Reviews:

Cancer Stem Cells: An Old Idea—A Paradigm Shift

Max S. Wicha, Suling Liu, and Gabriela Dontu
Cancer Res 2006 66: 1883-1890. [Abstract] [Full Text] [PDF]  

Identifying Cancer Stem Cells in Solid Tumors: Case Not Proven

Richard P. Hill
Cancer Res 2006 66: 1891-1896. [Abstract] [Full Text] [PDF]  

Perspectives in Cancer Research:

Cancer Risk Assessment at the Atomic Level

Alvaro N.A. Monteiro and Fergus J. Couch
Cancer Res 2006 66: 1897-1899. [Abstract] [Full Text] [PDF]  

Priority Reports:

Structurally Dependent Redox Property of Ribonucleotide Reductase Subunit p53R2

Lijun Xue, Bingsen Zhou, Xiyong Liu, Tieli Wang, Jennifer Shih, Christina Qi, Yvonne Heung, and Yun Yen
Cancer Res 2006 66: 1900-1905. [Abstract] [Full Text] [PDF]  

The Novel Tumor Suppressor p33ING2 Enhances Nucleotide Excision Repair via Inducement of Histone H4 Acetylation and Chromatin Relaxation

Jing Wang, Mei Yieng Chin, and Gang Li
Cancer Res 2006 66: 1906-1911. [Abstract] [Full Text] [PDF] Supplementary Data  

Ex vivo Detectable Human CD8 T-Cell Responses to Cancer-Testis Antigens

Petra Baumgaertner, Nathalie Rufer, Estelle Devevre, Laurent Derre, Donata Rimoldi, Christine Geldhof, Verena Voelter, Danielle Liénard, Pedro Romero, and Daniel E. Speiser
Cancer Res 2006 66: 1912-1916. [Abstract] [Full Text] [PDF]  

The Metastasis-Associated Gene CD24 Is Regulated by Ral GTPase and Is a Mediator of Cell Proliferation and Survival in Human Cancer

Steven C. Smith, Gary Oxford, Zhong Wu, Matthew D. Nitz, Mark Conaway, Henry F. Frierson, Garret Hampton, and Dan Theodorescu
Cancer Res 2006 66: 1917-1922. [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Mammary Tumorigenesis following Transgenic Expression of a Dominant Negative CHK2 Mutant

Eunice L. Kwak, Sang Kim, Jianmin Zhang, Robert D. Cardiff, Emmett V. Schmidt, and Daniel A. Haber
Cancer Res 2006 66: 1923-1928. [Abstract] [Full Text] [PDF]  

Pten Deficiency Activates Distinct Downstream Signaling Pathways in a Tissue-Specific Manner

Lina I. Yoo, David W. Liu, Sandrine Le Vu, Roderick T. Bronson, Hong Wu, and Junying Yuan
Cancer Res 2006 66: 1929-1939. [Abstract] [Full Text] [PDF] Supplementary Data  

Soluble IGF2 Receptor Rescues Apc^Min/+ Intestinal Adenoma Progression Induced by Igf2 Loss of Imprinting

James Harper, Jason L. Burns, Emily J. Foulstone, Massimo Pignatelli, Silvio Zaina, and A. Bassim Hassan
Cancer Res 2006 66: 1940-1948. [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of the IFITM Family as a New Molecular Marker in Human Colorectal Tumors

Pauline Andreu, Sabine Colnot, Cécile Godard, Pierre Laurent-Puig, Dominique Lamarque, Axel Kahn, Christine Perret, and Béatrice Romagnolo
Cancer Res 2006 66: 1949-1955. [Abstract] [Full Text] [PDF] Supplementary Data  

A Gene Expression Signature that Can Predict Green Tea Exposure and Chemopreventive Efficacy of Lung Cancer in Mice

Yan Lu, Ruisheng Yao, Ying Yan, Yian Wang, Yukihiko Hara, Ronald A. Lubet, and Ming You
Cancer Res 2006 66: 1956-1963. [Abstract] [Full Text] [PDF] Supplementary Data  

Dominant-Stable ß-Catenin Expression Causes Cell Fate Alterations and Wnt Signaling Antagonist Expression in a Murine Granulosa Cell Tumor Model

Derek Boerboom, Lisa D. White, Sophie Dalle, José Courty, and JoAnne S. Richards
Cancer Res 2006 66: 1964-1973. [Abstract] [Full Text] [PDF]  

Ras and Its Signals Diffuse through the Cell on Randomly Moving Nanoparticles

Barak Rotblat, Ofer Yizhar, Roni Haklai, Uri Ashery, and Yoel Kloog
Cancer Res 2006 66: 1974-1981. [Abstract] [Full Text] [PDF] Supplementary Data  

The Homeoprotein Six1 Transcriptionally Activates Multiple Protumorigenic Genes but Requires Ezrin to Promote Metastasis

Yanlin Yu, Elai Davicioni, Timothy J. Triche, and Glenn Merlino
Cancer Res 2006 66: 1982-1989. [Abstract] [Full Text] [PDF]  

Cell Type and Culture Condition–Dependent Alternative Splicing in Human Breast Cancer Cells Revealed by Splicing-Sensitive Microarrays

Chunxia Li, Mitsuo Kato, Lily Shiue, John E. Shively, Manuel Ares, Jr., and Ren-Jang Lin
Cancer Res 2006 66: 1990-1999. [Abstract] [Full Text] [PDF] Supplementary Data  

Genetic and Epigenetic Analysis of von Hippel-Lindau (VHL) Gene Alterations and Relationship with Clinical Variables in Sporadic Renal Cancer

Rosamonde E. Banks, Prasanna Tirukonda, Claire Taylor, Nick Hornigold, Dewi Astuti, Dena Cohen, Eamonn R. Maher, Anthea J. Stanley, Patricia Harnden, Adrian Joyce, Margaret Knowles, and Peter J. Selby
Cancer Res 2006 66: 2000-2011. [Abstract] [Full Text] [PDF] Supplementary Data  

BRCA1 DNA-Binding Activity Is Stimulated by BARD1

Amanda M. Simons, Andrew A. Horwitz, Lea M. Starita, Karen Griffin, R. Scott Williams, J.N. Mark Glover, and Jeffrey D. Parvin
Cancer Res 2006 66: 2012-2018. [Abstract] [Full Text] [PDF]  

Genetic and Histopathologic Evaluation of BRCA1 and BRCA2 DNA Sequence Variants of Unknown Clinical Significance

Georgia Chenevix-Trench, Sue Healey, Sunil Lakhani, Paul Waring, Margaret Cummings, Ross Brinkworth, Amie M. Deffenbaugh, Lynn Anne Burbidge, Dmitry Pruss, Thad Judkins, Tom Scholl, Anna Bekessy, Anna Marsh, Paul Lovelock, Ming Wong, Andrea Tesoriero, Helene Renard, Melissa Southey, John L. Hopper, Koulis Yannoukakos, Melissa Brown, kConFab Investigators, Douglas Easton, Sean V. Tavtigian, David Goldgar, and Amanda B. Spurdle
Cancer Res 2006 66: 2019-2027. [Abstract] [Full Text] [PDF]  

Cell, Tumor, and Stem Cell Biology:

ErbB2 Increases Vascular Endothelial Growth Factor Protein Synthesis via Activation of Mammalian Target of Rapamycin/p70S6K Leading to Increased Angiogenesis and Spontaneous Metastasis of Human Breast Cancer Cells

Kristine S. Klos, Shannon L. Wyszomierski, Menghong Sun, Ming Tan, Xiaoyan Zhou, Ping Li, Wentao Yang, Guosheng Yin, Walter N. Hittelman, and Dihua Yu
Cancer Res 2006 66: 2028-2037. [Abstract] [Full Text] [PDF]  

Differential Role of Transient Receptor Potential Channels in Ca²⁺ Entry and Proliferation of Prostate Cancer Epithelial Cells

Stephanie Thebault, Matthieu Flourakis, Karine Vanoverberghe, Franck Vandermoere, Morad Roudbaraki, V'yacheslav Lehen'kyi, Christian Slomianny, Benjamin Beck, Pascal Mariot, Jean-Louis Bonnal, Brigitte Mauroy, Yaroslav Shuba, Thierry Capiod, Roman Skryma, and Natalia Prevarskaya
Cancer Res 2006 66: 2038-2047. [Abstract] [Full Text] [PDF]  

Sprouty 2, an Inhibitor of Mitogen-Activated Protein Kinase Signaling, Is Down-Regulated in Hepatocellular Carcinoma

Chee Wai Fong, Mei-Sze Chua, Arthur B. McKie, Sharon Hee Ming Ling, Veronica Mason, Rui Li, Permeen Yusoff, Ting Ling Lo, Hing Y. Leung, Samuel K.S. So, and Graeme R. Guy
Cancer Res 2006 66: 2048-2058. [Abstract] [Full Text] [PDF] Supplementary Data  

Use of a Chemically Modified Antisense Oligonucleotide Library to Identify and Validate Eg5 (Kinesin-Like 1) as a Target for Antineoplastic Drug Development

Erich Koller, Stephanie Propp, Hong Zhang, Chenguang Zhao, Xiaokun Xiao, MingYi Chang, Scott A. Hirsch, Peter J. Shepard, Seongjoon Koo, Cain Murphy, Robert I. Glazer, and Nicholas M. Dean
Cancer Res 2006 66: 2059-2066. [Abstract] [Full Text] [PDF] Supplementary Data  

Stimulation of Cyclooxygenase-2 Expression by Bone-Derived Transforming Growth Factor-ß Enhances Bone Metastases in Breast Cancer

Toru Hiraga, Akira Myoui, Mary E. Choi, Hideki Yoshikawa, and Toshiyuki Yoneda
Cancer Res 2006 66: 2067-2073. [Abstract] [Full Text] [PDF]  

Effects of the Vascular Disrupting Agent ZD6126 on Interstitial Fluid Pressure and Cell Survival in Tumors

Julia V. Skliarenko, Sarah Jane Lunt, Maggie L. Gordon, Alex Vitkin, Michael Milosevic, and Richard P. Hill
Cancer Res 2006 66: 2074-2080. [Abstract] [Full Text] [PDF]  

Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression

Christelle Adolphe, Rehan Hetherington, Tammy Ellis, and Brandon Wainwright
Cancer Res 2006 66: 2081-2088. [Abstract] [Full Text] [PDF]  

Minimal Active Domain and Mechanism of Action of the Angiogenesis Inhibitor Histidine-Rich Glycoprotein

Johan Dixelius, Anna-Karin Olsson, Åsa Thulin, Chunsik Lee, Irja Johansson, and Lena Claesson-Welsh
Cancer Res 2006 66: 2089-2097. [Abstract] [Full Text] [PDF]  

Induction of Centrosome Amplification during Arsenite-Induced Mitotic Arrest in CGL-2 Cells

Ling-Huei Yih, Yun-Yu Tseng, Yi-Chen Wu, and Te-Chang Lee
Cancer Res 2006 66: 2098-2106. [Abstract] [Full Text] [PDF]  

Genistein Represses Telomerase Activity via Both Transcriptional and Posttranslational Mechanisms in Human Prostate Cancer Cells

Shankar Jagadeesh, Satoru Kyo, and Partha P. Banerjee
Cancer Res 2006 66: 2107-2115. [Abstract] [Full Text] [PDF]  

Multiple Oncogenic Changes (K-RAS^V12, p53 Knockdown, Mutant EGFRs, p16 Bypass, Telomerase) Are Not Sufficient to Confer a Full Malignant Phenotype on Human Bronchial Epithelial Cells

Mitsuo Sato, Melville B. Vaughan, Luc Girard, Michael Peyton, Woochang Lee, David S. Shames, Ruben D. Ramirez, Noriaki Sunaga, Adi F. Gazdar, Jerry W. Shay, and John D. Minna
Cancer Res 2006 66: 2116-2128. [Abstract] [Full Text] [PDF]  

Relationship of Gene Expression and Chromosomal Abnormalities in Colorectal Cancer

Dafna Tsafrir, Manny Bacolod, Zachariah Selvanayagam, Ilan Tsafrir, Jinru Shia, Zhaoshi Zeng, Hao Liu, Curtis Krier, Robert F. Stengel, Francis Barany, William L. Gerald, Philip B. Paty, Eytan Domany, and Daniel A. Notterman
Cancer Res 2006 66: 2129-2137. [Abstract] [Full Text] [PDF] Supplementary Data  

Increased Frequency of Aberrations in the p53/MDM2/p14^ARF Pathway in Neuroblastoma Cell Lines Established at Relapse

Jane Carr, Emma Bell, Andrew D.J. Pearson, Ursula R. Kees, Helen Beris, John Lunec, and Deborah A. Tweddle
Cancer Res 2006 66: 2138-2145. [Abstract] [Full Text] [PDF]  

Integrin ₄ß₁ Promotes Monocyte Trafficking and Angiogenesis in Tumors

Hui Jin, Jingmei Su, Barbara Garmy-Susini, Jeanine Kleeman, and Judy Varner
Cancer Res 2006 66: 2146-2152. [Abstract] [Full Text] [PDF] Supplementary Data  

The Forkhead Box m1 Transcription Factor Stimulates the Proliferation of Tumor Cells during Development of Lung Cancer

Il-Man Kim, Timothy Ackerson, Sneha Ramakrishna, Maria Tretiakova, I-Ching Wang, Tanya V. Kalin, Michael L. Major, Galina A. Gusarova, Helena M. Yoder, Robert H. Costa, and Vladimir V. Kalinichenko
Cancer Res 2006 66: 2153-2161. [Abstract] [Full Text] [PDF]  

Reduction of Cytosolic p27^Kip1 Inhibits Cancer Cell Motility, Survival, and Tumorigenicity

Frederick Y. Wu, Shizhen Emily Wang, Melinda E. Sanders, Incheol Shin, Federico Rojo, Jose Baselga, and Carlos L. Arteaga
Cancer Res 2006 66: 2162-2172. [Abstract] [Full Text] [PDF]  

Tumor Endothelial Cells Express Epidermal Growth Factor Receptor (EGFR) but not ErbB3 and Are Responsive to EGF and to EGFR Kinase Inhibitors

Dhara N. Amin, Kyoko Hida, Diane R. Bielenberg, and Michael Klagsbrun
Cancer Res 2006 66: 2173-2180. [Abstract] [Full Text] [PDF]  

Role of the CXCL12/CXCR4 Axis in Peritoneal Carcinomatosis of Gastric Cancer

Kazuo Yasumoto, Keiichi Koizumi, Atsuhiro Kawashima, Yurika Saitoh, Yoshihisa Arita, Kanna Shinohara, Takayuki Minami, Takashi Nakayama, Hiroaki Sakurai, Yutaka Takahashi, Osamu Yoshie, and Ikuo Saiki
Cancer Res 2006 66: 2181-2187. [Abstract] [Full Text] [PDF]  

Cooperation between FGF8b Overexpression and PTEN Deficiency in Prostate Tumorigenesis

Chen Zhong, Gohar Saribekyan, Chun-Peng Liao, Michael B. Cohen, and Pradip Roy-Burman
Cancer Res 2006 66: 2188-2194. [Abstract] [Full Text] [PDF]  

Runx2 and MYC Collaborate in Lymphoma Development by Suppressing Apoptotic and Growth Arrest Pathways In vivo

Karen Blyth, François Vaillant, Linda Hanlon, Nancy Mackay, Margaret Bell, Alma Jenkins, James C. Neil, and Ewan R. Cameron
Cancer Res 2006 66: 2195-2201. [Abstract] [Full Text] [PDF]  

The Tumor Suppressor Smad4 Is Required for Transforming Growth Factor ß–Induced Epithelial to Mesenchymal Transition and Bone Metastasis of Breast Cancer Cells

Martine Deckers, Maarten van Dinther, Jeroen Buijs, Ivo Que, Clemens Löwik, Gabri van der Pluijm, and Peter ten Dijke
Cancer Res 2006 66: 2202-2209. [Abstract] [Full Text] [PDF] Supplementary Data  

Enhanced Sensitivity to Cytochrome c–Induced Apoptosis Mediated by PHAPI in Breast Cancer Cells

Zachary T. Schafer, Amanda B. Parrish, Kevin M. Wright, Seth S. Margolis, Jeffrey R. Marks, Mohanish Deshmukh, and Sally Kornbluth
Cancer Res 2006 66: 2210-2218. [Abstract] [Full Text] [PDF]  

Direct Demonstration of Instabilities in Oxygen Concentrations within the Extravascular Compartment of an Experimental Tumor

Jennifer Lanzen, Rod D. Braun, Bruce Klitzman, David Brizel, Timothy W. Secomb, and Mark W. Dewhirst
Cancer Res 2006 66: 2219-2223. [Abstract] [Full Text] [PDF]  

The Ligand Status of the Aromatic Hydrocarbon Receptor Modulates Transcriptional Activation of BRCA-1 Promoter by Estrogen

Jennifer K. Hockings, Patricia A. Thorne, Michael Q. Kemp, Sherif S. Morgan, Ornella Selmin, and Donato F. Romagnolo
Cancer Res 2006 66: 2224-2232. [Abstract] [Full Text] [PDF]  

Stalled Replication Induces p53 Accumulation through Distinct Mechanisms from DNA Damage Checkpoint Pathways

Chui Chui Ho, Wai Yi Siu, Anita Lau, Wan Mui Chan, Talha Arooz, and Randy Y.C. Poon
Cancer Res 2006 66: 2233-2241. [Abstract] [Full Text] [PDF] Supplementary Data  

Role of Protein Kinase CK2 in the Regulation of Tumor Necrosis Factor–Related Apoptosis Inducing Ligand–Induced Apoptosis in Prostate Cancer Cells

Guixia Wang, Kashif A. Ahmad, and Khalil Ahmed
Cancer Res 2006 66: 2242-2249. [Abstract] [Full Text] [PDF]  

Parathyroid Hormone–Related Protein Localization in Breast Cancers Predict Improved Prognosis

Michael A. Henderson, Janine A. Danks, John L. Slavin, Graham B. Byrnes, Peter F.M. Choong, John B. Spillane, John L. Hopper, and T. John Martin
Cancer Res 2006 66: 2250-2256. [Abstract] [Full Text] [PDF]  

Xanthine Oxidase–Dependent Regulation of Hypoxia-Inducible Factor in Cancer Cells

Corinne E. Griguer, Claudia R. Oliva, Eric E. Kelley, Gregory I. Giles, Jack R. Lancaster, Jr., and G. Yancey Gillespie
Cancer Res 2006 66: 2257-2263. [Abstract] [Full Text] [PDF]  

The p38 Kinases MKK4 and MKK6 Suppress Metastatic Colonization in Human Ovarian Carcinoma

Jonathan A. Hickson, Dezheng Huo, Donald J. Vander Griend, Anning Lin, Carrie W. Rinker-Schaeffer, and S. Diane Yamada
Cancer Res 2006 66: 2264-2270. [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Targeting of the Receptor Protein Tyrosine Phosphatase ß with a Monoclonal Antibody Delays Tumor Growth in a Glioblastoma Model

Erik D. Foehr, Gustavo Lorente, Jane Kuo, Rosie Ram, Karoly Nikolich, and Roman Urfer
Cancer Res 2006 66: 2271-2278. [Abstract] [Full Text] [PDF]  

SKI-606 Decreases Growth and Motility of Colorectal Cancer Cells by Preventing pp60(c-Src)–Dependent Tyrosine Phosphorylation of ß-Catenin and Its Nuclear Signaling

Addolorata Maria Luce Coluccia, Daniela Benati, Hafedh Dekhil, Annamaria De Filippo, Cathy Lan, and Carlo Gambacorti-Passerini
Cancer Res 2006 66: 2279-2286. [Abstract] [Full Text] [PDF]  

-Sulfoquinovosylmonoacylglycerol Is a Novel Potent Radiosensitizer Targeting Tumor Angiogenesis

Ippei Sakimoto, Keisuke Ohta, Takayuki Yamazaki, Seiji Ohtani, Hiroeki Sahara, Fumio Sugawara, Kengo Sakaguchi, and Masahiko Miura
Cancer Res 2006 66: 2287-2295. [Abstract] [Full Text] [PDF]  

Expression of p53 Enhances Selenite-Induced Superoxide Production and Apoptosis in Human Prostate Cancer Cells

Rui Zhao, Nong Xiang, Frederick E. Domann, and Weixiong Zhong
Cancer Res 2006 66: 2296-2304. [Abstract] [Full Text] [PDF]  

Mechanism by Which Mammalian Target of Rapamycin Inhibitors Sensitize Multiple Myeloma Cells to Dexamethasone-Induced Apoptosis

Huajun Yan, Patrick Frost, Yijiang Shi, Bao Hoang, Sanjai Sharma, Myrna Fisher, Joseph Gera, and Alan Lichtenstein
Cancer Res 2006 66: 2305-2313. [Abstract] [Full Text] [PDF]  

Glioma Virotherapy: Effects of Innate Immune Suppression and Increased Viral Replication Capacity

Avner Friedman, Jianjun Paul Tian, Giulia Fulci, E. Antonio Chiocca, and Jin Wang
Cancer Res 2006 66: 2314-2319. [Abstract] [Full Text] [PDF]  

Protein Kinase B/Akt-Dependent Phosphorylation of Glycogen Synthase Kinase-3ß in Irradiated Vascular Endothelium

Jiahua Tan, Ling Geng, Eugenia M. Yazlovitskaya, and Dennis E. Hallahan
Cancer Res 2006 66: 2320-2327. [Abstract] [Full Text] [PDF]  

Lymphocyte Activation Antigen CD70 Expressed by Renal Cell Carcinoma Is a Potential Therapeutic Target for Anti-CD70 Antibody-Drug Conjugates

Che-Leung Law, Kristine A. Gordon, Brian E. Toki, Andrew K. Yamane, Michelle A. Hering, Charles G. Cerveny, Joseph M. Petroziello, Maureen C. Ryan, Leia Smith, Ronald Simon, Guido Sauter, Ezogelin Oflazoglu, Svetlana O. Doronina, Damon L. Meyer, Joseph A. Francisco, Paul Carter, Peter D. Senter, John A. Copland, Christopher G. Wood, and Alan F. Wahl
Cancer Res 2006 66: 2328-2337. [Abstract] [Full Text] [PDF]  

Cell Adhesion to Fibronectin (CAM-DR) Influences Acquired Mitoxantrone Resistance in U937 Cells

Lori A. Hazlehurst, Raul F. Argilagos, Michael Emmons, David Boulware, Craig A. Beam, Dan M. Sullivan, and William S. Dalton
Cancer Res 2006 66: 2338-2345. [Abstract] [Full Text] [PDF]  

Endocytic Recycling Compartments Altered in Cisplatin-Resistant Cancer Cells

Xing-Jie Liang, Sushmita Mukherjee, Ding-Wu Shen, Frederick R. Maxfield, and Michael M. Gottesman
Cancer Res 2006 66: 2346-2353. [Abstract] [Full Text] [PDF]  

Regression of Melanoma in a Murine Model by RLIP76 Depletion

Sharad S. Singhal, Yogesh C. Awasthi, and Sanjay Awasthi
Cancer Res 2006 66: 2354-2360. [Abstract] [Full Text] [PDF] Supplementary Data  

Multiple Robust Signatures for Detecting Lymph Node Metastasis in Head and Neck Cancer

Paul Roepman, Patrick Kemmeren, Lodewijk F.A. Wessels, Piet J. Slootweg, and Frank C.P. Holstege
Cancer Res 2006 66: 2361-2366. [Abstract] [Full Text] [PDF] Supplementary Data  

Identification of Small Molecules that Sensitize Resistant Tumor Cells to Tumor Necrosis Factor-Family Death Receptors

Aaron D. Schimmer, Michael P. Thomas, Rose Hurren, Marcela Gronda, Maurizio Pellecchia, Gregory R. Pond, Marina Konopleva, Debbie Gurfinkel, Imtiaz A. Mawji, Ewan Brown, and John C. Reed
Cancer Res 2006 66: 2367-2375. [Abstract] [Full Text] [PDF] Supplementary Data  

Activating Transcription Factor 3 and Early Growth Response 1 Are the Novel Targets of LY294002 in a Phosphatidylinositol 3-Kinase–Independent Pathway

Kiyoshi Yamaguchi, Seong-Ho Lee, Jong-Sik Kim, Jay Wimalasena, Shigetaka Kitajima, and Seung Joon Baek
Cancer Res 2006 66: 2376-2384. [Abstract] [Full Text] [PDF]  

C-fos Assessment as a Marker of Anti–Epidermal Growth Factor Receptor Effect

Antonio Jimeno, Peter Kulesza, Erik Kincaid, Nadia Bouaroud, Audrey Chan, Arlene Forastiere, Julie Brahmer, Douglas P. Clark, and Manuel Hidalgo
Cancer Res 2006 66: 2385-2390. [Abstract] [Full Text] [PDF]  

Down-regulation of Insulin Receptor by Antibodies against the Type I Insulin-Like Growth Factor Receptor: Implications for Anti–Insulin-Like Growth Factor Therapy in Breast Cancer

Deepali Sachdev, Rajeeva Singh, Yoko Fujita-Yamaguchi, and Douglas Yee
Cancer Res 2006 66: 2391-2402. [Abstract] [Full Text] [PDF]  

Molecular Target-Based Therapy of Pancreatic Cancer

Irina V. Lebedeva, Devanand Sarkar, Zao-Zhong Su, Rahul V. Gopalkrishnan, Mohammad Athar, Aaron Randolph, Kristoffer Valerie, Paul Dent, and Paul B. Fisher
Cancer Res 2006 66: 2403-2413. [Abstract] [Full Text] [PDF]  

Immunology:

Embryonic Stem Cell–Derived Dendritic Cells Expressing Glypican-3, a Recently Identified Oncofetal Antigen, Induce Protective Immunity against Highly Metastatic Mouse Melanoma, B16-F10

Yutaka Motomura, Satoru Senju, Tetsuya Nakatsura, Hidetake Matsuyoshi, Shinya Hirata, Mikio Monji, Hiroyuki Komori, Daiki Fukuma, Hideo Baba, and Yasuharu Nishimura
Cancer Res 2006 66: 2414-2422. [Abstract] [Full Text] [PDF]  

Melanosomal Targeting Sequences from gp100 Are Essential for MHC Class II–Restricted Endogenous Epitope Presentation and Mobilization to Endosomal Compartments

Stéphanie Lepage and Réjean Lapointe
Cancer Res 2006 66: 2423-2432. [Abstract] [Full Text] [PDF]  

Multiple Hepatic Receptors Cooperate to Eliminate Secretory Mucins Aberrantly Entering the Bloodstream: Are Circulating Cancer Mucins the "Tip of the Iceberg"?

Mark G. Wahrenbrock and Ajit Varki
Cancer Res 2006 66: 2433-2441. [Abstract] [Full Text] [PDF] Supplementary Data  

Low Surface Expression of B7-1 (CD80) Is an Immunoescape Mechanism of Colon Carcinoma

Iñigo Tirapu, Eduardo Huarte, Cristiana Guiducci, Ainhoa Arina, Mikel Zaratiegui, Oihana Murillo, Alvaro Gonzalez, Carmen Berasain, Pedro Berraondo, Puri Fortes, Jesús Prieto, Mario P. Colombo, Lieping Chen, and Ignacio Melero
Cancer Res 2006 66: 2442-2450. [Abstract] [Full Text] [PDF] Supplementary Data  

p53 Regulates Cellular Resistance to Complement Lysis through Enhanced Expression of CD59

Rossen M. Donev, Duncan S. Cole, Baalasubramanian Sivasankar, Timothy R. Hughes, and B. Paul Morgan
Cancer Res 2006 66: 2451-2458. [Abstract] [Full Text] [PDF]  

Endocrinology:

3-Methylcholanthrene and Other Aryl Hydrocarbon Receptor Agonists Directly Activate Estrogen Receptor

Maen Abdelrahim, Eric Ariazi, Kyounghyun Kim, Shaheen Khan, Rola Barhoumi, Robert Burghardt, Shengxi Liu, Denise Hill, Richard Finnell, Bogdan Wlodarczyk, V. Craig Jordan, and Stephen Safe
Cancer Res 2006 66: 2459-2467. [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Haplotype Analysis of the HSD17B1 Gene and Risk of Breast Cancer: A Comprehensive Approach to Multicenter Analyses of Prospective Cohort Studies

Heather Spencer Feigelson, David G. Cox, Howard M. Cann, Sholom Wacholder, Rudolf Kaaks, Brian E. Henderson, Demetrius Albanes, David Altshuler, Goran Berglund, Franco Berrino, Sheila Bingham, Julie E. Buring, Noel P. Burtt, Eugenia E. Calle, Stephen J. Chanock, Francoise Clavel-Chapelon, Graham Colditz, W. Ryan Diver, Matthew L. Freedman, Christopher A. Haiman, Susan E. Hankinson, Richard B. Hayes, Joel N. Hirschhorn, David Hunter, Laurence N. Kolonel, Peter Kraft, Loic LeMarchand, Jakob Linseisen, William Modi, Carmen Navarro, Petra H. Peeters, Malcolm C. Pike, Elio Riboli, V. Wendy Setiawan, Daniel O. Stram, Gilles Thomas, Michael J. Thun, Anne Tjonneland, and Dimitrios Trichopoulos
Cancer Res 2006 66: 2468-2475. [Abstract] [Full Text] [PDF] Supplementary Data  

Association between Plasma Prolactin Concentrations and Risk of Breast Cancer among Predominately Premenopausal Women

Shelley S. Tworoger, Patrick Sluss, and Susan E. Hankinson
Cancer Res 2006 66: 2476-2482. [Abstract] [Full Text] [PDF] Supplementary Data  

A Prospective Study of Serum C-Reactive Protein and Colorectal Cancer Risk in Men

Marc J. Gunter, Rachael Stolzenberg-Solomon, Amanda J. Cross, Michael F. Leitzmann, Stephanie Weinstein, Richard J. Wood, Jarmo Virtamo, Philip R. Taylor, Demetrius Albanes, and Rashmi Sinha
Cancer Res 2006 66: 2483-2487. [Abstract] [Full Text] [PDF]  

Potent Protection against Aflatoxin-Induced Tumorigenesis through Induction of Nrf2-Regulated Pathways by the Triterpenoid 1-[2-Cyano-3-,12-Dioxooleana-1,9(11)-Dien-28-Oyl]Imidazole

Melinda S. Yates, Mi-Kyoung Kwak, Patricia A. Egner, John D. Groopman, Sridevi Bodreddigari, Thomas R. Sutter, Karen J. Baumgartner, B.D. Roebuck, Karen T. Liby, Mark M. Yore, Tadashi Honda, Gordon W. Gribble, Michael B. Sporn, and Thomas W. Kensler
Cancer Res 2006 66: 2488-2494. [Abstract] [Full Text] [PDF]  

Correction:

Antilymphoma Activity of an Anti-CD40 Antibody

Cancer Res 2006 66: 2495. [Full Text] [PDF]  

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