REVIEWS:

von Hippel-Lindau: A Tumor Suppressor Links Microtubules to Ciliogenesis and Cancer Development

E. Wolfgang Kuehn, Gerd Walz, and Thomas Benzing
Cancer Res 2007 67: 4537-4540. doi: 10.1158/0008-5472.CAN-07-0391 [Abstract] [Full Text] [PDF]  

Perspectives in Cancer Research:

Faithful Companions: A Proposal for Neurooncology Trials in Pet Dogs

Jonathan Kimmelman and Josephine Nalbantoglu
Cancer Res 2007 67: 4541-4544. doi: 10.1158/0008-5472.CAN-06-3792 [Abstract] [Full Text] [PDF]  

Meeting Reports:

Towards Clinical Application of Methylated DNA Sequences as Cancer Biomarkers: A Joint NCI's EDRN and NIST Workshop on Standards, Methods, Assays, Reagents and Tools

Jacob Kagan, Sudhir Srivastava, Peter E. Barker, Steven A. Belinsky, and Paul Cairns
Cancer Res 2007 67: 4545-4549. doi: 10.1158/0008-5472.CAN-06-2888 [Abstract] [Full Text] [PDF]  

The 3rd Pacific Rim Meeting on Breast and Prostate Cancer: Progress in Hormonal Carcinogenesis and the Enduring Influence of Ron Ross

Juergen K.V. Reichardt and Wayne D. Tilley
Cancer Res 2007 67: 4550-4552. doi: 10.1158/0008-5472.CAN-07-0280 [Full Text] [PDF] Supplementary Data  

MicroRNA: Potential for Cancer Detection, Diagnosis, and Prognosis

James V. Tricoli and James W. Jacobson
Cancer Res 2007 67: 4553-4555. doi: 10.1158/0008-5472.CAN-07-0563 [Full Text] [PDF]  

In the Forefront of Basic and Translational Cancer Research: Seventh Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association

Laura DeBusk, Alisha J. Russell, Kohzoh Imai, and Lynn M. Matrisian
Cancer Res 2007 67: 4556-4559. doi: 10.1158/0008-5472.CAN-07-1102 [Full Text] [PDF]  

Meeting Report: Translational Research at the Aging and Cancer Interface

Christopher C. Benz, Judith Campisi, Harvey J. Cohen, William B. Ershler, and Irmgard Irminger-Finger
Cancer Res 2007 67: 4560-4563. doi: 10.1158/0008-5472.CAN-07-1236 [Full Text] [PDF]  

Priority Reports:

Myeloid Cell Leukemia-1 Inversely Correlates with Glycogen Synthase Kinase-3ß Activity and Associates with Poor Prognosis in Human Breast Cancer

Qingqing Ding, Xianghuo He, Weiya Xia, Jung-Mao Hsu, Chun-Te Chen, Long-Yuan Li, Dung-Fang Lee, Jer-Yen Yang, Xiaoming Xie, Jaw-Ching Liu, and Mien-Chie Hung
Cancer Res 2007 67: 4564-4571. Published Online First May 10, 2007. doi: 10.1158/0008-5472.CAN-06-1788 [Abstract] [Full Text] [PDF]  

Inhibition of p38 Mitogen-Activated Protein Kinase Prevents the Development of Osteolytic Bone Disease, Reduces Tumor Burden, and Increases Survival in Murine Models of Multiple Myeloma

Karin Vanderkerken, Satya Medicherla, Les Coulton, Hendrik De Raeve, Angelo Willems, Michelle Lawson, Ben Van Camp, Andrew A. Protter, Linda S. Higgins, Eline Menu, and Peter I. Croucher
Cancer Res 2007 67: 4572-4577. Published Online First May 10, 2007. doi: 10.1158/0008-5472.CAN-06-4361 [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Attenuated Expression of Xeroderma Pigmentosum Group C Is Associated with Critical Events in Human Bladder Cancer Carcinogenesis and Progression

Zhiwen Chen, Jin Yang, Gan Wang, Bo Song, Jin Li, and Zhigang Xu
Cancer Res 2007 67: 4578-4585. doi: 10.1158/0008-5472.CAN-06-0877 [Abstract] [Full Text] [PDF]  

Extensive Methylation Is Associated with ß-Catenin Mutations in Hepatocellular Carcinoma: Evidence for Two Distinct Pathways of Human Hepatocarcinogenesis

Naoshi Nishida, Takafumi Nishimura, Takeshi Nagasaka, Iwao Ikai, Goel Ajay, and C. Richard Boland
Cancer Res 2007 67: 4586-4594. doi: 10.1158/0008-5472.CAN-06-3464 [Abstract] [Full Text] [PDF] Supplementary Data  

Functional Analysis of Human MLH1 Variants Using Yeast and In vitro Mismatch Repair Assays

Masanobu Takahashi, Hideki Shimodaira, Corinne Andreutti-Zaugg, Richard Iggo, Richard D. Kolodner, and Chikashi Ishioka
Cancer Res 2007 67: 4595-4604. doi: 10.1158/0008-5472.CAN-06-3509 [Abstract] [Full Text] [PDF]  

Fundamental Differences in Cell Cycle Deregulation in Human Papillomavirus–Positive and Human Papillomavirus–Negative Head/Neck and Cervical Cancers

Dohun Pyeon, Michael A. Newton, Paul F. Lambert, Johan A. den Boon, Srikumar Sengupta, Carmen J. Marsit, Craig D. Woodworth, Joseph P. Connor, Thomas H. Haugen, Elaine M. Smith, Karl T. Kelsey, Lubomir P. Turek, and Paul Ahlquist
Cancer Res 2007 67: 4605-4619. doi: 10.1158/0008-5472.CAN-06-3619 [Abstract] [Full Text] [PDF] Supplementary Data  

Transcriptional Control of the Human High Mobility Group A1 Gene: Basal and Oncogenic Ras-Regulated Expression

Isabelle Cleynen, Christel Huysmans, Takehiko Sasazuki, Senji Shirasawa, Wim Van de Ven, and Kristel Peeters
Cancer Res 2007 67: 4620-4629. doi: 10.1158/0008-5472.CAN-06-4325 [Abstract] [Full Text] [PDF]  

DJ-1 Binds Androgen Receptor Directly and Mediates Its Activity in Hormonally Treated Prostate Cancer Cells

J. Erin Tillman, Jialing Yuan, Guangyu Gu, Ladan Fazli, Ritwik Ghosh, Alex S. Flynt, Martin Gleave, Paul S. Rennie, and Susan Kasper
Cancer Res 2007 67: 4630-4637. doi: 10.1158/0008-5472.CAN-06-4556 [Abstract] [Full Text] [PDF]  

Expression of Nicotinic Acetylcholine Receptor Subunit Genes in Non–Small-Cell Lung Cancer Reveals Differences between Smokers and Nonsmokers

David Chi-leung Lam, Luc Girard, Ruben Ramirez, Wing-shun Chau, Wai-sing Suen, Shelley Sheridan, Vicky P.C. Tin, Lap-ping Chung, Maria P. Wong, Jerry W. Shay, Adi F. Gazdar, Wah-kit Lam, and John D. Minna
Cancer Res 2007 67: 4638-4647. doi: 10.1158/0008-5472.CAN-06-4628 [Abstract] [Full Text] [PDF]  

Dominant-Negative but not Gain-of-Function Effects of a p53.R270H Mutation in Mouse Epithelium Tissue after DNA Damage

Susan W.P. Wijnhoven, Ewoud N. Speksnijder, Xiaoling Liu, Edwin Zwart, Conny Th. M. vanOostrom, Rudolf B. Beems, Esther M. Hoogervorst, Mirjam M. Schaap, Laura D. Attardi, Tyler Jacks, Harry van Steeg, Jos Jonkers, and Annemieke de Vries
Cancer Res 2007 67: 4648-4656. doi: 10.1158/0008-5472.CAN-06-4681 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor Suppressor Activity of CCAAT/Enhancer Binding Protein Is Epigenetically Down-regulated in Head and Neck Squamous Cell Carcinoma

Kristi L. Bennett, Björn Hackanson, Laura T. Smith, Carl D. Morrison, James C. Lang, David E. Schuller, Frank Weber, Charis Eng, and Christoph Plass
Cancer Res 2007 67: 4657-4664. doi: 10.1158/0008-5472.CAN-06-4793 [Abstract] [Full Text] [PDF] Supplementary Data  

EGFR-T790M Is a Rare Lung Cancer Susceptibility Allele with Enhanced Kinase Activity

Haris Vikis, Mitsuo Sato, Michael James, Daolong Wang, Yian Wang, Min Wang, Dongmei Jia, Yan Liu, Joan E. Bailey-Wilson, Christopher I. Amos, Susan M. Pinney, Gloria M. Petersen, Mariza de Andrade, Ping Yang, Jonathan S. Wiest, Pamela R. Fain, Ann G. Schwartz, Adi Gazdar, Colette Gaba, Henry Rothschild, Diptasri Mandal, Elena Kupert, Daniela Seminara, Avinash Viswanathan, Ramaswamy Govindan, John Minna, Marshall W. Anderson, and Ming You
Cancer Res 2007 67: 4665-4670. doi: 10.1158/0008-5472.CAN-07-0217 [Abstract] [Full Text] [PDF]  

Repression of Sestrin Family Genes Contributes to Oncogenic Ras-Induced Reactive Oxygen Species Up-regulation and Genetic Instability

Pavel B. Kopnin, Larissa S. Agapova, Boris P. Kopnin, and Peter M. Chumakov
Cancer Res 2007 67: 4671-4678. doi: 10.1158/0008-5472.CAN-06-2466 [Abstract] [Full Text] [PDF] Supplementary Data  

HMGA1 Controls Transcription of Insulin Receptor to Regulate Cyclin D1 Translation in Pancreatic Cancer Cells

Sebastian Kolb, Ralph Fritsch, Dieter Saur, Maximilian Reichert, Roland M. Schmid, and Günter Schneider
Cancer Res 2007 67: 4679-4686. doi: 10.1158/0008-5472.CAN-06-3308 [Abstract] [Full Text] [PDF] Supplementary Data  

Mitochondrial Genetic Background Modifies Breast Cancer Risk

Ren-Kui Bai, Suzanne M. Leal, Daniel Covarrubias, Aiyi Liu, and Lee-Jun C. Wong
Cancer Res 2007 67: 4687-4694. doi: 10.1158/0008-5472.CAN-06-3554 [Abstract] [Full Text] [PDF] Supplementary Data  

The Combined Effects of Xeroderma Pigmentosum C Deficiency and Mutagens on Mutation Rates in the Mouse Germ Line

Laurent Miccoli, Karen L-A. Burr, Peter Hickenbotham, Errol C. Friedberg, Jaime F. Angulo, and Yuri E. Dubrova
Cancer Res 2007 67: 4695-4699. doi: 10.1158/0008-5472.CAN-06-3844 [Abstract] [Full Text] [PDF]  

Hint1 Inhibits Growth and Activator Protein-1 Activity in Human Colon Cancer Cells

Lin Wang, Yujing Zhang, Haiyang Li, Zhiheng Xu, Regina M. Santella, and I. Bernard Weinstein
Cancer Res 2007 67: 4700-4708. doi: 10.1158/0008-5472.CAN-06-4645 [Abstract] [Full Text] [PDF]  

Regulation of Helicobacter pylori cagA Expression in Response to Salt

John T. Loh, Victor J. Torres, and Timothy L. Cover
Cancer Res 2007 67: 4709-4715. doi: 10.1158/0008-5472.CAN-06-4746 [Abstract] [Full Text] [PDF]  

Cell, Tumor, and Stem Cell Biology:

Angiostatin-Like Activity of a Monoclonal Antibody to the Catalytic Subunit of F₁F₀ ATP Synthase

Sulene L. Chi, Miriam L. Wahl, Yvonne M. Mowery, Siqing Shan, Somnath Mukhopadhyay, Susana C. Hilderbrand, Daniel J. Kenan, Barbara D. Lipes, Carrie E. Johnson, Michael F. Marusich, Roderick A. Capaldi, Mark W. Dewhirst, and Salvatore V. Pizzo
Cancer Res 2007 67: 4716-4724. doi: 10.1158/0008-5472.CAN-06-1094 [Abstract] [Full Text] [PDF]  

High-Level Expression of Chemokine CXCL16 by Tumor Cells Correlates with a Good Prognosis and Increased Tumor-Infiltrating Lymphocytes in Colorectal Cancer

Shozo Hojo, Keiichi Koizumi, Koichi Tsuneyama, Yoshihisa Arita, Zhengguo Cui, Kanna Shinohara, Takayuki Minami, Isaya Hashimoto, Takashi Nakayama, Hiroaki Sakurai, Yasuo Takano, Osamu Yoshie, Kazuhiro Tsukada, and Ikuo Saiki
Cancer Res 2007 67: 4725-4731. doi: 10.1158/0008-5472.CAN-06-3424 [Abstract] [Full Text] [PDF]  

Expression of p16^Ink4a Compensates for p18^Ink4c Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and Tissues

Matthew R. Ramsey, Janakiraman Krishnamurthy, Xin-Hai Pei, Chad Torrice, Weili Lin, Daniel R. Carrasco, Keith L. Ligon, Yue Xiong, and Norman E. Sharpless
Cancer Res 2007 67: 4732-4741. doi: 10.1158/0008-5472.CAN-06-3437 [Abstract] [Full Text] [PDF] Supplementary Data  

The Ability of Versican to Simultaneously Cause Apoptotic Resistance and Sensitivity

David P. LaPierre, Daniel Y. Lee, Sen-Zhu Li, Yi-Zhen Xie, Ling Zhong, Wang Sheng, Zhaoqun Deng, and Burton B. Yang
Cancer Res 2007 67: 4742-4750. doi: 10.1158/0008-5472.CAN-06-3610 [Abstract] [Full Text] [PDF] Supplementary Data  

Inactivation of Glutathione Peroxidase Activity Contributes to UV-Induced Squamous Cell Carcinoma Formation

Jennifer Walshe, Magdalena M. Serewko-Auret, Ngari Teakle, Sarina Cameron, Kelly Minto, Louise Smith, Philip C. Burcham, Terry Russell, Geoffrey Strutton, Anthony Griffin, Fong-Fong Chu, Stephen Esworthy, Vivienne Reeve, and Nicholas A. Saunders
Cancer Res 2007 67: 4751-4758. doi: 10.1158/0008-5472.CAN-06-4192 [Abstract] [Full Text] [PDF]  

Rap1 Integrates Tissue Polarity, Lumen Formation, and Tumorigenic Potential in Human Breast Epithelial Cells

Masahiko Itoh, Celeste M. Nelson, Connie A. Myers, and Mina J. Bissell
Cancer Res 2007 67: 4759-4766. doi: 10.1158/0008-5472.CAN-06-4246 [Abstract] [Full Text] [PDF]  

Chemotherapy-Induced Thrombocytopenia Derives from the Selective Death of Megakaryocyte Progenitors and Can Be Rescued by Stem Cell Factor

Ann Zeuner, Michele Signore, Daniela Martinetti, Monica Bartucci, Cesare Peschle, and Ruggero De Maria
Cancer Res 2007 67: 4767-4773. doi: 10.1158/0008-5472.CAN-06-4303 [Abstract] [Full Text] [PDF]  

Carcinoembryonic Antigen Inhibits Anoikis in Colorectal Carcinoma Cells by Interfering with Trail-R2 (DR5) Signaling

Raed N. Samara, Luciana M. Laguinge, and J. Milburn Jessup
Cancer Res 2007 67: 4774-4782. doi: 10.1158/0008-5472.CAN-06-4315 [Abstract] [Full Text] [PDF] Supplementary Data  

Scavenger Receptor-A–Targeted Leukocyte Depletion Inhibits Peritoneal Ovarian Tumor Progression

S. Peter Bak, Julie Jo Walters, Motohiro Takeya, Jose R. Conejo-Garcia, and Brent L. Berwin
Cancer Res 2007 67: 4783-4789. doi: 10.1158/0008-5472.CAN-06-4410 [Abstract] [Full Text] [PDF] Supplementary Data  

Nucleophosmin Mediates Mammalian Target of Rapamycin–Dependent Actin Cytoskeleton Dynamics and Proliferation in Neurofibromin-Deficient Astrocytes

Danielle K. Sandsmark, Huabiao Zhang, Balazs Hegedus, Corey L. Pelletier, Jason D. Weber, and David H. Gutmann
Cancer Res 2007 67: 4790-4799. doi: 10.1158/0008-5472.CAN-06-4470 [Abstract] [Full Text] [PDF] Supplementary Data  

Loss of Functional Fas Ligand Enhances Intestinal Tumorigenesis in the Min Mouse Model

Barbara Fingleton, Kathy J. Carter, and Lynn M. Matrisian
Cancer Res 2007 67: 4800-4806. doi: 10.1158/0008-5472.CAN-06-4473 [Abstract] [Full Text] [PDF]  

Prostate Cancer Cells with Stem Cell Characteristics Reconstitute the Original Human Tumor In vivo

Guangyu Gu, Jialing Yuan, Marcia Wills, and Susan Kasper
Cancer Res 2007 67: 4807-4815. doi: 10.1158/0008-5472.CAN-06-4608 [Abstract] [Full Text] [PDF] Supplementary Data  

Synergistic Activation of the Tumor Suppressor, HLJ1, by the Transcription Factors YY1 and Activator Protein 1

Chi-Chung Wang, Meng-Feng Tsai, Ting-Hao Dai, Tse-Ming Hong, Wing-Kai Chan, Jeremy J.W. Chen, and Pan-Chyr Yang
Cancer Res 2007 67: 4816-4826. doi: 10.1158/0008-5472.CAN-07-0504 [Abstract] [Full Text] [PDF]  

Side Population in Human Lung Cancer Cell Lines and Tumors Is Enriched with Stem-like Cancer Cells

Maria M. Ho, Alvin V. Ng, Stephen Lam, and Jaclyn Y. Hung
Cancer Res 2007 67: 4827-4833. doi: 10.1158/0008-5472.CAN-06-3557 [Abstract] [Full Text] [PDF] Supplementary Data  

Ras Transformation of RIE-1 Cells Activates Cap-Independent Translation of Ornithine Decarboxylase: Regulation by the Raf/MEK/ERK and Phosphatidylinositol 3-Kinase Pathways

Sofia Origanti and Lisa M. Shantz
Cancer Res 2007 67: 4834-4842. doi: 10.1158/0008-5472.CAN-06-4627 [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Modulation of Intracellular Ceramide Using Polymeric Nanoparticles to Overcome Multidrug Resistance in Cancer

Lilian E. van Vlerken, Zhenfeng Duan, Michael V. Seiden, and Mansoor M. Amiji
Cancer Res 2007 67: 4843-4850. doi: 10.1158/0008-5472.CAN-06-1648 [Abstract] [Full Text] [PDF]  

Tumor Angiogenesis Promoted by Ex vivo Differentiated Endothelial Progenitor Cells Is Effectively Inhibited by an Angiogenesis Inhibitor, TK1-2

Ho-Kyun Oh, Jung-Min Ha, Eunju O, Byung Hun Lee, Suk Keun Lee, Byoung-Shik Shim, Yong-Kil Hong, and Young Ae Joe
Cancer Res 2007 67: 4851-4859. doi: 10.1158/0008-5472.CAN-06-2979 [Abstract] [Full Text] [PDF] Supplementary Data  

Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer

Satsuki Owatari, Satoshi Akune, Masaharu Komatsu, Ryuji Ikeda, Stephen D. Firth, Xiao-Fang Che, Masatatsu Yamamoto, Kazutake Tsujikawa, Masaki Kitazono, Takashi Ishizawa, Toru Takeuchi, Takashi Aikou, Julian F.B. Mercer, Shin-ichi Akiyama, and Tatsuhiko Furukawa
Cancer Res 2007 67: 4860-4868. doi: 10.1158/0008-5472.CAN-06-3096 [Abstract] [Full Text] [PDF] Supplementary Data  

Enhanced Hepatocyte Growth Factor Signaling by Type II Transforming Growth Factor-ß Receptor Knockout Fibroblasts Promotes Mammary Tumorigenesis

Nikki Cheng, Anna Chytil, Yu Shyr, Alison Joly, and Harold L. Moses
Cancer Res 2007 67: 4869-4877. Published Online First May 10, 2007. doi: 10.1158/0008-5472.CAN-06-3381 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Basis of the Synergistic Antiangiogenic Activity of Bevacizumab and Mithramycin A

Zhiliang Jia, Jun Zhang, Daoyan Wei, Liwei Wang, Ping Yuan, Xiangdong Le, Qiang Li, James Yao, and Keping Xie
Cancer Res 2007 67: 4878-4885. doi: 10.1158/0008-5472.CAN-06-3494 [Abstract] [Full Text] [PDF]  

HIV Protease Inhibitors Enhance the Efficacy of Irradiation

Kyle C. Cuneo, Tianxiang Tu, Ling Geng, Allie Fu, Dennis E. Hallahan, and Christopher D. Willey
Cancer Res 2007 67: 4886-4893. doi: 10.1158/0008-5472.CAN-06-3684 [Abstract] [Full Text] [PDF]  

Honokiol Induces a Necrotic Cell Death through the Mitochondrial Permeability Transition Pore

Ling Li, Weidong Han, Ying Gu, Shuang Qiu, Qinghua Lu, Jie Jin, Jianhong Luo, and Xun Hu
Cancer Res 2007 67: 4894-4903. doi: 10.1158/0008-5472.CAN-06-3818 [Abstract] [Full Text] [PDF] Supplementary Data  

ERR Suppresses Cell Proliferation and Tumor Growth of Androgen-Sensitive and Androgen-Insensitive Prostate Cancer Cells and Its Implication as a Therapeutic Target for Prostate Cancer

Shan Yu, Xianghong Wang, Chi-Fai Ng, Shiuan Chen, and Franky L. Chan
Cancer Res 2007 67: 4904-4914. doi: 10.1158/0008-5472.CAN-06-3855 [Abstract] [Full Text] [PDF]  

P-Glycoprotein Mediates Celecoxib-Induced Apoptosis in Multiple Drug-Resistant Cell Lines

Ornella Fantappiè, Michela Solazzo, Nadia Lasagna, Francesca Platini, Luciana Tessitore, and Roberto Mazzanti
Cancer Res 2007 67: 4915-4923. doi: 10.1158/0008-5472.CAN-06-3952 [Abstract] [Full Text] [PDF] Supplementary Data  

Armed Antibodies Targeting the Mucin Repeats of the Ovarian Cancer Antigen, MUC16, Are Highly Efficacious in Animal Tumor Models

Youjun Chen, Suzanna Clark, Terence Wong, Yongmei Chen, Yvonne Chen, Mark S. Dennis, Elizabeth Luis, Fiona Zhong, Sheila Bheddah, Hartmut Koeppen, Alvin Gogineni, Sarajane Ross, Paul Polakis, and William Mallet
Cancer Res 2007 67: 4924-4932. doi: 10.1158/0008-5472.CAN-06-4512 [Abstract] [Full Text] [PDF] Supplementary Data  

Mutations in BRAF and KRAS Converge on Activation of the Mitogen-Activated Protein Kinase Pathway in Lung Cancer Mouse Models

Hongbin Ji, Zhenxiong Wang, Samanthi A. Perera, Danan Li, Mei-Chih Liang, Sara Zaghlul, Kate McNamara, Liang Chen, Mitchell Albert, Yanping Sun, Ruqayyah Al-Hashem, Lucian R. Chirieac, Robert Padera, Roderick T. Bronson, Roman K. Thomas, Levi A. Garraway, Pasi A. Jänne, Bruce E. Johnson, Lynda Chin, and Kwok-Kin Wong
Cancer Res 2007 67: 4933-4939. doi: 10.1158/0008-5472.CAN-06-4592 [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data  

The Antibody-Mediated Targeted Delivery of Interleukin-15 and GM-CSF to the Tumor Neovasculature Inhibits Tumor Growth and Metastasis

Manuela Kaspar, Eveline Trachsel, and Dario Neri
Cancer Res 2007 67: 4940-4948. doi: 10.1158/0008-5472.CAN-07-0283 [Abstract] [Full Text] [PDF]  

Suicide Gene Therapy of Human Colon Carcinoma Xenografts Using an Armed Oncolytic Adenovirus Expressing Carboxypeptidase G2

Silke Schepelmann, Lesley M. Ogilvie, Douglas Hedley, Frank Friedlos, Janet Martin, Ian Scanlon, Ping Chen, Richard Marais, and Caroline J. Springer
Cancer Res 2007 67: 4949-4955. doi: 10.1158/0008-5472.CAN-07-0297 [Abstract] [Full Text] [PDF]  

MMP-9 Short Interfering RNA Induced Senescence Resulting in Inhibition of Medulloblastoma Growth via p16^INK4a and Mitogen-Activated Protein Kinase Pathway

Jasti S. Rao, Praveen Bhoopathi, Chandramu Chetty, Meena Gujrati, and Sajani S. Lakka
Cancer Res 2007 67: 4956-4964. doi: 10.1158/0008-5472.CAN-07-0380 [Abstract] [Full Text] [PDF]  

Differential Effects of Targeted Disruption of Thiopurine Methyltransferase on Mercaptopurine and Thioguanine Pharmacodynamics

Christine Hartford, Erick Vasquez, Matthias Schwab, Mathew J. Edick, Jerold E. Rehg, Gerard Grosveld, Ching-Hon Pui, William E. Evans, and Mary V. Relling
Cancer Res 2007 67: 4965-4972. doi: 10.1158/0008-5472.CAN-06-3508 [Abstract] [Full Text] [PDF]  

The Farnesyltransferase Inhibitor R115777 Up-regulates the Expression of Death Receptor 5 and Enhances TRAIL-Induced Apoptosis in Human Lung Cancer Cells

Yuanzheng Qiu, Xiangguo Liu, Wei Zou, Ping Yue, Sagar Lonial, Fadlo R. Khuri, and Shi-Yong Sun
Cancer Res 2007 67: 4973-4980. doi: 10.1158/0008-5472.CAN-06-4044 [Abstract] [Full Text] [PDF]  

The Proteasome Inhibitor PS-341 (Bortezomib) Up-Regulates DR5 Expression Leading to Induction of Apoptosis and Enhancement of TRAIL-Induced Apoptosis Despite Up-Regulation of c-FLIP and Survivin Expression in Human NSCLC Cells

Xiangguo Liu, Ping Yue, Shuzhen Chen, Liping Hu, Sagar Lonial, Fadlo R. Khuri, and Shi-Yong Sun
Cancer Res 2007 67: 4981-4988. doi: 10.1158/0008-5472.CAN-06-4274 [Abstract] [Full Text] [PDF] Supplementary Data  

Survivin, a Member of the Inhibitor of Apoptosis Family, Is Induced by Photodynamic Therapy and Is a Target for Improving Treatment Response

Angela Ferrario, Natalie Rucker, Sam Wong, Marian Luna, and Charles J. Gomer
Cancer Res 2007 67: 4989-4995. doi: 10.1158/0008-5472.CAN-06-4785 [Abstract] [Full Text] [PDF]  

Immunology:

Scavenger Receptor-A Negatively Regulates Antitumor Immunity

Xiang-Yang Wang, John Facciponte, Xing Chen, John R. Subjeck, and Elizabeth A. Repasky
Cancer Res 2007 67: 4996-5002. doi: 10.1158/0008-5472.CAN-06-3138 [Abstract] [Full Text] [PDF]  

Chimeric NKG2D Receptor–Bearing T Cells as Immunotherapy for Ovarian Cancer

Amorette Barber, Tong Zhang, Leslie R. DeMars, Jose Conejo-Garcia, Katherine F. Roby, and Charles L. Sentman
Cancer Res 2007 67: 5003-5008. doi: 10.1158/0008-5472.CAN-06-4047 [Abstract] [Full Text] [PDF] Supplementary Data  

Extralymphatic Tumors Prepare Draining Lymph Nodes to Invasion via a T-Cell Cross-Tolerance Process

Olivier Preynat-Seauve, Emmanuel Contassot, Prisca Schuler, Vincent Piguet, Lars E. French, and Bertrand Huard
Cancer Res 2007 67: 5009-5016. doi: 10.1158/0008-5472.CAN-06-4494 [Abstract] [Full Text] [PDF] Supplementary Data  

Endocrinology:

Novel Estrogen Receptor- Binding Sites and Estradiol Target Genes Identified by Chromatin Immunoprecipitation Cloning in Breast Cancer

Zhihong Lin, Scott Reierstad, Chiang-Ching Huang, and Serdar E. Bulun
Cancer Res 2007 67: 5017-5024. doi: 10.1158/0008-5472.CAN-06-3696 [Abstract] [Full Text] [PDF] Supplementary Data  

SOCS1 Silencing Enhances Antitumor Activity of Type I IFNs by Regulating Apoptosis in Neuroendocrine Tumor Cells

Kathrin Zitzmann, Stephan Brand, Enrico N. De Toni, Sebastian Baehs, Burkhard Göke, Jennifer Meinecke, Gerald Spöttl, Heinrich H.H.D. Meyer, and Christoph J. Auernhammer
Cancer Res 2007 67: 5025-5032. doi: 10.1158/0008-5472.CAN-06-2575 [Abstract] [Full Text] [PDF]  

Clinical Research:

Intraprostatic Androgens and Androgen-Regulated Gene Expression Persist after Testosterone Suppression: Therapeutic Implications for Castration-Resistant Prostate Cancer

Elahe A. Mostaghel, Stephanie T. Page, Daniel W. Lin, Ladan Fazli, Ilsa M. Coleman, Lawrence D. True, Beatrice Knudsen, David L. Hess, Colleen C. Nelson, Alvin M. Matsumoto, William J. Bremner, Martin E. Gleave, and Peter S. Nelson
Cancer Res 2007 67: 5033-5041. doi: 10.1158/0008-5472.CAN-06-3332 [Abstract] [Full Text] [PDF] Supplementary Data  

Epidemiology and Prevention:

Immune Mechanisms in Non–Hodgkin Lymphoma: Joint Effects of the TNF G308A and IL10 T3575A Polymorphisms with Non–Hodgkin Lymphoma Risk Factors

Sophia S. Wang, Wendy Cozen, James R. Cerhan, Joanne S. Colt, Lindsay M. Morton, Eric A. Engels, Scott Davis, Richard K. Severson, Nathaniel Rothman, Stephen J. Chanock, and Patricia Hartge
Cancer Res 2007 67: 5042-5054. doi: 10.1158/0008-5472.CAN-06-4752 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Anti-VEGFR-3 Therapy and Lymph Node Metastasis

Timothy P. Padera, Marek Ancukiewicz, Tohru Hoshida, Dai Fukumura, and Rakesh K. Jain
Cancer Res 2007 67: 5055. doi: 10.1158/0008-5472.CAN-06-2935 [Full Text] [PDF]  

Anti-VEGFR-3 Therapy and Lymph Node Metastasis

Mihaela Skobe and James H. Godbold
Cancer Res 2007 67: 5056. doi: 10.1158/0008-5472.CAN-07-0620 [Full Text] [PDF]  

How Reliable Are BRCA1/2 Mutation Estimates?

Monica R. McClain, Glenn E. Palomaki, and James E. Haddow
Cancer Res 2007 67: 5057. doi: 10.1158/0008-5472.CAN-06-3365 [Full Text] [PDF]  

How Reliable Are BRCA1/2 Mutation Estimates?

Kathleen E. Malone, David R. Doody, Li Hsu, and Elaine A. Ostrander
Cancer Res 2007 67: 5057-5058. doi: 10.1158/0008-5472.CAN-07-0100 [Full Text] [PDF]  

Inhibition of Antitumor Immunity by B Cells

Joseph Rosenblatt, Yu Dana Zhang, and Tamar Tadmor
Cancer Res 2007 67: 5058. doi: 10.1158/0008-5472.CAN-06-3903 [Full Text] [PDF]  

Regulatory B Cells Inhibit Antitumor Immunity

Satoshi Inoue, Dorothy Scott, Basil Golding, and Wolfgang W. Leitner
Cancer Res 2007 67: 5059. doi: 10.1158/0008-5472.CAN-06-4780 [Full Text] [PDF]  

Correction:

Correction: Elucidating the Function of Secreted Maspin

Cancer Res 2007 67: 5060. doi: 10.1158/0008-5472.CAN-67-10-COR [Full Text] [PDF]  

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