Reviews:

Development and Cancer: At the Crossroads of Nodal and Notch Signaling

Luigi Strizzi, Katharine M. Hardy, Elisabeth A. Seftor, Fabricio F. Costa, Dawn A. Kirschmann, Richard E.B. Seftor, Lynne-Marie Postovit, and Mary J.C. Hendrix
Cancer Res 2009 69: 7131-7134. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-1199 [Abstract] [Full Text] [PDF]  

Epithelial-Mesenchymal Transition and Cell Cooperativity in Metastasis

Takanori Tsuji, Soichiro Ibaragi, and Guo-fu Hu
Cancer Res 2009 69: 7135-7139. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-1618 [Abstract] [Full Text] [PDF]  

Advances in Ewing's Sarcoma Research: Where Are We Now and What Lies Ahead?

José Luis Ordóñez, Daniel Osuna, David Herrero, Enrique de Álava, and Juan Madoz-Gúrpide
Cancer Res 2009 69: 7140-7150. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-08-4041 [Abstract] [Full Text] [PDF]  

Perspectives in Cancer Research:

Behavioral Oncology and the War on Cancer: Partnering with Biomedicine

Michael E. Stefanek, Michael A. Andrykowski, Caryn Lerman, Sharon Manne, Karen Glanz on behalf of the AACR Behavioral Science Task Force
Cancer Res 2009 69: 7151-7156. Published Online First August 25, 2009. doi: 10.1158/0008-5472.CAN-08-4005 [Abstract] [Full Text] [PDF]  

Meeting Report:

Tumor Immunology: New Perspectives

Stephanie E. McArdle and Robert C. Rees
Cancer Res 2009 69: 7157-7159. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-0631 [Abstract] [Full Text] [PDF]  

Priority Reports:

mTOR Signal and Hypoxia-Inducible Factor-1 Regulate CD133 Expression in Cancer Cells

Kazuko Matsumoto, Tokuzo Arao, Kaoru Tanaka, Hiroyasu Kaneda, Kanae Kudo, Yoshihiko Fujita, Daisuke Tamura, Keiichi Aomatsu, Tomohide Tamura, Yasuhide Yamada, Nagahiro Saijo, and Kazuto Nishio
Cancer Res 2009 69: 7160-7164. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-1289 [Abstract] [Full Text] [PDF] Supplementary Data  

miR-21: An Androgen Receptor–Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth

Judit Ribas, Xiaohua Ni, Michael Haffner, Erik A. Wentzel, Amirali Hassanzadeh Salmasi, Wasim H. Chowdhury, Tarana A. Kudrolli, Srinivasan Yegnasubramanian, Jun Luo, Ron Rodriguez, Joshua T. Mendell, and Shawn E. Lupold
Cancer Res 2009 69: 7165-7169. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-1448 [Abstract] [Full Text] [PDF] Supplementary Data  

Clear Differences in Levels of a Formaldehyde-DNA Adduct in Leukocytes of Smokers and Nonsmokers

Mingyao Wang, Guang Cheng, Silvia Balbo, Steven G. Carmella, Peter W. Villalta, and Stephen S. Hecht
Cancer Res 2009 69: 7170-7174. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-1571 [Abstract] [Full Text] [PDF]  

KDR Activating Mutations in Human Angiosarcomas Are Sensitive to Specific Kinase Inhibitors

Cristina R. Antonescu, Akihiko Yoshida, Tianhuo Guo, Ning-En Chang, Lei Zhang, Narasimhan P. Agaram, Li-Xuan Qin, Murray F. Brennan, Samuel Singer, and Robert G. Maki
Cancer Res 2009 69: 7175-7179. Published Online First September 1, 2009. doi: 10.1158/0008-5472.CAN-09-2068 [Abstract] [Full Text] [PDF]  

Cell, Tumor, and Stem Cell Biology:

Insulin Receptor Substrate-1 Suppresses Transforming Growth Factor-β1–Mediated Epithelial-Mesenchymal Transition

Jian Shi, Dong-Mei Wang, Chun-Mei Wang, Ying Hu, Ai-Hua Liu, Yong-Lian Zhang, Bing Sun, and Jian-Guo Song
Cancer Res 2009 69: 7180-7187. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-08-4470 [Abstract] [Full Text] [PDF] Supplementary Data  

Mouse Mammary Tumor Virus p75 and p110 CUX1 Transgenic Mice Develop Mammary Tumors of Various Histologic Types

Chantal Cadieux, Valérie Kedinger, Lu Yao, Charles Vadnais, Maria Drossos, Marilène Paquet, and Alain Nepveu
Cancer Res 2009 69: 7188-7197. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-08-4899 [Abstract] [Full Text] [PDF] Supplementary Data  

NEDD9 Promotes Oncogenic Signaling in Mammary Tumor Development

Eugene Izumchenko, Mahendra K. Singh, Olga V. Plotnikova, Nadezhda Tikhmyanova, Joy L. Little, Ilya G. Serebriiskii, Sachiko Seo, Mineo Kurokawa, Brian L. Egleston, Andres Klein-Szanto, Elena N. Pugacheva, Richard R. Hardy, Marina Wolfson, Denise C. Connolly, and Erica A. Golemis
Cancer Res 2009 69: 7198-7206. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-0795 [Abstract] [Full Text] [PDF]  

A Genetic Variant of Aurora Kinase A Promotes Genomic Instability Leading to Highly Malignant Skin Tumors

Enrique C. Torchia, Yiyun Chen, Hong Sheng, Hiroshi Katayama, James Fitzpatrick, William R. Brinkley, Carlos Caulin, Subrata Sen, and Dennis R. Roop
Cancer Res 2009 69: 7207-7215. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-1059 [Abstract] [Full Text] [PDF] Supplementary Data  

Epigenetic Loss of Mucosa-Associated Lymphoid Tissue 1 Expression in Patients with Oral Carcinomas

Tadashige Chiba, Genta Maeda, Shuichi Kawashiri, Koroku Kato, and Kazushi Imai
Cancer Res 2009 69: 7216-7223. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-1140 [Abstract] [Full Text] [PDF] Supplementary Data  

Tuberous Sclerosis Complex Suppression in Cerebellar Development and Medulloblastoma: Separate Regulation of Mammalian Target of Rapamycin Activity and p27^Kip1 Localization

Bobby Bhatia, Paul A. Northcott, Dolores Hambardzumyan, Baskaran Govindarajan, Daniel J. Brat, Jack L. Arbiser, Eric C. Holland, Michael D. Taylor, and Anna Marie Kenney
Cancer Res 2009 69: 7224-7234. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-1299 [Abstract] [Full Text] [PDF] Supplementary Data  

Mitochondrial Expression and Functional Activity of Breast Cancer Resistance Protein in Different Multiple Drug-Resistant Cell Lines

Michela Solazzo, Ornella Fantappiè, Massimo D'Amico, Chiara Sassoli, Alessia Tani, Greta Cipriani, Costanza Bogani, Lucia Formigli, and Roberto Mazzanti
Cancer Res 2009 69: 7235-7242. Published Online First August 25, 2009. doi: 10.1158/0008-5472.CAN-08-4315 [Abstract] [Full Text] [PDF]  

Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1

Chris Folkins, Yuval Shaked, Shan Man, Terence Tang, Christina R. Lee, Zhenping Zhu, Robert M. Hoffman, and Robert S. Kerbel
Cancer Res 2009 69: 7243-7251. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-0167 [Abstract] [Full Text] [PDF] Supplementary Data  

Matrix Metalloproteinase 12 Overexpression in Lung Epithelial Cells Plays a Key Role in Emphysema to Lung Bronchioalveolar Adenocarcinoma Transition

Peng Qu, Hong Du, Xi Wang, and Cong Yan
Cancer Res 2009 69: 7252-7261. Published Online First August 25, 2009. doi: 10.1158/0008-5472.CAN-09-0577 [Abstract] [Full Text] [PDF] Supplementary Data  

Irradiation Alters Selection for Oncogenic Mutations in Hematopoietic Progenitors

Andriy Marusyk, Matias Casás-Selves, Curtis J. Henry, Vadym Zaberezhnyy, Jelena Klawitter, Uwe Christians, and James DeGregori
Cancer Res 2009 69: 7262-7269. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-0604 [Abstract] [Full Text] [PDF] Supplementary Data  

Endocrinology:

Role of Cyclic AMP Response Element–Binding Protein in Insulin-like Growth Factor-I Receptor Up-regulation by Sex Steroids in Prostate Cancer Cells

Marco Genua, Giuseppe Pandini, Diego Sisci, Gabriella Castoria, Marcello Maggiolini, Riccardo Vigneri, and Antonino Belfiore
Cancer Res 2009 69: 7270-7277. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-0088 [Abstract] [Full Text] [PDF] Supplementary Data, updated 9/11/09  

Inactivation of the Carney Complex Gene 1 (Protein Kinase A Regulatory Subunit 1A) Inhibits SMAD3 Expression and TGFβ-Stimulated Apoptosis in Adrenocortical Cells

Bruno Ragazzon, Laure Cazabat, Marthe Rizk-Rabin, Guillaume Assie, Lionel Groussin, Hélène Fierrard, Karine Perlemoine, Antoine Martinez, and Jérôme Bertherat
Cancer Res 2009 69: 7278-7284. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-1601 [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Essential Role of DNA Base Excision Repair on Survival in an Acidic Tumor Microenvironment

Yuji Seo and Timothy J. Kinsella
Cancer Res 2009 69: 7285-7293. Published Online First September 1, 2009. doi: 10.1158/0008-5472.CAN-09-0624 [Abstract] [Full Text] [PDF]  

Structural Basis for the Inhibition of Human 5,10-Methenyltetrahydrofolate Synthetase by N10-Substituted Folate Analogues

Dong Wu, Yang Li, Gaojie Song, Chongyun Cheng, Rongguang Zhang, Andrzej Joachimiak, Neil Shaw, and Zhi-Jie Liu
Cancer Res 2009 69: 7294-7301. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-1927 [Abstract] [Full Text] [PDF] Supplementary Data  

17-Hydroxy-jolkinolide B Inhibits Signal Transducers and Activators of Transcription 3 Signaling by Covalently Cross-Linking Janus Kinases and Induces Apoptosis of Human Cancer Cells

Ying Wang, Xiuquan Ma, Shousheng Yan, Shensi Shen, Huiling Zhu, Yuan Gu, Hongbing Wang, Guowei Qin, and Qiang Yu
Cancer Res 2009 69: 7302-7310. Published Online First August 25, 2009. doi: 10.1158/0008-5472.CAN-09-0462 [Abstract] [Full Text] [PDF] Supplementary Data  

Genetic Alterations in the Phosphoinositide 3-Kinase/Akt Signaling Pathway Confer Sensitivity of Thyroid Cancer Cells to Therapeutic Targeting of Akt and Mammalian Target of Rapamycin

Dingxie Liu, Peng Hou, Zhi Liu, Guojun Wu, and Mingzhao Xing
Cancer Res 2009 69: 7311-7319. Published Online First August 25, 2009. doi: 10.1158/0008-5472.CAN-09-1077 [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

Integrin 2 Mediates Selective Metastasis to the Liver

Kiyoshi Yoshimura, Kristen F. Meckel, Lindsay S. Laird, Christina Y. Chia, Jang-June Park, Kelly L. Olino, Ryouichi Tsunedomi, Toshio Harada, Norio Iizuka, Shoichi Hazama, Yukihiko Kato, Jesse W. Keller, John M. Thompson, Fumin Chang, Lewis H. Romer, Ajay Jain, Christine Iacobuzio-Donahue, Masaaki Oka, Drew M. Pardoll, and Richard D. Schulick
Cancer Res 2009 69: 7320-7328. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-0315 [Abstract] [Full Text] [PDF] Supplementary Data  

In situ Stimulation of CD40 and Toll-like Receptor 3 Transforms Ovarian Cancer–Infiltrating Dendritic Cells from Immunosuppressive to Immunostimulatory Cells

Uciane K. Scarlett, Juan R. Cubillos-Ruiz, Yolanda C. Nesbeth, Diana G. Martinez, Xavier Engle, Andrew T. Gewirtz, Cory L. Ahonen, and Jose R. Conejo-Garcia
Cancer Res 2009 69: 7329-7337. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-0835 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

Mutation-Independent Anaplastic Lymphoma Kinase Overexpression in Poor Prognosis Neuroblastoma Patients

Lorena Passoni, Luca Longo, Paola Collini, Addolorata Maria Luce Coluccia, Fabio Bozzi, Marta Podda, Andrea Gregorio, Claudio Gambini, Alberto Garaventa, Vito Pistoia, Federica Del Grosso, Gian Paolo Tonini, Mangeng Cheng, Carlo Gambacorti-Passerini, Andrea Anichini, Franca Fossati-Bellani, Massimo Di Nicola, and Roberto Luksch
Cancer Res 2009 69: 7338-7346. Published Online First September 1, 2009. doi: 10.1158/0008-5472.CAN-08-4419 [Abstract] [Full Text] [PDF] Supplementary Data  

Pomalidomide and Lenalidomide Induce p21^WAF-1 Expression in Both Lymphoma and Multiple Myeloma through a LSD1-Mediated Epigenetic Mechanism

Laure Escoubet-Lozach, I-Lin Lin, Kristen Jensen-Pergakes, Helen A. Brady, Anita K. Gandhi, Peter H. Schafer, George W. Muller, Peter J. Worland, Kyle W.H. Chan, and Dominique Verhelle
Cancer Res 2009 69: 7347-7356. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-08-4898 [Abstract] [Full Text] [PDF]  

Identification of Novel Gene Amplifications in Breast Cancer and Coexistence of Gene Amplification with an Activating Mutation of PIK3CA

Mitsutaka Kadota, Misako Sato, Beverly Duncan, Akira Ooshima, Howard H. Yang, Natacha Diaz-Meyer, Sheryl Gere, Shun-Ichiro Kageyama, Junya Fukuoka, Takuya Nagata, Kazuhiro Tsukada, Barbara K. Dunn, Lalage M. Wakefield, and Maxwell P. Lee
Cancer Res 2009 69: 7357-7365. Published Online First August 25, 2009. doi: 10.1158/0008-5472.CAN-09-0064 [Abstract] [Full Text] [PDF] Supplementary Data  

Dysfunctional Transforming Growth Factor-β Receptor II Accelerates Prostate Tumorigenesis in the TRAMP Mouse Model

Hong Pu, Joanne Collazo, Elisabeth Jones, Dustin Gayheart, Shinichi Sakamoto, Adam Vogt, Bonnie Mitchell, and Natasha Kyprianou
Cancer Res 2009 69: 7366-7374. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-0758 [Abstract] [Full Text] [PDF] Supplementary Data  

Down-regulation of Suppressor of Cytokine Signaling-3 Causes Prostate Cancer Cell Death through Activation of the Extrinsic and Intrinsic Apoptosis Pathways

Martin Puhr, Frédéric R. Santer, Hannes Neuwirt, Martin Susani, Jeffrey A. Nemeth, Alfred Hobisch, Lukas Kenner, and Zoran Culig
Cancer Res 2009 69: 7375-7384. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-0806 [Abstract] [Full Text] [PDF] Supplementary Data  

Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma

Yujin Hoshida, Sebastian M.B. Nijman, Masahiro Kobayashi, Jennifer A. Chan, Jean-Philippe Brunet, Derek Y. Chiang, Augusto Villanueva, Philippa Newell, Kenji Ikeda, Masaji Hashimoto, Goro Watanabe, Stacey Gabriel, Scott L. Friedman, Hiromitsu Kumada, Josep M. Llovet, and Todd R. Golub
Cancer Res 2009 69: 7385-7392. Published Online First September 1, 2009. doi: 10.1158/0008-5472.CAN-09-1089 [Abstract] [Full Text] [PDF] Supplementary Data  

Glomus Tumors in Neurofibromatosis Type 1: Genetic, Functional, and Clinical Evidence of a Novel Association

Hilde Brems, Caroline Park, Ophélia Maertens, Alexander Pemov, Ludwine Messiaen, Meena Upadhyaya, Kathleen Claes, Eline Beert, Kristel Peeters, Victor Mautner, Jennifer L. Sloan, Lawrence Yao, Chyi-Chia Richard Lee, Raf Sciot, Luc De Smet, Eric Legius, and Douglas R. Stewart
Cancer Res 2009 69: 7393-7401. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-1752 [Abstract] [Full Text] [PDF] Supplementary Data  

The Neuroendocrine-Derived Peptide Parathyroid Hormone–Related Protein Promotes Prostate Cancer Cell Growth by Stabilizing the Androgen Receptor

John DaSilva, Daniel Gioeli, Michael J. Weber, and Sarah J. Parsons
Cancer Res 2009 69: 7402-7411. Published Online First August 25, 2009. doi: 10.1158/0008-5472.CAN-08-4687 [Abstract] [Full Text] [PDF]  

DNMT1 and DNMT3B Modulate Distinct Polycomb-Mediated Histone Modifications in Colon Cancer

Bilian Jin, Bing Yao, Jian-Liang Li, C. Robert Fields, Amber L. Delmas, Chen Liu, and Keith D. Robertson
Cancer Res 2009 69: 7412-7421. Published Online First September 1, 2009. doi: 10.1158/0008-5472.CAN-09-0116 [Abstract] [Full Text] [PDF] Supplementary Data  

Colorectal Cancer Risk Is Not Associated with Increased Levels of Homozygosity in a Population from the United Kingdom

Sarah L. Spain, Jean-Baptiste Cazier, The CORGI Consortium,, Richard Houlston, Luis Carvajal-Carmona, and Ian Tomlinson
Cancer Res 2009 69: 7422-7429. Published Online First September 1, 2009. doi: 10.1158/0008-5472.CAN-09-0659 [Abstract] [Full Text] [PDF] Supplementary Data  

The Receptor Tyrosine Kinase EPHB4 Has Tumor Suppressor Activities in Intestinal Tumorigenesis

Higinio Dopeso, Silvia Mateo-Lozano, Rocco Mazzolini, Paulo Rodrigues, Laura Lagares-Tena, Julian Ceron, Jordi Romero, Marielle Esteves, Stefania Landolfi, Javier Hernández-Losa, Julio Castaño, Andrew J. Wilson, Santiago Ramon y Cajal, John M. Mariadason, Simo Schwartz, Jr., and Diego Arango
Cancer Res 2009 69: 7430-7438. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-0706 [Abstract] [Full Text] [PDF] Supplementary Data  

Prevention:

Elevated Epithelial Insulin-like Growth Factor Expression Is a Risk Factor for Lung Cancer Development

Woo-Young Kim, Quanri Jin, Seung-Hyun Oh, Edward S. Kim, Youn Joo Yang, Dong Hoon Lee, Lei Feng, Carmen Behrens, Ludmila Prudkin, York E. Miller, J. Jack Lee, Scott M. Lippman, Waun Ki Hong, Ignacio I. Wistuba, and Ho-Young Lee
Cancer Res 2009 69: 7439-7448. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-08-3792 [Abstract] [Full Text] [PDF] Supplementary Data  

Resveratrol Suppresses Growth of Human Ovarian Cancer Cells in Culture and in a Murine Xenograft Model: Eukaryotic Elongation Factor 1A2 as a Potential Target

Mee-Hyun Lee, Bu Young Choi, Joydeb Kumar Kundu, Young Kee Shin, Hye-Kyung Na, and Young-Joon Surh
Cancer Res 2009 69: 7449-7458. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-1266 [Abstract] [Full Text] [PDF] Supplementary Data  

Systems Biology and Emerging Technologies:

A Risk Variant in an miR-125b Binding Site in BMPR1B Is Associated with Breast Cancer Pathogenesis

Pål Sætrom, Jacob Biesinger, Sierra M. Li, David Smith, Laurent F. Thomas, Karim Majzoub, Guillermo E. Rivas, Jessica Alluin, John J. Rossi, Theodore G. Krontiris, Jeffrey Weitzel, Mary B. Daly, Al B. Benson, John M. Kirkwood, Peter J. O'Dwyer, Rebecca Sutphen, James A. Stewart, David Johnson, and Garrett P. Larson
Cancer Res 2009 69: 7459-7465. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-09-1201 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor Microenvironment:

Inhibition of Tumor Growth Progression by Antiandrogens and mTOR Inhibitor in a Pten-Deficient Mouse Model of Prostate Cancer

Weisheng Zhang, Joe Zhu, Clay L. Efferson, Chris Ware, Jennifer Tammam, Minilik Angagaw, Jason Laskey, Kimberly A. Bettano, Shailaja Kasibhatla, John F. Reilly, Cyrille Sur, and Pradip K. Majumder
Cancer Res 2009 69: 7466-7472. Published Online First September 8, 2009. doi: 10.1158/0008-5472.CAN-08-4385 [Abstract] [Full Text] [PDF] Supplementary Data  

Parathyroid Hormone–Related Protein Protects against Mammary Tumor Emergence and Is Associated with Monocyte Infiltration in Ductal Carcinoma In situ

Nicholas I. Fleming, Melanie K. Trivett, Joshy George, John L. Slavin, William K. Murray, Jane M. Moseley, Robin L. Anderson, and David M. Thomas
Cancer Res 2009 69: 7473-7479. Published Online First September 1, 2009. doi: 10.1158/0008-5472.CAN-09-0194 [Abstract] [Full Text] [PDF]  

Letter to the Editor:

Confounding Effects in "A Six-Gene Signature Predicting Breast Cancer Lung Metastasis"

Aedín C. Culhane and John Quackenbush
Cancer Res 2009 69: 7480-7485. Published Online First September 1, 2009. doi: 10.1158/0008-5472.CAN-08-3350 [Abstract] [Full Text] [PDF] Supplementary Data  

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