Reviews:

EphB/EphrinB Receptors and Wnt Signaling in Colorectal Cancer

Hans Clevers and Eduard Batlle
Cancer Res 2006 66: 2-5. [Abstract] [Full Text] [PDF]  

Cyclin B1 and Other Cyclins as Tumor Antigens in Immunosurveillance and Immunotherapy of Cancer

Ann Marie Egloff, Laura A. Vella, and Olivera J. Finn
Cancer Res 2006 66: 6-9. [Abstract] [Full Text] [PDF]  

Meeting Reports:

Mouse Models of Human Cancers Consortium Workshop on Nervous System Tumors

David H. Gutmann, Elizabeth A. Maher, and Terry Van Dyke
Cancer Res 2006 66: 10-13. [Abstract] [Full Text] [PDF]  

Pancreatic Cancer in Mice and Man: The Penn Workshop 2004

Ralph H. Hruban, Anil K. Rustgi, Teresa A. Brentnall, Margaret A. Tempero, Christopher V. Wright, and David A. Tuveson
Cancer Res 2006 66: 14-17. [Abstract] [Full Text] [PDF]  

Priority Reports:

Down-regulation of Hepatoma-Derived Growth Factor Inhibits Anchorage-Independent Growth and Invasion of Non–Small Cell Lung Cancer Cells

Jun Zhang, Hening Ren, Ping Yuan, Wenhua Lang, Li Zhang, and Li Mao
Cancer Res 2006 66: 18-23. [Abstract] [Full Text] [PDF]  

Rhabdomyosarcoma Lysis by T Cells Expressing a Human Autoantibody-Based Chimeric Receptor Targeting the Fetal Acetylcholine Receptor

Stefan Gattenlöhner, Alexander Marx, Birgit Markfort, Sibylle Pscherer, Silke Landmeier, Heribert Juergens, Hans-Konrad Müller-Hermelink, Ian Matthews, David Beeson, Angela Vincent, and Claudia Rossig
Cancer Res 2006 66: 24-28. [Abstract] [Full Text] [PDF]  

Breast Cancer DNA Methylation Profiles in Cancer Cells and Tumor Stroma: Association with HER-2/neu Status in Primary Breast Cancer

Heidi Fiegl, Simone Millinger, Georg Goebel, Elisabeth Müller-Holzner, Christian Marth, Peter W. Laird, and Martin Widschwendter
Cancer Res 2006 66: 29-33. [Abstract] [Full Text] [PDF] Supplementary Data  

Ligand-Directed Surface Profiling of Human Cancer Cells with Combinatorial Peptide Libraries

Mikhail G. Kolonin, Laura Bover, Jessica Sun, Amado J. Zurita, Kim-Anh Do, Johanna Lahdenranta, Marina Cardó-Vila, Ricardo J. Giordano, Diana E. Jaalouk, Michael G. Ozawa, Catherine A. Moya, Glauco R. Souza, Fernanda I. Staquicini, Akihiko Kunyiasu, Dominic A. Scudiero, Susan L. Holbeck, Edward A. Sausville, Wadih Arap, and Renata Pasqualini
Cancer Res 2006 66: 34-40. [Abstract] [Full Text] [PDF] Supplementary Data  

BRCA1 Mutation Analysis of 41 Human Breast Cancer Cell Lines Reveals Three New Deleterious Mutants

Fons Elstrodt, Antoinette Hollestelle, Jord H.A. Nagel, Michael Gorin, Marijke Wasielewski, Ans van den Ouweland, Sofia D. Merajver, Stephen P. Ethier, and Mieke Schutte
Cancer Res 2006 66: 41-45. [Abstract] [Full Text] [PDF] Supplementary Data  

Vascular Endothelial Growth Factor Receptor-1 Activation Mediates Epithelial to Mesenchymal Transition in Human Pancreatic Carcinoma Cells

Anthony D. Yang, E. Ramsay Camp, Fan Fan, Lanlan Shen, Michael J. Gray, Wenbiao Liu, Ray Somcio, Todd W. Bauer, Yan Wu, Daniel J. Hicklin, and Lee M. Ellis
Cancer Res 2006 66: 46-51. [Abstract] [Full Text] [PDF]  

POTE Paralogs Are Induced and Differentially Expressed in Many Cancers

Tapan K. Bera, Ashley Saint Fleur, Yoomi Lee, Andre Kydd, Yoonsoo Hahn, Nicholas C. Popescu, Drazen B. Zimonjic, Byungkook Lee, and Ira Pastan
Cancer Res 2006 66: 52-56. [Abstract] [Full Text] [PDF]  

Proinflammatory CD4⁺CD45RB^hi Lymphocytes Promote Mammary and Intestinal Carcinogenesis in Apc^Min/+ Mice

Varada P. Rao, Theofilos Poutahidis, Zhongming Ge, Prashant R. Nambiar, Bruce H. Horwitz, James G. Fox, and Susan E. Erdman
Cancer Res 2006 66: 57-61. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology and Genetics:

An Imprinted Locus Epistatically Influences Nstr1 and Nstr2 to Control Resistance to Nerve Sheath Tumors in a Neurofibromatosis Type 1 Mouse Model

Karlyne M. Reilly, Karl W. Broman, Roderick T. Bronson, Shirley Tsang, Dagan A. Loisel, Emily S. Christy, Zhonghe Sun, John Diehl, David J. Munroe, and Robert G. Tuskan
Cancer Res 2006 66: 62-68. [Abstract] [Full Text] [PDF] Supplementary Data  

Germ-Line Mutation of NKX3.1 Cosegregates with Hereditary Prostate Cancer and Alters the Homeodomain Structure and Function

S. Lilly Zheng, Jeong-ho Ju, Bao-li Chang, Elizabeth Ortner, Jielin Sun, Sarah D. Isaacs, Jishang Sun, Kathy E. Wiley, Wennuan Liu, Micheas Zemedkun, Patrick C. Walsh, James Ferretti, James Gruschus, William B. Isaacs, Edward P. Gelmann, and Jianfeng Xu
Cancer Res 2006 66: 69-77. [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of Potential Human Oncogenes by Mapping the Common Viral Integration Sites in Avian Nephroblastoma

Petr Pajer, Vladimír Pecenka, Jarmila Králová, Vít Karafiát, Dana Pruková, Zdena Zemanová, Roman Kodet, and Michal Dvorák
Cancer Res 2006 66: 78-86. [Abstract] [Full Text] [PDF] Supplementary Data  

Increased Susceptibility to UV-Induced Skin Carcinogenesis in Polymerase –deficient Mice

Qingcong Lin, Alan B. Clark, Scott D. McCulloch, Tao Yuan, Roderick T. Bronson, Thomas A. Kunkel, and Raju Kucherlapati
Cancer Res 2006 66: 87-94. [Abstract] [Full Text] [PDF]  

Pathology of Genetically Engineered Mouse Models of Pancreatic Exocrine Cancer: Consensus Report and Recommendations

Ralph H. Hruban, N. Volkan Adsay, Jorge Albores-Saavedra, Miriam R. Anver, Andrew V. Biankin, Gregory P. Boivin, Emma E. Furth, Toru Furukawa, Alison Klein, David S. Klimstra, Gunter Kloppel, Gregory Y. Lauwers, Daniel S. Longnecker, Jutta Luttges, Anirban Maitra, G. Johan A. Offerhaus, Lucía Pérez-Gallego, Mark Redston, and David A. Tuveson
Cancer Res 2006 66: 95-106. [Abstract] [Full Text] [PDF]  

Consistent Rearrangement of Chromosomal Band 6p21 with Generation of Fusion Genes JAZF1/PHF1 and EPC1/PHF1 in Endometrial Stromal Sarcoma

Francesca Micci, Ioannis Panagopoulos, Bodil Bjerkehagen, and Sverre Heim
Cancer Res 2006 66: 107-112. [Abstract] [Full Text] [PDF]  

Telomere Repeat Binding Factor 2 Interacts with Base Excision Repair Proteins and Stimulates DNA Synthesis by DNA Polymerase ß

Meltem Muftuoglu, Heng Kuan Wong, Syed Z. Imam, David M. Wilson, III, Vilhelm A. Bohr, and Patricia L. Opresko
Cancer Res 2006 66: 113-124. [Abstract] [Full Text] [PDF]  

Characterization of Common UGT1A8, UGT1A9, and UGT2B7 Variants with Different Capacities to Inactivate Mutagenic 4-Hydroxylated Metabolites of Estradiol and Estrone

Jean Thibaudeau, Johanie Lépine, Jelena Tojcic, Yannick Duguay, Georges Pelletier, Marie Plante, Jacques Brisson, Bernard Têtu, Simon Jacob, Louis Perusse, Alain Bélanger, and Chantal Guillemette
Cancer Res 2006 66: 125-133. [Abstract] [Full Text] [PDF]  

Loss of DNA Polymerase Causes Chromosomal Instability in Mammalian Cells

John P. Wittschieben, Shalini C. Reshmi, Susanne M. Gollin, and Richard D. Wood
Cancer Res 2006 66: 134-142. [Abstract] [Full Text] [PDF]  

Thioredoxin-1 Modulates Transcription of Cyclooxygenase-2 via Hypoxia-Inducible Factor-1 in Non–Small Cell Lung Cancer

Ildiko Csiki, Kiyoshi Yanagisawa, Nobuhiro Haruki, Sorena Nadaf, Jason D. Morrow, David H. Johnson, and David P. Carbone
Cancer Res 2006 66: 143-150. [Abstract] [Full Text] [PDF] Supplementary Data  

Physical and Functional Interaction between hMSH5 and c-Abl

Wei Yi, Tai-Hsien Lee, Joshua D. Tompkins, Fengxue Zhu, Xiling Wu, and Chengtao Her
Cancer Res 2006 66: 151-158. [Abstract] [Full Text] [PDF]  

Cell, Tumor and Stem Cell Biology:

Distinct Transcription Profiles of Primary and Secondary Glioblastoma Subgroups

Cho-Lea Tso, William A. Freije, Allen Day, Zugen Chen, Barry Merriman, Ally Perlina, Yohan Lee, Ederlyn Q. Dia, Koji Yoshimoto, Paul S. Mischel, Linda M. Liau, Timothy F. Cloughesy, and Stanley F. Nelson
Cancer Res 2006 66: 159-167. [Abstract] [Full Text] [PDF] Supplementary Data  

The Kaposi's Sarcoma–Associated Herpesvirus G Protein–Coupled Receptor as a Therapeutic Target for the Treatment of Kaposi's Sarcoma

Silvia Montaner, Akrit Sodhi, Amanda K. Ramsdell, Daniel Martin, Jiadi Hu, Earl T. Sawai, and J. Silvio Gutkind
Cancer Res 2006 66: 168-174. [Abstract] [Full Text] [PDF]  

Interleukin-17 Receptor-Like Gene Is a Novel Antiapoptotic Gene Highly Expressed in Androgen-Independent Prostate Cancer

Zongbing You, Xu-Bao Shi, Grayson DuRaine, Dominik Haudenschild, Clifford G. Tepper, Su Hao Lo, Regina Gandour-Edwards, Ralph W. de Vere White, and A. Hari Reddi
Cancer Res 2006 66: 175-183. [Abstract] [Full Text] [PDF] Supplementary Data  

Bortezomib Mediates Antiangiogenesis in Multiple Myeloma via Direct and Indirect Effects on Endothelial Cells

Aldo Maria Roccaro, Teru Hideshima, Noopur Raje, Shaji Kumar, Kenji Ishitsuka, Hiroshi Yasui, Norihiko Shiraishi, Domenico Ribatti, Beatrice Nico, Angelo Vacca, Franco Dammacco, Paul Gerard Richardson, and Kenneth Carl Anderson
Cancer Res 2006 66: 184-191. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor Overexpression Results in Increased Tumor Cell Motility In vivo Coordinately with Enhanced Intravasation and Metastasis

Chengsen Xue, Jeffrey Wyckoff, Fubo Liang, Mazen Sidani, Stefania Violini, Kun-Lin Tsai, Zhong-Yin Zhang, Erik Sahai, John Condeelis, and Jeffrey E. Segall
Cancer Res 2006 66: 192-197. [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data  

Molecular Fingerprinting and Autocrine Growth Regulation of Endothelial Cells in a Murine Model of Hepatocellular Carcinoma

Eduard Ryschich, Paulius Lizdenis, Carina Ittrich, Axel Benner, Simone Stahl, Alf Hamann, Jan Schmidt, Percy Knolle, Bernd Arnold, Günter J. Hämmerling, and Ruth Ganss
Cancer Res 2006 66: 198-211. [Abstract] [Full Text] [PDF]  

Paclitaxel-Induced Nuclear Translocation of FOXO3a in Breast Cancer Cells Is Mediated by c-Jun NH₂-Terminal Kinase and Akt

Andrew Sunters, Patricia A. Madureira, Karen M. Pomeranz, Muriel Aubert, Jan J. Brosens, Simon J. Cook, Boudewijn M.T. Burgering, R. Charles Coombes, and Eric W.-F. Lam
Cancer Res 2006 66: 212-220. [Abstract] [Full Text] [PDF]  

Antagonism of Sphingosine-1-Phosphate Receptors by FTY720 Inhibits Angiogenesis and Tumor Vascularization

Kenneth LaMontagne, Amanda Littlewood-Evans, Christian Schnell, Terence O'Reilly, Lorenza Wyder, Teresa Sanchez, Beatrice Probst, Jeannene Butler, Alexander Wood, Gene Liau, Eric Billy, Andreas Theuer, Timothy Hla, and Jeanette Wood
Cancer Res 2006 66: 221-231. [Abstract] [Full Text] [PDF]  

Topological and Functional Discovery in a Gene Coexpression Meta-Network of Gastric Cancer

Amit Aggarwal, Dong Li Guo, Yujin Hoshida, Siu Tsan Yuen, Kent-Man Chu, Samuel So, Alex Boussioutas, Xin Chen, David Bowtell, Hiroyuki Aburatani, Suet Yi Leung, and Patrick Tan
Cancer Res 2006 66: 232-241. [Abstract] [Full Text] [PDF] Supplementary Data  

Mist1-Kras^G12D Knock-In Mice Develop Mixed Differentiation Metastatic Exocrine Pancreatic Carcinoma and Hepatocellular Carcinoma

David A. Tuveson, Liqin Zhu, Aarthi Gopinathan, Nicholas A. Willis, Leili Kachatrian, Rebecca Grochow, Christopher L. Pin, Natalia Y. Mitin, Elizabeth J. Taparowsky, Phyllis A. Gimotty, Ralph H. Hruban, Tyler Jacks, and Stephen F. Konieczny
Cancer Res 2006 66: 242-247. [Abstract] [Full Text] [PDF] Supplementary Data  

Activation of Vav/Rho GTPase Signaling by CXCL12 Controls Membrane-Type Matrix Metalloproteinase–Dependent Melanoma Cell Invasion

Rubén A. Bartolomé, Isabel Molina-Ortiz, Rafael Samaniego, Paloma Sánchez-Mateos, Xosé R. Bustelo, and Joaquin Teixidó
Cancer Res 2006 66: 248-258. [Abstract] [Full Text] [PDF] Supplementary Data  

Matrix Metalloproteinase-9 from Bone Marrow–Derived Cells Contributes to Survival but not Growth of Tumor Cells in the Lung Microenvironment

Heath B. Acuff, Kathy J. Carter, Barbara Fingleton, D. Lee Gorden, and Lynn M. Matrisian
Cancer Res 2006 66: 259-266. [Abstract] [Full Text] [PDF]  

Aneuploidy-Dependent Massive Deregulation of the Cellular Transcriptome and Apparent Divergence of the Wnt/ß-catenin Signaling Pathway in Human Rectal Carcinomas

Marian Grade, B. Michael Ghadimi, Sudhir Varma, Richard Simon, Danny Wangsa, Linda Barenboim-Stapleton, Torsten Liersch, Heinz Becker, Thomas Ried, and Michael J. Difilippantonio
Cancer Res 2006 66: 267-282. [Abstract] [Full Text] [PDF] Supplementary Data  

Somatic Mutations Lead to an Oncogenic Deletion of Met in Lung Cancer

Monica Kong-Beltran, Somasekar Seshagiri, Jiping Zha, Wenjing Zhu, Kaumudi Bhawe, Nerissa Mendoza, Thomas Holcomb, Kanan Pujara, Jeremy Stinson, Ling Fu, Christophe Severin, Linda Rangell, Ralph Schwall, Lukas Amler, Dineli Wickramasinghe, and Robert Yauch
Cancer Res 2006 66: 283-289. [Abstract] [Full Text] [PDF] Supplementary Data  

Genomic and Expression Profiling of Human Spermatocytic Seminomas: Primary Spermatocyte as Tumorigenic Precursor and DMRT1 as Candidate Chromosome 9 Gene

Leendert H.J. Looijenga, Remko Hersmus, Ad J.M. Gillis, Rolph Pfundt, Hans J. Stoop, Ruud J.H.L.M. van Gurp, Joris Veltman, H. Berna Beverloo, Ellen van Drunen, Ad Geurts van Kessel, Renee Reijo Pera, Dominik T. Schneider, Brenda Summersgill, Janet Shipley, Alan McIntyre, Peter van der Spek, Eric Schoenmakers, and J. Wolter Oosterhuis
Cancer Res 2006 66: 290-302. [Abstract] [Full Text] [PDF]  

Dual-Color Imaging of Nuclear-Cytoplasmic Dynamics, Viability, and Proliferation of Cancer Cells in the Portal Vein Area

Kazuhiko Tsuji, Kensuke Yamauchi, Meng Yang, Ping Jiang, Michael Bouvet, Hitoshi Endo, Yoshikatsu Kanai, Koji Yamashita, Abdool R. Moossa, and Robert M. Hoffman
Cancer Res 2006 66: 303-306. [Abstract] [Full Text] [PDF]  

Protease-Activated Receptor-2 Is Essential for Factor VIIa and Xa–Induced Signaling, Migration, and Invasion of Breast Cancer Cells

Dionne R. Morris, Yu Ding, Tiffany K. Ricks, Anuradha Gullapalli, Breann L. Wolfe, and JoAnn Trejo
Cancer Res 2006 66: 307-314. [Abstract] [Full Text] [PDF]  

Fibronectin Stimulates Non–Small Cell Lung Carcinoma Cell Growth through Activation of Akt/Mammalian Target of Rapamycin/S6 Kinase and Inactivation of LKB1/AMP-Activated Protein Kinase Signal Pathways

ShouWei Han, Fadlo R. Khuri, and Jesse Roman
Cancer Res 2006 66: 315-323. [Abstract] [Full Text] [PDF]  

The Role of 17ß-Hydroxysteroid Dehydrogenases in Modulating the Activity of 2-Methoxyestradiol in Breast Cancer Cells

Simon P. Newman, Christopher R. Ireson, Helena J. Tutill, Joanna M. Day, Michael F.C. Parsons, Mathew P. Leese, Barry V.L. Potter, Michael J. Reed, and Atul Purohit
Cancer Res 2006 66: 324-330. [Abstract] [Full Text] [PDF]  

ß₁ Integrins Modulate Cell Adhesion by Regulating Insulin-Like Growth Factor-II Levels in the Microenvironment

Hira Lal Goel, Loredana Moro, Michael King, Natalia Teider, Michael Centrella, Thomas L. McCarthy, Marina Holgado-Madruga, Albert J. Wong, Ersilia Marra, and Lucia R. Languino
Cancer Res 2006 66: 331-342. [Abstract] [Full Text] [PDF]  

Hematopoietic Stem Cells Are Not the Direct Target of Spontaneous Leukemic Transformation in p18^INK4C-Null Reconstituted Mice

Youzhong Yuan, Hui Yu, Matthew J. Boyer, Xianmin Song, Shaonan Cao, Hongmei Shen, and Tao Cheng
Cancer Res 2006 66: 343-351. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Functional Analysis of c-Met/Hepatocyte Growth Factor Pathway in Malignant Pleural Mesothelioma

Ramasamy Jagadeeswaran, Patrick C. Ma, Tanguy Y. Seiwert, Sujatha Jagadeeswaran, Osvaldo Zumba, Vidya Nallasura, Salman Ahmed, Rosangela Filiberti, Michela Paganuzzi, Riccardo Puntoni, Robert A. Kratzke, Gavin J. Gordon, David J. Sugarbaker, Raphael Bueno, Varalakshmi Janamanchi, Vytas P. Bindokas, Hedy L. Kindler, and Ravi Salgia
Cancer Res 2006 66: 352-361. [Abstract] [Full Text] [PDF]  

In vitro and In vivo Antitumor Effects of the Dual Insulin-Like Growth Factor-I/Insulin Receptor Inhibitor, BMS-554417

Paul Haluska, Joan M. Carboni, David A. Loegering, Francis Y. Lee, Mark Wittman, Mark G. Saulnier, David B. Frennesson, Kimberly R. Kalli, Cheryl A. Conover, Ricardo M. Attar, Scott H. Kaufmann, Marco Gottardis, and Charles Erlichman
Cancer Res 2006 66: 362-371. [Abstract] [Full Text] [PDF]  

In vivo Imaging of Adenovirus Transduction and Enhanced Therapeutic Efficacy of Combination Therapy with Conditionally Replicating Adenovirus and Adenovirus-p27

Choon-Taek Lee, Yoon-Jin Lee, Sung-Youn Kwon, Jaeho Lee, Kwang Il Kim, Kyung-Ho Park, Joo Hyun Kang, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, June-Key Chung, Young-Soo Shim, David T. Curiel, and David P. Carbone
Cancer Res 2006 66: 372-377. [Abstract] [Full Text] [PDF]  

Endostatin-Cytosine Deaminase Fusion Protein Suppresses Tumor Growth by Targeting Neovascular Endothelial Cells

Fu Ou-Yang, Keng-Li Lan, Chun-Te Chen, Jaw-Ching Liu, Chu-Li Weng, Chao-Kai Chou, Xiaoming Xie, Jen-Yu Hung, Yongkun Wei, Gabriel N. Hortobagyi, and Mien-Chie Hung
Cancer Res 2006 66: 378-384. [Abstract] [Full Text] [PDF]  

Inhibition of DNA Methyltransferase Activity Prevents Tumorigenesis in a Mouse Model of Prostate Cancer

Michael T. McCabe, Jonathan A. Low, Stephanie Daignault, Michael J. Imperiale, Kirk J. Wojno, and Mark L. Day
Cancer Res 2006 66: 385-392. [Abstract] [Full Text] [PDF] Supplementary Data  

Preferential Dependence of Breast Cancer Cells versus Normal Cells on Integrin-Linked Kinase for Protein Kinase B/Akt Activation and Cell Survival

Armelle A. Troussard, Paul C. McDonald, Elizabeth D. Wederell, Nasrin M. Mawji, Nolan R. Filipenko, Karen A. Gelmon, Jill E. Kucab, Sandra E. Dunn, Joanne T. Emerman, Marcel B. Bally, and Shoukat Dedhar
Cancer Res 2006 66: 393-403. [Abstract] [Full Text] [PDF]  

Blockade of EGFR and ErbB2 by the Novel Dual EGFR and ErbB2 Tyrosine Kinase Inhibitor GW572016 Sensitizes Human Colon Carcinoma GEO Cells to Apoptosis

Yunfei Zhou, Song Li, Yi P. Hu, Jing Wang, Jennie Hauser, Alexis N. Conway, Michelle A. Vinci, Lisa Humphrey, Elizabeth Zborowska, James K.V. Willson, and Michael G. Brattain
Cancer Res 2006 66: 404-411. [Abstract] [Full Text] [PDF]  

Inhibition of Bladder Tumor Growth by 1,1-Bis(3'-Indolyl)-1-(p-Substitutedphenyl)Methanes: A New Class of Peroxisome Proliferator-Activated Receptor Agonists

Wassim Kassouf, Sudhakar Chintharlapalli, Maen Abdelrahim, Gina Nelkin, Stephen Safe, and Ashish M. Kamat
Cancer Res 2006 66: 412-418. [Abstract] [Full Text] [PDF]  

A New IB Kinase ß Inhibitor Prevents Human Breast Cancer Progression through Negative Regulation of Cell Cycle Transition

Akane Tanaka, Susumu Muto, Masayo Konno, Akiko Itai, and Hiroshi Matsuda
Cancer Res 2006 66: 419-426. [Abstract] [Full Text] [PDF]  

Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of the Choline Kinase Inhibitor MN58b in Human Carcinoma Models

Nada M.S. Al-Saffar, Helen Troy, Ana Ramírez de Molina, Laura E. Jackson, Basetti Madhu, John R. Griffiths, Martin O. Leach, Paul Workman, Juan C. Lacal, Ian R. Judson, and Yuen-Li Chung
Cancer Res 2006 66: 427-434. [Abstract] [Full Text] [PDF]  

AZ703, an Imidazo[1,2-a]Pyridine Inhibitor of Cyclin-Dependent Kinases 1 and 2, Induces E2F-1-Dependent Apoptosis Enhanced by Depletion of Cyclin-Dependent Kinase 9

Dongpo Cai, Kate F. Byth, and Geoffrey I. Shapiro
Cancer Res 2006 66: 435-444. [Abstract] [Full Text] [PDF]  

Reversal of P-glycoprotein–Mediated Multidrug Resistance in Cancer Cells by the c-Jun NH₂-Terminal Kinase

Jun Zhou, Min Liu, Ritu Aneja, Ramesh Chandra, Hermann Lage, and Harish C. Joshi
Cancer Res 2006 66: 445-452. [Abstract] [Full Text] [PDF]  

Potent Antiandrogen and Androgen Receptor Activities of an Angelica gigas–Containing Herbal Formulation: Identification of Decursin as a Novel and Active Compound with Implications for Prevention and Treatment of Prostate Cancer

Cheng Jiang, Hyo-Jeong Lee, Guang-xun Li, Junming Guo, Barbara Malewicz, Yan Zhao, Eun-Ok Lee, Hyo-Jung Lee, Jae-Ho Lee, Min-Seok Kim, Sung-Hoon Kim, and Junxuan Lu
Cancer Res 2006 66: 453-463. [Abstract] [Full Text] [PDF] Supplementary Data  

Doxazosin Induces Apoptosis of Benign and Malignant Prostate Cells via a Death Receptor–Mediated Pathway

Jason B. Garrison and Natasha Kyprianou
Cancer Res 2006 66: 464-472. [Abstract] [Full Text] [PDF] Supplementary Data  

Dasatinib (BMS-354825), a Dual SRC/ABL Kinase Inhibitor, Inhibits the Kinase Activity of Wild-Type, Juxtamembrane, and Activation Loop Mutant KIT Isoforms Associated with Human Malignancies

Marcus M. Schittenhelm, Sharon Shiraga, Arin Schroeder, Amie S. Corbin, Diana Griffith, Francis Y. Lee, Carsten Bokemeyer, Michael W.N. Deininger, Brian J. Druker, and Michael C. Heinrich
Cancer Res 2006 66: 473-481. [Abstract] [Full Text] [PDF]  

Activation of RhoB by Hypoxia Controls Hypoxia-Inducible Factor-1 Stabilization through Glycogen Synthase Kinase-3 in U87 Glioblastoma Cells

Nicolas Skuli, Sylvie Monferran, Caroline Delmas, Isabelle Lajoie-Mazenc, Gilles Favre, Christine Toulas, and Elizabeth Cohen-Jonathan-Moyal
Cancer Res 2006 66: 482-489. [Abstract] [Full Text] [PDF]  

The Interaction between Two Radiosensitizers: 5-Iododeoxyuridine and Caffeine

Yuji Seo, Tao Yan, Jane E. Schupp, Kazuhiko Yamane, Tomas Radivoyevitch, and Timothy J. Kinsella
Cancer Res 2006 66: 490-498. [Abstract] [Full Text] [PDF]  

Histone Deacetylase Inhibitors Modulate the Sensitivity of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Resistant Bladder Tumor Cells

James K. Earel, Jr., Rebecca L. VanOosten, and Thomas S. Griffith
Cancer Res 2006 66: 499-507. [Abstract] [Full Text] [PDF]  

Immunology:

Genetically Induced Pancreatic Adenocarcinoma Is Highly Immunogenic and Causes Spontaneous Tumor-Specific Immune Responses

Annette I. Garbe, Benjamin Vermeer, Jaba Gamrekelashvili, Reinhard von Wasielewski, Florian R. Greten, Astrid M. Westendorf, Jan Buer, Roland M. Schmid, Michael P. Manns, Firouzeh Korangy, and Tim F. Greten
Cancer Res 2006 66: 508-516. [Abstract] [Full Text] [PDF] Supplementary Data  

Natural Killer Cells Produce T Cell–Recruiting Chemokines in Response to Antibody-Coated Tumor Cells

Julie M. Roda, Robin Parihar, Cynthia Magro, Gerard J. Nuovo, Susheela Tridandapani, and William E. Carson, III
Cancer Res 2006 66: 517-526. [Abstract] [Full Text] [PDF]  

Subversion of Protein Kinase C Signaling in Hematopoietic Progenitor Cells Results in the Generation of a B-Cell Chronic Lymphocytic Leukemia–Like Population In vivo

Rinako Nakagawa, Jae Won Soh, and Alison M. Michie
Cancer Res 2006 66: 527-534. [Abstract] [Full Text] [PDF]  

Endocrinology:

Expression of the Steroid and Xenobiotic Receptor and Its Possible Target Gene, Organic Anion Transporting Polypeptide-A, in Human Breast Carcinoma

Yasuhiro Miki, Takashi Suzuki, Kunio Kitada, Nami Yabuki, Rie Shibuya, Takuya Moriya, Takanori Ishida, Noriaki Ohuchi, Bruce Blumberg, and Hironobu Sasano
Cancer Res 2006 66: 535-542. [Abstract] [Full Text] [PDF]  

Interplay between Two Hormone-Independent Activation Domains in the Androgen Receptor

Leen Callewaert, Nora Van Tilborgh, and Frank Claessens
Cancer Res 2006 66: 543-553. [Abstract] [Full Text] [PDF]  

IFN-ß Is a Highly Potent Inhibitor of Gastroenteropancreatic Neuroendocrine Tumor Cell Growth In vitro

Giovanni Vitale, Wouter W. de Herder, Peter M. van Koetsveld, Marlijn Waaijers, Wenda Schoordijk, Ed Croze, Annamaria Colao, Steven W.J. Lamberts, and Leo J. Hofland
Cancer Res 2006 66: 554-562. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Identification of the NKG2D Haplotypes Associated with Natural Cytotoxic Activity of Peripheral Blood Lymphocytes and Cancer Immunosurveillance

Tomonori Hayashi, Kazue Imai, Yukari Morishita, Ikue Hayashi, Yoichiro Kusunoki, and Kei Nakachi
Cancer Res 2006 66: 563-570. [Abstract] [Full Text] [PDF]  

Tumor-Derived Interleukin-4 Reduces Tumor Clearance and Deviates the Cytokine and Granzyme Profile of Tumor-Induced CD8⁺ T Cells

Stuart Olver, Penny Groves, Kathy Buttigieg, Edward S. Morris, Michelle L. Janas, Anne Kelso, and Norbert Kienzle
Cancer Res 2006 66: 571-580. [Abstract] [Full Text] [PDF]  

Black Raspberry Extracts Inhibit Benzo(a)Pyrene Diol-Epoxide–Induced Activator Protein 1 Activation and VEGF Transcription by Targeting the Phosphotidylinositol 3-Kinase/Akt Pathway

Chuanshu Huang, Jingxia Li, Lun Song, Dongyun Zhang, Qiangsong Tong, Min Ding, Linda Bowman, Robeena Aziz, and Gary D. Stoner
Cancer Res 2006 66: 581-587. [Abstract] [Full Text] [PDF]  

Influence of Insulin-like Growth Factors on the Strength of the Relation of Vitamin D and Calcium Intakes to Mammographic Breast Density

Caroline Diorio, Sylvie Bérubé, Celia Byrne, Benoît Mâsse, Nicole Hébert-Croteau, Martin Yaffe, Gary Coté, Michael Pollak, and Jacques Brisson
Cancer Res 2006 66: 588-597. [Abstract] [Full Text] [PDF]  

Letter to the Editor:

The Magnetic Resonance Imaging Contrast Agent Mangafodipir Exerts Antitumor Activity via a Previously Described Superoxide Dismutase Mimetic Activity

Jan Olof G. Karlsson, Heidi Brurok, Rob Towart, Per Jynge, and Frederic Batteux
Cancer Res 2006 66: 598. [Full Text] [PDF]  

Correction:

Brca2 Deficiency Sensitizes Cells to PARP Inhibition

Cancer Res 2006 66: 599. [Full Text] [PDF]  

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