Reviews:

Retinoblastoma: From the Two-Hit Hypothesis to Targeted Chemotherapy

David MacPherson and Michael A. Dyer
Cancer Res 2007 67: 7547-7550. doi: 10.1158/0008-5472.CAN-07-0276 [Abstract] [Full Text] [PDF]  

4E-Binding Protein 1: A Key Molecular "Funnel Factor" in Human Cancer with Clinical Implications

Gemma Armengol, Federico Rojo, Josep Castellví, Carmela Iglesias, Miriam Cuatrecasas, Berta Pons, José Baselga, and Santiago Ramón y Cajal
Cancer Res 2007 67: 7551-7555. doi: 10.1158/0008-5472.CAN-07-0881 [Abstract] [Full Text] [PDF]  

Meeting Report:

Advances and Challenges in Aerodigestive Epithelial Cancer: Meeting Summary and Research Opportunities

Jennifer R. Grandis, David P. Carbone, and Anil K. Rustgi
Cancer Res 2007 67: 7556-7558. Published Online First August 8, 2007. doi: 10.1158/0008-5472.CAN-07-1733 [Full Text] [PDF]  

Priority Reports:

Nitric Oxide Boosts Chemoimmunotherapy via Inhibition of Acid Sphingomyelinase in a Mouse Model of Melanoma

Cristiana Perrotta, Laura Bizzozero, Sestina Falcone, Patrizia Rovere-Querini, Alessandro Prinetti, Edward H. Schuchman, Sandro Sonnino, Angelo A. Manfredi, and Emilio Clementi
Cancer Res 2007 67: 7559-7564. doi: 10.1158/0008-5472.CAN-07-0309 [Abstract] [Full Text] [PDF] Supplementary Data  

Myeloproliferative Defects following Targeting of the Drf1 Gene Encoding the Mammalian Diaphanous–Related Formin mDia1

Jun Peng, Susan M. Kitchen, Richard A. West, Robert Sigler, Kathryn M. Eisenmann, and Arthur S. Alberts
Cancer Res 2007 67: 7565-7571. doi: 10.1158/0008-5472.CAN-07-1467 [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

Involvement of RNA Helicases p68 and p72 in Colon Cancer

Sook Shin, Kari L. Rossow, Joseph P. Grande, and Ralf Janknecht
Cancer Res 2007 67: 7572-7578. doi: 10.1158/0008-5472.CAN-06-4652 [Abstract] [Full Text] [PDF] Supplementary Data  

Distinct ErbB-2–Coupled Signaling Pathways Promote Mammary Tumors with Unique Pathologic and Transcriptional Profiles

Babette Schade, Sonya H.L. Lam, Daniela Cernea, Virginie Sanguin-Gendreau, Robert D. Cardiff, Boonim L. Jung, Michael Hallett, and William J. Muller
Cancer Res 2007 67: 7579-7588. doi: 10.1158/0008-5472.CAN-06-4724 [Abstract] [Full Text] [PDF] Supplementary Data  

Loss of p53 and Ink4a/Arf Cooperate in a Cell Autonomous Fashion to Induce Metastasis of Hepatocellular Carcinoma Cells

Ya-Wen Chen, David S. Klimstra, Michelle E. Mongeau, Jessica L. Tatem, Victor Boyartchuk, and Brian C. Lewis
Cancer Res 2007 67: 7589-7596. doi: 10.1158/0008-5472.CAN-07-0381 [Abstract] [Full Text] [PDF]  

Zonal Heterogeneity for Gene Expression in Human Pancreatic Carcinoma

Toru Nakamura, Toshio Kuwai, Yasuhiko Kitadai, Takamitsu Sasaki, Dominic Fan, Kevin R. Coombes, Sun-Jin Kim, and Isaiah J. Fidler
Cancer Res 2007 67: 7597-7604. doi: 10.1158/0008-5472.CAN-07-0874 [Abstract] [Full Text] [PDF] Supplementary Data  

Bin1 Ablation Increases Susceptibility to Cancer during Aging, Particularly Lung Cancer

Mee Young Chang, Janette Boulden, Jessica B. Katz, Liwei Wang, Thomas J. Meyer, Alejandro Peralta Soler, Alexander J. Muller, and George C. Prendergast
Cancer Res 2007 67: 7605-7612. doi: 10.1158/0008-5472.CAN-07-1100 [Abstract] [Full Text] [PDF] Supplementary Data  

The LxCxE pRb Interaction Domain of Cyclin D1 Is Dispensable for Murine Development

Mark W. Landis, Nelson E. Brown, Gregory L. Baker, Anna Shifrin, Manjusri Das, Yan Geng, Piotr Sicinski, and Philip W. Hinds
Cancer Res 2007 67: 7613-7620. doi: 10.1158/0008-5472.CAN-07-1207 [Abstract] [Full Text] [PDF]  

The Early Response to DNA Damage Can Lead to Activation of Alternative Splicing Activity Resulting in CD44 Splice Pattern Changes

Valery Filippov, Maria Filippova, and Penelope J. Duerksen-Hughes
Cancer Res 2007 67: 7621-7630. doi: 10.1158/0008-5472.CAN-07-0145 [Abstract] [Full Text] [PDF]  

Cells with Defective p53-p21-pRb Pathway Are Susceptible to Apoptosis Induced by p84N5 via Caspase-6

Elizabeth Garner, Fabio Martinon, Jurg Tschopp, Peter Beard, and Kenneth Raj
Cancer Res 2007 67: 7631-7637. doi: 10.1158/0008-5472.CAN-07-0334 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

Serial In vivo Spectroscopic Nuclear Magnetic Resonance Imaging of Lactate and Extracellular pH in Rat Gliomas Shows Redistribution of Protons Away from Sites of Glycolysis

Peggy Provent, Marina Benito, Bassem Hiba, Régine Farion, Pilar López-Larrubia, Paloma Ballesteros, Chantal Rémy, Christoph Segebarth, Sebastián Cerdán, Jonathan A. Coles, and María Luisa García-Martín
Cancer Res 2007 67: 7638-7645. doi: 10.1158/0008-5472.CAN-06-3459 [Abstract] [Full Text] [PDF]  

Visualization of Hypoxia in Microscopic Tumors by Immunofluorescent Microscopy

Xiao-Feng Li, Sean Carlin, Muneyasu Urano, James Russell, C. Clifton Ling, and Joseph A. O'Donoghue
Cancer Res 2007 67: 7646-7653. doi: 10.1158/0008-5472.CAN-06-4353 [Abstract] [Full Text] [PDF] Supplementary Data  

Sequential Down-regulation of E-Cadherin with Squamous Cell Carcinoma Progression: Loss of E-Cadherin via a Prostaglandin E₂-EP2–Dependent Posttranslational Mechanism

Sabine Brouxhon, Stephanos Kyrkanides, M. Kerry O'Banion, Renee Johnson, David A. Pearce, Gina M. Centola, Jen-nie H. Miller, Kieran H. McGrath, Brandon Erdle, Glynis Scott, Sandra Schneider, JoAnne VanBuskirk, and Alice P. Pentland
Cancer Res 2007 67: 7654-7664. doi: 10.1158/0008-5472.CAN-06-4415 [Abstract] [Full Text] [PDF]  

Production of Wnt Inhibitors by Myeloma Cells: Potential Effects on Canonical Wnt Pathway in the Bone Microenvironment

Nicola Giuliani, Francesca Morandi, Sara Tagliaferri, Mirca Lazzaretti, Gaetano Donofrio, Sabrina Bonomini, Roberto Sala, Marcellina Mangoni, and Vittorio Rizzoli
Cancer Res 2007 67: 7665-7674. doi: 10.1158/0008-5472.CAN-06-4666 [Abstract] [Full Text] [PDF]  

Caveolin-1 Reduces Osteosarcoma Metastases by Inhibiting c-Src Activity and Met Signaling

Lara Cantiani, Maria Cristina Manara, Cinzia Zucchini, Paola De Sanctis, Monia Zuntini, Luisa Valvassori, Massimo Serra, Martina Olivero, Maria Flavia Di Renzo, Mario Paolo Colombo, Piero Picci, and Katia Scotlandi
Cancer Res 2007 67: 7675-7685. doi: 10.1158/0008-5472.CAN-06-4697 [Abstract] [Full Text] [PDF] Supplementary Data  

Mitotic Cell Death by Chromosome Fragmentation

Joshua B. Stevens, Guo Liu, Steven W. Bremer, Karen J. Ye, Wenxin Xu, Jing Xu, Yi Sun, Gen Sheng Wu, Sureyya Savasan, Stephen A. Krawetz, Christine J. Ye, and Henry H.Q. Heng
Cancer Res 2007 67: 7686-7694. doi: 10.1158/0008-5472.CAN-07-0472 [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptors with Tyrosine Kinase Domain Mutations Exhibit Reduced Cbl Association, Poor Ubiquitylation, and Down-regulation but Are Efficiently Internalized

David Padrón, Mitsuo Sato, Jerry W. Shay, Adi F. Gazdar, John D. Minna, and Michael G. Roth
Cancer Res 2007 67: 7695-7702. doi: 10.1158/0008-5472.CAN-07-0484 [Abstract] [Full Text] [PDF] Supplementary Data  

Expression of L1-CAM and ADAM10 in Human Colon Cancer Cells Induces Metastasis

Nancy Gavert, Michal Sheffer, Shani Raveh, Simone Spaderna, Michael Shtutman, Thomas Brabletz, Francis Barany, Phillip Paty, Daniel Notterman, Eytan Domany, and Avri Ben-Ze'ev
Cancer Res 2007 67: 7703-7712. doi: 10.1158/0008-5472.CAN-07-0991 [Abstract] [Full Text] [PDF] Supplementary Data  

The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells

Charles D. Johnson, Aurora Esquela-Kerscher, Giovanni Stefani, Mike Byrom, Kevin Kelnar, Dmitriy Ovcharenko, Mike Wilson, Xiaowei Wang, Jeffrey Shelton, Jaclyn Shingara, Lena Chin, David Brown, and Frank J. Slack
Cancer Res 2007 67: 7713-7722. doi: 10.1158/0008-5472.CAN-07-1083 [Abstract] [Full Text] [PDF] Supplementary Data  

p73 Loss Triggers Conversion to Squamous Cell Carcinoma Reversible upon Reconstitution with TAp73

Jodi Johnson, James Lagowski, Alexandra Sundberg, Sarah Lawson, Yuangang Liu, and Molly Kulesz-Martin
Cancer Res 2007 67: 7723-7730. doi: 10.1158/0008-5472.CAN-07-1195 [Abstract] [Full Text] [PDF]  

Epigenetic Modulation of Estrogen Receptor- by pRb Family Proteins: A Novel Mechanism in Breast Cancer

Marcella Macaluso, Micaela Montanari, Paul Bart Noto, Valter Gregorio, Christian Bronner, and Antonio Giordano
Cancer Res 2007 67: 7731-7737. doi: 10.1158/0008-5472.CAN-07-1476 [Abstract] [Full Text] [PDF]  

Tumor Suppressor Functions of ARLTS1 in Lung Cancers

Sai Yendamuri, Francesco Trapasso, Manuela Ferracin, Rossano Cesari, Cinzia Sevignani, Masayoshi Shimizu, Shashi Rattan, Tamotsu Kuroki, Kristoffel R. Dumon, Florencia Bullrich, Chang-gong Liu, Massimo Negrini, Noel N. Williams, Larry R. Kaiser, Carlo M. Croce, and George A. Calin
Cancer Res 2007 67: 7738-7745. doi: 10.1158/0008-5472.CAN-07-1481 [Abstract] [Full Text] [PDF] Supplementary Data  

Estrogen Receptor Inhibits p53-Mediated Transcriptional Repression: Implications for the Regulation of Apoptosis

Aejaz Sayeed, Santhi D. Konduri, Wensheng Liu, Sanjay Bansal, Fengzhi Li, and Gokul M. Das
Cancer Res 2007 67: 7746-7755. doi: 10.1158/0008-5472.CAN-06-3724 [Abstract] [Full Text] [PDF] Supplementary Data  

The Role of Glycogen Synthase Kinase 3ß in the Transformation of Epidermal Cells

Cuiling Ma, Jian Wang, Ying Gao, Tian-Wen Gao, Gang Chen, Kimberly A. Bower, Mohammed Odetallah, Min Ding, Zunji Ke, and Jia Luo
Cancer Res 2007 67: 7756-7764. doi: 10.1158/0008-5472.CAN-06-4665 [Abstract] [Full Text] [PDF]  

Platelet-Derived Growth Factor Receptor Regulates Myeloid and Monocytic Differentiation of HL-60 Cells

Gudrun Reiterer and Andrew Yen
Cancer Res 2007 67: 7765-7772. doi: 10.1158/0008-5472.CAN-07-0014 [Abstract] [Full Text] [PDF]  

Regulation of PTEN Expression in Intestinal Epithelial Cells by c-Jun NH₂-Terminal Kinase Activation and Nuclear Factor-B Inhibition

Qingding Wang, Yuning Zhou, Xiaofu Wang, Dai H. Chung, and B. Mark Evers
Cancer Res 2007 67: 7773-7781. doi: 10.1158/0008-5472.CAN-07-0187 [Abstract] [Full Text] [PDF]  

Androgen Receptor– and E2F-1–Targeted Thymoquinone Therapy for Hormone-Refractory Prostate Cancer

Ahmed O. Kaseb, Kannagi Chinnakannu, Di Chen, Arun Sivanandam, Sheela Tejwani, Mani Menon, Q. Ping Dou, and G. Prem-Veer Reddy
Cancer Res 2007 67: 7782-7788. doi: 10.1158/0008-5472.CAN-07-1483 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Hypoxia Enhances Metastatic Efficiency in HT1080 Fibrosarcoma Cells by Increasing Cell Survival in Lungs, Not Cell Adhesion and Invasion

Li Zhang and Richard P. Hill
Cancer Res 2007 67: 7789-7797. doi: 10.1158/0008-5472.CAN-06-4221 [Abstract] [Full Text] [PDF]  

Localized Hyperthermia Combined with Intratumoral Dendritic Cells Induces Systemic Antitumor Immunity

Arunika Mukhopadhaya, Joseph Mendecki, Xinyuan Dong, Laibin Liu, Shalom Kalnicki, Madhur Garg, Alan Alfieri, and Chandan Guha
Cancer Res 2007 67: 7798-7806. doi: 10.1158/0008-5472.CAN-07-0203 [Abstract] [Full Text] [PDF]  

Emergence of Epidermal Growth Factor Receptor T790M Mutation during Chronic Exposure to Gefitinib in a Non–Small Cell Lung Cancer Cell Line

Atsuko Ogino, Hiroyuki Kitao, Seiki Hirano, Akiko Uchida, Masamichi Ishiai, Toshiyuki Kozuki, Nagio Takigawa, Minoru Takata, Katsuyuki Kiura, and Mitsune Tanimoto
Cancer Res 2007 67: 7807-7814. doi: 10.1158/0008-5472.CAN-07-0681 [Abstract] [Full Text] [PDF]  

A Potent Indole-3-Carbinol–Derived Antitumor Agent with Pleiotropic Effects on Multiple Signaling Pathways in Prostate Cancer Cells

Jing-Ru Weng, Chen-Hsun Tsai, Samuel K. Kulp, Dasheng Wang, Chia-Hui Lin, Hsiao-Ching Yang, Yihui Ma, Aaron Sargeant, Chang-Fang Chiu, Ming-Hsui Tsai, and Ching-Shih Chen
Cancer Res 2007 67: 7815-7824. doi: 10.1158/0008-5472.CAN-07-0794 [Abstract] [Full Text] [PDF]  

Determination of the Role of Target Tissue Metabolism in Lung Carcinogenesis Using Conditional Cytochrome P450 Reductase-Null Mice

Yan Weng, Cheng Fang, Robert J. Turesky, Melissa Behr, Laurence S. Kaminsky, and Xinxin Ding
Cancer Res 2007 67: 7825-7832. doi: 10.1158/0008-5472.CAN-07-1006 [Abstract] [Full Text] [PDF] Supplementary Data  

Use of a Peptide Derived from Foot-and-Mouth Disease Virus for the Noninvasive Imaging of Human Cancer: Generation and Evaluation of 4-[¹⁸F]Fluorobenzoyl A20FMDV2 for In vivo Imaging of Integrin _vß₆ Expression with Positron Emission Tomography

Sven H. Hausner, Danielle DiCara, Jan Marik, John F. Marshall, and Julie L. Sutcliffe
Cancer Res 2007 67: 7833-7840. doi: 10.1158/0008-5472.CAN-07-1026 [Abstract] [Full Text] [PDF] Supplementary Data  

Involvement of Disulfide Bond Formation in the Activation of Heparanase

Siro Simizu, Takehiro Suzuki, Makoto Muroi, Ngit Shin Lai, Satoshi Takagi, Naoshi Dohmae, and Hiroyuki Osada
Cancer Res 2007 67: 7841-7849. doi: 10.1158/0008-5472.CAN-07-1053 [Abstract] [Full Text] [PDF] Supplementary Data  

Coadministration of a Herpes Simplex Virus-2–Based Oncolytic Virus and Cyclophosphamide Produces a Synergistic Antitumor Effect and Enhances Tumor-Specific Immune Responses

Hongtao Li, Zihua Zeng, Xinping Fu, and Xiaoliu Zhang
Cancer Res 2007 67: 7850-7855. doi: 10.1158/0008-5472.CAN-07-1087 [Abstract] [Full Text] [PDF]  

Ethacrynic Acid Butyl-Ester Induces Apoptosis in Leukemia Cells through a Hydrogen Peroxide–Mediated Pathway Independent of Glutathione S-Transferase P1-1 Inhibition

Rui Wang, Chunmin Li, Dandan Song, Guisen Zhao, Linxiang Zhao, and Yongkui Jing
Cancer Res 2007 67: 7856-7864. doi: 10.1158/0008-5472.CAN-07-0151 [Abstract] [Full Text] [PDF]  

Cisplatin-Induced Apoptosis Involves Membrane Fluidification via Inhibition of NHE1 in Human Colon Cancer Cells

Amélie Rebillard, Xavier Tekpli, Olivier Meurette, Odile Sergent, Gwenaëlle LeMoigne-Muller, Laurent Vernhet, Morgane Gorria, Martine Chevanne, Markus Christmann, Bernd Kaina, Laurent Counillon, Erich Gulbins, Dominique Lagadic-Gossmann, and Marie-Thérèse Dimanche-Boitrel
Cancer Res 2007 67: 7865-7874. doi: 10.1158/0008-5472.CAN-07-0353 [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

Mouse Dendritic-Endothelial Cell Hybrids and 4-1BB Costimulation Elicit Antitumor Effects Mediated by Broad Antiangiogenic Immunity

Eric Ko, Wei Luo, Liaomin Peng, Xinhui Wang, and Soldano Ferrone
Cancer Res 2007 67: 7875-7884. doi: 10.1158/0008-5472.CAN-06-1744 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Profiling of Matched Samples Identifies Biomarkers of Papillary Thyroid Carcinoma Lymph Node Metastasis

Janete M. Cerutti, Gisele Oler, Pedro Michaluart, Jr., Rosana Delcelo, Robert M. Beaty, Jennifer Shoemaker, and Gregory J. Riggins
Cancer Res 2007 67: 7885-7892. doi: 10.1158/0008-5472.CAN-06-4771 [Abstract] [Full Text] [PDF]  

B7-H3 Ligand Expression by Prostate Cancer: A Novel Marker of Prognosis and Potential Target for Therapy

Timothy J. Roth, Yuri Sheinin, Christine M. Lohse, Susan M. Kuntz, Xavier Frigola, Brant A. Inman, Amy E. Krambeck, Maureen E. Mckenney, R. Jeffrey Karnes, Michael L. Blute, John C. Cheville, Thomas J. Sebo, and Eugene D. Kwon
Cancer Res 2007 67: 7893-7900. Published Online First August 8, 2007. doi: 10.1158/0008-5472.CAN-07-1068 [Abstract] [Full Text] [PDF] Supplementary Data  

Clinical Research:

Up-regulation of 14-3-3 in Lung Cancer and Its Implication as Prognostic and Therapeutic Target

Tao Fan, Ruiyun Li, Nevins W. Todd, Qi Qiu, Hong-Bin Fang, Huijun Wang, Jianjun Shen, Richard Y. Zhao, Nancy P. Caraway, Ruth L. Katz, Sanford A. Stass, and Feng Jiang
Cancer Res 2007 67: 7901-7906. doi: 10.1158/0008-5472.CAN-07-0090 [Abstract] [Full Text] [PDF]  

Epidemiology and Prevention:

Syk Tyrosine Kinase Is Linked to Cell Motility and Progression in Squamous Cell Carcinomas of the Head and Neck

Sutima Luangdilok, Carol Box, Lisa Patterson, William Court, Kevin Harrington, Lisa Pitkin, Peter Rhys-Evans, Pornchai O-charoenrat, and Suzanne Eccles
Cancer Res 2007 67: 7907-7916. doi: 10.1158/0008-5472.CAN-07-0331 [Abstract] [Full Text] [PDF] Supplementary Data  

Regulation of Genes of the Circadian Clock in Human Colon Cancer: Reduced Period-1 and Dihydropyrimidine Dehydrogenase Transcription Correlates in High-Grade Tumors

Walter Krugluger, Anita Brandstaetter, Enikö Kállay, Johann Schueller, Elisabeth Krexner, Stefan Kriwanek, Elisabeth Bonner, and Heide S. Cross
Cancer Res 2007 67: 7917-7922. doi: 10.1158/0008-5472.CAN-07-0133 [Abstract] [Full Text] [PDF]  

Circulating Insulin-Like Growth Factor Binding Protein-1 and the Risk of Pancreatic Cancer

Brian M. Wolpin, Dominique S. Michaud, Edward L. Giovannucci, Eva S. Schernhammer, Meir J. Stampfer, JoAnn E. Manson, Barbara B. Cochrane, Thomas E. Rohan, Jing Ma, Michael N. Pollak, and Charles S. Fuchs
Cancer Res 2007 67: 7923-7928. doi: 10.1158/0008-5472.CAN-07-0373 [Abstract] [Full Text] [PDF]  

Farnesol-Induced Apoptosis in Human Lung Carcinoma Cells Is Coupled to the Endoplasmic Reticulum Stress Response

Joung Hyuck Joo, Grace Liao, Jennifer B. Collins, Sherry F. Grissom, and Anton M. Jetten
Cancer Res 2007 67: 7929-7936. doi: 10.1158/0008-5472.CAN-07-0931 [Abstract] [Full Text] [PDF] Supplementary Data  

Corrections:

Correction: Pharmacogenomics of EGFR Inhibitors

Cancer Res 2007 67: 7937 [Full Text] [PDF]  

Correction: Role of Pten in Hormone Refractory Prostate Cancer

Cancer Res 2007 67: 7937 [Full Text] [PDF]  

Correction: Polyepitope DNA Vaccine and Tumor Challenge

Cancer Res 2007 67: 7937 [Full Text] [PDF]  

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