi Rasmussen, Eleni Bagli, Einar K. Rofstad, and Theodore Fotsis
Cancer Res 2005 65: 1877-1886. [Abstract] [Full Text] [PDF]  

Functional Proteomic Screen Identifies a Modulating Role for CD44 in Death Receptor–Mediated Apoptosis

Robert S. Hauptschein, Kevin E. Sloan, Claudia Torella, Roya Moezzifard, Maryann Giel-Moloney, Carol Zehetmeier, Christine Unger, Leodevico L. Ilag, and Daniel G. Jay
Cancer Res 2005 65: 1887-1896. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets and Chemical Biology:

Imatinib Mesylate Inhibits Leydig Cell Tumor Growth: Evidence for In vitro and In vivo Activity

Sabrina Basciani, Marina Brama, Stefania Mariani, Gabriele De Luca, Mario Arizzi, Loredana Vesci, Claudio Pisano, Susanna Dolci, Giovanni Spera, and Lucio Gnessi
Cancer Res 2005 65: 1897-1903. [Abstract] [Full Text] [PDF] Supplementary Data  

Targeting ß-Transducin Repeat–Containing Protein E3 Ubiquitin Ligase Augments the Effects of Antitumor Drugs on Breast Cancer Cells

Weigang Tang, Ying Li, Duonan Yu, Andrei Thomas-Tikhonenko, Vladimir S. Spiegelman, and Serge Y. Fuchs
Cancer Res 2005 65: 1904-1908. [Abstract] [Full Text] [PDF]  

Real-time Detection of Gene Expression in Cancer Cells Using Molecular Beacon Imaging: New Strategies for Cancer Research

Xiang-Hong Peng, Ze-Hong Cao, Jin-Tang Xia, Grant W. Carlson, Melinda M. Lewis, William C. Wood, and Lily Yang
Cancer Res 2005 65: 1909-1917. [Abstract] [Full Text] [PDF]  

Activation of p53 by MDM2 Antagonists Can Protect Proliferating Cells from Mitotic Inhibitors

Daisy Carvajal, Christian Tovar, Hong Yang, Binh T. Vu, David C. Heimbrook, and Lyubomir T. Vassilev
Cancer Res 2005 65: 1918-1924. [Abstract] [Full Text] [PDF]  

Monoclonal Anti-idiotype Antibody 6G6.C4 Fused to GM-CSF Is Capable of Breaking Tolerance to Carcinoembryonic Antigen (CEA) in CEA–Transgenic Mice

Christian Schwegler, Alexandra Dorn-Beineke, Stefanie Nittka, Carol Stocking, and Michael Neumaier
Cancer Res 2005 65: 1925-1933. [Abstract] [Full Text] [PDF]  

The Excitatory Amino Acid Transporter-2 Induces Apoptosis and Decreases Glioma Growth In vitro and In vivo

John F. de Groot, Ta Jen Liu, Gregory Fuller, and W.K. Alfred Yung
Cancer Res 2005 65: 1934-1940. [Abstract] [Full Text] [PDF]  

Gene Therapy for Prostate Cancer by Controlling Adenovirus E1a and E4 Gene Expression with PSES Enhancer

Xiong Li, Yan-Ping Zhang, Hong-Sup Kim, Kyung-Hee Bae, Keith M. Stantz, Sang-Jin Lee, Chaeyong Jung, Juan A. Jiménez, Thomas A. Gardner, Meei-Huey Jeng, and Chinghai Kao
Cancer Res 2005 65: 1941-1951. [Abstract] [Full Text] [PDF]  

Cyclooxygenase-2 Inhibits Novel Ginseng Metabolite-Mediated Apoptosis

Hyung Woo Yim, Hyun-Soon Jong, Tai Young Kim, Hyun Ho Choi, Sang Gyun Kim, Sang Hyun Song, Juyong Kim, Seong-Gyu Ko, Jung Weon Lee, Tae-You Kim, and Yung-Jue Bang
Cancer Res 2005 65: 1952-1960. [Abstract] [Full Text] [PDF]  

Role of Glycogen Synthase Kinase 3ß in Rapamycin-Mediated Cell Cycle Regulation and Chemosensitivity

JinJiang Dong, Junying Peng, Haixia Zhang, Wallace H. Mondesire, Weiguo Jian, Gordon B. Mills, Mien-Chie Hung, and Funda Meric-Bernstam
Cancer Res 2005 65: 1961-1972. [Abstract] [Full Text] [PDF]  

Regulation of p38 Phosphorylation and Topoisomerase II Expression in the B-Cell Lymphoma Line Jiyoye by CD26/Dipeptidyl Peptidase IV Is Associated with Enhanced In vitro and In vivo Sensitivity to Doxorubicin

Toshiko Yamochi, Tadanori Yamochi, Ugur Aytac, Tsutomu Sato, Kazuya Sato, Kei Ohnuma, Kathryn S. McKee, Chikao Morimoto, and Nam H. Dang
Cancer Res 2005 65: 1973-1983. [Abstract] [Full Text] [PDF]  

Jasmonates: Novel Anticancer Agents Acting Directly and Selectively on Human Cancer Cell Mitochondria

Ronit Rotem, Alina Heyfets, Orit Fingrut, Dorit Blickstein, Mati Shaklai, and Eliezer Flescher
Cancer Res 2005 65: 1984-1993. [Abstract] [Full Text] [PDF]  

Inactivation of the Mitogen-Activated Protein Kinase Pathway as a Potential Target-Based Therapy in Ovarian Serous Tumors with KRAS or BRAF Mutations

Gudrun Pohl, Chung-Liang Ho, Robert J. Kurman, Robert Bristow, Tian-Li Wang, and Ie-Ming Shih
Cancer Res 2005 65: 1994-2000. [Abstract] [Full Text] [PDF]  

Immunology:

Bcl-2 Overexpression Enhances Tumor-Specific T-Cell Survival

Jehad Charo, Steven E. Finkelstein, Navrose Grewal, Nicholas P. Restifo, Paul F. Robbins, and Steven A. Rosenberg
Cancer Res 2005 65: 2001-2008. [Abstract] [Full Text] [PDF]  

Potent Selection of Antigen Loss Variants of B16 Melanoma following Inflammatory Killing of Melanocytes In vivo

Luis Sanchez-Perez, Timothy Kottke, Rosa Maria Diaz, Atique Ahmed, Jill Thompson, Heung Chong, Alan Melcher, Sheri Holmen, Gregory Daniels, and Richard G. Vile
Cancer Res 2005 65: 2009-2017. [Abstract] [Full Text] [PDF]  

CD4⁺ T Cell-Mediated Antigen-Specific Immunotherapy in a Mouse Model of Cervical Cancer

Dylan Daniel, Christopher Chiu, Enrico Giraudo, Masahiro Inoue, Lee A. Mizzen, N. Randall Chu, and Douglas Hanahan
Cancer Res 2005 65: 2018-2025. [Abstract] [Full Text] [PDF]  

Activated Marrow-Infiltrating Lymphocytes Effectively Target Plasma Cells and Their Clonogenic Precursors

Kimberly Noonan, William Matsui, Paolo Serafini, Rebecca Carbley, Gladys Tan, Jahan Khalili, Mark Bonyhadi, Hyam Levitsky, Katie Whartenby, and Ivan Borrello
Cancer Res 2005 65: 2026-2034. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Bax and Bak Are Required for Apoptosis Induction by Sulforaphane, a Cruciferous Vegetable–Derived Cancer Chemopreventive Agent

Sunga Choi and Shivendra V. Singh
Cancer Res 2005 65: 2035-2043. [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Efficacy of Trastuzumab

Charles L. Vogel, Josina C. Reddy, and Leonard M. Reyno
Cancer Res 2005 65: 2044. [Full Text] [PDF]  

Corrections:

Mitotic Checkpoint Control in Ovarian Cancer Cells

Cancer Res 2005 65: 2045. [Full Text] [PDF]  

MMP-2/MMP-9 Transport in Melanoma Cells

Cancer Res 2005 65: 2045. [Full Text] [PDF]  

Prognostic Value of Nuclear EGFR

Cancer Res 2005 65: 2045. [Full Text] [PDF]  

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