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Contents: January 15 2006, Volume 66, Issue 2   [Index by Author] 
       Reviews
       Priority Reports
       Molecular Biology, Pathobiology, and Genetics
       Cell, Tumor, and Stem Cell Biology
       Experimental Therapeutics, Molecular Targets, and Chemical Biology
       Immunology
       Endocrinology
       Clinical Research
       Epidemiology and Prevention
       Correction
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Reviews:

Cranking the Immunologic Engine with Chemotherapy: Using Context to Drive Tumor Antigen Cross-Presentation towards Useful Antitumor Immunity
Robbert G. van der Most, Andrew Currie, Bruce W.S. Robinson, and Richard A. Lake
Cancer Res 2006 66: 601-604. [Abstract] [Full Text] [PDF]  

Distinct Role of Macrophages in Different Tumor Microenvironments
Claire E. Lewis and Jeffrey W. Pollard
Cancer Res 2006 66: 605-612. [Abstract] [Full Text] [PDF]  

Priority Reports:

Combined Inhibitory Effects of Curcumin and Phenethyl Isothiocyanate on the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice
Tin Oo Khor, Young-Sam Keum, Wen Lin, Jung-Hwan Kim, Rong Hu, Guoxiang Shen, Changjiang Xu, Avanthika Gopalakrishnan, Bandaru Reddy, Xi Zheng, Allan H. Conney, and Ah-Ng Tony Kong
Cancer Res 2006 66: 613-621. [Abstract] [Full Text] [PDF]  

Significance of Murine Retroviral Mutagenesis for Identification of Disease Genes in Human Acute Myeloid Leukemia
Stefan J. Erkeland, Roel G.W. Verhaak, Peter J.M. Valk, Ruud Delwel, Bob Löwenberg, and Ivo P. Touw
Cancer Res 2006 66: 622-626. [Abstract] [Full Text] [PDF] Supplementary Data  

HIV-1 Vpr Induces DNA Double-Strand Breaks
Hiroaki Tachiwana, Mari Shimura, Chikako Nakai-Murakami, Kenzo Tokunaga, Yoshimasa Takizawa, Tetsutaro Sata, Hitoshi Kurumizaka, and Yukihito Ishizaka
Cancer Res 2006 66: 627-631. [Abstract] [Full Text] [PDF] Supplementary Data  

Comparison of Metabolic Pathways between Cancer Cells and Stromal Cells in Colorectal Carcinomas: a Metabolic Survival Role for Tumor-Associated Stroma
Michael I. Koukourakis, Alexandra Giatromanolaki, Adrian L. Harris, and Efthimios Sivridis
Cancer Res 2006 66: 632-637. [Abstract] [Full Text] [PDF]  

Ductal Access for Prevention and Therapy of Mammary Tumors
Satoshi Murata, Scott L. Kominsky, Mustafa Vali, Zhe Zhang, Elizabeth Garrett-Mayer, Dorian Korz, David Huso, Sharyn D. Baker, James Barber, Elizabeth Jaffee, R. Todd Reilly, and Saraswati Sukumar
Cancer Res 2006 66: 638-645. [Abstract] [Full Text] [PDF]  

The Single Nucleotide Polymorphism IVS1+309 in Mouse Double Minute 2 Does Not Affect Risk of Familial Breast Cancer
Stefan Wilkening, Justo Lorenzo Bermejo, Barbara Burwinkel, Rüdiger Klaes, Claus R. Bartram, Alfons Meindl, Peter Bugert, Rita K. Schmutzler, Barbara Wappenschmidt, Michael Untch, Kari Hemminki, and Asta Försti
Cancer Res 2006 66: 646-648. [Abstract] [Full Text] [PDF]  

Tumor Cell Lines Expressing the Proteasome Subunit Isoform LMP7E1 Exhibit Immunoproteasome Deficiency
Sylvia Heink, Benjamin Fricke, Daniela Ludwig, Peter-M. Kloetzel, and Elke Krüger
Cancer Res 2006 66: 649-652. [Abstract] [Full Text] [PDF]  

CpG Island Methylation and Expression of the Secreted Frizzled-Related Protein Gene Family in Chronic Lymphocytic Leukemia
Te-Hui Liu, Aparna Raval, Shih-Shih Chen, Jennifer J. Matkovic, John C. Byrd, and Christoph Plass
Cancer Res 2006 66: 653-658. [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Conversion Is a Frequent Mechanism of Inactivation of the Wild-Type Allele in Cancers from MLH1/MSH2 Deletion Carriers
Jian Zhang, Annette Lindroos, Saara Ollila, Anna Russell, Giancarlo Marra, Hansjakob Mueller, Paivi Peltomaki, Martina Plasilova, and Karl Heinimann
Cancer Res 2006 66: 659-664. [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

PEG10 Is a c-MYC Target Gene in Cancer Cells
Chi-Ming Li, Adam A. Margolin, Martha Salas, Lorenzo Memeo, Mahesh Mansukhani, Hanina Hibshoosh, Matthias Szabolcs, Apostolos Klinakis, and Benjamin Tycko
Cancer Res 2006 66: 665-672. [Abstract] [Full Text] [PDF]  

c-Myc Overexpression Causes Anaplasia in Medulloblastoma
Duncan Stearns, Aneeka Chaudhry, Ty W. Abel, Peter C. Burger, Chi V. Dang, and Charles G. Eberhart
Cancer Res 2006 66: 673-681. [Abstract] [Full Text] [PDF]  

De novo CpG Island Methylation in Human Cancer Cells
Kam-Wing Jair, Kurtis E. Bachman, Hiromu Suzuki, Angela H. Ting, Ina Rhee, Ray-Whay Chiu Yen, Stephen B. Baylin, and Kornel E. Schuebel
Cancer Res 2006 66: 682-692. [Abstract] [Full Text] [PDF]  

A Functional Variant in the Transcriptional Regulatory Region of Gene LOC344967 Cosegregates with Disease Phenotype in Familial Nasopharyngeal Carcinoma
Ri-Cheng Jiang, Hai-De Qin, Mu-Sheng Zeng, Wei Huang, Bing-Jian Feng, Feng Zhang, Han-Kui Chen, Wei-Hua Jia, Li-Zhen Chen, Qi-Sheng Feng, Ru-Hua Zhang, Xing-Juan Yu, Mei-Zhen Zheng, and Yi-Xin Zeng
Cancer Res 2006 66: 693-700. [Abstract] [Full Text] [PDF]  

Thymosin ß4 Is a Determinant of the Transformed Phenotype and Invasiveness of S-Adenosylmethionine Decarboxylase–Transfected Fibroblasts
Pirjo Nummela, Miao Yin, Mari Kielosto, Virna Leaner, Michael J. Birrer, and Erkki Hölttä
Cancer Res 2006 66: 701-712. [Abstract] [Full Text] [PDF]  

Protein Kinase C {delta} Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2
Moammir H. Aziz, Deric L. Wheeler, Bhushan Bhamb, and Ajit K. Verma
Cancer Res 2006 66: 713-722. [Abstract] [Full Text] [PDF]  

TC1 (C8orf4) Enhances the Wnt/ß-Catenin Pathway by Relieving Antagonistic Activity of Chibby
Yusun Jung, Seunghyun Bang, Kyungho Choi, Eunsoon Kim, Youngmi Kim, Jungtae Kim, Juhee Park, Hyunlyoung Koo, Randall T. Moon, Kyuyoung Song, and Inchul Lee
Cancer Res 2006 66: 723-728. [Abstract] [Full Text] [PDF] Supplementary Data  

Differential Requirement for DNA Methyltransferase 1 in Maintaining Human Cancer Cell Gene Promoter Hypermethylation
Angela H. Ting, Kam-wing Jair, Kornel E. Schuebel, and Stephen B. Baylin
Cancer Res 2006 66: 729-735. [Abstract] [Full Text] [PDF]  

PTEN Autoregulates Its Expression by Stabilization of p53 in a Phosphatase-Independent Manner
Yufang Tang and Charis Eng
Cancer Res 2006 66: 736-742. [Abstract] [Full Text] [PDF]  

Profiling Genetic Variation along the Androgen Biosynthesis and Metabolism Pathways Implicates Several Single Nucleotide Polymorphisms and Their Combinations as Prostate Cancer Risk Factors
Nina Mononen, Eija H. Seppälä, Priya Duggal, Ville Autio, Tarja Ikonen, Pekka Ellonen, Juha Saharinen, Janna Saarela, Mauno Vihinen, Teuvo L.J. Tammela, Olli Kallioniemi, Joan E. Bailey-Wilson, and Johanna Schleutker
Cancer Res 2006 66: 743-747. [Abstract] [Full Text] [PDF] Supplementary Data  

Critical Roles for Polymerase {zeta} in Cellular Tolerance to Nitric Oxide–Induced DNA Damage
Xiaohua Wu, Katsuya Takenaka, Eiichiro Sonoda, Helfrid Hochegger, Shosuke Kawanishi, Takuo Kawamoto, Shunichi Takeda, and Mitsuyoshi Yamazoe
Cancer Res 2006 66: 748-754. [Abstract] [Full Text] [PDF]  

In utero Exposure of Mice to Dibenzo[a,l]Pyrene Produces Lymphoma in the Offspring: Role of the Aryl Hydrocarbon Receptor
Zhen Yu, Christiane V. Loehr, Kay A. Fischer, Mandy A. Louderback, Sharon K. Krueger, Roderick H. Dashwood, Nancy I. Kerkvliet, Clifford B. Pereira, Jamie E. Jennings-Gee, Stephanie T. Dance, Mark Steven Miller, George S. Bailey, and David E. Williams
Cancer Res 2006 66: 755-762. [Abstract] [Full Text] [PDF]  

Altered Expression and Localization of Creatine Kinase B, Heterogeneous Nuclear Ribonucleoprotein F, and High Mobility Group Box 1 Protein in the Nuclear Matrix Associated with Colon Cancer
Manimalha Balasubramani, Billy W. Day, Robert E. Schoen, and Robert H. Getzenberg
Cancer Res 2006 66: 763-769. [Abstract] [Full Text] [PDF]  

Cell, Tumor, and Stem Cell Biology:

Nitric Oxide Is a Factor in the Stabilization of Hypoxia-Inducible Factor-1{alpha} in Cancer: Role of Free Radical Formation
Marisol Quintero, Peter A. Brennan, Gareth J. Thomas, and Salvador Moncada
Cancer Res 2006 66: 770-774. [Abstract] [Full Text] [PDF]  

Angiopoietin 2 Induces Glioma Cell Invasion by Stimulating Matrix Metalloprotease 2 Expression through the {alpha}vß1 Integrin and Focal Adhesion Kinase Signaling Pathway
Bo Hu, Michael J. Jarzynka, Ping Guo, Yorihisha Imanishi, David D. Schlaepfer, and Shi-Yuan Cheng
Cancer Res 2006 66: 775-783. [Abstract] [Full Text] [PDF] Supplementary Data  

Phospholipase D Prevents Etoposide-Induced Apoptosis by Inhibiting the Expression of Early Growth Response-1 and Phosphatase and Tensin Homologue Deleted on Chromosome 10
Joommo Kim, Young Han Lee, Taeg Kyu Kwon, Jong-Soo Chang, Kwang Chul Chung, and Do Sik Min
Cancer Res 2006 66: 784-793. [Abstract] [Full Text] [PDF]  

The Gene Expression Program of Prostate Fibroblast Senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms
Claes Bavik, Ilsa Coleman, James P. Dean, Beatrice Knudsen, Steven Plymate, and Peter S. Nelson
Cancer Res 2006 66: 794-802. [Abstract] [Full Text] [PDF]  

The Possible Role of EWS-Fli1 in Evasion of Senescence in Ewing Family Tumors
Tomoya Matsunobu, Kazuhiro Tanaka, Tomoyuki Nakamura, Fumihiko Nakatani, Riku Sakimura, Masuo Hanada, Xu Li, Takamitsu Okada, Yoshinao Oda, Masazumi Tsuneyoshi, and Yukihide Iwamoto
Cancer Res 2006 66: 803-811. [Abstract] [Full Text] [PDF] Supplementary Data  

Overexpression of c-Maf Contributes to T-Cell Lymphoma in Both Mice and Human
Naoki Morito, Keigyou Yoh, Yuki Fujioka, Takako Nakano, Homare Shimohata, Yuko Hashimoto, Akiko Yamada, Atsuko Maeda, Fumihiko Matsuno, Hiroyuki Hata, Atsushi Suzuki, Shigehiko Imagawa, Hiroaki Mitsuya, Hiroyasu Esumi, Akio Koyama, Masayuki Yamamoto, Naoyoshi Mori, and Satoru Takahashi
Cancer Res 2006 66: 812-819. [Abstract] [Full Text] [PDF]  

Down-Regulation of Stem Cell Genes, Including Those in a 200-kb Gene Cluster at 12p13.31, Is Associated with In vivo Differentiation of Human Male Germ Cell Tumors
James E. Korkola, Jane Houldsworth, Rajendrakumar S.V. Chadalavada, Adam B. Olshen, Debbie Dobrzynski, Victor E. Reuter, George J. Bosl, and R.S.K. Chaganti
Cancer Res 2006 66: 820-827. [Abstract] [Full Text] [PDF] Supplementary Data  

Helicobacter Infection Is Required for Inflammation and Colon Cancer in Smad3-Deficient Mice
Lillian Maggio-Price, Piper Treuting, Weiping Zeng, Mark Tsang, Helle Bielefeldt-Ohmann, and Brian M. Iritani
Cancer Res 2006 66: 828-838. [Abstract] [Full Text] [PDF] Supplementary Data  

Protein Kinase C-{delta} and Mitogen-Activated Protein/Extracellular Signal–Regulated Kinase-1 Control GLI Activation in Hedgehog Signaling
Natalia A. Riobo, Gwendolyn M. Haines, and Charles P. Emerson, Jr.
Cancer Res 2006 66: 839-845. [Abstract] [Full Text] [PDF]  

Roles of Myofibroblasts in Prostaglandin E2–Stimulated Intestinal Epithelial Proliferation and Angiogenesis
Jinyi Shao, George G. Sheng, Randy C. Mifflin, Don W. Powell, and Hongmiao Sheng
Cancer Res 2006 66: 846-855. [Abstract] [Full Text] [PDF]  

MSF-A Interacts with Hypoxia-Inducible Factor-1{alpha} and Augments Hypoxia-Inducible Factor Transcriptional Activation to Affect Tumorigenicity and Angiogenesis
Sharon Amir, Ruoxiang Wang, Haim Matzkin, Jonathan W. Simons, and Nicola J. Mabjeesh
Cancer Res 2006 66: 856-866. [Abstract] [Full Text] [PDF] Supplementary Data  

Differential Gene Expression Analysis Reveals Generation of an Autocrine Loop by a Mutant Epidermal Growth Factor Receptor in Glioma Cells
Deepti B. Ramnarain, Seongmi Park, Diana Y. Lee, Kimmo J. Hatanpaa, Shane O. Scoggin, Hasan Otu, Towia A. Libermann, Jack M. Raisanen, Raheela Ashfaq, Eric T. Wong, Julian Wu, Robert Elliott, and Amyn A. Habib
Cancer Res 2006 66: 867-874. [Abstract] [Full Text] [PDF] Supplementary Data  

Angiostatin Is Directly Cytotoxic to Tumor Cells at Low Extracellular pH: A Mechanism Dependent on Cell Surface–Associated ATP Synthase
Sulene L. Chi and Salvatore V. Pizzo
Cancer Res 2006 66: 875-882. [Abstract] [Full Text] [PDF]  

Increased Expression of Osteopontin Contributes to the Progression of Prostate Cancer
Ani C. Khodavirdi, Zhigang Song, Shangxin Yang, Chen Zhong, Shunyou Wang, Hong Wu, Colin Pritchard, Peter S. Nelson, and Pradip Roy-Burman
Cancer Res 2006 66: 883-888. [Abstract] [Full Text] [PDF] Supplementary Data  

Deregulation of the HOXA10 Homeobox Gene in Endometrial Carcinoma: Role in Epithelial-Mesenchymal Transition
Hiroyuki Yoshida, Russell Broaddus, Wenjun Cheng, SuSu Xie, and Honami Naora
Cancer Res 2006 66: 889-897. [Abstract] [Full Text] [PDF]  

Identification of a Putative Tumor Suppressor Gene Rap1GAP in Pancreatic Cancer
Lizhi Zhang, Li Chenwei, Redah Mahmood, Kenneth van Golen, Joel Greenson, Gangyong Li, Nisha J. D'Silva, Xiangquan Li, Charles F. Burant, Craig D. Logsdon, and Diane M. Simeone
Cancer Res 2006 66: 898-906. [Abstract] [Full Text] [PDF]  

The P2X7 Receptor Sustains the Growth of Human Neuroblastoma Cells through a Substance P–Dependent Mechanism
Lizzia Raffaghello, Paola Chiozzi, Simonetta Falzoni, Francesco Di Virgilio, and Vito Pistoia
Cancer Res 2006 66: 907-914. [Abstract] [Full Text] [PDF]  

Effect of Rapamycin on Mouse Chronic Lymphocytic Leukemia and the Development of Nonhematopoietic Malignancies in Eµ-TCL1 Transgenic Mice
Nicola Zanesi, Rami Aqeilan, Alessandra Drusco, Mohamed Kaou, Cinzia Sevignani, Stefan Costinean, Laura Bortesi, Gaspare La Rocca, Pavel Koldovsky, Stefano Volinia, Rita Mancini, George Calin, Charles P. Scott, Yuri Pekarsky, and Carlo M. Croce
Cancer Res 2006 66: 915-920. [Abstract] [Full Text] [PDF]  

Elevated Expression of ISG15 in Tumor Cells Interferes with the Ubiquitin/26S Proteasome Pathway
Shyamal D. Desai, Arthur L. Haas, Laurence M. Wood, Yu-Chen Tsai, Sidney Pestka, Eric H. Rubin, Ahamed Saleem, Alam Nur-E-Kamal, and Leroy F. Liu
Cancer Res 2006 66: 921-928. [Abstract] [Full Text] [PDF]  

Cisplatin Mimics ARF Tumor Suppressor Regulation of RelA (p65) Nuclear Factor-{kappa}B Transactivation
Kirsteen J. Campbell, James M. Witty, Sonia Rocha, and Neil D. Perkins
Cancer Res 2006 66: 929-935. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Efficient Inhibition of Intra-Peritoneal Tumor Growth and Dissemination of Human Ovarian Carcinoma Cells in Nude Mice by Anti-L1-Cell Adhesion Molecule Monoclonal Antibody Treatment
Matthias J.E. Arlt, Ilse Novak-Hofer, Daniela Gast, Verena Gschwend, Gerhard Moldenhauer, Jürgen Grünberg, Michael Honer, P. August Schubiger, Peter Altevogt, and Achim Krüger
Cancer Res 2006 66: 936-943. [Abstract] [Full Text] [PDF]  

Restoring E-Cadherin Expression Increases Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cell Lines
Samir E. Witta, Robert M. Gemmill, Fred R. Hirsch, Christopher D. Coldren, Karla Hedman, Larisa Ravdel, Barbara Helfrich, Rafal Dziadziuszko, Daniel C. Chan, Michio Sugita, Zeng Chan, Anna Baron, Wilbur Franklin, Harry A. Drabkin, Luc Girard, Adi F. Gazdar, John D. Minna, and Paul A. Bunn, Jr.
Cancer Res 2006 66: 944-950. [Abstract] [Full Text] [PDF]  

The Synthetic Compound CC-5079 Is a Potent Inhibitor of Tubulin Polymerization and Tumor Necrosis Factor-{alpha} Production with Antitumor Activity
Ling-Hua Zhang, Lei Wu, Heather K. Raymon, Roger S. Chen, Laura Corral, Michael A. Shirley, Rama Krishna Narla, Jim Gamez, George W. Muller, David I. Stirling, J. Blake Bartlett, Peter H. Schafer, and Faribourz Payvandi
Cancer Res 2006 66: 951-959. [Abstract] [Full Text] [PDF]  

Effect of Adenovirus-Mediated Heat Shock Protein Expression and Oncolysis in Combination with Low-Dose Cyclophosphamide Treatment on Antitumor Immune Responses
Nelson C. Di Paolo, Sebastian Tuve, Shaoheng Ni, Karl Erik Hellström, Ingegerd Hellström, and André Lieber
Cancer Res 2006 66: 960-969. [Abstract] [Full Text] [PDF]  

Targeting Cell-Impermeable Prodrug Activation to Tumor Microenvironment Eradicates Multiple Drug-Resistant Neoplasms
Wenyuan Wu, Yunping Luo, Chengzao Sun, Yuan Liu, Paul Kuo, Janos Varga, Rong Xiang, Ralph Reisfeld, Kim D. Janda, Thomas S. Edgington, and Cheng Liu
Cancer Res 2006 66: 970-980. [Abstract] [Full Text] [PDF]  

Synergistic Effects of Gemcitabine and Gefitinib in the Treatment of Head and Neck Carcinoma
Patrick Y. Chun, Felix Y. Feng, Ashley M. Scheurer, Mary A. Davis, Theodore S. Lawrence, and Mukesh K. Nyati
Cancer Res 2006 66: 981-988. [Abstract] [Full Text] [PDF] Supplementary Data  

Activity of the Adenoviral E1A Deletion Mutant dl922-947 in Ovarian Cancer: Comparison with E1A Wild-type Viruses, Bioluminescence Monitoring, and Intraperitoneal Delivery in Icodextrin
Michelle Lockley, Mario Fernandez, Yaohe Wang, N. Fiona Li, Susan Conroy, Nicholas Lemoine, and Iain McNeish
Cancer Res 2006 66: 989-998. [Abstract] [Full Text] [PDF]  

Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models
Klaus P. Hoeflich, Daniel C. Gray, Michael T. Eby, Janet Y. Tien, Leo Wong, Janeko Bower, Alvin Gogineni, Jiping Zha, Mary J. Cole, Howard M. Stern, Lesley J. Murray, David P. Davis, and Somasekar Seshagiri
Cancer Res 2006 66: 999-1006. [Abstract] [Full Text] [PDF] Supplementary Data  

Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680
Matthew A. Young, Neil P. Shah, Luke H. Chao, Markus Seeliger, Zdravko V. Milanov, William H. Biggs, III, Daniel K. Treiber, Hitesh K. Patel, Patrick P. Zarrinkar, David J. Lockhart, Charles L. Sawyers, and John Kuriyan
Cancer Res 2006 66: 1007-1014. [Abstract] [Full Text] [PDF]  

OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
Andrew J. Garton, Andrew P.A. Crew, Maryland Franklin, Andrew R. Cooke, Graham M. Wynne, Linda Castaldo, Jennifer Kahler, Shannon L. Winski, April Franks, Eric N. Brown, Mark A. Bittner, John F. Keily, Paul Briner, Chris Hidden, Mary C. Srebernak, Carrie Pirrit, Matthew O'Connor, Anna Chan, Bojana Vulevic, Dwight Henninger, Karen Hart, Regina Sennello, An-Hu Li, Tao Zhang, Frank Richardson, David L. Emerson, Arlindo L. Castelhano, Lee D. Arnold, and Neil W. Gibson
Cancer Res 2006 66: 1015-1024. [Abstract] [Full Text] [PDF] Supplementary Data  

Antitumor Activity of Epidermal Growth Factor Receptor–Related Protein Is Mediated by Inactivation of ErbB Receptors and Nuclear Factor-{kappa}B in Pancreatic Cancer
Yuxiang Zhang, Sanjeev Banerjee, Zhiwei Wang, Hu Xu, Liyue Zhang, Ramzi Mohammad, Amro Aboukameel, Nazmi V. Adsay, Mingxin Che, James L. Abbruzzese, Adhip P.N. Majumdar, and Fazlul H. Sarkar
Cancer Res 2006 66: 1025-1032. [Abstract] [Full Text] [PDF]  

The Penetration of Anticancer Drugs through Tumor Tissue as a Function of Cellular Adhesion and Packing Density of Tumor Cells
Rama Grantab, Shankar Sivananthan, and Ian F. Tannock
Cancer Res 2006 66: 1033-1039. [Abstract] [Full Text] [PDF]  

Farnesyl and Geranylgeranyl Transferase Inhibitors Induce G1 Arrest by Targeting the Proteasome
Ekem T. Efuet and Khandan Keyomarsi
Cancer Res 2006 66: 1040-1051. [Abstract] [Full Text] [PDF] Supplementary Data  

Radiation-Induced Changes in Gene Expression Involve Recruitment of Existing Messenger RNAs to and away from Polysomes
Xing Lü, Lorena de la Peña, Christopher Barker, Kevin Camphausen, and Philip J. Tofilon
Cancer Res 2006 66: 1052-1061. [Abstract] [Full Text] [PDF] Supplementary Data  

RNA Interference–Mediated Depletion of Phosphoinositide 3-Kinase Activates Forkhead Box Class O Transcription Factors and Induces Cell Cycle Arrest and Apoptosis in Breast Carcinoma Cells
Shannon Reagan-Shaw and Nihal Ahmad
Cancer Res 2006 66: 1062-1069. [Abstract] [Full Text] [PDF]  

Rapamycin Disrupts Cyclin/Cyclin-Dependent Kinase/p21/Proliferating Cell Nuclear Antigen Complexes and Cyclin D1 Reverses Rapamycin Action by Stabilizing These Complexes
Mary Law, Elizabeth Forrester, Anna Chytil, Patrick Corsino, Gail Green, Bradley Davis, Thomas Rowe, and Brian Law
Cancer Res 2006 66: 1070-1080. [Abstract] [Full Text] [PDF]  

Intracellular Signaling Pathways Involved in the Cell Growth Inhibition of Glioma Cells by Melatonin
Vanesa Martín, Federico Herrera, Pilar Carrera-Gonzalez, Guillermo García-Santos, Isaac Antolín, Jezabel Rodriguez-Blanco, and Carmen Rodriguez
Cancer Res 2006 66: 1081-1088. [Abstract] [Full Text] [PDF]  

17-Allylamino-17-Demethoxygeldanamycin Synergistically Potentiates Tumor Necrosis Factor–Induced Lung Cancer Cell Death by Blocking the Nuclear Factor-{kappa}B Pathway
Xia Wang, Wei Ju, Jordan Renouard, James Aden, Steven A. Belinsky, and Yong Lin
Cancer Res 2006 66: 1089-1095. [Abstract] [Full Text] [PDF]  

Immunology:

Selective Targeting of Antitumor Immune Responses with Engineered Live-Attenuated Listeria monocytogenes
Kiyoshi Yoshimura, Ajay Jain, Heather E. Allen, Lindsay S. Laird, Christina Y. Chia, Sowmya Ravi, Dirk G. Brockstedt, Martin A. Giedlin, Keith S. Bahjat, Meredith L. Leong, Jill E. Slansky, David N. Cook, Thomas W. Dubensky, Drew M. Pardoll, and Richard D. Schulick
Cancer Res 2006 66: 1096-1104. [Abstract] [Full Text] [PDF] Supplementary Data  

De novo Induction of a Cancer/Testis Antigen by 5-Aza-2'-Deoxycytidine Augments Adoptive Immunotherapy in a Murine Tumor Model
Z. Sheng Guo, Julie A. Hong, Kari R. Irvine, G. Aaron Chen, Paul J. Spiess, Yang Liu, Gang Zeng, John R. Wunderlich, Dao M. Nguyen, Nicholas P. Restifo, and David S. Schrump
Cancer Res 2006 66: 1105-1113. [Abstract] [Full Text] [PDF]  

Prostaglandin E2 Impairs CD4+ T Cell Activation by Inhibition of lck: Implications in Hodgkin's Lymphoma
Jens M. Chemnitz, Julia Driesen, Sabine Classen, James L. Riley, Svenja Debey, Marc Beyer, Alexey Popov, Thomas Zander, and Joachim L. Schultze
Cancer Res 2006 66: 1114-1122. [Abstract] [Full Text] [PDF] Supplementary Data  

Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host
Bo Huang, Ping-Ying Pan, Qingsheng Li, Alice I. Sato, David E. Levy, Jonathan Bromberg, Celia M. Divino, and Shu-Hsia Chen
Cancer Res 2006 66: 1123-1131. [Abstract] [Full Text] [PDF]  

The In vivo Expansion Rate of Properly Stimulated Transferred CD8+ T Cells Exceeds That of an Aggressively Growing Mouse Tumor
Leroy N. Hwang, Zhiya Yu, Douglas C. Palmer, and Nicholas P. Restifo
Cancer Res 2006 66: 1132-1138. [Abstract] [Full Text] [PDF]  

Radiofrequency Thermal Ablation of Hepatocellular Carcinoma Liver Nodules Can Activate and Enhance Tumor-Specific T-Cell Responses
Alessandro Zerbini, Massimo Pilli, Amalia Penna, Guido Pelosi, Claudia Schianchi, Atim Molinari, Simona Schivazappa, Carlo Zibera, Francesco F. Fagnoni, Carlo Ferrari, and Gabriele Missale
Cancer Res 2006 66: 1139-1146. [Abstract] [Full Text] [PDF]  

Tumor Cells Transduced with the MHC Class II Transactivator and CD80 Activate Tumor-Specific CD4+ T Cells Whether or Not They Are Silenced for Invariant Chain
James A. Thompson, Samudra K. Dissanayake, Bruce R. Ksander, Keith L. Knutson, Mary L. Disis, and Suzanne Ostrand-Rosenberg
Cancer Res 2006 66: 1147-1154. [Abstract] [Full Text] [PDF]  

Efficient Induction of Tumor Antigen–Specific CD8+ Memory T Cells by Recombinant Lentivectors
Laurence Chapatte, Sara Colombetti, Jean-Charles Cerottini, and Frédéric Lévy
Cancer Res 2006 66: 1155-1160. [Abstract] [Full Text] [PDF]  

Chaperoning Function of Stress Protein grp170, a Member of the hsp70 Superfamily, Is Responsible for its Immunoadjuvant Activity
Jun-Eui Park, John Facciponte, Xing Chen, Ian MacDonald, Elizabeth A. Repasky, Masoud H. Manjili, Xiang-Yang Wang, and John R. Subjeck
Cancer Res 2006 66: 1161-1168. [Abstract] [Full Text] [PDF]  

Vaccine with ß-Defensin 2–Transduced Leukemic Cells Activates Innate and Adaptive Immunity to Elicit Potent Antileukemia Responses
Xiao-Tong Ma, Bin Xu, Li-Li An, Cheng-Ya Dong, Yong-Min Lin, Yang Shi, and Ke-Fu Wu
Cancer Res 2006 66: 1169-1176. [Abstract] [Full Text] [PDF]  

Endocrinology:

Polymorphisms in RET and Its Coreceptors and Ligands as Genetic Modifiers of Multiple Endocrine Neoplasia Type 2A
Fabienne Lesueur, Arancha Cebrian, Mercedes Robledo, Patricia Niccoli-Sire, Karl-Axel Svensson, Stephane Pinson, Jean Leyland, Joanne Whittaker, Paul D. Pharoah, and Bruce A.J. Ponder
Cancer Res 2006 66: 1177-1180. [Abstract] [Full Text] [PDF]  

Clinical Research:

Diagnostic Markers of Ovarian Cancer by High-Throughput Antigen Cloning and Detection on Arrays
Madhumita Chatterjee, Saroj Mohapatra, Alexei Ionan, Gagandeep Bawa, Rouba Ali-Fehmi, Xiaoju Wang, James Nowak, Bin Ye, Fatimah A. Nahhas, Karen Lu, Steven S. Witkin, David Fishman, Adnan Munkarah, Robert Morris, Nancy K. Levin, Natalie N. Shirley, Gerard Tromp, Judith Abrams, Sorin Draghici, and Michael A. Tainsky
Cancer Res 2006 66: 1181-1190. [Abstract] [Full Text] [PDF] Supplementary Data  

Expression of a Fibroblast Growth Factor–Binding Protein during the Development of Adenocarcinoma of the Pancreas and Colon
Elena Tassi, Ralf T. Henke, Emma T. Bowden, Matthew R. Swift, David P. Kodack, Angera H. Kuo, Anirban Maitra, and Anton Wellstein
Cancer Res 2006 66: 1191-1198. [Abstract] [Full Text] [PDF]  

Induction of Metastasis by S100P in a Rat Mammary Model and Its Association with Poor Survival of Breast Cancer Patients
Guozheng Wang, Angela Platt-Higgins, Joe Carroll, Suzete de Silva Rudland, John Winstanley, Roger Barraclough, and Philip S. Rudland
Cancer Res 2006 66: 1199-1207. [Abstract] [Full Text] [PDF]  

DNA Methylation Alterations in the Pancreatic Juice of Patients with Suspected Pancreatic Disease
Hiroyuki Matsubayashi, Marcia Canto, Norihiro Sato, Alison Klein, Tadayoshi Abe, Keishi Yamashita, Charles J. Yeo, Anthony Kalloo, Ralph Hruban, and Michael Goggins
Cancer Res 2006 66: 1208-1217. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Age-Related Changes of the Cervix Influence Human Papillomavirus Type Distribution
Philip E. Castle, Jose Jeronimo, Mark Schiffman, Rolando Herrero, Ana C. Rodríguez, M. Concepción Bratti, Allan Hildesheim, Sholom Wacholder, L. Rodney Long, Leif Neve, Ruth Pfeiffer, and Robert D. Burk
Cancer Res 2006 66: 1218-1224. [Abstract] [Full Text] [PDF]  

Tagging Single-Nucleotide Polymorphisms in Antioxidant Defense Enzymes and Susceptibility to Breast Cancer
Arancha Cebrian, Paul D. Pharoah, Shahana Ahmed, Paula L. Smith, Craig Luccarini, Robert Luben, Karen Redman, Hannah Munday, Douglas F. Easton, Alison M. Dunning, and Bruce A.J. Ponder
Cancer Res 2006 66: 1225-1233. [Abstract] [Full Text] [PDF] Supplementary Data  

Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-Grade Prostate Intraepithelial Neoplasia: A Preliminary Report from a One-Year Proof-of-Principle Study
Saverio Bettuzzi, Maurizio Brausi, Federica Rizzi, Giovanni Castagnetti, Giancarlo Peracchia, and Arnaldo Corti
Cancer Res 2006 66: 1234-1240. [Abstract] [Full Text] [PDF]  

Dietary Soy Isoflavones Inhibit Estrogen Effects in the Postmenopausal Breast
Charles E. Wood, Thomas C. Register, Adrian A. Franke, Mary S. Anthony, and J. Mark Cline
Cancer Res 2006 66: 1241-1249. [Abstract] [Full Text] [PDF]  

Correction:

Promotion of Invasion and Metastatic Potential by Bcl-2

Cancer Res 2006 66: 1250. [Full Text] [PDF]  

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Cancer Research Clinical Cancer Research
Cancer Epidemiology Biomarkers & Prevention Molecular Cancer Therapeutics
Molecular Cancer Research Cell Growth & Differentiation
Copyright © 2006 by the American Association for Cancer Research.