Reviews:

Systemic Efficacy with Oncolytic Virus Therapeutics: Clinical Proof-of-Concept and Future Directions

Ta-Chiang Liu and David Kirn
Cancer Res 2007 67: 429-432. doi: 10.1158/0008-5472.CAN-06-2871 [Abstract] [Full Text] [PDF]  

Emerging Roles of MUC4 in Cancer: A Novel Target for Diagnosis and Therapy

Ajay P. Singh, Pallavi Chaturvedi, and Surinder K. Batra
Cancer Res 2007 67: 433-436. doi: 10.1158/0008-5472.CAN-06-3114 [Abstract] [Full Text] [PDF]  

Meeting Reports:

Meeting Report: Mitochondrial DNA and Cancer Epidemiology

Mukesh Verma, Robert K. Naviaux, Masashi Tanaka, Deepak Kumar, Claudio Franceschi, and Keshav K. Singh
Cancer Res 2007 67: 437-439. Published Online First January 9, 2007. doi: 10.1158/0008-5472.CAN-06-4119 [Full Text] [PDF]  

Priority Reports:

Angiogenic Response Caused by Oncolytic Herpes Simplex Virus–Induced Reduced Thrombospondin Expression Can Be Prevented by Specific Viral Mutations or by Administering a Thrombospondin-Derived Peptide

Manish Aghi, Samuel D. Rabkin, and Robert L. Martuza
Cancer Res 2007 67: 440-444. doi: 10.1158/0008-5472.CAN-06-3145 [Abstract] [Full Text] [PDF]  

Frequent Mutation of Apc Gene in Rat Colon Tumors and Mucin-Depleted Foci, Preneoplastic Lesions in Experimental Colon Carcinogenesis

Angelo Pietro Femia, Piero Dolara, Augusto Giannini, Maddalena Salvadori, Annibale Biggeri, and Giovanna Caderni
Cancer Res 2007 67: 445-449. doi: 10.1158/0008-5472.CAN-06-3861 [Abstract] [Full Text] [PDF]  

Nutlin3 Blocks Vascular Endothelial Growth Factor Induction by Preventing the Interaction between Hypoxia Inducible Factor 1 and Hdm2

Gretchen A. LaRusch, Mark W. Jackson, James D. Dunbar, Robert S. Warren, David B. Donner, and Lindsey D. Mayo
Cancer Res 2007 67: 450-454. doi: 10.1158/0008-5472.CAN-06-2710 [Abstract] [Full Text] [PDF]  

Molecular Biology, Pathobiology, and Genetics:

NKX3.1 Homeodomain Protein Binds to Topoisomerase I and Enhances Its Activity

Cai Bowen, August Stuart, Jeong-Ho Ju, Jenny Tuan, Josip Blonder, Thomas P. Conrads, Timothy D. Veenstra, and Edward P. Gelmann
Cancer Res 2007 67: 455-464. doi: 10.1158/0008-5472.CAN-06-1591 [Abstract] [Full Text] [PDF] Supplementary Data  

Distinguishing Cancer-Associated Missense Mutations from Common Polymorphisms

Joshua S. Kaminker, Yan Zhang, Allison Waugh, Peter M. Haverty, Brock Peters, Dragan Sebisanovic, Jeremy Stinson, William F. Forrest, J. Fernando Bazan, Somasekar Seshagiri, and Zemin Zhang
Cancer Res 2007 67: 465-473. doi: 10.1158/0008-5472.CAN-06-1736 [Abstract] [Full Text] [PDF] Supplementary Data  

IFN-–Stimulated Genes and Epstein-Barr Virus Gene Expression Distinguish WHO Type II and III Nasopharyngeal Carcinomas

D. Michiel Pegtel, Aravind Subramanian, David Meritt, Ching-Hwa Tsai, Tzung-Shiahn Sheen, Todd R. Golub, and David A. Thorley-Lawson
Cancer Res 2007 67: 474-481. doi: 10.1158/0008-5472.CAN-06-1882 [Abstract] [Full Text] [PDF]  

Drosophila split ends Homologue SHARP Functions as a Positive Regulator of Wnt/ß-Catenin/T-Cell Factor Signaling in Neoplastic Transformation

Ying Feng, Guido T. Bommer, Yali Zhai, Aytekin Akyol, Takao Hinoi, Ira Winer, Hua V. Lin, Ken M. Cadigan, Kathleen R. Cho, and Eric R. Fearon
Cancer Res 2007 67: 482-491. doi: 10.1158/0008-5472.CAN-06-2314 [Abstract] [Full Text] [PDF]  

Depletion of the Ras Association Domain Family 1, Isoform A–Associated Novel Microtubule-Associated Protein, C19ORF5/MAP1S, Causes Mitotic Abnormalities

Ashraf Dallol, Wendy N. Cooper, Fahd Al-Mulla, Angelo Agathanggelou, Eamonn R. Maher, and Farida Latif
Cancer Res 2007 67: 492-500. doi: 10.1158/0008-5472.CAN-06-3604 [Abstract] [Full Text] [PDF] Supplementary Data  

Cell, Tumor, and Stem Cell Biology:

Nestin Is Expressed in the Basal/Myoepithelial Layer of the Mammary Gland and Is a Selective Marker of Basal Epithelial Breast Tumors

Hua Li, Pratima Cherukuri, Na Li, Victoria Cowling, Michael Spinella, Michael Cole, Andrew K. Godwin, Wendy Wells, and James DiRenzo
Cancer Res 2007 67: 501-510. doi: 10.1158/0008-5472.CAN-05-4571 [Abstract] [Full Text] [PDF]  

Stromal-Epithelial Cell Interactions and Androgen Receptor-Coregulator Recruitment Is Altered in the Tissue Microenvironment of Prostate Cancer

Patricia Cano, Alejandro Godoy, Rosalba Escamilla, Rajiv Dhir, and Sergio A. Onate
Cancer Res 2007 67: 511-519. doi: 10.1158/0008-5472.CAN-06-1478 [Abstract] [Full Text] [PDF]  

Merlin/Neurofibromatosis Type 2 Suppresses Growth by Inhibiting the Activation of Ras and Rac

Helen Morrison, Tobias Sperka, Jan Manent, Marco Giovannini, Helmut Ponta, and Peter Herrlich
Cancer Res 2007 67: 520-527. doi: 10.1158/0008-5472.CAN-06-1608 [Abstract] [Full Text] [PDF] Supplementary Data  

SOX9 Is Expressed in Normal Prostate Basal Cells and Regulates Androgen Receptor Expression in Prostate Cancer Cells

Hongyun Wang, Nicole C. McKnight, Tao Zhang, Michael L. Lu, Steven P. Balk, and Xin Yuan
Cancer Res 2007 67: 528-536. doi: 10.1158/0008-5472.CAN-06-1672 [Abstract] [Full Text] [PDF]  

RUNX1 DNA-Binding Mutants, Associated with Minimally Differentiated Acute Myelogenous Leukemia, Disrupt Myeloid Differentiation

Jörg Cammenga, Birte Niebuhr, Stefan Horn, Ulla Bergholz, Gabriele Putz, Frank Buchholz, Jürgen Löhler, and Carol Stocking
Cancer Res 2007 67: 537-545. doi: 10.1158/0008-5472.CAN-06-1903 [Abstract] [Full Text] [PDF]  

Human prx1 Gene Is a Target of Nrf2 and Is Up-regulated by Hypoxia/Reoxygenation: Implication to Tumor Biology

Yun-Jeong Kim, Ji-Yeon Ahn, Ping Liang, Clement Ip, Yuesheng Zhang, and Young-Mee Park
Cancer Res 2007 67: 546-554. doi: 10.1158/0008-5472.CAN-06-2401 [Abstract] [Full Text] [PDF]  

Human Bone Marrow Activates the Akt Pathway in Metastatic Prostate Cells through Transactivation of the -Platelet–Derived Growth Factor Receptor

Nathan G. Dolloff, Mike R. Russell, Nick Loizos, and Alessandro Fatatis
Cancer Res 2007 67: 555-562. doi: 10.1158/0008-5472.CAN-06-2593 [Abstract] [Full Text] [PDF] Supplementary Data  

Hypoxia-Inducible Factor-1 Is a Key Regulator of Metastasis in a Transgenic Model of Cancer Initiation and Progression

Debbie Liao, Courtney Corle, Tiffany N. Seagroves, and Randall S. Johnson
Cancer Res 2007 67: 563-572. doi: 10.1158/0008-5472.CAN-06-2701 [Abstract] [Full Text] [PDF]  

An Antagonist of Dishevelled Protein-Protein Interaction Suppresses ß-Catenin–Dependent Tumor Cell Growth

Naoaki Fujii, Liang You, Zhidong Xu, Kazutsugu Uematsu, Jufang Shan, Biao He, Iwao Mikami, Lillian R. Edmondson, Geoffrey Neale, Jie Zheng, R. Kiplin Guy, and David M. Jablons
Cancer Res 2007 67: 573-579. doi: 10.1158/0008-5472.CAN-06-2726 [Abstract] [Full Text] [PDF] Supplementary Data  

O⁶-Methylguanine-DNA Methyltransferase Regulation by p53 in Astrocytic Cells

Michael D. Blough, Magdalena C. Zlatescu, and J. Gregory Cairncross
Cancer Res 2007 67: 580-584. doi: 10.1158/0008-5472.CAN-06-2782 [Abstract] [Full Text] [PDF]  

The Inflammatory Cytokine Tumor Necrosis Factor- Generates an Autocrine Tumor-Promoting Network in Epithelial Ovarian Cancer Cells

Hagen Kulbe, Richard Thompson, Julia L. Wilson, Stephen Robinson, Thorsten Hagemann, Rewas Fatah, David Gould, Ayse Ayhan, and Frances Balkwill
Cancer Res 2007 67: 585-592. doi: 10.1158/0008-5472.CAN-06-2941 [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth

Pirjo Laakkonen, Marika Waltari, Tanja Holopainen, Takashi Takahashi, Bronislaw Pytowski, Philipp Steiner, Daniel Hicklin, Kris Persaud, James R. Tonra, Larry Witte, and Kari Alitalo
Cancer Res 2007 67: 593-599. doi: 10.1158/0008-5472.CAN-06-3567 [Abstract] [Full Text] [PDF] Supplementary Data  

Gene Expression Profiling of Childhood Adrenocortical Tumors

Alina Nico West, Geoffrey A. Neale, Stanley Pounds, Bonald C. Figueredo, Carlos Rodriguez Galindo, Mara Albonei D. Pianovski, Antonio G. Oliveira Filho, David Malkin, Enzo Lalli, Raul Ribeiro, and Gerard P. Zambetti
Cancer Res 2007 67: 600-608. doi: 10.1158/0008-5472.CAN-06-3767 [Abstract] [Full Text] [PDF] Supplementary Data  

Suppression of Mammary Carcinoma Cell Growth by Retinoic Acid: the Cell Cycle Control Gene Btg2 Is a Direct Target for Retinoic Acid Receptor Signaling

Leslie J. Donato, Jean H. Suh, and Noa Noy
Cancer Res 2007 67: 609-615. doi: 10.1158/0008-5472.CAN-06-0989 [Abstract] [Full Text] [PDF]  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Heat Shock Protein 70 Increases Tumorigenicity and Inhibits Apoptosis in Pancreatic Adenocarcinoma

Ali Aghdassi, Phoebe Phillips, Vikas Dudeja, Dhara Dhaulakhandi, Rifat Sharif, Rajinder Dawra, Markus M. Lerch, and Ashok Saluja
Cancer Res 2007 67: 616-625. doi: 10.1158/0008-5472.CAN-06-1567 [Abstract] [Full Text] [PDF]  

Synuclein- Targeting Peptide Inhibitor that Enhances Sensitivity of Breast Cancer Cells to Antimicrotubule Drugs

Vinay K. Singh, Yue Zhou, Joseph A. Marsh, Vladimir N. Uversky, Julie D. Forman-Kay, Jingwen Liu, and Zongchao Jia
Cancer Res 2007 67: 626-633. doi: 10.1158/0008-5472.CAN-06-1820 [Abstract] [Full Text] [PDF] Supplementary Data  

Adenovirus-Mediated Expression of a Dominant Negative Ku70 Fragment Radiosensitizes Human Tumor Cells under Aerobic and Hypoxic Conditions

Fuqiu He, Ligeng Li, Dooha Kim, Bixiu Wen, Xuelong Deng, Philip H. Gutin, Clifton C. Ling, and Gloria C. Li
Cancer Res 2007 67: 634-642. doi: 10.1158/0008-5472.CAN-06-1860 [Abstract] [Full Text] [PDF]  

PRL-1 Tyrosine Phosphatase Regulates c-Src Levels, Adherence, and Invasion in Human Lung Cancer Cells

Hiroyuki Achiwa and John S. Lazo
Cancer Res 2007 67: 643-650. doi: 10.1158/0008-5472.CAN-06-2436 [Abstract] [Full Text] [PDF]  

Blocking CXCR4-Mediated Cyclic AMP Suppression Inhibits Brain Tumor Growth In vivo

Lihua Yang, Erin Jackson, B. Mark Woerner, Arie Perry, David Piwnica-Worms, and Joshua B. Rubin
Cancer Res 2007 67: 651-658. doi: 10.1158/0008-5472.CAN-06-2762 [Abstract] [Full Text] [PDF] Supplementary Data  

Increased ß₁ Integrin Is Associated with Decreased Survival in Invasive Breast Cancer

Evelyn S. Yao, Hui Zhang, Yunn-Yi Chen, Brian Lee, Karen Chew, Dan Moore, and Catherine Park
Cancer Res 2007 67: 659-664. doi: 10.1158/0008-5472.CAN-06-2768 [Abstract] [Full Text] [PDF]  

A Novel Mechanism of Resistance to Epidermal Growth Factor Receptor Antagonism In vivo

Ashwani Rajput, Alan P. Koterba, Jeffrey I. Kreisberg, Jason M. Foster, James K.V. Willson, and Michael G. Brattain
Cancer Res 2007 67: 665-673. doi: 10.1158/0008-5472.CAN-06-2773 [Abstract] [Full Text] [PDF]  

Nur77 Agonists Induce Proapoptotic Genes and Responses in Colon Cancer Cells through Nuclear Receptor–Dependent and Nuclear Receptor–Independent Pathways

Sung Dae Cho, Kyungsil Yoon, Sudhakar Chintharlapalli, Maen Abdelrahim, Ping Lei, Stanley Hamilton, Shaheen Khan, Shashi K. Ramaiah, and Stephen Safe
Cancer Res 2007 67: 674-683. doi: 10.1158/0008-5472.CAN-06-2907 [Abstract] [Full Text] [PDF]  

Activation of Integrin-Linked Kinase Is a Critical Prosurvival Pathway Induced in Leukemic Cells by Bone Marrow–Derived Stromal Cells

Yoko Tabe, Linhua Jin, Yuko Tsutsumi-Ishii, Yuanyuan Xu, Teresa McQueen, Waldemar Priebe, Gordon B. Mills, Akimichi Ohsaka, Isao Nagaoka, Michael Andreeff, and Marina Konopleva
Cancer Res 2007 67: 684-694. doi: 10.1158/0008-5472.CAN-06-3166 [Abstract] [Full Text] [PDF]  

Novel Chemical Enhancers of Heat Shock Increase Thermal Radiosensitization through a Mitotic Catastrophe Pathway

Konjeti R. Sekhar, Vijayakumar N. Sonar, Venkatraj Muthusamy, Soumya Sasi, Andrei Laszlo, Jamil Sawani, Nobuo Horikoshi, Ryuji Higashikubo, Robert G. Bristow, Michael J. Borrelli, Peter A. Crooks, James R. Lepock, Joseph L. Roti Roti, and Michael L. Freeman
Cancer Res 2007 67: 695-701. doi: 10.1158/0008-5472.CAN-06-3212 [Abstract] [Full Text] [PDF] Supplementary Data  

2-Methoxyestradiol Inhibits the Anaphase-Promoting Complex and Protein Translation in Human Breast Cancer Cells

Rajendra Bhati, Yesim Gökmen-Polar, George W. Sledge, Jr., Cheng Fan, Harikrishna Nakshatri, David Ketelsen, Christoph H. Borchers, Michael J. Dial, Cam Patterson, and Nancy Klauber-DeMore
Cancer Res 2007 67: 702-708. doi: 10.1158/0008-5472.CAN-06-3406 [Abstract] [Full Text] [PDF] Supplementary Data  

Synergistic Tumor Suppression by Coexpression of FUS1 and p53 Is Associated with Down-regulation of Murine Double Minute-2 and Activation of the Apoptotic Protease-Activating Factor 1–Dependent Apoptotic Pathway in Human Non–Small Cell Lung Cancer Cells

Wu-Guo Deng, Hiroyaki Kawashima, Guanglin Wu, Gitanjali Jayachandran, Kai Xu, John D. Minna, Jack A. Roth, and Lin Ji
Cancer Res 2007 67: 709-717. doi: 10.1158/0008-5472.CAN-06-3463 [Abstract] [Full Text] [PDF]  

Radioiodinated versus Radiometal-Labeled Anti–Carcinoembryonic Antigen Single-Chain Fv-Fc Antibody Fragments: Optimal Pharmacokinetics for Therapy

Vania Kenanova, Tove Olafsen, Lawrence E. Williams, Nora H. Ruel, Jeffrey Longmate, Paul J. Yazaki, John E. Shively, David Colcher, Andrew A. Raubitschek, and Anna M. Wu
Cancer Res 2007 67: 718-726. doi: 10.1158/0008-5472.CAN-06-0454 [Abstract] [Full Text] [PDF]  

Bortezomib Inhibits Cell-Cell Adhesion and Cell Migration and Enhances Epidermal Growth Factor Receptor Inhibitor–Induced Cell Death in Squamous Cell Cancer

Jochen H. Lorch, Tarita O. Thomas, and Hans-Joachim Schmoll
Cancer Res 2007 67: 727-734. doi: 10.1158/0008-5472.CAN-06-2162 [Abstract] [Full Text] [PDF] Supplementary Data  

Activation of Akt Predicts Poor Outcome in Neuroblastoma

Daniela Opel, Christopher Poremba, Thorsten Simon, Klaus-Michael Debatin, and Simone Fulda
Cancer Res 2007 67: 735-745. doi: 10.1158/0008-5472.CAN-06-2201 [Abstract] [Full Text] [PDF] Supplementary Data  

Lenalidomide and CC-4047 Inhibit the Proliferation of Malignant B Cells while Expanding Normal CD34⁺ Progenitor Cells

Dominique Verhelle, Laura G. Corral, Kevin Wong, Jessica H. Mueller, Laure Moutouh-de Parseval, Kristen Jensen-Pergakes, Peter H. Schafer, Roger Chen, Emilia Glezer, Gregory D. Ferguson, Antonia Lopez-Girona, George W. Muller, Helen A. Brady, and Kyle W.H. Chan
Cancer Res 2007 67: 746-755. doi: 10.1158/0008-5472.CAN-06-2317 [Abstract] [Full Text] [PDF]  

Sphingosine-Induced Apoptosis in Rhabdomyosarcoma Cell Lines Is Dependent on Pre-Mitochondrial Bax Activation and Post-Mitochondrial Caspases

Darren C. Phillips, Sophie Martin, Belinda T. Doyle, and Janet A. Houghton
Cancer Res 2007 67: 756-764. doi: 10.1158/0008-5472.CAN-06-2374 [Abstract] [Full Text] [PDF] Supplementary Data  

Small Ubiquitin-Related Modifier Pathway Is a Major Determinant of Doxorubicin Cytotoxicity in Saccharomyces cerevisiae

Ruea-Yea Huang, David Kowalski, Hans Minderman, Nishant Gandhi, and Erica S. Johnson
Cancer Res 2007 67: 765-772. doi: 10.1158/0008-5472.CAN-06-2839 [Abstract] [Full Text] [PDF] Supplementary Data  

Single Chemical Modifications of the C-1027 Enediyne Core, a Radiomimetic Antitumor Drug, Affect Both Drug Potency and the Role of Ataxia-Telangiectasia Mutated in Cellular Responses to DNA Double-Strand Breaks

Daniel R. Kennedy, Loretta S. Gawron, Jianhua Ju, Wen Liu, Ben Shen, and Terry A. Beerman
Cancer Res 2007 67: 773-781. doi: 10.1158/0008-5472.CAN-06-2893 [Abstract] [Full Text] [PDF]  

Mcl-1 Down-regulation Potentiates ABT-737 Lethality by Cooperatively Inducing Bak Activation and Bax Translocation

Shuang Chen, Yun Dai, Hisashi Harada, Paul Dent, and Steven Grant
Cancer Res 2007 67: 782-791. doi: 10.1158/0008-5472.CAN-06-3964 [Abstract] [Full Text] [PDF]  

Immunology:

Inhibition of Indoleamine 2,3-Dioxygenase in Dendritic Cells by Stereoisomers of 1-Methyl-Tryptophan Correlates with Antitumor Responses

De-Yan Hou, Alexander J. Muller, Madhav D. Sharma, James DuHadaway, Tinku Banerjee, Maribeth Johnson, Andrew L. Mellor, George C. Prendergast, and David H. Munn
Cancer Res 2007 67: 792-801. doi: 10.1158/0008-5472.CAN-06-2925 [Abstract] [Full Text] [PDF] Supplementary Data  

Epigallocatechin-3-Gallate Enhances CD8⁺ T Cell–Mediated Antitumor Immunity Induced by DNA Vaccination

Tae Heung Kang, Jin Hyup Lee, Chung Kil Song, Hee Dong Han, Byung Cheol Shin, Sara I. Pai, Chien-Fu Hung, Cornelia Trimble, Jong-Seok Lim, Tae Woo Kim, and T-C. Wu
Cancer Res 2007 67: 802-811. doi: 10.1158/0008-5472.CAN-06-2638 [Abstract] [Full Text] [PDF] Supplementary Data  

Endocrinology:

Cytochrome P450 1B1–Mediated Estrogen Metabolism Results in Estrogen-Deoxyribonucleoside Adduct Formation

Alexandra R. Belous, David L. Hachey, Sheila Dawling, Nady Roodi, and Fritz F. Parl
Cancer Res 2007 67: 812-817. doi: 10.1158/0008-5472.CAN-06-2133 [Abstract] [Full Text] [PDF]  

Clinical Research:

Deletion of Chromosome 11q Predicts Response to Anthracycline-Based Chemotherapy in Early Breast Cancer

Joan Climent, Peter Dimitrow, Jane Fridlyand, Jose Palacios, Reiner Siebert, Donna G. Albertson, Joe W. Gray, Daniel Pinkel, Ana Lluch, and Jose A. Martinez-Climent
Cancer Res 2007 67: 818-826. doi: 10.1158/0008-5472.CAN-06-3307 [Abstract] [Full Text] [PDF] Supplementary Data  

Epidemiology and Prevention:

Epidermal Growth Factor Receptor Signaling Is Required for Microadenoma Formation in the Mouse Azoxymethane Model of Colonic Carcinogenesis

Alessandro Fichera, Nathaniel Little, Sujatha Jagadeeswaran, Urszula Dougherty, Amikar Sehdev, Reba Mustafi, Sonia Cerda, Weihua Yuan, Sharad Khare, Maria Tretiakova, Can Gong, Michael Tallerico, Greg Cohen, Loren Joseph, John Hart, Jerrold R. Turner, and Marc Bissonnette
Cancer Res 2007 67: 827-835. doi: 10.1158/0008-5472.CAN-05-3343 [Abstract] [Full Text] [PDF] Supplementary Data  

Combinations of Tomato and Broccoli Enhance Antitumor Activity in Dunning R3327-H Prostate Adenocarcinomas

Kirstie Canene-Adams, Brian L. Lindshield, Shihua Wang, Elizabeth H. Jeffery, Steven K. Clinton, and John W. Erdman, Jr.
Cancer Res 2007 67: 836-843. Published Online First January 9, 2007. doi: 10.1158/0008-5472.CAN-06-3462 [Abstract] [Full Text] [PDF]  

Corrections:

Correction: Pharmacokinetics of Anti-CEA scFv-Fc and Variants

Cancer Res 2007 67: 844-845. doi: 10.1158/0008-5472.CAN-67-2-COR1 [Full Text] [PDF]  

Correction: Pregnancy-Induced Protection against Mammary Tumorigenesis

Cancer Res 2007 67: 844-845. doi: 10.1158/0008-5472.CAN-67-2-COR2 [Full Text] [PDF]  

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