Reviews:

Differences in Tumor Regulatory T-Cell Localization and Activation Status Impact Patient Outcome

Christine Ménétrier-Caux, Michael Gobert, and Christophe Caux
Cancer Res 2009 69: 7895-7898. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-1642 [Abstract] [Full Text] [PDF]  

Revving the Throttle on an Oncogene: CDK8 Takes the Driver Seat

Ron Firestein and William C. Hahn
Cancer Res 2009 69: 7899-7901. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-1704 [Abstract] [Full Text] [PDF]  

Meeting Report:

Frontiers of Biomedical Imaging Science 2009: Workshop Report and Research Opportunities

Thomas E. Yankeelov, Malcolm J. Avison, Bruce M. Damon, H. Charles Manning, Todd E. Peterson, and John C. Gore
Cancer Res 2009 69: 7902-7904. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-2521 [Full Text] [PDF]  

Priority Reports:

Direct Evidence that Bevacizumab, an Anti-VEGF Antibody, Up-regulates SDF1, CXCR4, CXCL6, and Neuropilin 1 in Tumors from Patients with Rectal Cancer

Lei Xu, Dan G. Duda, Emmanuelle di Tomaso, Marek Ancukiewicz, Daniel C. Chung, Gregory Y. Lauwers, Rekha Samuel, Paul Shellito, Brian G. Czito, Pei-Chun Lin, Martin Poleski, Rex Bentley, Jeffrey W. Clark, Christopher G. Willett, and Rakesh K. Jain
Cancer Res 2009 69: 7905-7910. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-09-2099 [Abstract] [Full Text] [PDF]  

A Novel PTEN-Dependent Link to Ubiquitination Controls FLIP_S Stability and TRAIL Sensitivity in Glioblastoma Multiforme

Amith Panner, Courtney A. Crane, Changjiang Weng, Alberto Feletti, Andrew T. Parsa, and Russell O. Pieper
Cancer Res 2009 69: 7911-7916. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-1287 [Abstract] [Full Text] [PDF]  

Cell, Tumor, and Stem Cell Biology:

Senescence-Associated Oxidative DNA Damage Promotes the Generation of Neoplastic Cells

Karo Gosselin, Sébastien Martien, Albin Pourtier, Chantal Vercamer, Peter Ostoich, Luc Morat, Laure Sabatier, Laurence Duprez, Claire T'Kint de Roodenbeke, Eric Gilson, Nicolas Malaquin, Nicolas Wernert, Predrag Slijepcevic, Marjan Ashtari, Fazia Chelli, Emeric Deruy, Bernard Vandenbunder, Yvan De Launoit, and Corinne Abbadie
Cancer Res 2009 69: 7917-7925. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-08-2510 [Abstract] [Full Text] [PDF] Supplementary Data  

In vivo, Noninvasive, Label-Free Detection and Eradication of Circulating Metastatic Melanoma Cells Using Two-Color Photoacoustic Flow Cytometry with a Diode Laser

Ekaterina I. Galanzha, Evgeny V. Shashkov, Paul M. Spring, James Y. Suen, and Vladimir P. Zharov
Cancer Res 2009 69: 7926-7934. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-08-4900 [Abstract] [Full Text] [PDF] Supplementary Data  

EBV-Induced Human CD8⁺ NKT Cells Suppress Tumorigenesis by EBV-Associated Malignancies

He Yuling, Xiao Ruijing, Li Li, Ji Xiang, Zhou Rui, Wang Yujuan, Zhang Lijun, Du Chunxian, Tan Xinti, Xiao Wei, Chen Lang, Jiang Yanping, Xiong Tao, Wu Mengjun, Xiong Jie, Jin Youxin, and Tan Jinquan
Cancer Res 2009 69: 7935-7944. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-0828 [Abstract] [Full Text] [PDF] Supplementary Data  

Magnetic Resonance Imaging Defines Cervicovaginal Anatomy, Cancer, and VEGF Trap Antiangiogenic Efficacy in Estrogen-Treated K14-HPV16 Transgenic Mice

Joel R. Garbow, Andrea C. Santeford, Jeff R. Anderson, John A. Engelbach, and Jeffrey M. Arbeit
Cancer Res 2009 69: 7945-7952. Published Online First September 29, 2009. doi: 10.1158/0008-5472.CAN-09-1271 [Abstract] [Full Text] [PDF] Supplementary Data  

Sox11 Prevents Tumorigenesis of Glioma-Initiating Cells by Inducing Neuronal Differentiation

Takuichiro Hide, Tatsuya Takezaki, Yuka Nakatani, Hideo Nakamura, Jun-ichi Kuratsu, and Toru Kondo
Cancer Res 2009 69: 7953-7959. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-2006 [Abstract] [Full Text] [PDF] Supplementary Data  

Phosphorylation and Degradation of MdmX Is Inhibited by Wip1 Phosphatase in the DNA Damage Response

Xinna Zhang, Lin Lin, Huarong Guo, Jianhua Yang, Stephen N. Jones, Aart Jochemsen, and Xiongbin Lu
Cancer Res 2009 69: 7960-7968. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-0634 [Abstract] [Full Text] [PDF] Supplementary Data  

Intravital Imaging Reveals Transient Changes in Pigment Production and Brn2 Expression during Metastatic Melanoma Dissemination

Sophie Pinner, Peter Jordan, Kirsty Sharrock, Laura Bazley, Lucy Collinson, Richard Marais, Elise Bonvin, Colin Goding, and Erik Sahai
Cancer Res 2009 69: 7969-7977. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-09-0781 [Abstract] [Full Text] [PDF] Supplementary Data  

The Cytoskeleton Protein Filamin-A Is Required for an Efficient Recombinational DNA Double Strand Break Repair

Jingyin Yue, Qin Wang, Huimei Lu, Mark Brenneman, Feiyue Fan, and Zhiyuan Shen
Cancer Res 2009 69: 7978-7985. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-2177 [Abstract] [Full Text] [PDF] Supplementary Data  

Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

Chendong Yang, Jessica Sudderth, Tuyen Dang, Robert G. Bachoo, Jeffrey G. McDonald, and Ralph J. DeBerardinis
Cancer Res 2009 69: 7986-7993. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-09-2266 [Abstract] [Full Text] [PDF] Supplementary Data  

Epidemiology:

Candidate Gene Association Study of Esophageal Squamous Cell Carcinoma in a High-Risk Region in Iran

Mohammad R. Akbari, Reza Malekzadeh, Ramin Shakeri, Dariush Nasrollahzadeh, Maryam Foumani, Yulong Sun, Akram Pourshams, Alireza Sadjadi, Elham Jafari, Masoud Sotoudeh, Farin Kamangar, Paolo Boffetta, Sanford M. Dawsey, Parviz Ghadirian, and Steven A. Narod
Cancer Res 2009 69: 7994-8000. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-09-1149 [Abstract] [Full Text] [PDF] Supplementary Data  

Apolipoprotein E/C1 Locus Variants Modify Renal Cell Carcinoma Risk

Lee E. Moore, Paul Brennan, Sara Karami, Idan Menashe, Sonja I. Berndt, Linda M. Dong, Allison Meisner, Meredith Yeager, Stephen Chanock, Joanne Colt, Kendra Schwartz, Faith Davis, David Zaridze, Vsevolod Mattveev, Vladimir Janout, Hellena Kollarova, Vladimir Bencko, Marie Navratilova, Neonilia Szeszenia-Dabrowska, Dana Mates, Ivana Holcatova, Paolo Boffetta, Wong-Ho Chow, Philip S. Rosenberg, and Nathaniel Rothman
Cancer Res 2009 69: 8001-8008. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-1734 [Abstract] [Full Text] [PDF] Supplementary Data  

Experimental Therapeutics, Molecular Targets, and Chemical Biology:

Inhibition of Tumor Cell Growth, Invasion, and Metastasis by EXEL-2880 (XL880, GSK1363089), a Novel Inhibitor of HGF and VEGF Receptor Tyrosine Kinases

Fawn Qian, Stefan Engst, Kyoko Yamaguchi, Peiwen Yu, Kwang-Ai Won, Lillian Mock, Tracy Lou, Jenny Tan, Connie Li, Danny Tam, Julie Lougheed, F. Michael Yakes, Frauke Bentzien, Wei Xu, Tal Zaks, Richard Wooster, Joel Greshock, and Alison H. Joly
Cancer Res 2009 69: 8009-8016. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-08-4889 [Abstract] [Full Text] [PDF] Supplementary Data  

A Novel Experimental Heme Oxygenase-1–Targeted Therapy for Hormone-Refractory Prostate Cancer

Moulay A. Alaoui-Jamali, Tarek A. Bismar, Ajay Gupta, Walter A. Szarek, Jie Su, Wei Song, Yingjie Xu, Bin Xu, Guoan Liu, Jason Z. Vlahakis, Gheorghe Roman, Jinsong Jiao, and Hyman M. Schipper
Cancer Res 2009 69: 8017-8024. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-0419 [Abstract] [Full Text] [PDF] Supplementary Data  

Structural Basis for the Binding of the Anticancer Compound 6-(7-Nitro-2,1,3-Benzoxadiazol-4-Ylthio)Hexanol to Human Glutathione S-Transferases

Luca Federici, Carlo Lo Sterzo, Silvia Pezzola, Adele Di Matteo, Flavio Scaloni, Giorgio Federici, and Anna Maria Caccuri
Cancer Res 2009 69: 8025-8034. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-1314 [Abstract] [Full Text] [PDF]  

Overexpression of Kinesins Mediates Docetaxel Resistance in Breast Cancer Cells

Sarmishtha De, Rocky Cipriano, Mark W. Jackson, and George R. Stark
Cancer Res 2009 69: 8035-8042. Published Online First September 29, 2009. doi: 10.1158/0008-5472.CAN-09-1224 [Abstract] [Full Text] [PDF]  

Tpl2 Is a Key Mediator of Arsenite-Induced Signal Transduction

Kyung Mi Lee, Ki Won Lee, Ann M. Bode, Hyong Joo Lee, and Zigang Dong
Cancer Res 2009 69: 8043-8049. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-2316 [Abstract] [Full Text] [PDF] Supplementary Data  

Immunology:

Anticancer Chemotherapy Inhibits MHC Class I–Related Chain A Ectodomain Shedding by Downregulating ADAM10 Expression in Hepatocellular Carcinoma

Keisuke Kohga, Tetsuo Takehara, Tomohide Tatsumi, Takuya Miyagi, Hisashi Ishida, Kazuyoshi Ohkawa, Tatsuya Kanto, Naoki Hiramatsu, and Norio Hayashi
Cancer Res 2009 69: 8050-8057. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-09-0789 [Abstract] [Full Text] [PDF] Supplementary Data  

Immunoselection of Breast and Ovarian Cancer Cells with Trastuzumab and Natural Killer Cells: Selective Escape of CD44^high/CD24^low/HER2^low Breast Cancer Stem Cells

Florian Reim, Yvonne Dombrowski, Cathrin Ritter, Mathias Buttmann, Sebastian Häusler, Monika Ossadnik, Mathias Krockenberger, Dagmar Beier, Christoph P. Beier, Johannes Dietl, Jürgen C. Becker, Arnd Hönig, and Jörg Wischhusen
Cancer Res 2009 69: 8058-8066. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-09-0834 [Abstract] [Full Text] [PDF]  

Kupffer Cell Suppression of CD8⁺ T Cells in Human Hepatocellular Carcinoma Is Mediated by B7-H1/Programmed Death-1 Interactions

Ke Wu, Ilona Kryczek, Lieping Chen, Weiping Zou, and Theodore H. Welling
Cancer Res 2009 69: 8067-8075. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-09-0901 [Abstract] [Full Text] [PDF]  

Human Suppressor of Cytokine Signaling 1 Controls Immunostimulatory Activity of Monocyte-Derived Dendritic Cells

Bangxing Hong, Wenhong Ren, Xiao-Tong Song, Kevin Evel-Kabler, Si-Yi Chen, and Xue F. Huang
Cancer Res 2009 69: 8076-8084. Published Online First September 29, 2009. doi: 10.1158/0008-5472.CAN-09-1507 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor Antigen–Specific FOXP3+ CD4 T Cells Identified in Human Metastatic Melanoma: Peptide Vaccination Results in Selective Expansion of Th1-like Counterparts

Camilla Jandus, Gilles Bioley, Danijel Dojcinovic, Laurent Derré, Lukas Baitsch, Sébastien Wieckowski, Nathalie Rufer, William W. Kwok, Jean-Marie Tiercy, Immanuel F. Luescher, Daniel E. Speiser, and Pedro Romero
Cancer Res 2009 69: 8085-8093. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-2226 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Biology, Pathobiology, and Genetics:

Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling Complex

Xi Wang, Courtney G. Sansam, Christopher S. Thom, Daniel Metzger, Julia A. Evans, Phuong T.L. Nguyen, and Charles W.M. Roberts
Cancer Res 2009 69: 8094-8101. Published Online First September 29, 2009. doi: 10.1158/0008-5472.CAN-09-0733 [Abstract] [Full Text] [PDF] Supplementary Data  

Induction of Prostatic Intraepithelial Neoplasia and Modulation of Androgen Receptor by ETS Variant 1/ETS-Related Protein 81

Sook Shin, Tae-Dong Kim, Fang Jin, Jan M. van Deursen, Scott M. Dehm, Donald J. Tindall, Joseph P. Grande, Jan-Marie Munz, George Vasmatzis, and Ralf Janknecht
Cancer Res 2009 69: 8102-8110. Published Online First September 29, 2009. doi: 10.1158/0008-5472.CAN-09-0941 [Abstract] [Full Text] [PDF] Supplementary Data  

Runt-Related Transcription Factor RUNX3 Is a Target of MDM2-Mediated Ubiquitination

Xin-Zi Chi, Jiyeon Kim, Yong-Hee Lee, Jung-Won Lee, Kyeong-Sook Lee, Heejun Wee, Wun-Jae Kim, Woo-Yoon Park, Byung-Chul Oh, Gary S. Stein, Yoshiaki Ito, Andre J. van Wijnen, and Suk-Chul Bae
Cancer Res 2009 69: 8111-8119. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-1057 [Abstract] [Full Text] [PDF] Supplementary Data  

ARTEMIS Nuclease Facilitates Apoptotic Chromatin Cleavage

Sébastien Britton, Philippe Frit, Denis Biard, Bernard Salles, and Patrick Calsou
Cancer Res 2009 69: 8120-8126. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-08-4400 [Abstract] [Full Text] [PDF] Supplementary Data  

Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines

Matthias Schaefer, Sabine Hagemann, Katharina Hanna, and Frank Lyko
Cancer Res 2009 69: 8127-8132. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-0458 [Abstract] [Full Text] [PDF]  

Novel Lipogenic Enzyme ELOVL7 Is Involved in Prostate Cancer Growth through Saturated Long-Chain Fatty Acid Metabolism

Kenji Tamura, Asami Makino, Françoise Hullin-Matsuda, Toshihide Kobayashi, Mutsuo Furihata, Suyoun Chung, Shingo Ashida, Tsuneharu Miki, Tomoaki Fujioka, Taro Shuin, Yusuke Nakamura, and Hidewaki Nakagawa
Cancer Res 2009 69: 8133-8140. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-09-0775 [Abstract] [Full Text] [PDF] Supplementary DataSupplementary Data  

Increased Expression of Androgen Receptor Sensitizes Prostate Cancer Cells to Low Levels of Androgens

Kati K. Waltering, Merja A. Helenius, Biswajyoti Sahu, Visa Manni, Marika J. Linja, Olli A. Jänne, and Tapio Visakorpi
Cancer Res 2009 69: 8141-8149. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-0919 [Abstract] [Full Text] [PDF] Supplementary Data  

A Modified Sleeping Beauty Transposon System That Can Be Used to Model a Wide Variety of Human Cancers in Mice

Adam J. Dupuy, Laura M. Rogers, Jinsil Kim, Kishore Nannapaneni, Timothy K. Starr, Pentao Liu, David A. Largaespada, Todd E. Scheetz, Nancy A. Jenkins, and Neal G. Copeland
Cancer Res 2009 69: 8150-8156. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-1135 [Abstract] [Full Text] [PDF] Supplementary Data  

microRNA-21 Negatively Regulates Cdc25A and Cell Cycle Progression in Colon Cancer Cells

Peng Wang, Fangdong Zou, Xiaodong Zhang, Hua Li, Austin Dulak, Robert J. Tomko, Jr., John S. Lazo, Zhenghe Wang, Lin Zhang, and Jian Yu
Cancer Res 2009 69: 8157-8165. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-09-1996 [Abstract] [Full Text] [PDF] Supplementary Data  

Prevention:

Combination of Sulindac and Antimicrobial Eradication of Helicobacter pylori Prevents Progression of Gastric Cancer in Hypergastrinemic INS-GAS Mice

Chung-Wei Lee, Barry Rickman, Arlin B. Rogers, Sureshkumar Muthupalani, Shigeo Takaishi, Peiying Yang, Timothy C. Wang, and James G. Fox
Cancer Res 2009 69: 8166-8174. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-08-3856 [Abstract] [Full Text] [PDF] Supplementary Data  

Inhibition of Azoxymethane-Induced Colorectal Cancer by CP-31398, a TP53 Modulator, Alone or in Combination with Low Doses of Celecoxib in Male F344 Rats

Chinthalapally V. Rao, Vernon E. Steele, Malisetty V. Swamy, Jagan M.R. Patlolla, Suresh Guruswamy, and Levy Kopelovich
Cancer Res 2009 69: 8175-8182. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-09-1377 [Abstract] [Full Text] [PDF] Supplementary Data  

Molecular Consequences of Genetic Variations in the Glutathione Peroxidase 1 Selenoenzyme

Pin Zhuo, Marci Goldberg, Lauren Herman, Bao-Shiang Lee, Hengbing Wang, Rhonda L. Brown, Charles B. Foster, Ulrike Peters, and Alan M. Diamond
Cancer Res 2009 69: 8183-8190. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-09-1791 [Abstract] [Full Text] [PDF]  

Systems Biology and Emerging Technologies:

RAS Mutations Affect Tumor Necrosis Factor–Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects

Pamela K. Kreeger, Roli Mandhana, Shannon K. Alford, Kevin M. Haigis, and Douglas A. Lauffenburger
Cancer Res 2009 69: 8191-8199. Published Online First September 29, 2009. doi: 10.1158/0008-5472.CAN-09-1921 [Abstract] [Full Text] [PDF] Supplementary Data  

Protein Kinase CK2 Regulates Cytoskeletal Reorganization during Ionizing Radiation–Induced Senescence of Human Mesenchymal Stem Cells

Daojing Wang and Deok-Jin Jang
Cancer Res 2009 69: 8200-8207. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-09-1976 [Abstract] [Full Text] [PDF] Supplementary Data  

Tumor Microenvironment:

Aldehyde Dehydrogenase–Expressing Colon Stem Cells Contribute to Tumorigenesis in the Transition from Colitis to Cancer

Joseph E. Carpentino, Mark J. Hynes, Henry D. Appelman, Tong Zheng, Dennis A. Steindler, Edward W. Scott, and Emina H. Huang
Cancer Res 2009 69: 8208-8215. Published Online First October 6, 2009. doi: 10.1158/0008-5472.CAN-09-1132 [Abstract] [Full Text] [PDF] Supplementary Data  

Corrections:

Correction: Glomus Tumors in Neurofibromatosis Type 1: Genetic, Functional, and Clinical Evidence of a Novel Association

Cancer Res 2009 69: 8216. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-69-20-COR1 [Full Text] [PDF]  

Correction: Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1

Cancer Res 2009 69: 8216. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-69-20-COR2 [Full Text] [PDF]  

Correction: Genetic Alterations in the Phosphoinositide 3-Kinase/Akt Signaling Pathway Confer Sensitivity of Thyroid Cancer Cells to Therapeutic Targeting of Akt and Mammalian Target of Rapamycin

Cancer Res 2009 69: 8216. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-69-20-COR3 [Full Text] [PDF]  

Correction: Elevated Epithelial Insulin-Like Growth Factor Expression Is a RiskFactor for Lung Cancer Development

Cancer Res 2009 69: 8216. Published Online First October 13, 2009. doi: 10.1158/0008-5472.CAN-69-20-COR4 [Full Text] [PDF]  

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