Reviews:

Tumor-Driven Evolution of Immunosuppressive Networks during Malignant Progression

Ryungsa Kim, Manabu Emi, Kazuaki Tanabe, and Koji Arihiro
Cancer Res 2006 66: 5527-5536. [Abstract] [Full Text] [PDF]  

A Systems Approach to Model Metastatic Progression

Barry S. Taylor, Sooryanarayana Varambally, and Arul M. Chinnaiyan
Cancer Res 2006 66: 5537-5539. [Abstract] [Full Text] [PDF]  

Position Paper:

Serum Proteomic Profiling by Matrix-Assisted Laser Desorption-Ionization Time-of-Flight Mass Spectrometry for Cancer Diagnosis: Next Steps

Eleftherios P. Diamandis
Cancer Res 2006 66: 5540-5541. [Full Text] [PDF]  

Priority Reports:

Dasatinib (BMS-354825) Selectively Induces Apoptosis in Lung Cancer Cells Dependent on Epidermal Growth Factor Receptor Signaling for Survival

Lanxi Song, Mark Morris, Tapan Bagui, Francis Y. Lee, Richard Jove, and Eric B. Haura
Cancer Res 2006 66: 5542-5548. [Abstract] [Full Text] [PDF] Supplementary Data  

Antiangiogenic Potential of the Mammalian Target of Rapamycin Inhibitor Temsirolimus

Donatella Del Bufalo, Ludovica Ciuffreda, Daniela Trisciuoglio, Marianna Desideri, Francesco Cognetti, Gabriella Zupi, and Michele Milella
Cancer Res 2006 66: 5549-5554. [Abstract] [Full Text] [PDF]  

Human Papillomavirus Type 16 E7 Up-regulates AKT Activity through the Retinoblastoma Protein

Craig W. Menges, Laurel A. Baglia, Randi Lapoint, and Dennis J. McCance
Cancer Res 2006 66: 5555-5559. [Abstract] [Full Text] [PDF]  

Targeted Deletion of MKK4 in Cancer Cells: A Detrimental Phenotype Manifests as Decreased Experimental Metastasis and Suggests a Counterweight to the Evolution of Tumor-Suppressor Loss

Steven C. Cunningham, Eike Gallmeier, Tomas Hucl, David A. Dezentje, Eric S. Calhoun, Geppino Falco, Kotb Abdelmohsen, Myriam Gorospe, and Scott E. Kern
Cancer Res 2006 66: 5560-5564. [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

Mnt-Deficient Mammary Glands Exhibit Impaired Involution and Tumors with Characteristics of Myc Overexpression

Kazuhito Toyo-oka, Timothy J. Bowen, Shinji Hirotsune, Zirong Li, Sonia Jain, Sara Ota, Laure Escoubet Lozach, Ivan Garcia Bassett, Jean Lozach, Michael G. Rosenfeld, Christopher K. Glass, Robert Eisenman, Bing Ren, Peter Hurlin, and Anthony Wynshaw-Boris
Cancer Res 2006 66: 5565-5573. [Abstract] [Full Text] [PDF] Supplementary Data  

Oncoprotein EWS-FLI1 Activity Is Enhanced by RNA Helicase A

Jeffrey A. Toretsky, Verda Erkizan, Amy Levenson, Ogan D. Abaan, Jeffrey D. Parvin, Timothy P. Cripe, Anna M. Rice, Sean Bong Lee, and Aykut Üren
Cancer Res 2006 66: 5574-5581. [Abstract] [Full Text] [PDF]  

Dominant-Negative Histone H3 Lysine 27 Mutant Derepresses Silenced Tumor Suppressor Genes and Reverses the Drug-Resistant Phenotype in Cancer Cells

Phillip H. Abbosh, John S. Montgomery, Jason A. Starkey, Milos Novotny, Eleanor G. Zuhowski, Merrill J. Egorin, Annie P. Moseman, Adam Golas, Kate M. Brannon, Curtis Balch, Tim H.M. Huang, and Kenneth P. Nephew
Cancer Res 2006 66: 5582-5591. [Abstract] [Full Text] [PDF] Supplementary Data  

D4-GDI, a Rho GTPase Regulator, Promotes Breast Cancer Cell Invasiveness

Yaqin Zhang and Baolin Zhang
Cancer Res 2006 66: 5592-5598. [Abstract] [Full Text] [PDF]  

SSeCKS Metastasis-Suppressing Activity in MatLyLu Prostate Cancer Cells Correlates with Vascular Endothelial Growth Factor Inhibition

Bing Su, Qiao Zheng, Mary M. Vaughan, Yahao Bu, and Irwin H. Gelman
Cancer Res 2006 66: 5599-5607. [Abstract] [Full Text] [PDF]  

Conditional Deletion of c-myc Does Not Impair Liver Regeneration

Feng Li, Yan Xiang, James Potter, Ramani Dinavahi, Chi V. Dang, and Linda A. Lee
Cancer Res 2006 66: 5608-5612. [Abstract] [Full Text] [PDF]  

Regression of Latent Endometrial Precancers by Progestin Infiltrated Intrauterine Device

Anne Ørbo, Cecil E. Rise, and George L. Mutter
Cancer Res 2006 66: 5613-5617. [Abstract] [Full Text] [PDF]  

AKT Activation in Human Glioblastomas Enhances Proliferation via TSC2 and S6 Kinase Signaling

Markus J. Riemenschneider, Rebecca A. Betensky, Saskia M. Pasedag, and David N. Louis
Cancer Res 2006 66: 5618-5623. [Abstract] [Full Text] [PDF]  

Developmental Exposure to Estradiol and Bisphenol A Increases Susceptibility to Prostate Carcinogenesis and Epigenetically Regulates Phosphodiesterase Type 4 Variant 4

Shuk-Mei Ho, Wan-Yee Tang, Jessica Belmonte de Frausto, and Gail S. Prins
Cancer Res 2006 66: 5624-5632. [Abstract] [Full Text] [PDF] Supplementary Data  

Mechanistic Investigation and Implications of Photodynamic Therapy Induction of Vascular Endothelial Growth Factor in Prostate Cancer

Nicolas Solban, Selbo K. Pål, Sinha K. Alok, Chang K. Sung, and Tayyaba Hasan
Cancer Res 2006 66: 5633-5640. [Abstract] [Full Text] [PDF]  

Role of ETS Transcription Factors in the Hypoxia-Inducible Factor-2 Target Gene Selection

Olga Aprelikova, Matthew Wood, Sean Tackett, Gadisetti V.R. Chandramouli, and J. Carl Barrett
Cancer Res 2006 66: 5641-5647. [Abstract] [Full Text] [PDF] Supplementary Data  

Activation of Abl Tyrosine Kinases Promotes Invasion of Aggressive Breast Cancer Cells

Divyamani Srinivasan and Rina Plattner
Cancer Res 2006 66: 5648-5655. [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

Epidermal Growth Factor Receptor Signaling Is Up-regulated in Human Colonic Aberrant Crypt Foci

Greg Cohen, Reba Mustafi, Anusara Chumsangsri, Nathaniel Little, Jeff Nathanson, Sonia Cerda, Sujatha Jagadeeswaran, Urszula Dougherty, Loren Joseph, John Hart, Lisa Yerian, Maria Tretiakova, Weihua Yuan, Piotr Obara, Sharad Khare, Frank A. Sinicrope, Alessandro Fichera, Gerry R. Boss, Robert Carroll, and Marc Bissonnette
Cancer Res 2006 66: 5656-5664. [Abstract] [Full Text] [PDF] Supplementary Data  

Deletion of the COOH-Terminal Domain of CXC Chemokine Receptor 4 Leads to the Down-regulation of Cell-to-Cell Contact, Enhanced Motility and Proliferation in Breast Carcinoma Cells

Yukiko Ueda, Nicole F. Neel, Evemie Schutyser, Dayanidhi Raman, and Ann Richmond
Cancer Res 2006 66: 5665-5675. [Abstract] [Full Text] [PDF] Supplementary Data  

A Critical Role for the Inflammatory Response in a Mouse Model of Preneoplastic Progression

Kathryn L. Schwertfeger, Wa Xian, Alan M. Kaplan, Sandra H. Burnett, Donald A. Cohen, and Jeffrey M. Rosen
Cancer Res 2006 66: 5676-5685. [Abstract] [Full Text] [PDF] Supplementary Data  

Dissociation of Angiogenesis and Tumorigenesis in Follistatin- and Activin-Expressing Tumors

Jelena Krneta, Jens Kroll, Frauke Alves, Claudia Prahst, Farahnaz Sananbenesi, Christian Dullin, Sarah Kimmina, David J. Phillips, and Hellmut G. Augustin
Cancer Res 2006 66: 5686-5695. [Abstract] [Full Text] [PDF] Supplementary Data  

Lymphatic Zip Codes in Premalignant Lesions and Tumors

Lianglin Zhang, Enrico Giraudo, Jason A. Hoffman, Douglas Hanahan, and Erkki Ruoslahti
Cancer Res 2006 66: 5696-5706. [Abstract] [Full Text] [PDF] Supplementary Data  

Mutation of Tumor Suppressor Gene Men1 Acutely Enhances Proliferation of Pancreatic Islet Cells

Robert W. Schnepp, Ya-Xiong Chen, Haoren Wang, Tim Cash, Albert Silva, J. Alan Diehl, Eric Brown, and Xianxin Hua
Cancer Res 2006 66: 5707-5715. [Abstract] [Full Text] [PDF]  

Specific Recruitment of CC Chemokine Receptor 4–Positive Regulatory T Cells in Hodgkin Lymphoma Fosters Immune Privilege

Takashi Ishida, Toshihiko Ishii, Atsushi Inagaki, Hiroki Yano, Hirokazu Komatsu, Shinsuke Iida, Hiroshi Inagaki, and Ryuzo Ueda
Cancer Res 2006 66: 5716-5722. [Abstract] [Full Text] [PDF]  

Androgen-Dependent Regulation of Her-2/neu in Prostate Cancer Cells

Raanan Berger, Douglas I. Lin, Maria Nieto, Ewa Sicinska, Levi A. Garraway, Heiner Adams, Sabina Signoretti, William C. Hahn, and Massimo Loda
Cancer Res 2006 66: 5723-5728. [Abstract] [Full Text] [PDF]  

COOH-Terminal Src Kinase–Mediated c-Jun Phosphorylation Promotes c-Jun Degradation and Inhibits Cell Transformation

Feng Zhu, Bu Young Choi, Wei-Ya Ma, Zhongliang Zhao, Yiguo Zhang, Yong Yeon Cho, Hong Seok Choi, Akira Imamoto, Ann M. Bode, and Zigang Dong
Cancer Res 2006 66: 5729-5736. [Abstract] [Full Text] [PDF]  

Identification of Specific Gene Copy Number Changes in Asbestos-Related Lung Cancer

Penny Nymark, Harriet Wikman, Salla Ruosaari, Jaakko Hollmén, Esa Vanhala, Antti Karjalainen, Sisko Anttila, and Sakari Knuutila
Cancer Res 2006 66: 5737-5743. [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Inhibition of Poly(ADP-Ribose) Polymerase Modulates Tumor-Related Gene Expression, Including Hypoxia-Inducible Factor-1 Activation, during Skin Carcinogenesis

David Martin-Oliva, Rocío Aguilar-Quesada, Francisco O'Valle, Jose Antonio Muñoz-Gámez, Rubén Martínez-Romero, Raimundo García del Moral, José Mariano Ruiz de Almodóvar, Raquel Villuendas, Miguel Angel Piris, and F. Javier Oliver
Cancer Res 2006 66: 5744-5756. [Abstract] [Full Text] [PDF]  

Role of Src Kinases in Neu-Induced Tumorigenesis: Challenging the Paradigm Using Csk Homologous Kinase Transgenic Mice

Rafal Kaminski, Radoslaw Zagozdzon, Yigong Fu, Pawel Mroz, Wei Fu, Seyha Seng, Shalom Avraham, and Hava Karsenty Avraham
Cancer Res 2006 66: 5757-5762. [Abstract] [Full Text] [PDF]  

Assembly of Mutant-Template Telomerase RNA into Catalytically Active Telomerase Ribonucleoprotein That Can Act on Telomeres Is Required for Apoptosis and Cell Cycle Arrest in Human Cancer Cells

Amir Goldkorn and Elizabeth H. Blackburn
Cancer Res 2006 66: 5763-5771. [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of Glutathione Synthesis Overcomes Bcl-2-Mediated Topoisomerase Inhibitor Resistance and Induces Nonapoptotic Cell Death via Mitochondrial-Independent Pathway

Akira Yoshida, Haruyuki Takemura, Hitoshi Inoue, Toshiyuki Miyashita, and Takanori Ueda
Cancer Res 2006 66: 5772-5780. [Abstract] [Full Text] [PDF]  

The Histone Deacetylase Inhibitor LBH589 Is a Potent Antimyeloma Agent that Overcomes Drug Resistance

Patricia Maiso, Xonia Carvajal-Vergara, Enrique M. Ocio, Ricardo López-Pérez, Gema Mateo, Norma Gutiérrez, Peter Atadja, Atanasio Pandiella, and Jesús F. San Miguel
Cancer Res 2006 66: 5781-5789. [Abstract] [Full Text] [PDF]  

The Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain Elucidates Its Inhibitory Activity against Imatinib-Resistant ABL Mutants

John S. Tokarski, John A. Newitt, Chieh Ying J. Chang, Janet D. Cheng, Michael Wittekind, Susan E. Kiefer, Kevin Kish, Francis Y.F. Lee, Robert Borzillerri, Louis J. Lombardo, Dianlin Xie, Yaqun Zhang, and Herbert E. Klei
Cancer Res 2006 66: 5790-5797. [Abstract] [Full Text] [PDF]  

Recombinant Baculovirus Containing the Diphtheria Toxin A Gene for Malignant Glioma Therapy

Chao-Yang Wang, Feng Li, Yi Yang, Hai-Yan Guo, Chun-Xiao Wu, and Shu Wang
Cancer Res 2006 66: 5798-5806. [Abstract] [Full Text] [PDF]  

Emodin Inhibits Tumor Cell Adhesion through Disruption of the Membrane Lipid Raft-Associated Integrin Signaling Pathway

Qing Huang, Han-Ming Shen, Guanghou Shui, Markus R. Wenk, and Choon-Nam Ong
Cancer Res 2006 66: 5807-5815. [Abstract] [Full Text] [PDF]  

Connective Tissue Growth Factor–Specific Monoclonal Antibody Therapy Inhibits Pancreatic Tumor Growth and Metastasis

Nadja Dornhöfer, Suzanne Spong, Kevin Bennewith, Ali Salim, Stephen Klaus, Neeraja Kambham, Carol Wong, Fiona Kaper, Patrick Sutphin, Rendall Nacalumi, Michael Höckel, Quynh Le, Michael Longaker, George Yang, Albert Koong, and Amato Giaccia
Cancer Res 2006 66: 5816-5827. [Abstract] [Full Text] [PDF]  

Sulforaphane Causes Autophagy to Inhibit Release of Cytochrome c and Apoptosis in Human Prostate Cancer Cells

Anna Herman-Antosiewicz, Daniel E. Johnson, and Shivendra V. Singh
Cancer Res 2006 66: 5828-5835. [Abstract] [Full Text] [PDF]  

Down-regulation of Polo-like Kinase 1 Elevates Drug Sensitivity of Breast Cancer Cells In vitro and In vivo

Birgit Spänkuch, Sandra Heim, Elisabeth Kurunci-Csacsko, Christine Lindenau, Juping Yuan, Manfred Kaufmann, and Klaus Strebhardt
Cancer Res 2006 66: 5836-5846. [Abstract] [Full Text] [PDF]  

SV40 T/t-Common Polypeptide Specifically Induces Apoptosis in Human Cancer Cells that Overexpress HER2/neu

Chun-Chiang Wen, Shih-An Cheng, Shu-Ping Hsuen, Ya-Ling Huang, Zong-Keng Kuo, Hsin-Fang Lee, Chou-Hua Kuo, Jia-Ling Du, and Won-Bo Wang
Cancer Res 2006 66: 5847-5857. [Abstract] [Full Text] [PDF]  

Flavopiridol Targets c-KIT Transcription and Induces Apoptosis in Gastrointestinal Stromal Tumor Cells

Elliot B. Sambol, Grazia Ambrosini, Rula C. Geha, Peter T. Kennealey, Penelope DeCarolis, Rachael O'Connor, Yuhsin V. Wu, Monica Motwani, Jin-Hong Chen, Gary K. Schwartz, and Samuel Singer
Cancer Res 2006 66: 5858-5866. [Abstract] [Full Text] [PDF]  

Cardiac Glycosides Initiate Apo2L/TRAIL-Induced Apoptosis in Non–Small Cell Lung Cancer Cells by Up-regulation of Death Receptors 4 and 5

Steffen Frese, Manuela Frese-Schaper, Anne-Catherine Andres, Daniela Miescher, Beatrice Zumkehr, and Ralph A. Schmid
Cancer Res 2006 66: 5867-5874. [Abstract] [Full Text] [PDF]  

Synergistic Induction of Folate Receptor ß by All-Trans Retinoic Acid and Histone Deacetylase Inhibitors in Acute Myelogenous Leukemia Cells: Mechanism and Utility in Enhancing Selective Growth Inhibition by Antifolates

Huiling Qi and Manohar Ratnam
Cancer Res 2006 66: 5875-5882. [Abstract] [Full Text] [PDF]  

Immunology:

Identification of Interleukin-13 Receptor 2 Peptide Analogues Capable of Inducing Improved Antiglioma CTL Responses

Junichi Eguchi, Manabu Hatano, Fumihiko Nishimura, Xinmei Zhu, Jill E. Dusak, Hidemitsu Sato, Ian F. Pollack, Walter J. Storkus, and Hideho Okada
Cancer Res 2006 66: 5883-5891. [Abstract] [Full Text] [PDF]  

BCR-ABL Is Not an Immunodominant Antigen in Chronic Myelogenous Leukemia

Frank Grünebach, Valbona Mirakaj, Valdete Mirakaj, Martin R. Müller, Tim Brümmendorf, and Peter Brossart
Cancer Res 2006 66: 5892-5900. [Abstract] [Full Text] [PDF]  

A New Anticancer Glycolipid Monoclonal Antibody, SC104, which Directly Induces Tumor Cell Apoptosis

Lindy G. Durrant, Stephen J. Harding, Nicola H. Green, Lorraine D. Buckberry, and Tina Parsons
Cancer Res 2006 66: 5901-5909. [Abstract] [Full Text] [PDF]  

Immunologic and Clinical Responses after Vaccinations with Peptide-Pulsed Dendritic Cells in Metastatic Renal Cancer Patients

Jan Wierecky, Martin R. Müller, Stefan Wirths, Edith Halder-Oehler, Daniela Dörfel, Susanne M. Schmidt, Maik Häntschel, Wolfram Brugger, Stephen Schröder, Marius S. Horger, Lothar Kanz, and Peter Brossart
Cancer Res 2006 66: 5910-5918. [Abstract] [Full Text] [PDF] Supplementary Data  

CD4⁺ T-Cell Response to Mitochondrial Cytochrome b in Human Melanoma

Kui Shin Voo, Gang Zeng, Jian-Bing Mu, Juhua Zhou, Xin-Zhuan Su, and Rong-Fu Wang
Cancer Res 2006 66: 5919-5926. [Abstract] [Full Text] [PDF]  

Generation of Antitumor Responses by Genetic Modification of Primary Human T Cells with a Chimeric NKG2D Receptor

Tong Zhang, Amorette Barber, and Charles L. Sentman
Cancer Res 2006 66: 5927-5933. [Abstract] [Full Text] [PDF] Supplementary Data  

Endocrinology:

Mechanism of Apoptosis Induced by the Inhibition of Fatty Acid Synthase in Breast Cancer Cells

Sucharita Bandyopadhyay, Rui Zhan, Ying Wang, Sudha K. Pai, Shigeru Hirota, Sadahiro Hosobe, Yukio Takano, Ken Saito, Eiji Furuta, Megumi Iiizumi, Sonia Mohinta, Misako Watabe, Charles Chalfant, and Kounosuke Watabe
Cancer Res 2006 66: 5934-5940. [Abstract] [Full Text] [PDF]  

Dynein Light Chain 1 Contributes to Cell Cycle Progression by Increasing Cyclin-Dependent Kinase 2 Activity in Estrogen-Stimulated Cells

Petra den Hollander and Rakesh Kumar
Cancer Res 2006 66: 5941-5949. [Abstract] [Full Text] [PDF]  

Elevated Expression of Mitogen-Activated Protein Kinase Phosphatase 3 in Breast Tumors: A Mechanism of Tamoxifen Resistance

Yukun Cui, Irma Parra, Mao Zhang, Susan G. Hilsenbeck, Anna Tsimelzon, Toru Furukawa, Akira Horii, Zhong-Yin Zhang, Robert I. Nicholson, and Suzanne A.W. Fuqua
Cancer Res 2006 66: 5950-5959. [Abstract] [Full Text] [PDF]  

Grape Seed Extract Is an Aromatase Inhibitor and a Suppressor of Aromatase Expression

Ikuko Kijima, Sheryl Phung, Gene Hur, Sum-Ling Kwok, and Shiuan Chen
Cancer Res 2006 66: 5960-5967. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Involvement of the Paxillin Pathway in JB6 Cl41 Cell Transformation

Yasuaki Tatsumi, Yong-Yeon Cho, Zhiwei He, Hideya Mizuno, Hong Seok Choi, Ann M. Bode, and Zigang Dong
Cancer Res 2006 66: 5968-5974. [Abstract] [Full Text] [PDF]  

Corrections:

Photomicrograph Showing Migration of hMSCs toward Glioma

Cancer Res 2006 66: 5975. [Full Text] [PDF]  

NKG2D Haplotypes and Cancer Immunosurveillance

Cancer Res 2006 66: 5976. [Full Text] [PDF]  

Human mAbs to HGF with Therapeutic Potential

Cancer Res 2006 66: 5976. [Full Text] [PDF]  

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